{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T23:14:03Z","timestamp":1792106043063,"version":"4.4.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Toxicology"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.reprotox.2024.108654","type":"journal-article","created":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T17:22:05Z","timestamp":1719854525000},"page":"108654","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Usnic acid alleviates testicular ischemia\/reperfusion injury in rats by modulating endoplasmic reticulum stress"],"prefix":"10.1016","volume":"128","author":[{"given":"Selim","family":"Demir","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilke Onur","family":"Kazaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sevdegul Aydin","family":"Mungan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nihal Turkmen","family":"Alemdar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nijazi","family":"Perolli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elif Ayazoglu","family":"Demir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet","family":"Mentese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.reprotox.2024.108654_bib1","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.3892\/etm.2017.4289","article-title":"Medical perspective in testicular ischemia\u2011reperfusion injury (review)","volume":"13","author":"Arena","year":"2017","journal-title":"Exp. Ther. Med."},{"issue":"3","key":"10.1016\/j.reprotox.2024.108654_bib2","doi-asserted-by":"crossref","first-page":"298","DOI":"10.5534\/wjmh.190037","article-title":"The impact of testicular torsion on testicular function","volume":"38","author":"Jacobsen","year":"2020","journal-title":"World J. Mens. Health"},{"key":"10.1016\/j.reprotox.2024.108654_bib3","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1111\/iju.13110","article-title":"Testicular torsion-detorsion and potential therapeutic treatments: a possible role for ischemic postconditioning","volume":"23","author":"Shimizu","year":"2016","journal-title":"Int. J. Urol."},{"issue":"5","key":"10.1016\/j.reprotox.2024.108654_bib4","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1111\/j.1742-1241.2008.01727.x","article-title":"Testicular torsion: a race against time","volume":"62","author":"Kapoor","year":"2008","journal-title":"Int. J. Clin. Pract."},{"issue":"1","key":"10.1016\/j.reprotox.2024.108654_bib5","first-page":"1","article-title":"A review of main controversial aspects of acute testicular torsion","volume":"5","author":"Feher","year":"2016","journal-title":"J. Acute\u00a0Dis."},{"issue":"7","key":"10.1016\/j.reprotox.2024.108654_bib6","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1111\/andr.13418","article-title":"Testicular torsion in vivo models: mechanisms and treatments","volume":"11","author":"Minas","year":"2023","journal-title":"Andrology"},{"issue":"7","key":"10.1016\/j.reprotox.2024.108654_bib7","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/nrurol.2014.135","article-title":"Mechanisms of testicular torsion and potential protective agents","volume":"11","author":"Karaguzel","year":"2014","journal-title":"Nat. Rev. Urol."},{"key":"10.1016\/j.reprotox.2024.108654_bib8","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.arcped.2020.10.006","article-title":"Perinatal testicular torsion","volume":"28","author":"Kylat","year":"2021","journal-title":"Arch. Pediatr."},{"issue":"4","key":"10.1016\/j.reprotox.2024.108654_bib9","doi-asserted-by":"crossref","first-page":"792","DOI":"10.3390\/ijms18040792","article-title":"Endoplasmic reticulum stress and homeostasis in reproductive physiology and pathology","volume":"18","author":"Guzel","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.reprotox.2024.108654_bib10","doi-asserted-by":"crossref","first-page":"681","DOI":"10.3109\/00207454.2015.1059836","article-title":"Endoplasmic reticulum stress in brain ischemia","volume":"126","author":"Su","year":"2015","journal-title":"Int. J. Neurosci."},{"key":"10.1016\/j.reprotox.2024.108654_bib11","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/5529810","article-title":"Novel insight into the role of endoplasmic reticulum stress in the pathogenesis of myocardial ischemia-reperfusion injury","volume":"2021","author":"Zhu","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.reprotox.2024.108654_bib12","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.neuint.2014.02.001","article-title":"Endoplasmic reticulum stress in cerebral ischemia","volume":"68","author":"Xin","year":"2014","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.reprotox.2024.108654_bib13","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.phrs.2018.04.013","article-title":"Natural products targeting ER stress pathway for the treatment of cardiovascular diseases","volume":"132","author":"Choy","year":"2018","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.reprotox.2024.108654_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2020.111229","article-title":"Natural antioxidants' effects on endoplasmic reticulum stress-related diseases","volume":"138","author":"Reyes-Ferm\u00edn","year":"2020","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.reprotox.2024.108654_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.neubiorev.2022.104818","article-title":"Targeting endoplasmic reticulum stress using natural products in neurological disorders","volume":"141","author":"Jangra","year":"2022","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"6","key":"10.1016\/j.reprotox.2024.108654_bib16","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1080\/13543776.2018.1472239","article-title":"Usnic acid and its derivatives for pharmaceutical use: a patent review (2000-2017)","volume":"28","author":"Luzina","year":"2018","journal-title":"Expert. Opin. Ther. Pat."},{"key":"10.1016\/j.reprotox.2024.108654_bib17","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s00114-002-0305-3","article-title":"A review on usnic acid, an interesting natural compound","volume":"89","author":"Cocchietto","year":"2002","journal-title":"Naturwissenschaften"},{"issue":"21","key":"10.1016\/j.reprotox.2024.108654_bib18","doi-asserted-by":"crossref","first-page":"7469","DOI":"10.3390\/molecules27217469","article-title":"Advances in research on bioactivity, toxicity, metabolism, and pharmacokinetics of usnic acid in vitro and in vivo","volume":"27","author":"Wang","year":"2022","journal-title":"Molecules"},{"issue":"12","key":"10.1016\/j.reprotox.2024.108654_bib19","doi-asserted-by":"crossref","first-page":"2752","DOI":"10.18203\/2319-2003.ijbcp20175072","article-title":"Usnic acid biological activity: History, evaluation and usage","volume":"6","author":"Alahmadi","year":"2017","journal-title":"Int. J. Basic. Clin. Pharmacol."},{"issue":"9","key":"10.1016\/j.reprotox.2024.108654_bib20","first-page":"1225","article-title":"Usnic acid improves memory impairment after cerebral ischemia\/reperfusion injuries by anti-neuroinflammatory, anti-oxidant, and anti-apoptotic properties","volume":"23","author":"Erfani","year":"2020","journal-title":"Iran. J. Basic. Med. Sci."},{"issue":"3","key":"10.1016\/j.reprotox.2024.108654_bib21","first-page":"101","article-title":"Effects of usnic acid on apoptosis and expression of Bax and Bcl-2 proteins in hippocampal CA1 neurons following cerebral ischemia-reperfusion","volume":"30","author":"Erfani","year":"2022","journal-title":"J. Ilam. Uni. Med. Sci. 2022"},{"issue":"5","key":"10.1016\/j.reprotox.2024.108654_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.jksus.2022.102061","article-title":"Fungal metabolite isolated from Mycosphaerella nawae AM20 and its protective role in cerebral ischemia","volume":"34","author":"Ismail","year":"2022","journal-title":"J. King Saud. Univ. Sci."},{"issue":"6","key":"10.1016\/j.reprotox.2024.108654_bib23","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1095\/biolreprod57.6.1267","article-title":"Acute testicular ischemia results in germ cell-specific apoptosis in the rat","volume":"57","author":"Turner","year":"1997","journal-title":"Biol. Reprod."},{"issue":"3","key":"10.1016\/j.reprotox.2024.108654_bib24","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.jpurol.2019.02.005","article-title":"N-acetylcysteine protects testicular tissue against ischemia\/reperfusion injury via inhibiting endoplasmic reticulum stress and apoptosis","volume":"15","author":"Kazaz","year":"2019","journal-title":"J. Pediatr. Urol."},{"issue":"5","key":"10.1016\/j.reprotox.2024.108654_bib25","doi-asserted-by":"crossref","DOI":"10.1111\/and.13243","article-title":"Testicular torsion and reperfusion: germ cell DNA damage and development","volume":"51","author":"Talebi","year":"2019","journal-title":"Andrologia"},{"issue":"3","key":"10.1016\/j.reprotox.2024.108654_bib26","article-title":"Propolis ameliorates ischemia\/reperfusion-induced testicular damage by reducing oxidative stress","volume":"21","author":"Demir","year":"2023","journal-title":"Rev. Int. Androl."},{"issue":"1","key":"10.1016\/j.reprotox.2024.108654_bib27","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jep.2005.06.043","article-title":"Gastroprotective and antioxidant effects of usnic acid on indomethacin-induced gastric ulcer in rats","volume":"103","author":"Odabasoglu","year":"2006","journal-title":"J. Ethnopharmacol."},{"issue":"2","key":"10.1016\/j.reprotox.2024.108654_bib28","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.intimp.2014.06.043","article-title":"Usnic acid protects LPS-induced acute lung injury in mice through attenuating inflammatory responses and oxidative stress","volume":"22","author":"Su","year":"2014","journal-title":"Int. Immunopharmacol."},{"issue":"12","key":"10.1016\/j.reprotox.2024.108654_bib29","first-page":"2563","article-title":"Usnic acid ameliorates bleomycin-induced pulmonary fibrosis in mice via inhibition of inflammatory responses and oxidative stress","volume":"18","author":"Huang","year":"2019","journal-title":"Trop. J. Pharm. Res."},{"issue":"3","key":"10.1016\/j.reprotox.2024.108654_bib30","doi-asserted-by":"crossref","first-page":"253","DOI":"10.4274\/jus.galenos.2023.2022.0080","article-title":"Alleviating effect of alpha-pinene on testicular torsion and detorsion injury in rats","volume":"10","author":"Demir","year":"2023","journal-title":"J. Urol. Surg."},{"key":"10.1016\/j.reprotox.2024.108654_bib31","doi-asserted-by":"crossref","DOI":"10.1100\/2012\/489248","article-title":"The effects of \u03b1-lipoic acid against testicular ischemia-reperfusion injury in rats","volume":"2012","author":"Ozbal","year":"2012","journal-title":"Sci. World J."},{"issue":"1","key":"10.1016\/j.reprotox.2024.108654_bib32","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/0003-2697(85)90442-7","article-title":"Measurement of protein using bicinchoninic acid","volume":"150","author":"Smith","year":"1985","journal-title":"Anal. Biochem."},{"issue":"1","key":"10.1016\/j.reprotox.2024.108654_bib33","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0003-2697(78)90342-1","article-title":"Determination of malonaldehyde precursor in tissues by thiobarbituric acid test","volume":"86","author":"Mihara","year":"1978","journal-title":"Anal. Biochem."},{"issue":"2","key":"10.1016\/j.reprotox.2024.108654_bib34","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1111\/jog.15119","article-title":"p-Coumaric acid alleviates cisplatin-induced ovarian toxicity in rats","volume":"48","author":"Demir","year":"2022","journal-title":"J. Obstet. Gynaecol. Res."},{"issue":"4","key":"10.1016\/j.reprotox.2024.108654_bib35","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1080\/10520295.2019.1695947","article-title":"Effect of ethyl pyruvate on oxidative state and endoplasmic reticulum stress in a rat model of testicular torsion","volume":"95","author":"Demir","year":"2020","journal-title":"Biotech. Histochem."},{"key":"10.1016\/j.reprotox.2024.108654_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111975","article-title":"Omega-3 fatty acid rescues ischaemia\/perfusion-induced testicular and sperm damage via modulation of lactate transport and xanthine oxidase\/uric acid signaling","volume":"142","author":"Akhigbe","year":"2021","journal-title":"Biomed. Pharmacother."},{"issue":"3","key":"10.1016\/j.reprotox.2024.108654_bib37","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s12192-017-0855-0","article-title":"Testicular torsion and reperfusion: evidences for biochemical and molecular alterations","volume":"23","author":"Shamsi-Gamchi","year":"2018","journal-title":"Cell. Stress. Chaperones"},{"issue":"8","key":"10.1016\/j.reprotox.2024.108654_bib38","doi-asserted-by":"crossref","DOI":"10.1111\/and.14117","article-title":"Sinapic acid reduces ischemia\/reperfusion injury due to testicular torsion\/detorsion in rats","volume":"53","author":"Unsal","year":"2021","journal-title":"Andrologia"},{"issue":"6","key":"10.1016\/j.reprotox.2024.108654_bib39","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1080\/13510002.2017.1322750","article-title":"Betulinic acid protects against N-nitrosodimethylamine-induced redox imbalance in testes of rats","volume":"22","author":"Adeleke","year":"2017","journal-title":"Redox Rep."},{"issue":"12","key":"10.1016\/j.reprotox.2024.108654_bib40","doi-asserted-by":"crossref","first-page":"787","DOI":"10.3390\/biom9120787","article-title":"Betulinic acid attenuates T-2-toxin-induced testis oxidative damage through regulation of the JAK2\/STAT3 signaling pathway in mice","volume":"9","author":"Wu","year":"2019","journal-title":"Biomolecules"},{"key":"10.1016\/j.reprotox.2024.108654_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113561","article-title":"Ameliorative effect of betulinic acid against zearalenone exposure triggers testicular dysfunction and oxidative stress in mice via p38\/ERK MAPK inhibition and Nrf2-mediated antioxidant defense activation","volume":"238","author":"Lin","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.reprotox.2024.108654_bib42","doi-asserted-by":"crossref","first-page":"17715","DOI":"10.1021\/acsomega.0c02306","article-title":"Is usnic acid a promising radical scavenger?","volume":"5","author":"Hoa","year":"2020","journal-title":"ACS Omega"},{"key":"10.1016\/j.reprotox.2024.108654_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2020.104283","article-title":"A comprehensive review on secondary metabolites and health-promoting effects of edible lichen","volume":"80","author":"Zhao","year":"2021","journal-title":"J. Funct. Foods"},{"issue":"4","key":"10.1016\/j.reprotox.2024.108654_bib44","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.3390\/life13041046","article-title":"Critical assessment of the anti-inflammatory potential of usnic acid and its derivatives-a review","volume":"13","author":"Pa\u017adziora","year":"2023","journal-title":"Life"},{"key":"10.1016\/j.reprotox.2024.108654_bib45","article-title":"Anti-inflammatory effects of usnic acid in an MPTP-induced mouse model of Parkinson's disease","volume":"1730","author":"Lee","year":"2020","journal-title":"Brain\u00a0Res."},{"key":"10.1016\/j.reprotox.2024.108654_bib46","doi-asserted-by":"crossref","first-page":"771","DOI":"10.3390\/ijms18040771","article-title":"Endoplasmic reticulum stress and oxidative stress: a vicious nexus implicated in bowel disease pathophysiology","volume":"18","author":"Chong","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"17","key":"10.1016\/j.reprotox.2024.108654_bib47","first-page":"2538","article-title":"Usnic acid inhibits ER stress activation through AMPK signaling pathway in rat cardiomyocytes","volume":"18","author":"Li","year":"2014","journal-title":"Eur. Rev. Med. Pharmacol. Sci."}],"container-title":["Reproductive Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623824001217?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623824001217?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T20:03:59Z","timestamp":1724443439000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0890623824001217"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":47,"alternative-id":["S0890623824001217"],"URL":"https:\/\/doi.org\/10.1016\/j.reprotox.2024.108654","relation":{},"ISSN":["0890-6238"],"issn-type":[{"value":"0890-6238","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Usnic acid alleviates testicular ischemia\/reperfusion injury in rats by modulating endoplasmic reticulum stress","name":"articletitle","label":"Article Title"},{"value":"Reproductive Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.reprotox.2024.108654","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"108654"}}