{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T03:05:37Z","timestamp":1765422337453},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T00:00:00Z","timestamp":1718755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Toxicology"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.reprotox.2024.108648","type":"journal-article","created":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T05:15:52Z","timestamp":1719033352000},"page":"108648","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["The role of DNA damage response in human embryonic stem cells exposed to atmospheric oxygen tension: Implications for embryo development and differentiation"],"prefix":"10.1016","volume":"128","author":[{"given":"Yuanyuan","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fenglei","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linyun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quanmin","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujia","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijun","family":"Lou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuchan","family":"Mao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liya","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.reprotox.2024.108648_bib1","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2017.0213","article-title":"Pluripotent stem cells: induction and self-renewal","volume":"373","author":"Abu-Dawud","year":"2018","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.reprotox.2024.108648_bib2","article-title":"Oxidative stress and assisted reproduction: a comprehensive review of its pathophysiological role and strategies for optimizing embryo culture environment","volume":"11","author":"Agarwal","year":"2022","journal-title":"Antioxid. (Basel)"},{"key":"10.1016\/j.reprotox.2024.108648_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-0716-0644-5_1","article-title":"Detection of DNA double-strand breaks by gamma-H2AX immunodetection","volume":"2153","author":"Barroso","year":"2021","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.reprotox.2024.108648_bib4","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1080\/19396368.2020.1754961","article-title":"The effect of low and ultra-low oxygen tensions on mammalian embryo culture and development in experimental and clinical IVF","volume":"66","author":"Belli","year":"2020","journal-title":"Syst. Biol. Reprod. Med"},{"key":"10.1016\/j.reprotox.2024.108648_bib5","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1093\/humrep\/dez011","article-title":"Oxygen concentration alters mitochondrial structure and function in in vitro fertilized preimplantation mouse embryos","volume":"34","author":"Belli","year":"2019","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.reprotox.2024.108648_bib6","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1093\/humrep\/deaa047","article-title":"Oxygen concentration alters mitochondrial structure and function in in vitro fertilized preimplantation mouse embryos","volume":"35","author":"Belli","year":"2020","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.reprotox.2024.108648_bib7","doi-asserted-by":"crossref","first-page":"5958","DOI":"10.1158\/0008-5472.CAN-19-0840","article-title":"Cleaved caspase-3 transcriptionally regulates angiogenesis-promoting chemotherapy resistance","volume":"79","author":"Bernard","year":"2019","journal-title":"Cancer Res"},{"key":"10.1016\/j.reprotox.2024.108648_bib8","doi-asserted-by":"crossref","first-page":"4206","DOI":"10.1242\/dev.107086","article-title":"Stem cells and the impact of ROS signaling","volume":"141","author":"Bigarella","year":"2014","journal-title":"Development"},{"key":"10.1016\/j.reprotox.2024.108648_bib9","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1007\/s10815-017-0971-x","article-title":"Using stem cell oxygen physiology to optimize blastocyst culture while minimizing hypoxic stress","volume":"34","author":"Bolnick","year":"2017","journal-title":"J. Assist Reprod. Genet"},{"key":"10.1016\/j.reprotox.2024.108648_bib10","doi-asserted-by":"crossref","first-page":"hoz044","DOI":"10.1093\/hropen\/hoz044","article-title":"Survey on ART and IUI: legislation, regulation, funding and registries in European countries: The European IVF-monitoring Consortium (EIM) for the European Society of Human Reproduction and Embryology (ESHRE)","volume":"2020","author":"Calhaz-Jorge","year":"2020","journal-title":"Hum. Reprod. Open"},{"key":"10.1016\/j.reprotox.2024.108648_bib11","doi-asserted-by":"crossref","DOI":"10.1007\/s10815-023-02943-4","article-title":"Oxygen concentration from days 1 to 3 after insemination affects the embryo culture quality, cumulative live birth rate, and perinatal outcomes","author":"Chen","year":"2023","journal-title":"J. Assist Reprod. Genet"},{"key":"10.1016\/j.reprotox.2024.108648_bib12","doi-asserted-by":"crossref","first-page":"5050527","DOI":"10.1155\/2021\/5050527","article-title":"Dynamic oxygen conditions promote the translocation of HIF-1alpha to the nucleus in mouse blastocysts","volume":"2021","author":"Choi","year":"2021","journal-title":"Biomed. Res Int"},{"key":"10.1016\/j.reprotox.2024.108648_bib13","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.fertnstert.2013.03.044","article-title":"Reduced oxygen tension improves embryo quality but not clinical pregnancy rates: a randomized clinical study into ovum donation cycles","volume":"100","author":"de los Santos","year":"2013","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.reprotox.2024.108648_bib14","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1093\/humrep\/dey370","article-title":"Influence of ultra-low oxygen (2%) tension on in-vitro human embryo development","volume":"34","author":"De Munck","year":"2019","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.reprotox.2024.108648_bib15","doi-asserted-by":"crossref","first-page":"F95","DOI":"10.1530\/REP-22-0121","article-title":"Oxidative stress and reproductive function: Reactive oxygen species in the mammalian pre-implantation embryo","volume":"164","author":"Deluao","year":"2022","journal-title":"Reproduction"},{"key":"10.1016\/j.reprotox.2024.108648_bib16","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/cdd.2014.150","article-title":"Oxidative stress and autophagy: the clash between damage and metabolic needs","volume":"22","author":"Filomeni","year":"2015","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.reprotox.2024.108648_bib17","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/s41563-020-00829-9","article-title":"Stem-cell-based embryo models for fundamental research and translation","volume":"20","author":"Fu","year":"2021","journal-title":"Nat. Mater."},{"key":"10.1016\/j.reprotox.2024.108648_bib18","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/s41586-020-2759-x","article-title":"Initiation of a conserved trophectoderm program in human, cow and mouse embryos","volume":"587","author":"Gerri","year":"2020","journal-title":"nature"},{"key":"10.1016\/j.reprotox.2024.108648_bib19","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s13148-017-0318-6","article-title":"Global DNA methylation levels are altered by modifiable clinical manipulations in assisted reproductive technologies","volume":"9","author":"Ghosh","year":"2017","journal-title":"Clin. Epigenetics"},{"key":"10.1016\/j.reprotox.2024.108648_bib20","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21113743","article-title":"Urinary 8-OHdG as a biomarker for oxidative stress: a systematic literature review and meta-analysis","volume":"21","author":"Graille","year":"2020","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.reprotox.2024.108648_bib21","doi-asserted-by":"crossref","DOI":"10.3390\/genes14071346","article-title":"Therapeutic targeting of DNA replication stress in cancer","volume":"14","author":"Gu","year":"2023","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.reprotox.2024.108648_bib22","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1089\/scd.2009.0313","article-title":"Effects of oxidative stress on mouse embryonic stem cell proliferation, apoptosis, senescence, and self-renewal","volume":"19","author":"Guo","year":"2010","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.reprotox.2024.108648_bib23","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-01488-9","article-title":"Impact of oxygen tension according to embryo stage of development: a prospective randomized study","volume":"11","author":"Herbemont","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.reprotox.2024.108648_bib24","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1002\/bdrc.20056","article-title":"Regulation of proliferation and apoptosis during development of the preimplantation embryo and the placenta","volume":"75","author":"Huppertz","year":"2005","journal-title":"Birth Defects Res C. Embryo Today"},{"key":"10.1016\/j.reprotox.2024.108648_bib25","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/S0039-9140(97)00017-9","article-title":"A highly water-soluble disulfonated tetrazolium salt as a chromogenic indicator for NADH as well as cell viability","volume":"44","author":"Ishiyama","year":"1997","journal-title":"Talanta"},{"key":"10.1016\/j.reprotox.2024.108648_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2022.153314","article-title":"Arsenic exposure during porcine oocyte maturation negatively affects embryonic development by triggering oxidative stress-induced mitochondrial dysfunction and apoptosis","volume":"480","author":"Kang","year":"2022","journal-title":"Toxicology"},{"key":"10.1016\/j.reprotox.2024.108648_bib27","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21113934","article-title":"Advances in DNA repair-emerging players in the arena of eukaryotic DNA repair","volume":"21","author":"Kciuk","year":"2020","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.reprotox.2024.108648_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.pbiomolbio.2023.10.002","article-title":"Growth or death? Control of cell destiny by mTOR and autophagy pathways","author":"Khalil","year":"2023","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"10.1016\/j.reprotox.2024.108648_bib29","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2021108863","article-title":"Autophagy in major human diseases","volume":"40","author":"Klionsky","year":"2021","journal-title":"EMBO J."},{"key":"10.1016\/j.reprotox.2024.108648_bib30","doi-asserted-by":"crossref","first-page":"77007","DOI":"10.1289\/EHP7349","article-title":"Characterizing the low-dose effects of methylmercury on the early stages of embryo development using cultured human embryonic stem cells","volume":"129","author":"Li","year":"2021","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.reprotox.2024.108648_bib31","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/s41392-023-01548-8","article-title":"A new wave of innovations within the DNA damage response","volume":"8","author":"Li","year":"2023","journal-title":"Signal Transduct. Target Ther."},{"key":"10.1016\/j.reprotox.2024.108648_bib32","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.ydbio.2019.06.019","article-title":"Dnmt1 is required for proximal-distal patterning of the lung endoderm and for restraining alveolar type 2 cell fate","volume":"454","author":"Liberti","year":"2019","journal-title":"Dev. Biol."},{"key":"10.1016\/j.reprotox.2024.108648_bib33","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.stem.2009.10.009","article-title":"HLA-matching potential of an established human embryonic stem cell bank in China","volume":"5","author":"Lin","year":"2009","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.reprotox.2024.108648_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2021.153083","article-title":"Toxicity mechanism of acrolein on DNA damage and apoptosis in BEAS-2B cells: Insights from cell biology and molecular docking analyses","volume":"466","author":"Liu","year":"2022","journal-title":"Toxicology"},{"key":"10.1016\/j.reprotox.2024.108648_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110919","article-title":"Stub1 maintains proteostasis of master transcription factors in embryonic stem cells","volume":"39","author":"Mamun","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.reprotox.2024.108648_bib36","article-title":"Unraveling the Consequences of oxygen imbalance on early embryo development: exploring mitigation strategies","volume":"13","author":"Marsico","year":"2023","journal-title":"Anim. (Basel)"},{"key":"10.1016\/j.reprotox.2024.108648_bib37","doi-asserted-by":"crossref","first-page":"F125","DOI":"10.1530\/REP-22-0189","article-title":"Oxidative stress and reproductive function: sperm telomeres, oxidative stress, and infertility","volume":"164","author":"Moazamian","year":"2022","journal-title":"Reproduction"},{"key":"10.1016\/j.reprotox.2024.108648_bib38","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/j.stemcr.2021.03.026","article-title":"From embryos to embryoids: How external signals and self-organization drive embryonic development","volume":"16","author":"Morales","year":"2021","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.reprotox.2024.108648_bib39","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1016\/j.bbagen.2012.09.001","article-title":"DNA double-strand break response in stem cells: mechanisms to maintain genomic integrity","volume":"1830","author":"Nagaria","year":"2013","journal-title":"Biochim Biophys. Acta"},{"key":"10.1016\/j.reprotox.2024.108648_bib40","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.fertnstert.2016.02.037","article-title":"Low versus atmospheric oxygen tension for embryo culture in assisted reproduction: a systematic review and meta-analysis","volume":"106","author":"Nastri","year":"2016","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.reprotox.2024.108648_bib41","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/humupd\/dmx028","article-title":"In vivo oxygen, temperature and pH dynamics in the female reproductive tract and their importance in human conception: a systematic review","volume":"24","author":"Ng","year":"2018","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.reprotox.2024.108648_bib42","first-page":"562","article-title":"Complete human day 14 post-implantation embryo models from naive ES cells","volume":"622","author":"Oldak","year":"2023","journal-title":"nature"},{"key":"10.1016\/j.reprotox.2024.108648_bib43","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s00018-015-2071-3","article-title":"Autophagy in stem and progenitor cells","volume":"73","author":"Rodolfo","year":"2016","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.reprotox.2024.108648_bib44","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.febslet.2011.12.039","article-title":"Back-reactions, short-circuits, leaks and other energy wasteful reactions in biological electron transfer: redox tuning to survive life in O(2)","volume":"586","author":"Rutherford","year":"2012","journal-title":"FEBS Lett."},{"key":"10.1016\/j.reprotox.2024.108648_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119942","article-title":"Reactive oxygen species: role in carcinogenesis, cancer cell signaling and tumor progression","volume":"284","author":"Sarmiento-Salinas","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.reprotox.2024.108648_bib46","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21061996","article-title":"Proteomics analysis reveals that warburg effect along with modification in lipid metabolism improves in vitro embryo development under low oxygen","volume":"21","author":"Shahzad","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.reprotox.2024.108648_bib47","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.12688\/f1000research.9495.2","article-title":"Human brain harbors single nucleotide somatic variations in functionally relevant genes possibly mediated by oxidative stress","volume":"5","author":"Sharma","year":"2016","journal-title":"F1000Res"},{"key":"10.1016\/j.reprotox.2024.108648_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2018.101084","article-title":"ROS and the DNA damage response in cancer","volume":"25","author":"Srinivas","year":"2019","journal-title":"Redox Biol."},{"key":"10.1016\/j.reprotox.2024.108648_bib49","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1126\/science.282.5391.1145","article-title":"Embryonic stem cell lines derived from human blastocysts","volume":"282","author":"Thomson","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.reprotox.2024.108648_bib50","article-title":"Comprehensive transcriptome analysis of mRNA expression patterns of early embryo development in goat under hypoxic and normoxic conditions","volume":"10","author":"Wan","year":"2021","journal-title":"Biol. (Basel)"},{"key":"10.1016\/j.reprotox.2024.108648_bib51","article-title":"Autophagy in disease onset and progression","author":"Wang","year":"2023","journal-title":"Aging Dis."},{"key":"10.1016\/j.reprotox.2024.108648_bib52","doi-asserted-by":"crossref","first-page":"565","DOI":"10.4252\/wjsc.v11.i9.565","article-title":"Effects of environmental stressors on stem cells","volume":"11","author":"Worley","year":"2019","journal-title":"World J. Stem Cells"},{"key":"10.1016\/j.reprotox.2024.108648_bib53","article-title":"Early life oxidative stress and long-lasting cardiovascular effects on offspring conceived by assisted reproductive technologies: a review","volume":"21","author":"Yang","year":"2020","journal-title":"Int J. Mol. Sci."}],"container-title":["Reproductive Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623824001151?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623824001151?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T20:02:27Z","timestamp":1724443347000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0890623824001151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":53,"alternative-id":["S0890623824001151"],"URL":"https:\/\/doi.org\/10.1016\/j.reprotox.2024.108648","relation":{},"ISSN":["0890-6238"],"issn-type":[{"type":"print","value":"0890-6238"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of DNA damage response in human embryonic stem cells exposed to atmospheric oxygen tension: Implications for embryo development and differentiation","name":"articletitle","label":"Article Title"},{"value":"Reproductive Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.reprotox.2024.108648","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"108648"}}