{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:46:18Z","timestamp":1792799178437,"version":"4.5.0"},"reference-count":190,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Toxicology"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.reprotox.2023.108531","type":"journal-article","created":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T12:21:26Z","timestamp":1704198086000},"page":"108531","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"special_numbering":"C","title":["Unravelling the epigenetic impact: Oxidative stress and its role in male infertility-associated sperm dysfunction"],"prefix":"10.1016","volume":"124","author":[{"given":"Gokul","family":"Sudhakaran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Kesavan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karthikeyan","family":"Kandaswamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Guru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesu","family":"Arockiaraj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.reprotox.2023.108531_bib1","doi-asserted-by":"crossref","first-page":"191","DOI":"10.4103\/0974-1208.170370","article-title":"Trends of male factor infertility, an important cause of infertility: a review of literature","volume":"8","author":"Kumar","year":"2015","journal-title":"J. Hum. Reprod. Sci."},{"key":"10.1016\/j.reprotox.2023.108531_bib2","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1002\/ajum.12096","article-title":"Rotterdam criteria, the end","volume":"21","author":"Smet","year":"2018","journal-title":"Australas. J. Ultrasound Med."},{"key":"10.1016\/j.reprotox.2023.108531_bib3","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.aju.2017.10.005","article-title":"Prediction of male infertility by the World Health Organization laboratory manual for assessment of semen analysis: A systematic review","volume":"16","author":"Patel","year":"2018","journal-title":"Arab J. Urol."},{"key":"10.1016\/j.reprotox.2023.108531_bib4","doi-asserted-by":"crossref","first-page":"246","DOI":"10.3390\/diagnostics11020246","article-title":"Mini-review regarding the applicability of genome editing techniques developed for studying infertility","volume":"11","author":"Doroftei","year":"2021","journal-title":"Diagnostics"},{"key":"10.1016\/j.reprotox.2023.108531_bib5","doi-asserted-by":"crossref","first-page":"29","DOI":"10.2147\/IJGM.S241099","article-title":"Some of the factors involved in male infertility: a prospective review","volume":"Volume 13","author":"Babakhanzadeh","year":"2020","journal-title":"Int. J. Gen. Med."},{"key":"10.1016\/j.reprotox.2023.108531_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5534\/wjmh.2014.32.1.1","article-title":"Effect of oxidative stress on male reproduction","volume":"32","author":"Agarwal","year":"2014","journal-title":"World J. Mens. Health"},{"key":"10.1016\/j.reprotox.2023.108531_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2020.581838","article-title":"The role of genetics and oxidative stress in the etiology of male infertility\u2014a unifying hypothesis?","volume":"11","author":"Aitken","year":"2020","journal-title":"Front. Endocrinol. (Lausanne)."},{"key":"10.1016\/j.reprotox.2023.108531_bib8","doi-asserted-by":"crossref","DOI":"10.4061\/2011\/686137","article-title":"Impacts of oxidative stress and antioxidants on semen functions","volume":"2011","author":"Bansal","year":"2011","journal-title":"Vet. Med. Int."},{"key":"10.1016\/j.reprotox.2023.108531_bib9","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1093\/humupd\/dmp048","article-title":"World Health Organization reference values for human semen characteristics","volume":"16","author":"Cooper","year":"2010","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.reprotox.2023.108531_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/life11121368","article-title":"The sixth edition of the WHO manual for human semen analysis: a critical review and SWOT analysis","volume":"11","author":"Boitrelle","year":"2021","journal-title":"Life"},{"key":"10.1016\/j.reprotox.2023.108531_bib11","first-page":"1","article-title":"Epigenetic modifications, a new approach to male infertility etiology: a review","volume":"16","author":"Marzouni","year":"2022","journal-title":"Int. J. Fertil. Steril."},{"key":"10.1016\/j.reprotox.2023.108531_bib12","doi-asserted-by":"crossref","DOI":"10.1111\/and.13706","article-title":"Etiologies of sperm DNA damage and its impact on male infertility","volume":"53","author":"Panner Selvam","year":"2021","journal-title":"Andrologia"},{"key":"10.1016\/j.reprotox.2023.108531_bib13","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1111\/andr.12199","article-title":"Total motile sperm count has a superior predictive value over the WHO 2010 cut-off values for the outcomes of intracytoplasmic sperm injection cycles","volume":"4","author":"Borges","year":"2016","journal-title":"Andrology"},{"key":"10.1016\/j.reprotox.2023.108531_bib14","doi-asserted-by":"crossref","first-page":"4","DOI":"10.4103\/jhrs.JHRS_150_18","article-title":"Role of oxidative stress in male infertility: an updated review","volume":"12","author":"Alahmar","year":"2019","journal-title":"J. Hum. Reprod. Sci."},{"key":"10.1016\/j.reprotox.2023.108531_bib15","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1016\/j.fertnstert.2005.10.055","article-title":"Carnitine for the treatment of idiopathic asthenospermia: a randomized, double-blind, placebo-controlled trial","volume":"85","author":"Sigman","year":"2006","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.reprotox.2023.108531_bib16","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1038\/cdd.2013.138","article-title":"Cell death and diseases related to oxidative stress:4-hydroxynonenal (HNE) in the balance","volume":"20","author":"Dalleau","year":"2013","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.reprotox.2023.108531_bib17","doi-asserted-by":"crossref","first-page":"185","DOI":"10.4103\/0970-9371.117682","article-title":"Immature germ cells in semen - correlation with total sperm count and sperm motility","volume":"30","author":"Patil","year":"2013","journal-title":"J. Cytol."},{"key":"10.1016\/j.reprotox.2023.108531_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2020\/8819719","article-title":"Oxidative, reductive, and nitrosative stress effects on epigenetics and on posttranslational modification of enzymes in cardiometabolic diseases","volume":"2020","author":"P\u00e9rez-Torres","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.reprotox.2023.108531_bib19","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1017\/S0007114514000610","article-title":"Effects of dietary microencapsulated sodium butyrate on growth, intestinal mucosal morphology, immune response and adhesive bacteria in juvenile common carp (Cyprinus carpio) pre-fed with or without oxidised oil","volume":"112","author":"Liu","year":"2014","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.reprotox.2023.108531_bib20","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.23223","article-title":"Exposure to environmental pollutant bisphenol A causes oxidative damage and lipid accumulation in Zebrafish larvae: Protective role of WL15 peptide derived from cysteine and glycine\u2010rich protein 2","volume":"37","author":"Guru","year":"2023","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.reprotox.2023.108531_bib21","doi-asserted-by":"crossref","first-page":"561","DOI":"10.3390\/jcm8040561","article-title":"Environment and male fertility: effects of Benzo-\u03b1-Pyrene and resveratrol on human sperm function in vitro","volume":"8","author":"Alamo","year":"2019","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.reprotox.2023.108531_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.111429","article-title":"Bisphenol A induces apoptosis through GPER-dependent activation of the ROS\/Ca2+-ASK1-JNK pathway in human granulosa cell line KGN","volume":"208","author":"Huang","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.reprotox.2023.108531_bib23","doi-asserted-by":"crossref","unstructured":"V. Zhaku, A. Agarwal, S. Beadini, R. Henkel, R. Finelli, N. Beadini, S. Micic, Male Infertility, Oxidative Stress and Antioxidants, in: 2021. \u3008https:\/\/doi.org\/10.5772\/intechopen.98204\u3009.","DOI":"10.5772\/intechopen.98204"},{"key":"10.1016\/j.reprotox.2023.108531_bib24","first-page":"215","article-title":"Human sperm quality and metal toxicants: protective effects of some flavonoids on male reproductive function","volume":"10","author":"Jamalan","year":"2016","journal-title":"Int. J. Fertil. Steril."},{"key":"10.1016\/j.reprotox.2023.108531_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/and.13646","article-title":"Environmental contaminants and male infertility: effects and mechanisms","volume":"53","author":"Selvaraju","year":"2021","journal-title":"Andrologia"},{"key":"10.1016\/j.reprotox.2023.108531_bib26","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.tig.2022.03.010","article-title":"DNA methylation: a historical perspective","volume":"38","author":"Mattei","year":"2022","journal-title":"Trends Genet"},{"key":"10.1016\/j.reprotox.2023.108531_bib27","first-page":"1","article-title":"Diagnosis and treatment of infertility in men: AUA\/ ASRM guideline","author":"AUA|ASRM","year":"2020","journal-title":"Am. Soc. Reprod. Med."},{"key":"10.1016\/j.reprotox.2023.108531_bib28","doi-asserted-by":"crossref","DOI":"10.1186\/s12958-018-0430-2","article-title":"Air pollution from natural and anthropic sources and male fertility","volume":"16","author":"Jurewicz","year":"2018","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.reprotox.2023.108531_bib29","doi-asserted-by":"crossref","DOI":"10.1186\/s12302-021-00585-w","article-title":"Impact of environmental factors on human semen quality and male fertility: a narrative review","volume":"34","author":"Kumar","year":"2022","journal-title":"Environ. Sci. Eur."},{"issue":"1","key":"10.1016\/j.reprotox.2023.108531_bib30","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s12958-018-0431-1","article-title":"Radiations and male fertility","volume":"16","author":"Kesari","year":"2018","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.reprotox.2023.108531_bib31","first-page":"1","article-title":"Microplastics: a threat for male fertility","volume":"18","author":"D\u2019Angelo","year":"2021","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.reprotox.2023.108531_bib32","doi-asserted-by":"crossref","first-page":"53804","DOI":"10.18632\/oncotarget.17479","article-title":"Epigenetic dynamics and interplay during spermatogenesis and embryogenesis: implications for male fertility and offspring health","volume":"8","author":"Ge","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.reprotox.2023.108531_bib33","doi-asserted-by":"crossref","first-page":"181","DOI":"10.5152\/tud.2013.037","article-title":"The role of epigenetics in spermatogenesis","volume":"39","author":"Gunes","year":"2014","journal-title":"T\u00fcrk \u00dcroloji Derg. \/Turk. J. Urol."},{"key":"10.1016\/j.reprotox.2023.108531_bib34","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a019133","article-title":"DNA Methylation in Mammals","volume":"6","author":"Li","year":"2014","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.reprotox.2023.108531_bib35","doi-asserted-by":"crossref","DOI":"10.1186\/s13148-015-0155-4","article-title":"Epigenetics and male reproduction: the consequences of paternal lifestyle on fertility, embryo development, and children lifetime health","volume":"7","author":"Stuppia","year":"2015","journal-title":"Clin. Epigen."},{"key":"10.1016\/j.reprotox.2023.108531_bib36","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.689624","article-title":"Epigenetics of male infertility: the role of DNA methylation","volume":"9","author":"Rotondo","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.reprotox.2023.108531_bib37","doi-asserted-by":"crossref","first-page":"R47","DOI":"10.1093\/hmg\/ddi114","article-title":"Epigenetic reprogramming in mammals","volume":"14","author":"Morgan","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.reprotox.2023.108531_bib38","doi-asserted-by":"crossref","first-page":"257","DOI":"10.3390\/genes10040257","article-title":"DNA methylation reprogramming during mammalian development","volume":"10","author":"Zeng","year":"2019","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.reprotox.2023.108531_bib39","article-title":"Idiopathic male infertility and polymorphisms in the DNA methyltransferase genes involved in epigenetic marking","volume":"7","author":"Tang","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.reprotox.2023.108531_bib40","doi-asserted-by":"crossref","unstructured":"M. Barchi, E. Guida, S. Dolci, P. Rossi, P. Grimaldi, Endocannabinoid system and epigenetics in spermatogenesis and testicular cancer, in: 2023: pp. 75\u2013106. \u3008https:\/\/doi.org\/10.1016\/bs.vh.2023.01.002\u3009.","DOI":"10.1016\/bs.vh.2023.01.002"},{"key":"10.1016\/j.reprotox.2023.108531_bib41","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1042\/EBC20190043","article-title":"The role and mechanisms of DNA methylation in the oocyte","volume":"63","author":"Send\u017eikait\u0117","year":"2019","journal-title":"Essays Biochem."},{"key":"10.1016\/j.reprotox.2023.108531_bib42","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s00404-013-2801-4","article-title":"Influence of reactive oxygen species on human sperm functions and fertilizing capacity including therapeutical approaches","volume":"288","author":"Chen","year":"2013","journal-title":"Arch. Gynecol. Obstet."},{"key":"10.1016\/j.reprotox.2023.108531_bib43","doi-asserted-by":"crossref","first-page":"132","DOI":"10.3390\/antiox7100132","article-title":"Oxidative stress in the male germline: a review of novel strategies to reduce 4-hydroxynonenal production","volume":"7","author":"Walters","year":"2018","journal-title":"Antioxidants"},{"key":"10.1016\/j.reprotox.2023.108531_bib44","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1080\/15592294.2019.1646572","article-title":"Epigenetic changes and assisted reproductive technologies","volume":"15","author":"Mani","year":"2020","journal-title":"Epigenetics"},{"key":"10.1016\/j.reprotox.2023.108531_bib45","doi-asserted-by":"crossref","DOI":"10.1111\/and.13586","article-title":"Role of genetics and epigenetics in male infertility","volume":"53","author":"Gunes","year":"2021","journal-title":"Andrologia"},{"key":"10.1016\/j.reprotox.2023.108531_bib46","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1177\/1947601910393957","article-title":"DNA methylation: superior or subordinate in the epigenetic hierarchy?","volume":"2","author":"Jin","year":"2011","journal-title":"Genes Cancer"},{"key":"10.1016\/j.reprotox.2023.108531_bib47","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/npp.2012.112","article-title":"DNA methylation and its basic function","volume":"38","author":"Moore","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.reprotox.2023.108531_bib48","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1080\/19396368.2016.1274791","article-title":"Sperm epigenetics in the study of male fertility, offspring health, and potential clinical applications","volume":"63","author":"Jenkins","year":"2017","journal-title":"Syst. Biol. Reprod. Med."},{"key":"10.1016\/j.reprotox.2023.108531_bib49","doi-asserted-by":"crossref","DOI":"10.1186\/s13148-015-0058-4","article-title":"Methylation analysis of histone H4K12ac-associated promoters in sperm of healthy donors and subfertile patients","volume":"7","author":"Vieweg","year":"2015","journal-title":"Clin. Epigenet."},{"key":"10.1016\/j.reprotox.2023.108531_bib50","doi-asserted-by":"crossref","DOI":"10.21037\/atm-20-3364","article-title":"DNA methylation status of imprinted H19 and KvDMR1 genes in human placentas after conception using assisted reproductive technology","volume":"8","author":"Chi","year":"2020","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.reprotox.2023.108531_bib51","doi-asserted-by":"crossref","DOI":"10.1186\/s12864-019-6317-6","article-title":"Epigenetic analysis of high and low motile sperm populations reveals methylation variation in satellite regions within the pericentromeric position and in genes functionally related to sperm DNA organization and maintenance in Bos taurus","volume":"20","author":"Capra","year":"2019","journal-title":"BMC Genom."},{"key":"10.1016\/j.reprotox.2023.108531_bib52","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/andr.12001","article-title":"Sperm global DNA methylation level: association with semen parameters and genome integrity","volume":"3","author":"Montjean","year":"2015","journal-title":"Andrology"},{"key":"10.1016\/j.reprotox.2023.108531_bib53","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1101\/gad.276568.115","article-title":"Role of TET enzymes in DNA methylation, development, and cancer","volume":"30","author":"Rasmussen","year":"2016","journal-title":"Genes Dev."},{"key":"10.1016\/j.reprotox.2023.108531_bib54","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1111\/bph.14888","article-title":"Dietary antioxidants remodel DNA methylation patterns in chronic disease","volume":"177","author":"Beetch","year":"2020","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.reprotox.2023.108531_bib55","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1038\/nature12750","article-title":"TET enzymes, TDG and the dynamics of DNA demethylation","volume":"502","author":"Kohli","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.reprotox.2023.108531_bib56","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.756458","article-title":"Crosstalk between inflammatory signaling and methylation in cancer","volume":"9","author":"Das","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.reprotox.2023.108531_bib57","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.696280","article-title":"The role of host cell DNA methylation in the immune response to bacterial infection","volume":"12","author":"Qin","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.reprotox.2023.108531_bib58","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.3892\/etm.2016.3569","article-title":"DNA methylation in spermatogenesis and male infertility","volume":"12","author":"Cui","year":"2016","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.reprotox.2023.108531_bib59","doi-asserted-by":"crossref","first-page":"2720","DOI":"10.3390\/ijms23052720","article-title":"Epigenetic regulation in uterine fibroids\u2014the role of ten-eleven translocation enzymes and their potential therapeutic application","volume":"23","author":"W\u0142odarczyk","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.reprotox.2023.108531_bib60","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1093\/humrep\/dew096","article-title":"TET enzymes are successively expressed during human spermatogenesis and their expression level is pivotal for male fertility","volume":"31","author":"Ni","year":"2016","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.reprotox.2023.108531_bib61","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-05844-6","article-title":"Methyl-CpG binding domain proteins inhibit interspecies courtship and promote aggression in Drosophila","volume":"7","author":"Gupta","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.reprotox.2023.108531_bib62","first-page":"1640","article-title":"DNA methylation and mRNA expression of imprinted genes in blastocysts derived from an improved in vitro maturation method for oocytes from small antral follicles in polycystic ovary syndrome patients","volume":"34","author":"Zhao","year":"2018","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.reprotox.2023.108531_bib63","article-title":"Role of RNA N6-methyladenosine modification in male infertility and genital system tumors","volume":"9","author":"Liu","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.reprotox.2023.108531_bib64","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.1749-6632.1992.tb38657.x","article-title":"Genotoxic-stress-response genes and growth-arrest genes","volume":"663","author":"Fornace","year":"1992","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.reprotox.2023.108531_bib65","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-93780-x","article-title":"Growth arrest and DNA damage-inducible proteins (GADD45) in psoriasis","volume":"11","author":"Rodr\u00edguez-Jim\u00e9nez","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.reprotox.2023.108531_bib66","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/nrg2843","article-title":"The widespread regulation of microRNA biogenesis, function and decay","volume":"11","author":"Krol","year":"2010","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.reprotox.2023.108531_bib67","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1261\/rna.7240905","article-title":"Microarray profiling of microRNAs reveals frequent coexpression with neighboring miRNAs and host genes","volume":"11","author":"Baskerville","year":"2005","journal-title":"RNA"},{"key":"10.1016\/j.reprotox.2023.108531_bib68","doi-asserted-by":"crossref","DOI":"10.1038\/ncb2544","article-title":"miRNAs and cell-cycle control in ESCs","volume":"14","author":"Le Bot","year":"2012","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.reprotox.2023.108531_bib69","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1101\/gr.082701.108","article-title":"Most mammalian mRNAs are conserved targets of microRNAs","volume":"19","author":"Friedman","year":"2009","journal-title":"Genome Res"},{"key":"10.1016\/j.reprotox.2023.108531_bib70","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1038\/nrcardio.2009.56","article-title":"MicroRNAs and cardiac pathology","volume":"6","author":"Latronico","year":"2009","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.reprotox.2023.108531_bib71","first-page":"3119","article-title":"Hypermethylation of miR-34b\/c is associated with early clinical stages and tumor differentiation in Kazakh patients with esophageal squamous cell carcinoma","volume":"12","author":"Wang","year":"2019","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.reprotox.2023.108531_bib72","doi-asserted-by":"crossref","first-page":"3765","DOI":"10.7150\/jca.25576","article-title":"MicroRNA-34 family in breast cancer: from research to therapeutic potential","volume":"9","author":"Imani","year":"2018","journal-title":"J. Cancer"},{"key":"10.1016\/j.reprotox.2023.108531_bib73","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1080\/15592294.2016.1273308","article-title":"Mutual regulation of microRNAs and DNA methylation in human cancers","volume":"12","author":"Wang","year":"2017","journal-title":"Epigenetics"},{"key":"10.1016\/j.reprotox.2023.108531_bib74","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.bbcan.2015.07.001","article-title":"LncRNA HOTAIR: a master regulator of chromatin dynamics and cancer","volume":"1856","author":"Bhan","year":"2015","journal-title":"Biochim. Biophys. Acta\u00a0Rev. Cancer"},{"key":"10.1016\/j.reprotox.2023.108531_bib75","doi-asserted-by":"crossref","first-page":"13579","DOI":"10.3390\/ijms222413579","article-title":"Long noncoding RNAs: recent insights into their role in male infertility and their potential as biomarkers and therapeutic targets","volume":"22","author":"Zhao","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.reprotox.2023.108531_bib76","doi-asserted-by":"crossref","DOI":"10.1186\/s12958-020-00660-6","article-title":"Long non-coding RNAs (lncRNAs) in spermatogenesis and male infertility","volume":"18","author":"Joshi","year":"2020","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.reprotox.2023.108531_bib77","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1007\/s43032-022-00885-3","article-title":"Circular RNAs: novel biomarkers in spermatogenesis defects and male infertility","volume":"30","author":"Saberiyan","year":"2023","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.reprotox.2023.108531_bib78","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2020.00395","article-title":"CircRNA role and circRNA-dependent network (ceRNET) in Asthenozoospermia","volume":"11","author":"Manfrevola","year":"2020","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.reprotox.2023.108531_bib79","article-title":"Epigenetic roles of PIWI\u2011interacting RNAs (piRNAs) in cancer metastasis (review)","author":"Liu","year":"2018","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.reprotox.2023.108531_bib80","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/nature25018","article-title":"piRNA-mediated regulation of transposon alternative splicing in the soma and germ line","volume":"552","author":"Teixeira","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.reprotox.2023.108531_bib81","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1266\/ggs.88.9","article-title":"The epigenetic regulation of transposable elements by PIWI-interacting RNAs in drosophila","volume":"88","author":"Saito","year":"2013","journal-title":"Genes Genet. Syst."},{"key":"10.1016\/j.reprotox.2023.108531_bib82","doi-asserted-by":"crossref","first-page":"783","DOI":"10.3390\/biom10050783","article-title":"snoRNPs: functions in ribosome biogenesis","volume":"10","author":"Ojha","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/j.reprotox.2023.108531_bib83","doi-asserted-by":"crossref","DOI":"10.1038\/s41420-022-01056-8","article-title":"snoRNAs: functions and mechanisms in biological processes, and roles in tumor pathophysiology","volume":"8","author":"Huang","year":"2022","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.reprotox.2023.108531_bib84","doi-asserted-by":"crossref","DOI":"10.1177\/1933719118765972","article-title":"Regulatory functions of MicroRNAs in male reproductive health: a new approach to understanding male infertility","author":"Harchegani","year":"2018","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.reprotox.2023.108531_bib85","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1095\/biolreprod.108.067827","article-title":"Dicer1 is required for differentiation of the mouse male Germline1","volume":"79","author":"Maatouk","year":"2008","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.reprotox.2023.108531_bib86","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0001738","article-title":"MicroRNA biogenesis is required for mouse primordial germ cell development and spermatogenesis","volume":"3","author":"Hayashi","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.reprotox.2023.108531_bib87","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0025241","article-title":"Dicer1 depletion in male germ cells leads to infertility due to cumulative meiotic and spermiogenic defects","volume":"6","author":"Romero","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.reprotox.2023.108531_bib88","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1407777111","article-title":"Two miRNA clusters, miR-34b\/c and miR-449, are essential for normal brain development, motile ciliogenesis, and spermatogenesis","volume":"111","author":"Wu","year":"2014","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.reprotox.2023.108531_bib89","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.fertnstert.2014.03.040","article-title":"New insights into the expression profile and function of micro-ribonucleic acid in human spermatozoa","volume":"102","author":"Salas-Huetos","year":"2014","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.reprotox.2023.108531_bib90","doi-asserted-by":"crossref","DOI":"10.1186\/1477-7827-7-13","article-title":"Altered microRNA expression in patients with non-obstructive azoospermia","volume":"7","author":"Lian","year":"2009","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.reprotox.2023.108531_bib91","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.fertnstert.2013.09.009","article-title":"MicroRNA expression profiles in human testicular tissues of infertile men with different histopathologic patterns","volume":"101","author":"Abu-Halima","year":"2014","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.reprotox.2023.108531_bib92","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1093\/humrep\/det099","article-title":"Genome-wide microRNA expression profiling in idiopathic non-obstructive azoospermia: significant up-regulation of miR-141, miR-429 and miR-7-1-3p","volume":"28","author":"Wu","year":"2013","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.reprotox.2023.108531_bib93","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.fertnstert.2014.07.001","article-title":"Panel of five microRNAs as potential biomarkers for the diagnosis and assessment of male infertility","volume":"102","author":"Abu-Halima","year":"2014","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.reprotox.2023.108531_bib94","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1016\/j.fertnstert.2012.11.054","article-title":"Altered microRNA expression profiles of human spermatozoa in patients with different spermatogenic impairments","volume":"99","author":"Abu-Halima","year":"2013","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.reprotox.2023.108531_bib95","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.3390\/jcm9051400","article-title":"Diet and nutritional factors in male (in)fertility\u2014underestimated factors","volume":"9","author":"Skoracka","year":"2020","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.reprotox.2023.108531_bib96","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1093\/gerona\/gly082","article-title":"Testicular aging: an overview of ultrastructural, cellular, and molecular alterations","volume":"74","author":"Santiago","year":"2019","journal-title":"J. Gerontol. Ser. A."},{"key":"10.1016\/j.reprotox.2023.108531_bib97","doi-asserted-by":"crossref","DOI":"10.2174\/1381612823666170503150313","article-title":"Fertility and sperm quality in the aging male","volume":"23","author":"Almeida","year":"2017","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.reprotox.2023.108531_bib98","doi-asserted-by":"crossref","first-page":"4198","DOI":"10.3390\/ijms21124198","article-title":"Discovery of the involvement in DNA oxidative damage of human sperm nuclear basic proteins of healthy young men living in polluted areas","volume":"21","author":"Lettieri","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.reprotox.2023.108531_bib99","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/S0015-0282(16)57017-4","article-title":"Superoxide anion in human semen related to seminal parameters and clinical aspects","volume":"62","author":"Mazzilli","year":"1994","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.reprotox.2023.108531_bib100","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1002\/jemt.10319","article-title":"Ubiquitin-dependent proteolysis in mammalian spermatogenesis, fertilization, and sperm quality control: Killing three birds with one stone","volume":"61","author":"Sutovsky","year":"2003","journal-title":"Microsc. Res. Tech."},{"key":"10.1016\/j.reprotox.2023.108531_bib101","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1093\/humrep\/dev003","article-title":"Aged men share the sperm protein PATE1 defect with young asthenozoospermia patients","volume":"30","author":"Liu","year":"2015","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.reprotox.2023.108531_bib102","doi-asserted-by":"crossref","first-page":"109","DOI":"10.2119\/molmed.2014.00158","article-title":"Investigation on the origin of sperm DNA fragmentation: role of apoptosis, immaturity and oxidative stress","volume":"21","author":"Muratori","year":"2015","journal-title":"Mol. Med."},{"key":"10.1016\/j.reprotox.2023.108531_bib103","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S0025-7125(03)00150-0","article-title":"Male factor infertility","volume":"88","author":"Brugh","year":"2004","journal-title":"Med. Clin. North Am."},{"key":"10.1016\/j.reprotox.2023.108531_bib104","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1093\/humrep\/dez121","article-title":"DNA methylation and mRNA expression of imprinted genes in blastocysts derived from an improved in vitro maturation method for oocytes from small antral follicles in polycystic ovary syndrome patients","volume":"34","author":"Saenz-De-Juano","year":"2019","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.reprotox.2023.108531_bib105","doi-asserted-by":"crossref","DOI":"10.3390\/antiox9020111","article-title":"The importance of oxidative stress in determining the functionality of mammalian spermatozoa: a two-edged sword","volume":"9","author":"Aitken","year":"2020","journal-title":"Antioxidants"},{"key":"10.1016\/j.reprotox.2023.108531_bib106","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.jphs.2018.09.012","article-title":"Lipid-modulate activity of Cichorium glandulosum Boiss. et Huet polysaccharide in nonalcoholic fatty liver disease larval zebrafish model","volume":"138","author":"Li","year":"2018","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.reprotox.2023.108531_bib107","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1210\/me.2014-1042","article-title":"Early embryonic androgen exposure induces transgenerational epigenetic and metabolic changes","volume":"28","author":"Xu","year":"2014","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.reprotox.2023.108531_bib108","first-page":"705","article-title":"Transformation of human granulosa cells with the e6 and e7 regions of human papillomavirus","volume":"78","author":"Rainey","year":"1994","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.reprotox.2023.108531_bib109","doi-asserted-by":"crossref","DOI":"10.1016\/j.etap.2021.103779","article-title":"In utero exposure to endocrine-disrupting chemicals, maternal factors and alterations in the epigenetic landscape underlying later-life health effects","volume":"89","author":"Lite","year":"2022","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.reprotox.2023.108531_bib110","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.tjog.2022.05.013","article-title":"Characterization of altered microRNAs related to different phenotypes of polycystic ovarian syndrome (PCOS) in serum, follicular fluid, and cumulus cells","volume":"61","author":"Motahari Rad","year":"2022","journal-title":"Taiwan. J. Obstet. Gynecol."},{"key":"10.1016\/j.reprotox.2023.108531_bib111","first-page":"1","article-title":"Impact of metformin on reproductive tissues: an overview from gametogenesis to gestation","volume":"2","author":"Bertoldo","year":"2014","journal-title":"Ann. Transl. Med"},{"key":"10.1016\/j.reprotox.2023.108531_bib112","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep21982","article-title":"BPA-induced deregulation of epigenetic patterns: effects on female zebrafish reproduction","volume":"6","author":"Santangeli","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.reprotox.2023.108531_bib113","article-title":"Exposure to environmental pollutant bisphenol A causes oxidative damage and lipid accumulation in Zebrafish larvae: Protective role of WL15 peptide derived from cysteine and glycine-rich protein 2","author":"Guru","year":"2022","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.reprotox.2023.108531_bib114","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.reprotox.2019.08.014","article-title":"Male exposure to bisphenol A (BPA) and semen quality in the home observation of periconceptional exposures (HOPE) cohort","volume":"90","author":"Pollard","year":"2019","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.reprotox.2023.108531_bib115","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1093\/humrep\/dey357","article-title":"Cytological and molecular aspects of the ageing sperm","volume":"34","author":"Paoli","year":"2019","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.reprotox.2023.108531_bib116","doi-asserted-by":"crossref","DOI":"10.1186\/s40795-020-00387-y","article-title":"Vitamin C ameliorates tetrahydrocannabinol-induced spermatotoxicity in-vitro","volume":"6","author":"Alagbonsi","year":"2020","journal-title":"BMC Nutr."},{"key":"10.1016\/j.reprotox.2023.108531_bib117","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1210\/er.2006-0006","article-title":"Jekyll and hyde: two faces of cannabinoid signaling in male and female fertility","volume":"27","author":"Wang","year":"2006","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.reprotox.2023.108531_bib118","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1095\/biolreprod.109.079210","article-title":"A gradient of 2-Arachidonoylglycerol regulates mouse epididymal sperm cell start-up1","volume":"82","author":"Cobellis","year":"2010","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.reprotox.2023.108531_bib119","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.toxicon.2020.01.006","article-title":"Podophyllotoxin affects porcine oocyte maturation by inducing oxidative stress-mediated early apoptosis","volume":"176","author":"Jiang","year":"2020","journal-title":"Toxicon"},{"key":"10.1016\/j.reprotox.2023.108531_bib120","first-page":"1","article-title":"Oxidation of sperm dna and male infertility","volume":"10","author":"Ghaleno","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.reprotox.2023.108531_bib121","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/antiox9020134","article-title":"Molecular changes induced by oxidative stress that impair human sperm motility","volume":"9","author":"Nowicka\u2010bauer","year":"2020","journal-title":"Antioxidants"},{"key":"10.1016\/j.reprotox.2023.108531_bib122","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.102071","article-title":"Male subfertility and oxidative stress","volume":"46","author":"Evans","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.reprotox.2023.108531_bib123","doi-asserted-by":"crossref","DOI":"10.1186\/s43043-022-00096-5","article-title":"Toxicological outcome of phthalate exposure on male fertility: Ameliorative impacts of the co-administration of N-acetylcysteine and zinc sulfate in rats","volume":"27","author":"Emojevwe","year":"2022","journal-title":"Middle East Fertil. Soc. J."},{"key":"10.1016\/j.reprotox.2023.108531_bib124","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/j.fertnstert.2016.07.1118","article-title":"Effects of bisphenol A on male and couple reproductive health: a review","volume":"106","author":"M\u00ednguez-Alarc\u00f3n","year":"2016","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.reprotox.2023.108531_bib125","doi-asserted-by":"crossref","first-page":"122","DOI":"10.3109\/19396360903443658","article-title":"Exposure to polychlorinated biphenyls (PCBs) and male reproduction","volume":"56","author":"Meeker","year":"2010","journal-title":"Syst. Biol. Reprod. Med."},{"key":"10.1016\/j.reprotox.2023.108531_bib126","doi-asserted-by":"crossref","first-page":"3387","DOI":"10.18203\/2320-1770.ijrcog20173448","article-title":"Pesticides, insecticides and male infertility","volume":"6","author":"Roy","year":"2017","journal-title":"Int. J. Reprod. Contracept., Obstet. Gynecol."},{"key":"10.1016\/j.reprotox.2023.108531_bib127","doi-asserted-by":"crossref","DOI":"10.5935\/1518-0557.20220013","article-title":"The effects of toxic heavy metals lead, cadmium and copper on the epidemiology of male and female infertility","author":"Manouchehri","year":"2022","journal-title":"JBRA Assist. Reprod."},{"key":"10.1016\/j.reprotox.2023.108531_bib128","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.114525","article-title":"Three organophosphate flame retardants (OPFRs) reduce sperm quality in Chinese rare minnows (Gobiocypris rarus)","volume":"263","author":"Chen","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.reprotox.2023.108531_bib129","doi-asserted-by":"crossref","DOI":"10.5812\/ircmj.17(4)2015.26930","article-title":"Air pollution and quality of sperm: a meta-analysis","volume":"17","author":"Fathi Najafi","year":"2015","journal-title":"Iran. Red. Crescent Med. J."},{"key":"10.1016\/j.reprotox.2023.108531_bib130","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/nrurol.2015.145","article-title":"Adverse effects of common medications on male fertility","volume":"12","author":"Samplaski","year":"2015","journal-title":"Nat. Rev. Urol."},{"key":"10.1016\/j.reprotox.2023.108531_bib131","first-page":"24","article-title":"The effects of exposure to low frequencelectromagnetic fields on male fertility","volume":"24","author":"Darbandi","year":"2018","journal-title":"Altern. Ther. Health Med."},{"key":"10.1016\/j.reprotox.2023.108531_bib132","series-title":"Male Infertil","first-page":"161","article-title":"The Impact of Cell Phone, Laptop Computer, and Microwave Oven Usage on Male Fertility","author":"McGill","year":"2014"},{"key":"10.1016\/j.reprotox.2023.108531_bib133","doi-asserted-by":"crossref","DOI":"10.5812\/semj.101741","article-title":"The impact of radiofrequency waves on male infertility: a systematic review","volume":"22","author":"Darvish","year":"2020","journal-title":"Shiraz E-Med. J."},{"key":"10.1016\/j.reprotox.2023.108531_bib134","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpap.2021.100093","article-title":"Deleterious impact of short duration UV-A exposure on the human sperm cell \u2013an in vitro study","volume":"9","author":"Rajput","year":"2022","journal-title":"J. Photochem. Photobiol."},{"key":"10.1016\/j.reprotox.2023.108531_bib135","series-title":"Male Infertil","first-page":"185","article-title":"Ionizing Radiation and Male Fertility","author":"Ahmad","year":"2017"},{"key":"10.1016\/j.reprotox.2023.108531_bib136","series-title":"Lead Chem","article-title":"Effects of Lead on Reproductive Health","author":"La Llave Le\u00f3n","year":"2020"},{"key":"10.1016\/j.reprotox.2023.108531_bib137","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/aja.2012.121","article-title":"Environmental mercury exposure, semen quality and reproductive hormones in Greenlandic Inuit and European men: a cross-sectional study","volume":"15","author":"Mocevic","year":"2013","journal-title":"Asian J. Androl."},{"key":"10.1016\/j.reprotox.2023.108531_bib138","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.reprotox.2019.02.012","article-title":"Exposure to mercury and human reproductive health: a systematic review","volume":"85","author":"Henriques","year":"2019","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.reprotox.2023.108531_bib139","doi-asserted-by":"crossref","DOI":"10.1111\/and.14516","article-title":"Impacts of cadmium on male fertility: lessons learnt so far","volume":"54","author":"Ikokide","year":"2022","journal-title":"Andrologia"},{"key":"10.1016\/j.reprotox.2023.108531_bib140","article-title":"Toxicological effects of cadmium on mammalian testis","volume":"11","author":"Zhu","year":"2020","journal-title":"Front. Genet."},{"key":"10.1016\/j.reprotox.2023.108531_bib141","doi-asserted-by":"crossref","DOI":"10.1111\/and.12791","article-title":"Review on arsenic-induced toxicity in male reproductive system and its amelioration","volume":"49","author":"Zubair","year":"2017","journal-title":"Andrologia"},{"key":"10.1016\/j.reprotox.2023.108531_bib142","doi-asserted-by":"crossref","first-page":"167","DOI":"10.12717\/DR.2015.19.4.167","article-title":"Arsenic toxicity in male reproduction and development","volume":"19","author":"Kim","year":"2015","journal-title":"Dev. Reprod."},{"key":"10.1016\/j.reprotox.2023.108531_bib143","doi-asserted-by":"crossref","first-page":"214","DOI":"10.3390\/jox12030016","article-title":"Arsenic, oxidative stress and reproductive system","volume":"12","author":"Zargari","year":"2022","journal-title":"J. Xenobiotics."},{"key":"10.1016\/j.reprotox.2023.108531_bib144","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2021.799294","article-title":"The impact of oxidative stress in male infertility","volume":"8","author":"Mannucci","year":"2022","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.reprotox.2023.108531_bib145","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.fsi.2016.05.030","article-title":"Coagulation profile, gene expression and bioinformatics characterization of coagulation factor X of striped murrel Channa striatus","volume":"55","author":"Arasu","year":"2016","journal-title":"Fish. Shellfish Immunol."},{"key":"10.1016\/j.reprotox.2023.108531_bib146","first-page":"64","article-title":"Toxic effects of heavy metals (mercury and arsenic) on the male fertility","volume":"28","author":"Ilieva","year":"2021","journal-title":"Pathol. Anthropol. Mus. Bulg. Anat. Soc. Acta Morphol. Anthropol."},{"key":"10.1016\/j.reprotox.2023.108531_bib147","doi-asserted-by":"crossref","unstructured":"W.J. Elliott, Hypertension Curriculum Review Donald G. Vidt, MD, Section Editor. Drug Interactions and Drugs That Affect Blood Pressure, J. Clin. Hypertens. 8 (2006) 731\u2013737. https:\/\/doi.org\/10.1111\/j.1524\u20136175.2006.05939.x.","DOI":"10.1111\/j.1524-6175.2006.05939.x"},{"key":"10.1016\/j.reprotox.2023.108531_bib148","article-title":"Heavy metals, biomarkers of oxidative stress and changes in sperm function: a case-control study","author":"Chinyere Nsonwu-Anyanwu","year":"2019","journal-title":"Int. J. Reprod. Biomed."},{"key":"10.1016\/j.reprotox.2023.108531_bib149","doi-asserted-by":"crossref","DOI":"10.1186\/1476-069X-10-6","article-title":"Relationships between heavy metal concentrations in three different body fluids and male reproductive parameters: a pilot study","volume":"10","author":"Mendiola","year":"2011","journal-title":"Environ. Heal."},{"key":"10.1016\/j.reprotox.2023.108531_bib150","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.3390\/antiox10091473","article-title":"Impact of heavy metals on human male fertility\u2014an overview","volume":"10","author":"L\u00f3pez-Botella","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.reprotox.2023.108531_bib151","doi-asserted-by":"crossref","first-page":"147","DOI":"10.3109\/19396360903582216","article-title":"Adverse effects of low level heavy metal exposure on male reproductive function","volume":"56","author":"Wirth","year":"2010","journal-title":"Syst. Biol. Reprod. Med."},{"key":"10.1016\/j.reprotox.2023.108531_bib152","doi-asserted-by":"crossref","first-page":"58","DOI":"10.4103\/0970-1591.78428","article-title":"Varicocele-induced infertility: newer insights into its pathophysiology","volume":"27","author":"Lipshultz","year":"2011","journal-title":"Indian J. Urol."},{"key":"10.1016\/j.reprotox.2023.108531_bib153","doi-asserted-by":"crossref","DOI":"10.1016\/j.jogoh.2021.102101","article-title":"Relationship between nuclear DNA fragmentation, mitochondrial DNA damage and standard sperm parameters in spermatozoa of infertile patients with leukocytospermia","volume":"50","author":"Derbel","year":"2021","journal-title":"J. Gynecol. Obstet. Hum. Reprod."},{"key":"10.1016\/j.reprotox.2023.108531_bib154","doi-asserted-by":"crossref","first-page":"105","DOI":"10.3390\/foods10010105","article-title":"Consumer preference, quality, and safety of organic and conventional fresh fruits, vegetables, and cereals","volume":"10","author":"Rahman","year":"2021","journal-title":"Foods"},{"key":"10.1016\/j.reprotox.2023.108531_bib155","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1093\/humupd\/dmi013","article-title":"Androgen excess fetal programming of female reproduction: a developmental aetiology for polycystic ovary syndrome?","volume":"11","author":"Abbott","year":"2005","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.reprotox.2023.108531_bib156","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1016\/j.fertnstert.2010.04.078","article-title":"Influence of microwave exposure on fertility of male rats","volume":"95","author":"Kumar","year":"2011","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.reprotox.2023.108531_bib157","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3109\/15368378.2012.700292","article-title":"Evidence for mobile phone radiation exposure effects on reproductive pattern of male rats: Role of ROS","volume":"31","author":"Kesari","year":"2012","journal-title":"Electromagn. Biol. Med."},{"key":"10.1016\/j.reprotox.2023.108531_bib158","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.fertnstert.2007.01.166","article-title":"Effect of cell phone usage on semen analysis in men attending infertility clinic: an observational study","volume":"89","author":"Agarwal","year":"2008","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.reprotox.2023.108531_bib159","series-title":"Gen. Appl. Toxicol.","article-title":"Biological Correlates of Low-Level Electromagnetic-Field Exposure","author":"Behari","year":"2009"},{"key":"10.1016\/j.reprotox.2023.108531_bib160","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s12013-012-9414-6","article-title":"Biophysical evaluation of radiofrequency electromagnetic field effects on male reproductive pattern","volume":"65","author":"Kesari","year":"2013","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.reprotox.2023.108531_bib161","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0165-7992(86)90155-7","article-title":"An increased frequency of human sperm chromosomal abnormalities after radiotherapy","volume":"174","author":"Martin","year":"1986","journal-title":"Mutat. Res. Lett."},{"key":"10.1016\/j.reprotox.2023.108531_bib162","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1109\/TBMEL.1962.4322972","article-title":"Effects of chronic microwave irradiation on mice","volume":"9","author":"Prausnitz","year":"1962","journal-title":"Ire Trans. Biomed. Electron."},{"key":"10.1016\/j.reprotox.2023.108531_bib163","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1016\/S0015-0282(16)55584-8","article-title":"Comparison of three methods to detect white blood cells in semen: leukocyte esterase dipstick test, granulocyte elastase enzymeimmunoassay, and peroxidase cytochemistry","volume":"58","author":"Wolff","year":"1992","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.reprotox.2023.108531_bib164","doi-asserted-by":"crossref","DOI":"10.1177\/1557988320970053","article-title":"Reactive oxygen species secreted by leukocytes in semen induce self-expression of interleukin-6 and affect sperm quality","volume":"14","author":"Li","year":"2020","journal-title":"Am. J. Mens. Health"},{"key":"10.1016\/j.reprotox.2023.108531_bib165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2019\/7261842","article-title":"Relationships between ghrelin and obestatin with MDA, proinflammatory cytokines, GSH\/GSSG ratio, catalase activity, and semen parameters in infertile patients with leukocytospermia and varicocele","volume":"2019","author":"Micheli","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.reprotox.2023.108531_bib166","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.fertnstert.2014.04.017","article-title":"Resistin, interleukin-6, tumor necrosis factor-alpha, and human semen parameters in the presence of leukocytospermia, smoking habit, and varicocele","volume":"102","author":"Moretti","year":"2014","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.reprotox.2023.108531_bib167","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/S0015-0282(16)56952-0","article-title":"Stimulation of oxidant generation by human sperm suspensions using phorbol esters and formyl peptides: relationships with motility and fertilization in vitro","volume":"62","author":"Krausz","year":"1994","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.reprotox.2023.108531_bib168","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0301-2115(99)00073-1","article-title":"Seminal immune response in infertile men with leukocytospermia: effect on antioxidant activity","volume":"86","author":"Omu","year":"1999","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.reprotox.2023.108531_bib169","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S0015-0282(00)00709-3","article-title":"Are seminal fluid microorganisms of significance or merely contaminants?","volume":"74","author":"Cottell","year":"2000","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.reprotox.2023.108531_bib170","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.fertnstert.2006.08.109","article-title":"Prevalence of sexually transmissible pathogens in semen from asymptomatic male infertility patients with and without leukocytospermia","volume":"87","author":"Bezold","year":"2007","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.reprotox.2023.108531_bib171","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1093\/humrep\/dey038","article-title":"Accuracy of human sperm DNA oxidation quantification and threshold determination using an 8-OHdG immuno-detection assay","volume":"33","author":"Vorilhon","year":"2018","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.reprotox.2023.108531_bib172","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1071\/RD16090","article-title":"The effects in vitro of TNF-\u03b1 and its antagonist \u2018etanercept\u2019 on ejaculated human sperm","volume":"29","author":"Pascarelli","year":"2017","journal-title":"Reprod. Fertil. Dev."},{"key":"10.1016\/j.reprotox.2023.108531_bib173","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1007\/s10989-018-9793-7","article-title":"Xenobiotic binding domain of glutathione s-transferase has cryptic antimicrobial peptides","volume":"25","author":"Horam","year":"2019","journal-title":"Int. J. Pept. Res. Ther."},{"key":"10.1016\/j.reprotox.2023.108531_bib174","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.ijbiomac.2019.12.218","article-title":"Russula alutacea Fr. polysaccharide ameliorates inflammation in both RAW264.7 and zebrafish (Danio rerio) larvae","volume":"145","author":"Li","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.reprotox.2023.108531_bib175","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/0890-6238(94)90070-1","article-title":"Effects of crude aqueous extract of Carica papaya seeds in male albino mice","volume":"8","author":"Chinoy","year":"1994","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.reprotox.2023.108531_bib176","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114375","article-title":"Caesalpinia bonduc (L.) Roxb. as a promising source of pharmacological compounds to treat Poly Cystic Ovary Syndrome (PCOS): a review","volume":"279","author":"Kandasamy","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.reprotox.2023.108531_bib177","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.yfrne.2007.12.005","article-title":"Estradiol and neurodegenerative oxidative stress","volume":"29","author":"Nilsen","year":"2008","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.reprotox.2023.108531_bib178","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1530\/EJE-12-0288","article-title":"A cohort effect on serum testosterone levels in Finnish men","volume":"168","author":"Perheentupa","year":"2013","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.reprotox.2023.108531_bib179","doi-asserted-by":"crossref","first-page":"4154","DOI":"10.1210\/jc.2006-1309","article-title":"Cis-unsaturated fatty acids stimulate reactive oxygen species generation and lipid peroxidation in human spermatozoa","volume":"91","author":"Aitken","year":"2006","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.reprotox.2023.108531_bib180","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1002\/ptr.7685","article-title":"Nimbin analog N2 alleviates high testosterone induced oxidative stress in CHO cells and alters the expression of Tox3 and Dennd1a signal transduction pathway involved in the PCOS zebrafish","volume":"37","author":"Sudhakaran","year":"2023","journal-title":"Phyther. Res."},{"key":"10.1016\/j.reprotox.2023.108531_bib181","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1111\/andr.12157","article-title":"Involvement of homocysteine, homocysteine thiolactone, and paraoxonase type 1 ( <scp>PON<\/scp> \u20101) in the etiology of defective human sperm function","volume":"4","author":"Aitken","year":"2016","journal-title":"Andrology"},{"key":"10.1016\/j.reprotox.2023.108531_bib182","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mrfmmm.2008.02.002","article-title":"Impact of estrogenic compounds on DNA integrity in human spermatozoa: evidence for cross-linking and redox cycling activities","volume":"641","author":"Bennetts","year":"2008","journal-title":"Mutat. Res. Mol. Mech. Mutagen."},{"key":"10.1016\/j.reprotox.2023.108531_bib183","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.reprotox.2016.09.014","article-title":"In vitro exposure of human spermatozoa to bisphenol A induces pro-oxidative\/apoptotic mitochondrial dysfunction","volume":"66","author":"Barbonetti","year":"2016","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.reprotox.2023.108531_bib184","doi-asserted-by":"crossref","DOI":"10.1186\/s12958-016-0186-5","article-title":"17\u03b2-estradiol modifies human spermatozoa mitochondrial function in vitro","volume":"14","author":"Kotwicka","year":"2016","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.reprotox.2023.108531_bib185","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1111\/andr.12499","article-title":"Parabens generate reactive oxygen species in human spermatozoa","volume":"6","author":"Samarasinghe","year":"2018","journal-title":"Andrology"},{"key":"10.1016\/j.reprotox.2023.108531_bib186","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/j.2047-2927.2012.00056.x","article-title":"On methods for the detection of reactive oxygen species generation by human spermatozoa: analysis of the cellular responses to catechol oestrogen, lipid aldehyde, menadione and arachidonic acid","volume":"1","author":"Aitken","year":"2013","journal-title":"Andrology"},{"key":"10.1016\/j.reprotox.2023.108531_bib187","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/aja.2011.70","article-title":"Male sexual dysfunction and infertility associated with neurological disorders","volume":"14","author":"Fode","year":"2012","journal-title":"Asian J. Androl."},{"key":"10.1016\/j.reprotox.2023.108531_bib188","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/S0140-6736(07)60238-4","article-title":"Sexual function in men and women with neurological disorders","volume":"369","author":"Rees","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.reprotox.2023.108531_bib189","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1093\/humrep\/dem077","article-title":"Insulin dependant diabetes mellitus: implications for male reproductive function","volume":"22","author":"Agbaje","year":"2007","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.reprotox.2023.108531_bib190","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0015-0282(99)00154-5","article-title":"Leukocytes in semen from men with spinal cord injuries","volume":"72","author":"Aird","year":"1999","journal-title":"Fertil. Steril."}],"container-title":["Reproductive Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623823002058?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623823002058?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T14:02:30Z","timestamp":1760191350000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0890623823002058"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":190,"alternative-id":["S0890623823002058"],"URL":"https:\/\/doi.org\/10.1016\/j.reprotox.2023.108531","relation":{},"ISSN":["0890-6238"],"issn-type":[{"value":"0890-6238","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Unravelling the epigenetic impact: Oxidative stress and its role in male infertility-associated sperm dysfunction","name":"articletitle","label":"Article Title"},{"value":"Reproductive Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.reprotox.2023.108531","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108531"}}