{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T23:08:54Z","timestamp":1792451334387,"version":"4.5.0"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Toxicology"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.reprotox.2023.108520","type":"journal-article","created":{"date-parts":[[2023,12,5]],"date-time":"2023-12-05T02:22:17Z","timestamp":1701742937000},"page":"108520","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Cantharidin-induced toxic injury, oxidative stress, and autophagy attenuated by Astragalus polysaccharides in mouse testis"],"prefix":"10.1016","volume":"123","author":[{"given":"Yuanyuan","family":"Xiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruxia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenchao","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changfu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.reprotox.2023.108520_bib1","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1111\/bph.12675","article-title":"New insight into male (in)fertility: the importance of NO","volume":"172","author":"Buzadzic","year":"2015","journal-title":"Br. J. Pharm."},{"issue":"9","key":"10.1016\/j.reprotox.2023.108520_bib2","doi-asserted-by":"crossref","first-page":"3116","DOI":"10.1016\/j.fct.2008.06.084","article-title":"Liposome encapsulation reduces cantharidin toxicity","volume":"46","author":"Chang","year":"2008","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.reprotox.2023.108520_bib3","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jinorgbio.2018.10.007","article-title":"Methylmercury-induced testis damage is associated with activation of oxidative stress and germ cell autophagy","volume":"190","author":"Chen","year":"2019","journal-title":"J. Inorg. Biochem"},{"issue":"7","key":"10.1016\/j.reprotox.2023.108520_bib4","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/nrendo.2010.71","article-title":"A local autocrine axis in the testes that regulates spermatogenesis","volume":"6","author":"Cheng","year":"2010","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.reprotox.2023.108520_bib5","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.tox.2016.01.004","article-title":"4-Nonylphenol induces apoptosis, autophagy and necrosis in Sertoli cells: Involvement of ROS-mediated AMPK\/AKT-mTOR and JNK pathways","volume":"341\u2013343","author":"Duan","year":"2016","journal-title":"Toxicology"},{"issue":"7","key":"10.1016\/j.reprotox.2023.108520_bib6","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1093\/humrep\/der132","article-title":"The role of sperm oxidative stress in male infertility and the significanceof oral antioxidant therapy","volume":"26","author":"Gharagozloo","year":"2011","journal-title":"Hum. Reprod."},{"issue":"1","key":"10.1016\/j.reprotox.2023.108520_bib7","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s13238-011-1127-x","article-title":"The crosstalk between autophagy and apoptosis: where does this lead?","volume":"3","author":"Gordy","year":"2012","journal-title":"Protein Cell"},{"key":"10.1016\/j.reprotox.2023.108520_bib8","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.615678","article-title":"Low doses of glyphosate\/roundupalter blood-testis barrier integrity in juvenile rats","volume":"12","author":"Gorga","year":"2021","journal-title":"Front Endocrinol. (Lausanne)"},{"key":"10.1016\/j.reprotox.2023.108520_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.102227","article-title":"Induction of autophagy via the ROS-dependent AMPK-mTOR pathway protects copper-induced spermatogenesis disorder","volume":"49","author":"Guo","year":"2022","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.reprotox.2023.108520_bib10","doi-asserted-by":"crossref","first-page":"9871","DOI":"10.1038\/s41598-019-46264-y","article-title":"Repair effects of astragalus polysaccharides with different molecular weights on oxidatively damaged HK-2 cells","volume":"9","author":"Han","year":"2019","journal-title":"Sci. Rep. 8"},{"key":"10.1016\/j.reprotox.2023.108520_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2022.112986","article-title":"Endoplasmic reticulum stress contributes to autophagy and apoptosis in cantharidin-induced nephrotoxicity","volume":"163","author":"He","year":"2022","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.reprotox.2023.108520_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2022.113541","article-title":"Mice kidney biometabolic process analysis after cantharidin exposure using widely-targeted metabolomics combined with network pharmacology","volume":"171","author":"He","year":"2023","journal-title":"Food Chem. Toxicol."},{"issue":"24","key":"10.1016\/j.reprotox.2023.108520_bib13","first-page":"3310","article-title":"Research advances of mylabris-induced hepatorenal toxicity in recent years","volume":"39","author":"He","year":"2022","journal-title":"Chin. J. Mod. Appl. Pharm."},{"issue":"5","key":"10.1016\/j.reprotox.2023.108520_bib14","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1111\/rda.14335","article-title":"Effects of Astragalus polysaccharide to boar sperm on bisphenol A exposure","volume":"58","author":"Hu","year":"2023","journal-title":"Reprod. Domest. Anim."},{"issue":"1","key":"10.1016\/j.reprotox.2023.108520_bib15","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/bcpt.13585","article-title":"Protective mechanism of astragalus polysaccharides against cantharidin-induced liver injury determined in vivo by liquid chromatography\/mass spectrometry metabolomics","volume":"129","author":"Huang","year":"2021","journal-title":"Basic Clin. Pharm. Toxicol."},{"issue":"3","key":"10.1016\/j.reprotox.2023.108520_bib16","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1093\/jee\/tov057","article-title":"Lethal and sublethal effects of cantharidin on development and reproduction of Plutella xylostella (Lepidoptera: Plutellidae)","volume":"108","author":"Huang","year":"2015","journal-title":"J. Econ. Entomol."},{"issue":"33","key":"10.1016\/j.reprotox.2023.108520_bib17","doi-asserted-by":"crossref","first-page":"22847","DOI":"10.1074\/jbc.M802182200","article-title":"Structural basis for sorting mechanism of p62 in selective autophagy","volume":"283","author":"Ichimura","year":"2008","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.reprotox.2023.108520_bib18","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/S0735-6757(96)90158-8","article-title":"Poisoning from \"Spanish fly\" (cantharidin)","volume":"14","author":"Karras","year":"1996","journal-title":"Am. J. Emerg. Med."},{"issue":"17","key":"10.1016\/j.reprotox.2023.108520_bib19","doi-asserted-by":"crossref","first-page":"8804","DOI":"10.1158\/0008-5472.CAN-05-3513","article-title":"Mechanism of action of sulforaphane: inhibition of p38 mitogen-activated protein kinase isoforms contributing to the induction of antioxidant response element-mediated heme oxygenase-1 in human hepatoma HepG2 cells","volume":"66","author":"Keum","year":"2006","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.reprotox.2023.108520_bib20","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1002\/ps.3517","article-title":"Lethal and sublethal effects of cantharidin on the life history traits and population parameters of Helicoverpa armigera (H\u00fcbner) (Lepidoptera: Noctuidae)","volume":"70","author":"Khan","year":"2014","journal-title":"Pest Manag Sci."},{"issue":"39","key":"10.1016\/j.reprotox.2023.108520_bib21","doi-asserted-by":"crossref","first-page":"55140","DOI":"10.1007\/s11356-021-14853-y","article-title":"Long-term copper exposure promotes apoptosis and autophagy by inducing oxidative stress in pig testis","volume":"28","author":"Li","year":"2021","journal-title":"Environ. Sci. Pollut. Res. Int."},{"issue":"42","key":"10.1016\/j.reprotox.2023.108520_bib22","doi-asserted-by":"crossref","first-page":"17998","DOI":"10.1073\/pnas.1007047107","article-title":"Connexin 43 is critical to maintain the homeostasis of the blood-testis barrier via its effects on tight junction reassembly","volume":"107","author":"Li","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"12","key":"10.1016\/j.reprotox.2023.108520_bib23","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1002\/jat.4022","article-title":"Cantharidin-induced LO2 cell autophagy and apoptosis via endoplasmic reticulum stress pathway in vitro","volume":"40","author":"Liu","year":"2020","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.reprotox.2023.108520_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2023.116450","article-title":"Transcriptomic profiling and differential analysis reveal the renal toxicity mechanisms of mice under cantharidin exposure","volume":"465","author":"Liu","year":"2023","journal-title":"Toxicol. Appl. Pharm."},{"key":"10.1016\/j.reprotox.2023.108520_bib25","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1146\/annurev-pharmtox-011112-140320","article-title":"Role of nrf2 in oxidative stress and toxicity","volume":"53","author":"Ma","year":"2013","journal-title":"Annu Rev. Pharm. Toxicol."},{"issue":"4","key":"10.1016\/j.reprotox.2023.108520_bib26","doi-asserted-by":"crossref","first-page":"620","DOI":"10.4103\/1008-682X.163189","article-title":"Claudin-11 and Occludin are major contributors to Sertoli cell tight junction function, in vitro","volume":"18","author":"McCabe","year":"2016","journal-title":"Asian J. Androl."},{"key":"10.1016\/j.reprotox.2023.108520_bib27","doi-asserted-by":"crossref","first-page":"137","DOI":"10.3389\/fcell.2018.00137","article-title":"Beclin 1 phosphorylation-at the center of autophagy regulation","volume":"6","author":"Menon","year":"2018","journal-title":"Front Cell Dev. Biol."},{"issue":"7182","key":"10.1016\/j.reprotox.2023.108520_bib28","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/nature06639","article-title":"Autophagy fights disease through cellularself-digestion","volume":"451","author":"Mizushima","year":"2008","journal-title":"Nature 28"},{"issue":"10","key":"10.1016\/j.reprotox.2023.108520_bib29","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1001\/archderm.137.10.1357","article-title":"Cantharidin revisited: a blistering defense of an ancient medicine","volume":"137","author":"Moed","year":"2001","journal-title":"Arch. Dermatol."},{"issue":"5","key":"10.1016\/j.reprotox.2023.108520_bib30","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1210\/er.2014-1101","article-title":"The mammalian blood-testis barrier: its biology and regulation","volume":"36","author":"Mruk","year":"2015","journal-title":"Endocr. Rev."},{"issue":"9","key":"10.1016\/j.reprotox.2023.108520_bib31","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1016\/j.freeradbiomed.2010.07.019","article-title":"Knockout of the transcription factor NRF2 disrupts spermatogenesis in an age-dependent manner","volume":"49","author":"Nakamura","year":"2010","journal-title":"Free Radic. Biol. Med."},{"issue":"14","key":"10.1016\/j.reprotox.2023.108520_bib32","doi-asserted-by":"crossref","first-page":"3279","DOI":"10.3390\/molecules25143279","article-title":"Anticancer attributes of cantharidin: involved molecular mechanisms and pathways","volume":"25","author":"Naz","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.reprotox.2023.108520_bib33","doi-asserted-by":"crossref","first-page":"457327","DOI":"10.4061\/2011\/457327","article-title":"Oxidative stress in lead and cadmium toxicity and its amelioration","volume":"2011","author":"Patra","year":"2011","journal-title":"Vet. Med. Int."},{"issue":"1","key":"10.1016\/j.reprotox.2023.108520_bib34","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0379-0738(92)90144-L","article-title":"A fatal case of poisoning with cantharidin","volume":"56","author":"Polettini","year":"1992","journal-title":"Forensic Sci. Int."},{"key":"10.1016\/j.reprotox.2023.108520_bib35","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.ijbiomac.2019.08.191","article-title":"Effect of Astragalus membranaceus polysaccharide on the serum cytokine levels and spermatogenesis of mice","volume":"140","author":"Qiu","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"issue":"1","key":"10.1016\/j.reprotox.2023.108520_bib36","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1093\/toxsci\/kft129","article-title":"Sertoli cellis a potential target for perfluorooctane sulfonate-induced reproductive dysfunction in male mice","volume":"135","author":"Qiu","year":"2013","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.reprotox.2023.108520_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114903","article-title":"Novel treatment and insight for irradiation-induced injuries: dibucaine ameliorates irradiation-induced testicular injury by inhibiting fatty acid oxidation in primary Leydig cells","volume":"164","author":"Ran","year":"2023","journal-title":"Biomed. Pharm."},{"key":"10.1016\/j.reprotox.2023.108520_bib38","doi-asserted-by":"crossref","unstructured":"Rezakhaniha B., Ganjiani V., Siroosbakht S., Ahmadi N., Meimandi-Parizi A., Divar M.R., Shrifiyazdi H., Mirghazanfari S.M. The evaluation of citral effects on experimental unilateral testicular ischemia\/reperfusion injury. Andrologia. 2022 Dec;54(11):e14605. doi: 10.1111\/and.14605. Epub 2022 Sep 26. PMID: 36163582.","DOI":"10.1111\/and.14605"},{"key":"10.1016\/j.reprotox.2023.108520_bib39","article-title":"Antitumor potential of the protein phosphatase inhibitor, cantharidin, and selected derivatives","author":"Ren","year":"2021","journal-title":"Bioorg. Med. Chem. 2021,32:116012"},{"issue":"1","key":"10.1016\/j.reprotox.2023.108520_bib40","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1007\/s12011-021-02628-y","article-title":"Astragalus polysaccharide protects against cadmium-induced autophagy injury through reactive oxygen species (ROS) pathway in chicken embryo fibroblast","volume":"200","author":"Shen","year":"2022","journal-title":"Biol. Trace Elem. Res."},{"issue":"03","key":"10.1016\/j.reprotox.2023.108520_bib41","first-page":"284","article-title":"Protection effect of Astragalus mongholicus against cadmium toxicity on the expression of vimentin & e-cadherin and the ultrastructure of Sertoli cells in rats","volume":"21","author":"Shi","year":"2012","journal-title":"Chin. J. Histochem. Cytochem."},{"key":"10.1016\/j.reprotox.2023.108520_bib42","doi-asserted-by":"crossref","first-page":"25029","DOI":"10.1074\/jbc.M501049200","article-title":"Sertoli-germ cell anchoring junction dynamics in the testis are regulated by an interplay of lipid and protein kinases","volume":"280","author":"Siu","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.reprotox.2023.108520_bib43","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.semcdb.2014.02.012","article-title":"The regulation of spermatogenesis by androgens","volume":"30","author":"Smith","year":"2014","journal-title":"Semin Cell Dev. Biol."},{"issue":"12","key":"10.1016\/j.reprotox.2023.108520_bib44","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1016\/S0041-0101(00)00093-3","article-title":"Cantharidin poisoning due to \"Blister beetle\" ingestion","volume":"38","author":"Tagwireyi","year":"2000","journal-title":"Toxicon"},{"key":"10.1016\/j.reprotox.2023.108520_bib45","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.etap.2018.09.009","article-title":"Effects of sodium fluoride on the reproductive development of Bombyx mori","volume":"64","author":"Tang","year":"2018","journal-title":"Environ. Toxicol. Pharm."},{"issue":"1\u20132","key":"10.1016\/j.reprotox.2023.108520_bib46","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.etp.2010.06.003","article-title":"Cantharidin and norcantharidin inhibit caprine luteal cell steroidogenesis in vitro","volume":"64","author":"Twu","year":"2012","journal-title":"Exp. Toxicol. Pathol."},{"key":"10.1016\/j.reprotox.2023.108520_bib47","doi-asserted-by":"crossref","first-page":"120111","DOI":"10.1016\/j.lfs.2021.120111","article-title":"Nrf2\/Keap1\/ARE signaling: Towards specific regulation","volume":"291","author":"Ulasov","year":"2022","journal-title":"Life Sci."},{"issue":"17","key":"10.1016\/j.reprotox.2023.108520_bib48","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.2174\/0929867324666170414165253","article-title":"Overview of cantharidin and its analogues","volume":"25","author":"Wang","year":"2018","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.reprotox.2023.108520_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.jinorgbio.2020.111310","article-title":"Protective effect of naringenin against cadmium-induced testicular toxicity in male SD rats","volume":"214","author":"Wang","year":"2021","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.reprotox.2023.108520_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112536","article-title":"Palliative effects of metforminon testicular damage induced by triptolide in male rats","volume":"222","author":"Wang","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"4","key":"10.1016\/j.reprotox.2023.108520_bib51","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/smrj.62","article-title":"Natural aphrodisiacs-A review of selected sexual enhancers","volume":"3","author":"West","year":"2015","journal-title":"Sex Med. Rev."},{"issue":"2","key":"10.1016\/j.reprotox.2023.108520_bib52","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/0304-4165(85)90120-5","article-title":"Comparative reactivities of various biological compounds with myeloperoxidase-hydrogen peroxide-chloride, and similarity of the oxidant to hypochlorite","volume":"840","author":"Winterbourn","year":"1985","journal-title":"Biochim. Biophys. Acta 18"},{"issue":"39","key":"10.1016\/j.reprotox.2023.108520_bib53","doi-asserted-by":"crossref","first-page":"54647","DOI":"10.1007\/s11356-021-14486-1","article-title":"Evaluation of toxic effects induced by arsenic trioxide or\/and antimony on autophagy and apoptosis in testis of adult mice","volume":"28","author":"Wu","year":"2021","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.reprotox.2023.108520_bib54","first-page":"7","article-title":"The part of pharmacology research on Mylabris phalerata pall-contraindicational medicine in gestational period. J Yunnan Univ Trad","volume":"1","author":"Xiao","year":"2000","journal-title":"Chin. Med."},{"key":"10.1016\/j.reprotox.2023.108520_bib55","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1096\/fj.06-070342","article-title":"Blood-testis barrier dynamics are regulated by testosterone and cytokines via their differential effects on the kinetics of protein endocytosis and recycling in Sertoli cells","volume":"22","author":"Yan","year":"2008","journal-title":"Faseb J."},{"issue":"4","key":"10.1016\/j.reprotox.2023.108520_bib56","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1293\/tox.2016-0026","article-title":"Quercetin inhibited cadmium-induced autophagy in the mouse kidney via inhibition of oxidative stress","volume":"29","author":"Yuan","year":"2016","journal-title":"J. Toxicol. Pathol."},{"key":"10.1016\/j.reprotox.2023.108520_bib57","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.fct.2016.05.017","article-title":"Sodium fluoride and sulfur dioxide affectedmale reproduction by disturbing blood-testis barrier in mice","volume":"94","author":"Zhang","year":"2016","journal-title":"Food Chem. Toxicol."},{"issue":"4","key":"10.1016\/j.reprotox.2023.108520_bib58","first-page":"545","article-title":"Research progress on multiple organ damage and mechanism of cantharidin poisoning","volume":"36","author":"Zhang","year":"2020","journal-title":"Fa Yi Xue Za Zhi"},{"key":"10.1016\/j.reprotox.2023.108520_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107544","article-title":"Genome-wide alternation and effect of DNA methylation in the impairments of steroidogenesis and spermatogenesis after PM2.5 exposure","volume":"169","author":"Zhang","year":"2022","journal-title":"Environ. Int."},{"issue":"1","key":"10.1016\/j.reprotox.2023.108520_bib60","doi-asserted-by":"crossref","first-page":"3320","DOI":"10.1038\/s41598-018-21567-8","article-title":"Zearalenone altered the cytoskeletal structure via ER stress-autophagy- oxidative stress pathway in mouse TM4 Sertoli cells","volume":"8","author":"Zheng","year":"2018","journal-title":"Sci. Rep."},{"issue":"11","key":"10.1016\/j.reprotox.2023.108520_bib61","doi-asserted-by":"crossref","first-page":"349","DOI":"10.3389\/fphar.2020.00349","article-title":"A review of the pharmacological action of astragalus polysaccharide","volume":"24","author":"Zheng","year":"2020","journal-title":"Front Pharm."},{"key":"10.1016\/j.reprotox.2023.108520_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.152247","article-title":"Environmental cadmium impairs blood-testis barrier via activating HRI-responsive mitochondrial stress in mice","volume":"810","author":"Zhou","year":"2022","journal-title":"Sci. Total Environ."},{"issue":"6","key":"10.1016\/j.reprotox.2023.108520_bib63","doi-asserted-by":"crossref","first-page":"3043","DOI":"10.1210\/endo-124-6-3043","article-title":"Ewing L.L. Maintenance of advanced spermatogenic cells in the adult rat testis: quantitative relationship to testosterone concentration within the testis","volume":"124","author":"Zirkin","year":"1989","journal-title":"Endocrinology"}],"container-title":["Reproductive Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623823001946?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623823001946?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T14:02:42Z","timestamp":1760191362000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0890623823001946"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":63,"alternative-id":["S0890623823001946"],"URL":"https:\/\/doi.org\/10.1016\/j.reprotox.2023.108520","relation":{},"ISSN":["0890-6238"],"issn-type":[{"value":"0890-6238","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cantharidin-induced toxic injury, oxidative stress, and autophagy attenuated by Astragalus polysaccharides in mouse testis","name":"articletitle","label":"Article Title"},{"value":"Reproductive Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.reprotox.2023.108520","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108520"}}