{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T03:35:30Z","timestamp":1781321730321,"version":"3.54.1"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004410","name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu","doi-asserted-by":"publisher","award":["119S511"],"award-info":[{"award-number":["119S511"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Toxicology"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.reprotox.2023.108519","type":"journal-article","created":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T12:13:14Z","timestamp":1701432794000},"page":"108519","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Establishment of a 3D multicellular placental microtissues for investigating the effect of antidepressant vortioxetine"],"prefix":"10.1016","volume":"123","author":[{"given":"Selen","family":"\u00d6zt\u00fcrk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merve","family":"Demir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Arzu","family":"Ko\u00e7kaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cagatay","family":"Karaaslan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aysun K\u0131l\u0131\u00e7","family":"S\u00fclo\u011flu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.reprotox.2023.108519_bib1","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1016\/j.tiv.2009.07.028","article-title":"Modeling placental transport: correlation of in vitro BeWo cell permeability and ex vivo human placental perfusion","volume":"23","author":"Poulsen","year":"2009","journal-title":"Toxicol. Vitr."},{"key":"10.1016\/j.reprotox.2023.108519_bib2","series-title":"Biomarkers Toxicol","first-page":"325","article-title":"Biomarkers of toxicity in human placenta","author":"V\u00e4h\u00e4kangas","year":"2014"},{"key":"10.1016\/j.reprotox.2023.108519_bib3","article-title":"Placenta and trophoblast","volume":"Volume I","author":"Soares J","year":"2006","journal-title":"Methods Protoc."},{"key":"10.1016\/j.reprotox.2023.108519_bib4","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1124\/dmd.110.033571","article-title":"The role of the placenta in fetal exposure to xenobiotics: importance of membrane transporters and human models for transfer studies","volume":"38","author":"Prouillac","year":"2010","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.reprotox.2023.108519_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-23410-6","article-title":"An advanced human in vitro co-culture model for translocation studies across the placental barrier","volume":"8","author":"Aengenheister","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.reprotox.2023.108519_bib6","first-page":"1","article-title":"Engineering multi\u2010cellular spheroids for tissue engineering and regenerative medicine","volume":"0","author":"Kim","year":"2020","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.reprotox.2023.108519_bib7","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.reprotox.2017.07.002","article-title":"Beyond organoids: in vitro vasculogenesis and angiogenesis using cells from mammals and zebrafish","volume":"73","author":"Ibrahim","year":"2017","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.reprotox.2023.108519_bib8","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1089\/ten.2006.0190","article-title":"Dynamics of the self-assembly of complex cellular aggregates on micromolded nonadhesive hydrogels","volume":"13","author":"Napolitano","year":"2007","journal-title":"Tissue Eng."},{"key":"10.1016\/j.reprotox.2023.108519_bib9","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1089\/ten.tec.2011.0478","article-title":"Quantification of the kinetics and extent of self-sorting in three dimensional spheroids","volume":"18","author":"Achilli","year":"2012","journal-title":"Tissue Eng. - Part C. Methods"},{"key":"10.1016\/j.reprotox.2023.108519_bib10","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1089\/ten.tec.2015.0135","article-title":"Three-dimensional neural spheroid culture: an in vitro model for cortical studies","volume":"21","author":"Dingle","year":"2015","journal-title":"Tissue Eng. Part C. Methods"},{"key":"10.1016\/j.reprotox.2023.108519_bib11","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1089\/ten.tec.2014.0439","article-title":"Bio-pick, place, and perfuse: a new instrument for three-dimensional tissue engineering","volume":"21","author":"Blakely","year":"2015","journal-title":"Tissue Eng. - Part C. Methods"},{"key":"10.1016\/j.reprotox.2023.108519_bib12","first-page":"142","article-title":"Gebelikte Depresyon: S\u0131kl\u0131k, Risk Fakt\u00f6rleri ve Tedavisi","volume":"3","author":"\u00c7al\u0131k","year":"2011","journal-title":"Psikiyatr. G\u00fcncel Yakla\u015f\u0131mlar"},{"key":"10.1016\/j.reprotox.2023.108519_bib13","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.neubiorev.2017.06.008","article-title":"The effects of maternal antidepressant use on offspring behaviour and brain development: Implications for risk of neurodevelopmental disorders","volume":"80","author":"Millard","year":"2017","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.reprotox.2023.108519_bib14","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1007\/s00737-016-0637-1","article-title":"Use of selective serotonin reuptake inhibitors (SSRIs) in women delivering liveborn infants and other women of child-bearing age within the U.S. Food and Drug Administration\u2019s Mini-Sentinel program","volume":"19","author":"Andrade","year":"2016","journal-title":"Arch. Women\u2019s. Ment. Health"},{"key":"10.1016\/j.reprotox.2023.108519_bib15","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1080\/17460441.2019.1546691","article-title":"Vortioxetine: a novel antidepressant for the treatment of major depressive disorder","volume":"14","author":"Gonda","year":"2019","journal-title":"Expert Opin. Drug Discov."},{"key":"10.1016\/j.reprotox.2023.108519_bib16","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1177\/1060028014528305","article-title":"Vortioxetine for the treatment of depression","volume":"48","author":"Pearce","year":"2014","journal-title":"Ann. Pharmacother."},{"key":"10.1016\/j.reprotox.2023.108519_bib17","first-page":"379","article-title":"Acute effects of vortioxetine and duloxetine on resting-state functional connectivity in the awake rat","volume":"128","author":"Hamilton","year":"2018","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.reprotox.2023.108519_bib18","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/s40262-017-0612-7","article-title":"Vortioxetine: clinical pharmacokinetics and drug interactions","volume":"57","author":"Chen","year":"2018","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.reprotox.2023.108519_bib19","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1002\/cpdd.381","article-title":"Pharmacokinetics, safety, and tolerability of vortioxetine following single- and multiple-dose administration in healthy Japanese adults","volume":"7","author":"Matsuno","year":"2018","journal-title":"Clin. Pharmacol. Drug Dev."},{"key":"10.1016\/j.reprotox.2023.108519_bib20","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.biochi.2017.07.008","article-title":"Human placenta expresses both peripheral and neuronal isoform of tryptophan hydroxylase","volume":"140","author":"Laurent","year":"2017","journal-title":"Biochimie"},{"key":"10.1016\/j.reprotox.2023.108519_bib21","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.mce.2016.11.021","article-title":"Fluoxetine and its active metabolite norfluoxetine disrupt estrogen synthesis in a co-culture model of the feto-placental unit","volume":"442","author":"Hudon Thibeault","year":"2017","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.reprotox.2023.108519_bib22","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.placenta.2011.06.003","article-title":"Stimulation of serotonergic 5-HT 2A receptor signaling increases placental aromatase (CYP19) activity and expression in BeWo and JEG-3 human choriocarcinoma cells","volume":"32","author":"Klempan","year":"2011","journal-title":"Placenta"},{"key":"10.1016\/j.reprotox.2023.108519_bib23","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/sj.bjp.0701025","article-title":"Inhibition of the constitutive activity of human 5-HT1A receptors by the inverse agonist, spiperone but not the neutral antagonist, way 100,635","volume":"120","author":"Newman-Tancredi","year":"1997","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.reprotox.2023.108519_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2021.05.005","article-title":"An overview of in vitro, ex vivo and in vivo models for studying the transport of drugs across intestinal barriers","volume":"175","author":"Xu","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.reprotox.2023.108519_bib25","article-title":"Vortioxetine, highlight of precribing information","volume":"3381579","author":"Food","year":"2013","journal-title":"Ref. ID"},{"key":"10.1016\/j.reprotox.2023.108519_bib26","unstructured":"A. Government, The Australian categorisation system for prescribing medicines in pregnancy, Dep. Heal. Aged Care-Therapeutic Goods Adm. 2023 1\u20137. https:\/\/www.tga.gov.au\/products\/medicines\/find-information-about-medicine\/prescribing-medicines-pregnancy-database."},{"key":"10.1016\/j.reprotox.2023.108519_bib27","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1002\/bdr2.1864","article-title":"Pregnancy outcome after first trimester exposure to vortioxetine: a case series","volume":"113","author":"Shweiki","year":"2021","journal-title":"Birth Defects Res"},{"key":"10.1016\/j.reprotox.2023.108519_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.reprotox.2023.108365","article-title":"Maternal SSRI use during pregnancy and offspring depression or anxiety disorders: a review of the literature and description of a study protocol for a register-based cohort study","volume":"118","author":"Upadhyaya","year":"2023","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.reprotox.2023.108519_bib29","first-page":"1","article-title":"E-cadherin, actin, microtubules and FAK dominate different spheroid formation phases and important elements of tissue integrity","volume":"8","author":"Smyrek","year":"2019","journal-title":"Biol. Open."},{"key":"10.1016\/j.reprotox.2023.108519_bib30","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1093\/molehr\/7.3.279","article-title":"Expression of ZO-1 and occludin in normal human placenta and in hydatidiform moles","volume":"7","author":"Marzioni","year":"2001","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.reprotox.2023.108519_bib31","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.placenta.2004.08.003","article-title":"Expression of the 5-HT2A serotoninergic receptor in human placenta and choriocarcinoma cells: mitogenic implications of serotonin","volume":"26","author":"Sonier","year":"2005","journal-title":"Placenta"},{"key":"10.1016\/j.reprotox.2023.108519_bib32","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0143-4004(96)90039-9","article-title":"Functional expression of the plasma membrane serotonin transporter but not the vesicular monoamine transporter in human placental trophoblasts and choriocarcinoma cells","volume":"17","author":"Prasad","year":"1996","journal-title":"Placenta"},{"key":"10.1016\/j.reprotox.2023.108519_bib33","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1530\/acta.0.XXXIIS009","article-title":"Hormone production of the isolated human placenta","volume":"32","author":"Cassmer","year":"1959","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.reprotox.2023.108519_bib34","doi-asserted-by":"crossref","unstructured":"A.A. Do\u011fan, \u015e. Ta\u015fdemir, A. \u015eendemir \u00dcrkmez, COMPARISON OF MICROTISSUE FORMING CAPACITY OF SH- SY5Y, DOKUZ EYL\u00dcL \u00dcN\u0130VERS\u0130TES\u0130 M\u00dcHEND\u0130SL\u0130K FAK\u00dcLTES\u0130 FEN VE M\u00dcHEND\u0130SL\u0130K DERG\u0130S\u0130. 18 (2016) 40\u201348.","DOI":"10.21205\/deufmd.20165217544"},{"key":"10.1016\/j.reprotox.2023.108519_bib35","article-title":"Determination of minimum serum concentration to develop scaffold free micro-tissue","volume":"90","author":"Karaman","year":"2017","journal-title":"Eur. Res. J."},{"key":"10.1016\/j.reprotox.2023.108519_bib36","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.placenta.2013.05.006","article-title":"In vitro simulation of placental transport: part II. Glucose transfer across the placental barrier model","volume":"34","author":"Levkovitz","year":"2013","journal-title":"Placenta"},{"key":"10.1016\/j.reprotox.2023.108519_bib37","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.placenta.2013.03.014","article-title":"In vitro simulation of placental transport: part I. Biological model of the placental barrier","volume":"34","author":"Levkovitz","year":"2013","journal-title":"Placenta"},{"key":"10.1016\/j.reprotox.2023.108519_bib38","first-page":"17322","article-title":"A 3D co-culture microtissue model of the human placenta for nanotoxicity assessment","volume":"8","author":"Muoth","year":"2016","journal-title":"R. Soc. Chem."},{"key":"10.1016\/j.reprotox.2023.108519_bib39","doi-asserted-by":"crossref","unstructured":"S. Przyborski, 2017. Technology Platforms for 3D Cell Culture, First, UK. https:\/\/doi.org\/10.1002\/9781118851647.","DOI":"10.1002\/9781118851647"},{"key":"10.1016\/j.reprotox.2023.108519_bib40","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1002\/2211-5463.12944","article-title":"Vortioxetine induces apoptosis and autophagy of gastric cancer AGS cells via the PI3K\/AKT pathway","volume":"10","author":"Lv","year":"2020","journal-title":"FEBS Open Bio"},{"key":"10.1016\/j.reprotox.2023.108519_bib41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41389-023-00472-4","article-title":"Vortioxetine hydrobromide inhibits the growth of gastric cancer cells in vivo and in vitro by targeting JAK2 and SRC","volume":"12","author":"Li","year":"2023","journal-title":"Oncogenesis"},{"key":"10.1016\/j.reprotox.2023.108519_bib42","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/bph.14074","article-title":"Vortioxetine exerts anti-inflammatory and immunomodulatory effects on human monocytes\/macrophages","volume":"175","author":"Talmon","year":"2018","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.reprotox.2023.108519_bib43","first-page":"1","article-title":"Placental drug transport-on-a-chip: a microengineered in vitro model of transporter-mediated drug efflux in the human placental barrier","volume":"7","author":"Blundell","year":"2018","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.reprotox.2023.108519_bib44","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1242\/dev.113.3.767","article-title":"E-cadherin expression during the differentiation of human trophoblasts","volume":"113","author":"Coutifaris","year":"1991","journal-title":"Development"},{"key":"10.1016\/j.reprotox.2023.108519_bib45","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s00404-015-3830-y","article-title":"The cytoskeletal protein LASP-1 differentially regulates migratory activities of choriocarcinoma cells","volume":"293","author":"Segerer","year":"2016","journal-title":"Arch. Gynecol. Obstet."},{"key":"10.1016\/j.reprotox.2023.108519_bib46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-23379-2","article-title":"RNA-Seq identifies genes whose proteins are transformative in the differentiation of cytotrophoblast to syncytiotrophoblast, in human primary villous and BeWo trophoblasts","volume":"8","author":"Azar","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.reprotox.2023.108519_bib47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-017-06364-z","article-title":"A comparative study of five physiological key parameters between four different human trophoblast-derived cell lines","volume":"7","author":"Rothbauer","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.reprotox.2023.108519_bib48","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1021\/acschemneuro.5b00225","article-title":"Binding of the multimodal antidepressant drug vortioxetine to the human serotonin transporter","volume":"6","author":"Andersen","year":"2015","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.reprotox.2023.108519_bib49","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.euroneuro.2017.10.032","article-title":"Can we increase speed and efficacy of antidepressant treatments? Part I: general aspects and monoamine-based strategies","volume":"28","author":"Artigas","year":"2018","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.reprotox.2023.108519_bib50","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1289\/ehp.1307518","article-title":"A unique co-culture model for fundamental and applied studies of human fetoplacental steroidogenesis and interference by environmental chemicals","volume":"122","author":"Thibeault","year":"2014","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.reprotox.2023.108519_bib51","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics13081306","article-title":"Effect of selected antidepressants on placental homeostasis of serotonin: maternal and fetal perspectives","volume":"13","author":"Horackova","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.reprotox.2023.108519_bib52","doi-asserted-by":"crossref","DOI":"10.1002\/cmdc.202200092","article-title":"Jumping from fragment to drug via smart scaffolds","volume":"17","author":"Farahani","year":"2022","journal-title":"ChemMedChem"},{"key":"10.1016\/j.reprotox.2023.108519_bib53","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.reprotox.2022.06.005","article-title":"Placental model as an important tool to study maternal-fetal interface","volume":"112","author":"Gon\u00e7alves","year":"2022","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.reprotox.2023.108519_bib54","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.reprotox.2010.02.007","article-title":"Placental transport and in vitro effects of Bisphenol A","volume":"30","author":"M\u00f8rck","year":"2010","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.reprotox.2023.108519_bib55","doi-asserted-by":"crossref","first-page":"3356","DOI":"10.1021\/acsbiomaterials.8b00653","article-title":"Placental barrier-on-a-chip: modeling placental inflammatory responses to bacterial infection","volume":"4","author":"Zhu","year":"2018","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.reprotox.2023.108519_bib56","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1530\/REP-10-0221","article-title":"The choriocarcinoma cell line BeWo: syncytial fusion and expression of syncytium-specific proteins","volume":"140","author":"Orendi","year":"2010","journal-title":"Reproduction"},{"key":"10.1016\/j.reprotox.2023.108519_bib57","article-title":"Effects of a complex mixture of persistent organic pollutants (POPs) on steroidogenesis in H295R cells under 10 \u03bcM forskolin stimulation - results from a pilot study","author":"Mohammed Ahmed","year":"2018","journal-title":"BioRxiv"}],"container-title":["Reproductive Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623823001934?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623823001934?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T14:02:59Z","timestamp":1760191379000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0890623823001934"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":57,"alternative-id":["S0890623823001934"],"URL":"https:\/\/doi.org\/10.1016\/j.reprotox.2023.108519","relation":{},"ISSN":["0890-6238"],"issn-type":[{"value":"0890-6238","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Establishment of a 3D multicellular placental microtissues for investigating the effect of antidepressant vortioxetine","name":"articletitle","label":"Article Title"},{"value":"Reproductive Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.reprotox.2023.108519","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108519"}}