{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T03:54:53Z","timestamp":1791863693411,"version":"4.3.4"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,29]],"date-time":"2024-09-29T00:00:00Z","timestamp":1727568000000},"content-version":"am","delay-in-days":364,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","award":["JPMJSP2114"],"award-info":[{"award-number":["JPMJSP2114"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19H01142"],"award-info":[{"award-number":["19H01142"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Toxicology"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.reprotox.2023.108472","type":"journal-article","created":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T22:21:42Z","timestamp":1694816502000},"page":"108472","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Early-life exposure to acephate inhibits sexual development and induces testicular and ovarian toxicity in mice"],"prefix":"10.1016","volume":"121","author":[{"given":"Takahiro","family":"Sasaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenshiro","family":"Hara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kentaro","family":"Tanemura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.reprotox.2023.108472_bib1","unstructured":"National Center for Biotechnology Information (2022). PubChem compound summary for CID 1982, acephate. [Accessed August 17, 2022]. \u3008https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/Acephate\u3009."},{"key":"10.1016\/j.reprotox.2023.108472_bib2","unstructured":"Pesticides Action Network. Substances banned and authorise. [Accessed April 11, 2023]. \u3008https:\/\/www.pan-europe.info\/old\/Archive\/About%20pesticides\/Banned%20and%20authorised.htm\u3009. Europe (2006)."},{"key":"10.1016\/j.reprotox.2023.108472_bib3","doi-asserted-by":"crossref","DOI":"10.1186\/s12940-019-0488-0","article-title":"The USA lags behind other agricultural nations in banning harmful pesticides","volume":"18","author":"Donley","year":"2019","journal-title":"Environ. Health"},{"key":"10.1016\/j.reprotox.2023.108472_bib4","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1007\/BF01183993","article-title":"Biological monitoring of human exposure to acephate","volume":"19","author":"Maroni","year":"1990","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.reprotox.2023.108472_bib5","series-title":"Encyclopedia of Toxicology","first-page":"20","author":"Acephate","year":"2014"},{"key":"10.1016\/j.reprotox.2023.108472_bib6","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S0890-6238(00)00094-0","article-title":"Reproductive toxicology of acephate in male mice","volume":"14","author":"Farag","year":"2000","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.reprotox.2023.108472_bib7","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.tiv.2015.01.001","article-title":"In vitro study of the neuropathic potential of the organophosphorus compounds trichlorfon and acephate","volume":"29","author":"Fernandes","year":"2015","journal-title":"Toxicol. Vitr."},{"key":"10.1016\/j.reprotox.2023.108472_bib8","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.bbrc.2018.05.205","article-title":"Diphenyl diselenide abrogates chlorpyrifos-induced hypothalamic-pituitary-testicular axis impairment in rats","volume":"503","author":"Adedara","year":"2018","journal-title":"Biochem Biophys. Res Commun."},{"key":"10.1016\/j.reprotox.2023.108472_bib9","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jhazmat.2011.12.073","article-title":"Endocrine-disrupting and cytotoxic potential of anticholinesterase insecticide, diazinon in reproductive toxicity of male mice","volume":"209","author":"ElMazoudy","year":"2012","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.reprotox.2023.108472_bib10","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.5897\/AJPP12.1332","article-title":"Ameliorating effect of Withania somnifera on acephate administered male albino rats","volume":"7","author":"Jasuja","year":"2013","journal-title":"Afr. J. Pharm. Pharm."},{"key":"10.1016\/j.reprotox.2023.108472_bib11","first-page":"137","article-title":"Effect of acephate on testicular functions of albino rats","volume":"3","author":"Joshi","year":"2012","journal-title":"Res. J. Pharm. Biol. Chem. Sci."},{"key":"10.1016\/j.reprotox.2023.108472_bib12","doi-asserted-by":"crossref","first-page":"5482","DOI":"10.1007\/s11356-019-07209-0","article-title":"Impairment of testicular development in rats exposed to acephate during maternal gestation and lactation","volume":"27","author":"Sampaio","year":"2020","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.reprotox.2023.108472_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2019.125597","article-title":"Acephate interferes with androgen synthesis in rat immature Leydig cells","volume":"245","author":"Wang","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.reprotox.2023.108472_bib14","doi-asserted-by":"crossref","first-page":"78","DOI":"10.6065\/apem.2019.24.2.78","article-title":"Early-life exposure to endocrine-disrupting chemicals and pubertal development in girls","volume":"24","author":"Lee","year":"2019","journal-title":"Ann. Pedia Endocrinol. Metab."},{"key":"10.1016\/j.reprotox.2023.108472_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2021.112584","article-title":"Impacts of endocrine disrupting chemicals on reproduction in wildlife and humans","volume":"208","author":"Marlatt","year":"2022","journal-title":"Environ. Res"},{"key":"10.1016\/j.reprotox.2023.108472_bib16","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/S0031-9384(00)00431-5","article-title":"Effects of stress during pregnancy on maternal behavior in mice","volume":"72","author":"Meek","year":"2001","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.reprotox.2023.108472_bib17","doi-asserted-by":"crossref","DOI":"10.3389\/fnbeh.2019.00197","article-title":"How early life stress impact maternal care: a systematic review of rodent studies","volume":"13","author":"Orso","year":"2019","journal-title":"Front Behav. Neurosci."},{"key":"10.1016\/j.reprotox.2023.108472_bib18","doi-asserted-by":"crossref","DOI":"10.1186\/s40781-018-0168-6","article-title":"Effect of cold stress on infanticide by female Swiss albino mice Mus musculus: a pilot study","volume":"60","author":"Zafar","year":"2018","journal-title":"J. Anim. Sci. Technol."},{"key":"10.1016\/j.reprotox.2023.108472_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2021.100684","article-title":"Polycystic ovary syndrome mouse model by prenatal exposure to high anti-M\u00fcllerian hormone","volume":"2","author":"Mimouni","year":"2021","journal-title":"STAR Protoc."},{"key":"10.1016\/j.reprotox.2023.108472_bib20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0035538","article-title":"Mouse estrous cycle identification tool and images","volume":"7","author":"Byers","year":"2012","journal-title":"PLOS ONE"},{"key":"10.1016\/j.reprotox.2023.108472_bib21","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.bbrc.2018.03.044","article-title":"Effects of doxorubicin on sperm DNA methylation in mouse models of testicular toxicity","volume":"498","author":"Sakai","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.reprotox.2023.108472_bib22","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1095\/biolreprod.105.039719","article-title":"The mouse epididymal transcriptome: transcriptional profiling of segmental gene expression in the epididymis","volume":"73","author":"Johnston","year":"2005","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.reprotox.2023.108472_bib23","first-page":"265","article-title":"Placental and milk transfer, disposition and elimination of a single oral dose of [14c acetyl] acephate in sprague dawley rats","volume":"1","author":"Bakry","year":"1992","journal-title":"J. Occup. Med Toxicol."},{"key":"10.1016\/j.reprotox.2023.108472_bib24","first-page":"EN-353","volume":"9","author":"EFSA","year":"2012"},{"key":"10.1016\/j.reprotox.2023.108472_bib25","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1210\/er.2011-1050","article-title":"Hormones and endocrine-disrupting chemicals: Low-dose effects and nonmonotonic dose responses","volume":"33","author":"Vandenberg","year":"2012","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.reprotox.2023.108472_bib26","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1089\/107555302317371479","article-title":"Chemical toxins: a hypothesis to explain the global obesity epidemic","volume":"8","author":"Baillie-Hamilton","year":"2002","journal-title":"J. Alter. Complement Med"},{"key":"10.1016\/j.reprotox.2023.108472_bib27","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.cmet.2014.03.031","article-title":"Estradiol regulates brown adipose tissue thermogenesis via hypothalamic AMPK","volume":"20","author":"de Morentin","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/j.reprotox.2023.108472_bib28","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/s12276-022-00741-z","article-title":"Hypothalamic control of energy expenditure and thermogenesis","volume":"54","author":"Tran","year":"2022","journal-title":"Exp. Mol. Med"},{"key":"10.1016\/j.reprotox.2023.108472_bib29","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/B978-0-12-800095-3.00003-1","article-title":"Endocrine-disrupting chemicals: elucidating our understanding of their role in sex and gender-relevant end points","volume":"94","author":"Frye","year":"2014","journal-title":"Vitam. Horm."},{"key":"10.1016\/j.reprotox.2023.108472_bib30","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s00204-018-2350-5","article-title":"Anogenital distance as a toxicological or clinical marker for fetal androgen action and risk for reproductive disorders","volume":"93","author":"Schwartz","year":"2019","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.reprotox.2023.108472_bib31","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1111\/j.1365-2605.2007.00838.x","article-title":"Endocrine-disrupting properties in vivo of widely used azole fungicides","volume":"31","author":"Taxvig","year":"2008","journal-title":"Int J. Androl."},{"key":"10.1016\/j.reprotox.2023.108472_bib32","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1530\/REP-13-0377","article-title":"Low-dose effects of bisphenol A on early sexual development in male and female rats","volume":"147","author":"Christiansen","year":"2014","journal-title":"Reproduction"},{"key":"10.1016\/j.reprotox.2023.108472_bib33","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1093\/toxsci\/kfw079","article-title":"Multiple endocrine disrupting effects in rats perinatally exposed to butylparaben","volume":"152","author":"Boberg","year":"2016","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.reprotox.2023.108472_bib34","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1093\/toxsci\/kfv332","article-title":"Intrauterine exposure to paracetamol and aniline impairs female reproductive development by reducing follicle reserves and fertility","volume":"150","author":"Holm","year":"2016","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.reprotox.2023.108472_bib35","series-title":"Delayed Puberty","author":"Tang","year":"2023"},{"key":"10.1016\/j.reprotox.2023.108472_bib36","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1210\/edrv-8-3-338","article-title":"The endocrinology and developmental biology of the prostate","volume":"8","author":"Cunha","year":"1987","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.reprotox.2023.108472_bib37","author":"McKay","year":"2022","journal-title":"Anatomy, abdomen and pelvis, seminal vesicle"},{"key":"10.1016\/j.reprotox.2023.108472_bib38","first-page":"1004","article-title":"Reproductive toxicity of organophosphate pesticides","volume":"1","author":"Mitra","year":"2018","journal-title":"Ann. Clin. Toxicol."},{"key":"10.1016\/j.reprotox.2023.108472_bib39","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.semcdb.2021.06.016","article-title":"Sertoli cells as key drivers of testis function","volume":"121","author":"O\u2019Donnell","year":"2022","journal-title":"Semin Cell Dev. Biol."},{"key":"10.1016\/j.reprotox.2023.108472_bib40","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1365-2605.1993.tb01156.x","article-title":"Histological and histopathological evaluation of the testis","volume":"16","author":"Russell","year":"1993","journal-title":"Int J. Androl."},{"key":"10.1016\/j.reprotox.2023.108472_bib41","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0378-4274(01)00298-3","article-title":"Hormones and testis development and the possible adverse effects of environmental chemicals","volume":"120","author":"Sharpe","year":"2001","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.reprotox.2023.108472_bib42","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1095\/biolreprod59.5.1084","article-title":"Abnormalities in functional development of the Sertoli cells in rats treated neonatally with diethylstilbestrol: A possible role for estrogens in Sertoli cell developmen","volume":"59","author":"Sharpe","year":"1998","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.reprotox.2023.108472_bib43","doi-asserted-by":"crossref","first-page":"5364","DOI":"10.1210\/endo.140.11.7108","article-title":"Permanent effects of neonatal estrogen exposure in rats on reproductive hormone levels, Sertoli cell number, and the efficiency of spermatogenesis in adulthood","volume":"140","author":"Atanassova","year":"1999","journal-title":"Endocrinology"},{"key":"10.1016\/j.reprotox.2023.108472_bib44","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1677\/joe.1.05884","article-title":"Evidence that androgens and oestrogens, as well as follicle-stimulating hormone, can alter Sertoli cell number in the neonatal rat","volume":"184","author":"Atanassova","year":"2005","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.reprotox.2023.108472_bib45","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.reprotox.2020.10.003","article-title":"Effect of vitamin E deficiency on spermatogenesis in mice and its similarity to aging","volume":"98","author":"Saito","year":"2020","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.reprotox.2023.108472_bib46","doi-asserted-by":"crossref","first-page":"40S","DOI":"10.1177\/0192623312454337","article-title":"Proliferative and nonproliferative lesions of the rat and mouse male reproductive system","volume":"40","author":"Creasy","year":"2012","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.reprotox.2023.108472_bib47","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.etap.2014.10.015","article-title":"Exposure to a low dose of bisphenol A impairs pituitary-ovarian axis in prepubertal rats: effects on early folliculogenesis","volume":"39","author":"Gamez","year":"2015","journal-title":"Environ. Toxicol. Pharm."},{"key":"10.1016\/j.reprotox.2023.108472_bib48","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.jsbmb.2015.11.016","article-title":"Ovarian dysfunctions in adult female rat offspring born to mothers perinatally exposed to low doses of bisphenol A","volume":"158","author":"Santamaria","year":"2016","journal-title":"J. Steroid Biochem Mol. Biol."},{"key":"10.1016\/j.reprotox.2023.108472_bib49","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.reprotox.2016.03.045","article-title":"Perinatal exposure to mixtures of endocrine disrupting chemicals reduces female rat follicle reserves and accelerates reproductive aging","volume":"61","author":"Johansson","year":"2016","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.reprotox.2023.108472_bib50","series-title":"Toxicology of organophosphate & carbamate compounds","first-page":"89","article-title":"Chapter 8 - global epidemiology of organophosphate and carbamate poisonings","author":"Satoh","year":"2006"},{"key":"10.1016\/j.reprotox.2023.108472_bib51","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.pestbp.2010.07.006","article-title":"Role of oxidative stress in organophosphate insecticide toxicity - short review","volume":"98","author":"Lukaszewicz-Hussain","year":"2010","journal-title":"Pest. Biochem Phys."},{"key":"10.1016\/j.reprotox.2023.108472_bib52","first-page":"137","article-title":"Frequent tail-tip blood sampling in mice for the assessment of pulsatile luteinizing hormone secretion","author":"McCosh","year":"2018","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.reprotox.2023.108472_bib53","doi-asserted-by":"crossref","first-page":"989","DOI":"10.3390\/ani10060989","article-title":"The impact of common recovery blood sampling methods, in mice (Mus musculus), on well-being and sample quality: a systematic review","volume":"10","author":"Whittaker","year":"2020","journal-title":"Animals"},{"issue":"Suppl 1","key":"10.1016\/j.reprotox.2023.108472_bib54","doi-asserted-by":"crossref","first-page":"SP189","DOI":"10.2131\/jts.34.S189","article-title":"Morphological characterization of the ovary under normal cycling in rats and its viewpoints of ovarian toxicity detection","volume":"34","author":"Yoshida","year":"2009","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.reprotox.2023.108472_bib55","doi-asserted-by":"crossref","first-page":"5482","DOI":"10.1007\/s11356-019-07209-0","article-title":"Impairment of testicular development in rats exposed to acephate during maternal gestation and lactation","volume":"27","author":"Sampaio","year":"2020","journal-title":"Environ. Sci. Pollut. Res"}],"container-title":["Reproductive Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623823001466?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623823001466?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T12:30:39Z","timestamp":1778761839000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0890623823001466"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":55,"alternative-id":["S0890623823001466"],"URL":"https:\/\/doi.org\/10.1016\/j.reprotox.2023.108472","relation":{},"ISSN":["0890-6238"],"issn-type":[{"value":"0890-6238","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Early-life exposure to acephate inhibits sexual development and induces testicular and ovarian toxicity in mice","name":"articletitle","label":"Article Title"},{"value":"Reproductive Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.reprotox.2023.108472","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108472"}}