{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:49:39Z","timestamp":1790621379069,"version":"4.1.0"},"reference-count":140,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Toxicology"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.reprotox.2024.108720","type":"journal-article","created":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T20:26:22Z","timestamp":1726777582000},"page":"108720","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["The convergence of mTOR signaling and ethanol teratogenesis"],"prefix":"10.1016","volume":"130","author":[{"given":"Scott K.","family":"Tucker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johann K.","family":"Eberhart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2-3","key":"10.1016\/j.reprotox.2024.108720_bib1","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.drugalcdep.2006.11.007","article-title":"The epidemiology of fetal alcohol syndrome and partial FAS in a South African community","volume":"88","author":"May","year":"2007","journal-title":"Drug Alcohol Depend."},{"issue":"5","key":"10.1016\/j.reprotox.2024.108720_bib2","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1001\/jama.2017.21896","article-title":"Prevalence of fetal alcohol spectrum disorders in 4 US communities","volume":"319","author":"May","year":"2018","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/j.reprotox.2024.108720_bib3","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/acer.12939","article-title":"Worldwide prevalence of fetal alcohol spectrum disorders: a systematic literature review including meta-analysis","volume":"40","author":"Roozen","year":"2016","journal-title":"Alcohol Clin. Exp. Res"},{"key":"10.1016\/j.reprotox.2024.108720_bib4","unstructured":"The National Institute on Alcohol Abuse and Alcoholism. Fetal Alcohol Exposure. \u3008https:\/\/www.niaaa.nih.gov\/sites\/default\/files\/publications\/Fetal-Alcohol-Exposure_0.pdf\u3009."},{"issue":"4523","key":"10.1016\/j.reprotox.2024.108720_bib5","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1126\/science.6795717","article-title":"Fetal alcohol syndrome: embryogenesis in a mouse model","volume":"214","author":"Sulik","year":"1981","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.reprotox.2024.108720_bib6","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1111\/j.1530-0277.1995.tb01519.x","article-title":"Increased cell death and reduced neural crest cell numbers in ethanol-exposed embryos: partial basis for the fetal alcohol syndrome phenotype","volume":"19","author":"Cartwright","year":"1995","journal-title":"Alcohol Clin. Exp. Res"},{"issue":"10","key":"10.1016\/j.reprotox.2024.108720_bib7","first-page":"1523","article-title":"Selective vulnerability of embryonic cell populations to ethanol-induced apoptosis: implications for alcohol-related birth defects and neurodevelopmental disorder","volume":"25","author":"Dunty","year":"2001","journal-title":"Alcohol Clin. Exp. Res"},{"issue":"4","key":"10.1016\/j.reprotox.2024.108720_bib8","doi-asserted-by":"crossref","first-page":"677","DOI":"10.4161\/auto.27918","article-title":"Alcohol-induced autophagy contributes to loss in skeletal muscle mass","volume":"10","author":"Thapaliya","year":"2014","journal-title":"Autophagy"},{"issue":"10","key":"10.1016\/j.reprotox.2024.108720_bib9","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1152\/japplphysiol.00180.2014","article-title":"Alcohol impairs skeletal muscle protein synthesis and mTOR signaling in a time-dependent manner following electrically stimulated muscle contraction","volume":"117","author":"Steiner","year":"2014","journal-title":"J. Appl. Physiol."},{"issue":"7","key":"10.1016\/j.reprotox.2024.108720_bib10","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1111\/acer.12457","article-title":"High-throughput transcriptome sequencing identifies candidate genetic modifiers of vulnerability to fetal alcohol spectrum disorders","volume":"38","author":"Garic","year":"2014","journal-title":"Alcohol Clin. Exp. Res"},{"issue":"1","key":"10.1016\/j.reprotox.2024.108720_bib11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0169351","article-title":"Transcriptome profiling identifies ribosome biogenesis as a target of alcohol teratogenicity and vulnerability during early embryogenesis","volume":"12","author":"Berres","year":"2017","journal-title":"PLOS ONE"},{"issue":"12","key":"10.1016\/j.reprotox.2024.108720_bib12","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.4161\/15548627.2014.981916","article-title":"Autophagy and ethanol neurotoxicity","volume":"10","author":"Luo","year":"2014","journal-title":"Autophagy"},{"issue":"15","key":"10.1016\/j.reprotox.2024.108720_bib13","first-page":"3254","article-title":"Pdgfra protects against ethanol-induced craniofacial defects in a zebrafish model of FASD","volume":"140","author":"McCarthy","year":"2013","journal-title":"Dev. Camb. Engl."},{"issue":"3","key":"10.1016\/j.reprotox.2024.108720_bib14","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0376-8716(01)00173-9","article-title":"Effect of maternal methionine pre-treatment on alcohol-induced exencephaly and axial skeletal dysmorphogenesis in mouse fetuses","volume":"65","author":"Padmanabhan","year":"2002","journal-title":"Drug Alcohol Depend."},{"issue":"8","key":"10.1016\/j.reprotox.2024.108720_bib15","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.alcohol.2008.08.008","article-title":"Chronic binge ethanol-mediated acidemia reduces availability of glutamine and related amino acids in maternal plasma of pregnant sheep","volume":"42","author":"Ramadoss","year":"2008","journal-title":"Alcohol Fayettev. N."},{"issue":"4","key":"10.1016\/j.reprotox.2024.108720_bib16","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1111\/j.1530-0277.1994.tb00063.x","article-title":"Chronic ethanol exposure inhibits insulin and IGF-1 stimulated amino acid uptake in cultured human placental trophoblasts","volume":"18","author":"Karl","year":"1994","journal-title":"Alcohol Clin. Exp. Res"},{"issue":"8","key":"10.1016\/j.reprotox.2024.108720_bib17","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1007\/s00726-014-1751-x","article-title":"Effects of L-glutamine supplementation on maternal and fetal hemodynamics in gestating ewes exposed to alcohol","volume":"46","author":"Sawant","year":"2014","journal-title":"Amino Acids"},{"issue":"6","key":"10.1016\/j.reprotox.2024.108720_bib18","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/j.cell.2017.02.004","article-title":"mTOR Signaling in growth, metabolism, and disease","volume":"168","author":"Saxton","year":"2017","journal-title":"Cell"},{"issue":"10","key":"10.1016\/j.reprotox.2024.108720_bib19","doi-asserted-by":"crossref","first-page":"727","DOI":"10.7164\/antibiotics.28.727","article-title":"Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization","volume":"28","author":"Sehgal","year":"1975","journal-title":"J. Antibiot. (Tokyo)"},{"issue":"10","key":"10.1016\/j.reprotox.2024.108720_bib20","doi-asserted-by":"crossref","first-page":"721","DOI":"10.7164\/antibiotics.28.721","article-title":"Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle","volume":"28","author":"V\u00e9zina","year":"1975","journal-title":"J. Antibiot. (Tokyo)"},{"key":"10.1016\/j.reprotox.2024.108720_bib21","unstructured":"Sehgal A. \u3008http:\/\/www.sehgal.net\/surenshistory.htm\u3009."},{"key":"10.1016\/j.reprotox.2024.108720_bib22","unstructured":"Duffin J. Stanley\u2019s Dream: The Medical Expedition to Easter Island (Carleton Library Series): Duffin, Jacalyn: 9780773557109: Amazon.Com: Books. Accessed September 8, 2022. \u3008https:\/\/www.amazon.com\/Stanleys-Dream-Medical-Expedition-Carleton\/dp\/0773557105\u3009."},{"issue":"4","key":"10.1016\/j.reprotox.2024.108720_bib23","doi-asserted-by":"crossref","first-page":"697","DOI":"10.4103\/ijc.IJC_84_18","article-title":"Surendra nath sehgal: a pioneer in rapamycin discovery","volume":"54","author":"Samanta","year":"2017","journal-title":"Indian J. Cancer"},{"issue":"10","key":"10.1016\/j.reprotox.2024.108720_bib24","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.7164\/antibiotics.37.1231","article-title":"Activity of rapamycin (AY-22,989) against transplanted tumors","volume":"37","author":"Eng","year":"1984","journal-title":"J. Antibiot. (Tokyo)"},{"issue":"1","key":"10.1016\/j.reprotox.2024.108720_bib25","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1139\/y77-007","article-title":"Inhibition of the immune response by rapamycin, a new antifungal antibiotic","volume":"55","author":"Martel","year":"1977","journal-title":"Can. J. Physiol. Pharm."},{"issue":"3","key":"10.1016\/j.reprotox.2024.108720_bib26","first-page":"1718","article-title":"Rapamycin sensitivity in Saccharomyces cerevisiae is mediated by a peptidyl-prolyl cis-trans isomerase related to human FK506-binding protein","volume":"11","author":"Koltin","year":"1991","journal-title":"Mol. Cell Biol."},{"issue":"5022","key":"10.1016\/j.reprotox.2024.108720_bib27","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1126\/science.1715094","article-title":"Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast","volume":"253","author":"Heitman","year":"1991","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.reprotox.2024.108720_bib28","first-page":"251","article-title":"Distinct mechanisms of suppression of murine T cell activation by the related macrolides FK-506 and rapamycin","volume":"144","author":"Dumont","year":"1990","journal-title":"J. Immunol. Balt. Md 1950"},{"issue":"1","key":"10.1016\/j.reprotox.2024.108720_bib29","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1091\/mbc.5.1.105","article-title":"TOR1 and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast","volume":"5","author":"Helliwell","year":"1994","journal-title":"Mol. Biol. Cell"},{"issue":"3","key":"10.1016\/j.reprotox.2024.108720_bib30","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/0092-8674(93)90144-F","article-title":"Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression","volume":"73","author":"Kunz","year":"1993","journal-title":"Cell"},{"issue":"6483","key":"10.1016\/j.reprotox.2024.108720_bib31","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/369756a0","article-title":"A mammalian protein targeted by G1-arresting rapamycin-receptor complex","volume":"369","author":"Brown","year":"1994","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.reprotox.2024.108720_bib32","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0092-8674(94)90570-3","article-title":"RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs","volume":"78","author":"Sabatini","year":"1994","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.reprotox.2024.108720_bib33","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1074\/jbc.270.2.815","article-title":"Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells","volume":"270","author":"Sabers","year":"1995","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.reprotox.2024.108720_bib34","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.cell.2016.02.035","article-title":"The CASTOR proteins are arginine sensors for the mTORC1 pathway","volume":"165","author":"Chantranupong","year":"2016","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.reprotox.2024.108720_bib35","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.cell.2013.11.049","article-title":"Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome","volume":"156","author":"Menon","year":"2014","journal-title":"Cell"},{"issue":"23","key":"10.1016\/j.reprotox.2024.108720_bib36","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1101\/gad.1256804","article-title":"Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1\/TSC2 tumor suppressor complex","volume":"18","author":"Brugarolas","year":"2004","journal-title":"Genes Dev."},{"issue":"2","key":"10.1016\/j.reprotox.2024.108720_bib37","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.molcel.2008.03.003","article-title":"AMPK phosphorylation of raptor mediates a metabolic checkpoint","volume":"30","author":"Gwinn","year":"2008","journal-title":"Mol. Cell"},{"issue":"15","key":"10.1016\/j.reprotox.2024.108720_bib38","doi-asserted-by":"crossref","first-page":"10240","DOI":"10.1074\/jbc.272.15.10240","article-title":"Identification of phosphorylation sites in the translational regulator, PHAS-I, that are controlled by insulin and rapamycin in rat adipocytes","volume":"272","author":"Fadden","year":"1997","journal-title":"J. Biol. Chem."},{"issue":"51","key":"10.1016\/j.reprotox.2024.108720_bib39","doi-asserted-by":"crossref","first-page":"32547","DOI":"10.1074\/jbc.272.51.32547","article-title":"The mammalian target of rapamycin phosphorylates sites having a (Ser\/Thr)-Pro motif and is activated by antibodies to a region near its COOH terminus","volume":"272","author":"Brunn","year":"1997","journal-title":"J. Biol. Chem."},{"issue":"36","key":"10.1016\/j.reprotox.2024.108720_bib40","doi-asserted-by":"crossref","first-page":"21396","DOI":"10.1074\/jbc.270.36.21396","article-title":"Rapamycin, wortmannin, and the methylxanthine SQ20006 inactivate p70s6k by inducing dephosphorylation of the same subset of sites","volume":"270","author":"Han","year":"1995","journal-title":"J. Biol. Chem."},{"issue":"21","key":"10.1016\/j.reprotox.2024.108720_bib41","doi-asserted-by":"crossref","first-page":"5279","DOI":"10.1002\/j.1460-2075.1995.tb00212.x","article-title":"The principal target of rapamycin-induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain","volume":"14","author":"Pearson","year":"1995","journal-title":"EMBO J."},{"issue":"9","key":"10.1016\/j.reprotox.2024.108720_bib42","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1111\/j.1530-0277.2007.00450.x","article-title":"Insulin and insulin-like growth factor resistance with neurodegeneration in an adult chronic ethanol exposure model","volume":"31","author":"Cohen","year":"2007","journal-title":"Alcohol Clin. Exp. Res"},{"issue":"Suppl 2","key":"10.1016\/j.reprotox.2024.108720_bib43","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1440-1746.2011.07023.x","article-title":"Alcohol, insulin resistance and the liver-brain axis","volume":"27","author":"de la Monte","year":"2012","journal-title":"J. Gastroenterol. Hepatol."},{"issue":"9","key":"10.1016\/j.reprotox.2024.108720_bib44","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1111\/j.1530-0277.2008.00731.x","article-title":"Insulin and insulin-like growth factor resistance in alcoholic neurodegeneration","volume":"32","author":"de la Monte","year":"2008","journal-title":"Alcohol Clin. Exp. Res"},{"issue":"3","key":"10.1016\/j.reprotox.2024.108720_bib45","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1242\/dmm.006411","article-title":"A drosophila model for fetal alcohol syndrome disorders: role for the insulin pathway","volume":"4","author":"McClure","year":"2011","journal-title":"Dis. Model Mech."},{"issue":"2","key":"10.1016\/j.reprotox.2024.108720_bib46","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.semcdb.2003.12.021","article-title":"Human cancer, PTEN and the PI-3 kinase pathway","volume":"15","author":"Parsons","year":"2004","journal-title":"Semin Cell Dev. Biol."},{"issue":"1","key":"10.1016\/j.reprotox.2024.108720_bib47","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S1097-2765(02)00568-3","article-title":"Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase\/akt pathway","volume":"10","author":"Manning","year":"2002","journal-title":"Mol. Cell"},{"issue":"9","key":"10.1016\/j.reprotox.2024.108720_bib48","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/ncb839","article-title":"TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling","volume":"4","author":"Inoki","year":"2002","journal-title":"Nat. Cell Biol."},{"issue":"4","key":"10.1016\/j.reprotox.2024.108720_bib49","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.molcel.2012.06.009","article-title":"TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1","volume":"47","author":"Dibble","year":"2012","journal-title":"Mol. Cell"},{"issue":"8","key":"10.1016\/j.reprotox.2024.108720_bib50","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1172\/JCI32278","article-title":"ErbB receptors: from oncogenes to targeted cancer therapies","volume":"117","author":"Zhang","year":"2007","journal-title":"J. Clin. Invest"},{"issue":"8","key":"10.1016\/j.reprotox.2024.108720_bib51","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1172\/JCI200317222","article-title":"Loss of Tsc1\/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR","volume":"112","author":"Zhang","year":"2003","journal-title":"J. Clin. Invest"},{"issue":"16","key":"10.1016\/j.reprotox.2024.108720_bib52","doi-asserted-by":"crossref","first-page":"13663","DOI":"10.1074\/jbc.M300862200","article-title":"The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3","volume":"278","author":"Li","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"37","key":"10.1016\/j.reprotox.2024.108720_bib53","doi-asserted-by":"crossref","first-page":"13489","DOI":"10.1073\/pnas.0405659101","article-title":"Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase","volume":"101","author":"Roux","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"3","key":"10.1016\/j.reprotox.2024.108720_bib54","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1073\/pnas.0409143102","article-title":"Quantitative phosphorylation profiling of the ERK\/p90 ribosomal S6 kinase-signaling cassette and its targets, the tuberous sclerosis tumor suppressors","volume":"102","author":"Ballif","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"5","key":"10.1016\/j.reprotox.2024.108720_bib55","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.cell.2006.06.055","article-title":"TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth","volume":"126","author":"Inoki","year":"2006","journal-title":"Cell"},{"issue":"29","key":"10.1016\/j.reprotox.2024.108720_bib56","doi-asserted-by":"crossref","first-page":"21777","DOI":"10.1016\/S0021-9258(20)80610-3","article-title":"Ethanol inhibits the autophosphorylation of the insulin-like growth factor 1 (IGF-1) receptor and IGF-1-mediated proliferation of 3T3 cells","volume":"268","author":"Resnicoff","year":"1993","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.reprotox.2024.108720_bib57","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1046\/j.1471-4159.2001.00025.x","article-title":"Inhibition of insulin-like growth factor-1 receptor and IRS-2 signaling by ethanol in SH-SY5Y neuroblastoma cells","volume":"76","author":"Seiler","year":"2001","journal-title":"J. Neurochem"},{"issue":"5","key":"10.1016\/j.reprotox.2024.108720_bib58","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1111\/j.1530-0277.1996.tb05278.x","article-title":"Ethanol-induced inhibition of cell proliferation is modulated by insulin-like growth factor-I receptor levels","volume":"20","author":"Resnicoff","year":"1996","journal-title":"Alcohol Clin. Exp. Res"},{"issue":"29","key":"10.1016\/j.reprotox.2024.108720_bib59","doi-asserted-by":"crossref","first-page":"26929","DOI":"10.1074\/jbc.M300401200","article-title":"Ethanol impairs insulin-stimulated neuronal survival in the developing brain: role of PTEN phosphatase","volume":"278","author":"Xu","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"17","key":"10.1016\/j.reprotox.2024.108720_bib60","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1007\/s00018-006-6208-2","article-title":"Chronic gestational exposure to ethanol causes insulin and IGF resistance and impairs acetylcholine homeostasis in the brain","volume":"63","author":"Soscia","year":"2006","journal-title":"Cell Mol. Life Sci. CMLS"},{"issue":"26","key":"10.1016\/j.reprotox.2024.108720_bib61","doi-asserted-by":"crossref","first-page":"15020","DOI":"10.1073\/pnas.011318098","article-title":"PDK1 regulates growth through Akt and S6K in Drosophila","volume":"98","author":"Rintelen","year":"2001","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"1","key":"10.1016\/j.reprotox.2024.108720_bib62","first-page":"49","article-title":"Developmental ethanol exposure leads to dysregulation of lipid metabolism and oxidative stress in drosophila","volume":"5","author":"Logan-Garbisch","year":"2014","journal-title":"G3 Genes."},{"issue":"3","key":"10.1016\/j.reprotox.2024.108720_bib63","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.ejphar.2004.07.115","article-title":"Glycogen synthase kinase-3 inhibitors prevent caspase-dependent apoptosis induced by ethanol in cultured rat cortical neurons","volume":"499","author":"Takadera","year":"2004","journal-title":"Eur. J. Pharm."},{"issue":"49","key":"10.1016\/j.reprotox.2024.108720_bib64","doi-asserted-by":"crossref","first-page":"20924","DOI":"10.1073\/pnas.0910813106","article-title":"Glycogen synthase kinase-3\/Shaggy mediates ethanol-induced excitotoxic cell death of Drosophila olfactory neurons","volume":"106","author":"French","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"4","key":"10.1016\/j.reprotox.2024.108720_bib65","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0033575","article-title":"Genetic dissection of acute ethanol responsive gene networks in prefrontal cortex: functional and mechanistic implications","volume":"7","author":"Wolen","year":"2012","journal-title":"PloS One"},{"issue":"1","key":"10.1016\/j.reprotox.2024.108720_bib66","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1159\/000242030","article-title":"Plasma Amino Acids and Glucose Levels in the Rat Fetus and Dam after Chronic Maternal Alcohol Consumption","volume":"46","author":"Marquis","year":"1984","journal-title":"Neonatology"},{"issue":"6","key":"10.1016\/j.reprotox.2024.108720_bib67","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1016\/j.cell.2012.07.032","article-title":"Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1","volume":"150","author":"Bar-Peled","year":"2012","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.reprotox.2024.108720_bib68","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.cell.2010.02.024","article-title":"Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids","volume":"141","author":"Sancak","year":"2010","journal-title":"Cell"},{"issue":"6218","key":"10.1016\/j.reprotox.2024.108720_bib69","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1126\/science.1259472","article-title":"Metabolism. Differential regulation of mTORC1 by leucine and glutamine","volume":"347","author":"Jewell","year":"2015","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.reprotox.2024.108720_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.molcel.2013.09.016","article-title":"The Folliculin tumor suppressor is a GAP for RagC\/D GTPases that signal amino acid levels to mTORC1","volume":"52","author":"Tsun","year":"2013","journal-title":"Mol. Cell"},{"issue":"6136","key":"10.1016\/j.reprotox.2024.108720_bib71","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1126\/science.1232044","article-title":"A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1","volume":"340","author":"Bar-Peled","year":"2013","journal-title":"Science"},{"issue":"7645","key":"10.1016\/j.reprotox.2024.108720_bib72","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1038\/nature21423","article-title":"KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1","volume":"543","author":"Wolfson","year":"2017","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.reprotox.2024.108720_bib73","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.celrep.2014.09.014","article-title":"The Sestrins Interact with GATOR2 to Negatively Regulate the Amino-Acid-Sensing Pathway Upstream of mTORC1","volume":"9","author":"Chantranupong","year":"2014","journal-title":"Cell Rep."},{"issue":"6268","key":"10.1016\/j.reprotox.2024.108720_bib74","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1126\/science.aab2674","article-title":"Sestrin2 is a leucine sensor for the mTORC1 pathway","volume":"351","author":"Wolfson","year":"2016","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.reprotox.2024.108720_bib75","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1038\/s41467-020-16164-1","article-title":"Single-cell RNA sequencing demonstrates the molecular and cellular reprogramming of metastatic lung adenocarcinoma","volume":"11","author":"Kim","year":"2020","journal-title":"Nat. Commun."},{"issue":"6264","key":"10.1016\/j.reprotox.2024.108720_bib76","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1126\/science.aac7041","article-title":"Identification and characterization of essential genes in the human genome","volume":"350","author":"Wang","year":"2015","journal-title":"Science"},{"issue":"6364","key":"10.1016\/j.reprotox.2024.108720_bib77","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1126\/science.aao3265","article-title":"SAMTOR is an adenosylmethionine sensor for the mTORC1 pathway","volume":"358","author":"Gu","year":"2017","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.reprotox.2024.108720_bib78","first-page":"265","article-title":"[Alcohol induced changes of amino acid metabolism]","volume":"8","author":"Shaw","year":"1978","journal-title":"Leber Magen Darm"},{"issue":"1","key":"10.1016\/j.reprotox.2024.108720_bib79","first-page":"E13","article-title":"Production and utilization of amino acids by ovine placenta in vivo","volume":"274","author":"Chung","year":"1998","journal-title":"Am. J. Physiol."},{"issue":"6085","key":"10.1016\/j.reprotox.2024.108720_bib80","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/323276a0","article-title":"Weak acids may act as teratogens by accumulating in the basic milieu of the early mammalian embryo","volume":"323","author":"Nau","year":"1986","journal-title":"Nature"},{"key":"10.1016\/j.reprotox.2024.108720_bib81","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.alcohol.2017.07.010","article-title":"Regional dysregulation of taurine and related amino acids in the fetal rat brain following gestational alcohol exposure","volume":"66","author":"Lunde-Young","year":"2018","journal-title":"Alcohol Fayettev. N."},{"issue":"7","key":"10.1016\/j.reprotox.2024.108720_bib82","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1111\/j.1530-0277.1996.tb01118.x","article-title":"Effects of chronic alcohol consumption on enzyme activities and active methionine absorption in the small intestine of pregnant rats","volume":"20","author":"Polache","year":"1996","journal-title":"Alcohol Clin. Exp. Res"},{"issue":"5","key":"10.1016\/j.reprotox.2024.108720_bib83","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.3390\/nu14051096","article-title":"Untargeted metabolome analysis reveals reductions in maternal hepatic glucose and amino acid content that correlate with fetal organ weights in a mouse model of fetal alcohol spectrum disorders","volume":"14","author":"Saini","year":"2022","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.reprotox.2024.108720_bib84","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1146\/annurev.biochem.68.1.913","article-title":"eIF4 Initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation","volume":"68","author":"Gingras","year":"1999","journal-title":"Annu Rev. Biochem"},{"issue":"5","key":"10.1016\/j.reprotox.2024.108720_bib85","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1152\/physiol.00024.2006","article-title":"The mTOR pathway in the control of protein synthesis","volume":"21","author":"Wang","year":"2006","journal-title":"Physiology"},{"issue":"14","key":"10.1016\/j.reprotox.2024.108720_bib86","first-page":"2848","article-title":"mTORC1 signaling controls mammalian skeletal growth through stimulation of protein synthesis","volume":"141","author":"Chen","year":"2014","journal-title":"Dev. Camb. Engl."},{"issue":"1","key":"10.1016\/j.reprotox.2024.108720_bib87","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s12964-015-0091-0","article-title":"Distinct inhibitory effects on mTOR signaling by ethanol and INK128 in diffuse large B-cell lymphoma","volume":"13","author":"Mazan-Mamczarz","year":"2015","journal-title":"Cell Commun. Signal"},{"issue":"6","key":"10.1016\/j.reprotox.2024.108720_bib88","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1111\/acer.14348","article-title":"Chronic Binge Alcohol Exposure During Pregnancy Alters mTOR System in Rat Fetal Hippocampus","volume":"44","author":"Lee","year":"2020","journal-title":"Alcohol Clin. Exp. Res"},{"issue":"9","key":"10.1016\/j.reprotox.2024.108720_bib89","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1002\/j.1460-2075.1996.tb00582.x","article-title":"Regulation of translation elongation factor-2 by insulin via a rapamycin-sensitive signalling pathway","volume":"15","author":"Redpath","year":"1996","journal-title":"EMBO J."},{"issue":"8","key":"10.1016\/j.reprotox.2024.108720_bib90","doi-asserted-by":"crossref","first-page":"3112","DOI":"10.1128\/MCB.24.8.3112-3124.2004","article-title":"S6K1(-\/-)\/S6K2(-\/-) Mice Exhibit Perinatal Lethality and Rapamycin-Sensitive 5\u2032-Terminal Oligopyrimidine mRNA Translation and Reveal a Mitogen-Activated Protein Kinase-Dependent S6 Kinase Pathway","volume":"24","author":"Pende","year":"2004","journal-title":"Mol. Cell Biol."},{"issue":"4","key":"10.1016\/j.reprotox.2024.108720_bib91","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.cell.2005.10.024","article-title":"mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events","volume":"123","author":"Holz","year":"2005","journal-title":"Cell"},{"issue":"11","key":"10.1016\/j.reprotox.2024.108720_bib92","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.4161\/auto.21376","article-title":"Autophagy is a protective response to ethanol neurotoxicity","volume":"8","author":"Chen","year":"2012","journal-title":"Autophagy"},{"issue":"1","key":"10.1016\/j.reprotox.2024.108720_bib93","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ccr.2007.05.008","article-title":"Defining the Role of mTOR in Cancer","volume":"12","author":"Guertin","year":"2007","journal-title":"Cancer Cell"},{"issue":"5","key":"10.1016\/j.reprotox.2024.108720_bib94","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1139\/H09-073","article-title":"mTOR function in skeletal muscle: a focal point for overnutrition and exercise","volume":"34","author":"Rivas","year":"2009","journal-title":"Appl. Physiol. Nutr. Metab."},{"issue":"S2","key":"10.1016\/j.reprotox.2024.108720_bib95","doi-asserted-by":"crossref","first-page":"S43","DOI":"10.1038\/onc.2009.352","article-title":"Common corruption of the mTOR signaling network in human tumors","volume":"27","author":"Menon","year":"2008","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/j.reprotox.2024.108720_bib96","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s00726-008-0230-7","article-title":"mTOR phosphorylated at S2448 binds to raptor and rictor","volume":"38","author":"Rosner","year":"2010","journal-title":"Amino Acids"},{"issue":"21","key":"10.1016\/j.reprotox.2024.108720_bib97","doi-asserted-by":"crossref","first-page":"7428","DOI":"10.1128\/MCB.22.21.7428-7438.2002","article-title":"The rapamycin-binding domain governs substrate selectivity by the mammalian target of rapamycin","volume":"22","author":"McMahon","year":"2002","journal-title":"Mol. Cell Biol."},{"issue":"10","key":"10.1016\/j.reprotox.2024.108720_bib98","doi-asserted-by":"crossref","first-page":"2541","DOI":"10.1210\/me.2007-0036","article-title":"Dose-dependent effects of alcohol on insulin signaling: partial explanation for biphasic alcohol impact on human health","volume":"21","author":"He","year":"2007","journal-title":"Mol. Endocrinol."},{"issue":"2","key":"10.1016\/j.reprotox.2024.108720_bib99","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.bbrc.2003.07.023","article-title":"Autophagy: a regulated bulk degradation process inside cells","volume":"313","author":"Yoshimori","year":"2004","journal-title":"Biochem Biophys. Res Commun."},{"key":"10.1016\/j.reprotox.2024.108720_bib100","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.taap.2018.03.007","article-title":"Autophagy as a compensation mechanism participates in ethanol-induced fetal adrenal dysfunction in female rats","volume":"345","author":"Huang","year":"2018","journal-title":"Toxicol. Appl. Pharm."},{"issue":"2","key":"10.1016\/j.reprotox.2024.108720_bib101","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2017.29","article-title":"Prenatal alcohol exposure impairs autophagy in neonatal brain cortical microvessels","volume":"8","author":"Girault","year":"2017","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.reprotox.2024.108720_bib102","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2019.112981","article-title":"MicroRNA-34a mediates ethanol-induced impairment of neural differentiation of neural crest cells by targeting autophagy-related gene 9a","volume":"320","author":"Fan","year":"2019","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.reprotox.2024.108720_bib103","doi-asserted-by":"crossref","first-page":"778","DOI":"10.3389\/fendo.2018.00778","article-title":"Chaperone mediated autophagy in the crosstalk of neurodegenerative diseases and metabolic disorders","volume":"9","author":"Alfaro","year":"2019","journal-title":"Front Endocrinol."},{"issue":"6","key":"10.1016\/j.reprotox.2024.108720_bib104","doi-asserted-by":"crossref","DOI":"10.1002\/bies.201800008","article-title":"Three distinct types of microautophagy based on membrane dynamics and molecular machineries","volume":"40","author":"Oku","year":"2018","journal-title":"BioEssays"},{"issue":"10","key":"10.1016\/j.reprotox.2024.108720_bib105","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1038\/ncb1007-1102","article-title":"Autophagosome formation: core machinery and adaptations","volume":"9","author":"Xie","year":"2007","journal-title":"Nat. Cell Biol."},{"issue":"10","key":"10.1016\/j.reprotox.2024.108720_bib106","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.3390\/cancers11101422","article-title":"The Emerging Roles of mTORC1 in Macromanaging Autophagy","volume":"11","author":"Dossou","year":"2019","journal-title":"Cancers"},{"issue":"4","key":"10.1016\/j.reprotox.2024.108720_bib107","doi-asserted-by":"crossref","first-page":"549","DOI":"10.4161\/auto.28448","article-title":"Autophagosomes, phagosomes, autolysosomes, phagolysosomes, autophagolysosomes\u2026 Wait, I\u2019m confused","volume":"10","author":"Klionsky","year":"2014","journal-title":"Autophagy"},{"issue":"6","key":"10.1016\/j.reprotox.2024.108720_bib108","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/s41580-018-0003-4","article-title":"Mechanism and medical implications of mammalian autophagy","volume":"19","author":"Dikic","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.reprotox.2024.108720_bib109","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/15548627.2020.1797280","article-title":"Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1","volume":"17","author":"Klionsky","year":"2021","journal-title":"Autophagy"},{"issue":"2","key":"10.1016\/j.reprotox.2024.108720_bib110","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2014.46","article-title":"TLR4 mediates the impairment of ubiquitin-proteasome and autophagy-lysosome pathways induced by ethanol treatment in brain","volume":"5","author":"Pla","year":"2014","journal-title":"Cell Death Dis."},{"issue":"4","key":"10.1016\/j.reprotox.2024.108720_bib111","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0153097","article-title":"Autophagy constitutes a protective mechanism against ethanol toxicity in mouse astrocytes and neurons","volume":"11","author":"Pla","year":"2016","journal-title":"PLOS ONE"},{"issue":"10","key":"10.1016\/j.reprotox.2024.108720_bib112","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1111\/acer.14688","article-title":"Loss of tumor protein 53 protects against alcohol-induced facial malformations in mice and zebrafish","volume":"45","author":"Fish","year":"2021","journal-title":"Alcohol Clin. Exp. Res"},{"issue":"1","key":"10.1016\/j.reprotox.2024.108720_bib113","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.bbrc.2004.09.213","article-title":"Abrogation of hepatocyte apoptosis and early appearance of liver dysplasia in ethanol-fed p53-deficient mice","volume":"325","author":"Pani","year":"2004","journal-title":"Biochem Biophys. Res Commun."},{"issue":"7","key":"10.1016\/j.reprotox.2024.108720_bib114","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0180873","article-title":"Heterogeneity of p53 dependent genomic responses following ethanol exposure in a developmental mouse model of fetal alcohol spectrum disorder","volume":"12","author":"Camargo Moreno","year":"2017","journal-title":"PLOS ONE"},{"issue":"2","key":"10.1016\/j.reprotox.2024.108720_bib115","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S1097-2765(01)00323-9","article-title":"Regulation of PTEN Transcription by p53","volume":"8","author":"Stambolic","year":"2001","journal-title":"Mol. Cell"},{"issue":"23","key":"10.1016\/j.reprotox.2024.108720_bib116","doi-asserted-by":"crossref","first-page":"8204","DOI":"10.1073\/pnas.0502857102","article-title":"The coordinate regulation of the p53 and mTOR pathways in cells","volume":"102","author":"Feng","year":"2005","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"4","key":"10.1016\/j.reprotox.2024.108720_bib117","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0960-9822(06)00125-4","article-title":"Is programmed cell death required for neural tube closure?","volume":"7","author":"Weil","year":"1997","journal-title":"Curr. Biol."},{"issue":"1","key":"10.1016\/j.reprotox.2024.108720_bib118","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1242\/dev.119.1.233","article-title":"Even-numbered rhombomeres control the apoptotic elimination of neural crest cells from odd-numbered rhombomeres in the chick hindbrain","volume":"119","author":"Graham","year":"1993","journal-title":"Development"},{"issue":"2","key":"10.1016\/j.reprotox.2024.108720_bib119","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1006\/dbio.2000.9644","article-title":"Medial edge epithelial cell fate during palatal fusion","volume":"220(","author":"Mart\u0131\u0301nez-\u00c1lvarez","year":"2000","journal-title":"Dev. Biol."},{"issue":"1","key":"10.1016\/j.reprotox.2024.108720_bib120","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1083\/jcb.136.1.205","article-title":"Bcl-2 Lies Downstream of Parathyroid Hormone\u2013related Peptide in a Signaling Pathway That Regulates Chondrocyte Maturation during Skeletal Development","volume":"136","author":"Amling","year":"1997","journal-title":"J. Cell Biol."},{"issue":"4","key":"10.1016\/j.reprotox.2024.108720_bib121","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/0736-5748(92)90016-S","article-title":"Patterns of ethanol-induced cell death in the developing nervous system of mice; Neural fold states through the time of anterior neural tube closure","volume":"10","author":"Kotch","year":"1992","journal-title":"Int J. Dev. Neurosci."},{"issue":"1-2","key":"10.1016\/j.reprotox.2024.108720_bib122","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.devbrainres.2003.08.012","article-title":"Ethanol-induced neuronal death in organotypic cultures of rat cerebral cortex","volume":"147","author":"Mooney","year":"2003","journal-title":"Brain Res Dev. Brain Res"},{"issue":"2","key":"10.1016\/j.reprotox.2024.108720_bib123","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/s41418-018-0246-9","article-title":"Mutant p53 as a guardian of the cancer cell","volume":"26","author":"Mantovani","year":"2019","journal-title":"Cell Death Differ."},{"issue":"6","key":"10.1016\/j.reprotox.2024.108720_bib124","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2013.176","article-title":"Consequences of the combined loss of BOK and BAK or BOK and BAX","volume":"4","author":"Ke","year":"2013","journal-title":"Cell Death Dis."},{"issue":"10","key":"10.1016\/j.reprotox.2024.108720_bib125","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2015.304","article-title":"Impact of the combined loss of BOK, BAX and BAK on the hematopoietic system is slightly more severe than compound loss of BAX and BAK","volume":"6","author":"Ke","year":"2015","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.reprotox.2024.108720_bib126","doi-asserted-by":"crossref","DOI":"10.1002\/bdr2.2009","article-title":"The pro-apoptotic Bax gene modifies susceptibility to craniofacial dysmorphology following gastrulation-stage alcohol exposure","author":"Fish","year":"2022","journal-title":"Birth Defects Res"},{"key":"10.1016\/j.reprotox.2024.108720_bib127","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.neuroscience.2017.11.013","article-title":"Neuronal loss in the developing cerebral cortex of normal and bax-deficient mice: effects of ethanol exposure","volume":"369","author":"Britton","year":"2018","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.reprotox.2024.108720_bib128","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s12935-015-0231-z","article-title":"Etoposide induces cell death via mitochondrial-dependent actions of p53","volume":"15","author":"Jamil","year":"2015","journal-title":"Cancer Cell Int"},{"issue":"27","key":"10.1016\/j.reprotox.2024.108720_bib129","doi-asserted-by":"crossref","first-page":"23977","DOI":"10.1074\/jbc.C200171200","article-title":"AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling","volume":"277","author":"Bolster","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.reprotox.2024.108720_bib130","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/S0092-8674(03)00929-2","article-title":"TSC2 Mediates cellular energy response to control cell growth and survival","volume":"115","author":"Inoki","year":"2003","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.reprotox.2024.108720_bib131","article-title":"Zebrafish raptor mutation inhibits the activity of mTORC1, inducing craniofacial defects due to autophagy-induced neural crest cell death","volume":"151","author":"Tucker","year":"2024","journal-title":"Dev. Camb. Engl."},{"issue":"6648","key":"10.1016\/j.reprotox.2024.108720_bib132","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/38525","article-title":"A model for p53-induced apoptosis","volume":"389","author":"Polyak","year":"1997","journal-title":"Nature"},{"issue":"32","key":"10.1016\/j.reprotox.2024.108720_bib133","doi-asserted-by":"crossref","first-page":"29346","DOI":"10.1074\/jbc.M504852200","article-title":"The p53-induced Gene-6 (Proline Oxidase) Mediates Apoptosis through a Calcineurin-dependent Pathway","volume":"280","author":"Rivera","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"46","key":"10.1016\/j.reprotox.2024.108720_bib134","doi-asserted-by":"crossref","first-page":"32596","DOI":"10.1074\/jbc.274.46.32596","article-title":"Hydrogen Peroxide Activates p70S6k Signaling Pathway","volume":"274","author":"Bae","year":"1999","journal-title":"J. Biol. Chem."},{"issue":"15","key":"10.1016\/j.reprotox.2024.108720_bib135","first-page":"4300","article-title":"Modulation of radiation response and tumor-induced angiogenesis after epidermal growth factor receptor inhibition by ZD1839 (Iressa)","volume":"62","author":"Huang","year":"2002","journal-title":"Cancer Res"},{"issue":"2","key":"10.1016\/j.reprotox.2024.108720_bib136","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0092-8674(02)00808-5","article-title":"mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery","volume":"110","author":"Kim","year":"2002","journal-title":"Cell"},{"issue":"8","key":"10.1016\/j.reprotox.2024.108720_bib137","first-page":"1445","article-title":"Alcohol-induced modulation of rictor and mTORC2 activity in C2C12 myoblasts","volume":"35","author":"Hong-Brown","year":"2011","journal-title":"Alcohol Clin. Exp. Res"},{"issue":"6","key":"10.1016\/j.reprotox.2024.108720_bib138","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1111\/adb.12464","article-title":"Region specific activation of the AKT and mTORC1 pathway in response to excessive alcohol intake in rodents","volume":"22","author":"Laguesse","year":"2017","journal-title":"Addict. Biol."},{"issue":"6","key":"10.1016\/j.reprotox.2024.108720_bib139","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1158\/1541-7786.MCR-09-0409","article-title":"Rictor phosphorylation on the Thr-1135 site does not require mammalian target of rapamycin complex 2","volume":"8","author":"Boulbes","year":"2010","journal-title":"Mol. Cancer Res MCR"},{"issue":"7","key":"10.1016\/j.reprotox.2024.108720_bib140","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1038\/s41386-018-0012-1","article-title":"mTORC2 in the dorsomedial striatum of mice contributes to alcohol-dependent F-Actin polymerization, structural modifications, and consumption","volume":"43","author":"Laguesse","year":"2018","journal-title":"Neuropsychopharmacol. Publ. Am. Coll. Neuropsychopharmacol."}],"container-title":["Reproductive Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623824001874?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623824001874?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T02:48:19Z","timestamp":1733366899000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0890623824001874"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":140,"alternative-id":["S0890623824001874"],"URL":"https:\/\/doi.org\/10.1016\/j.reprotox.2024.108720","relation":{},"ISSN":["0890-6238"],"issn-type":[{"value":"0890-6238","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The convergence of mTOR signaling and ethanol teratogenesis","name":"articletitle","label":"Article Title"},{"value":"Reproductive Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.reprotox.2024.108720","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"108720"}}