{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T06:36:43Z","timestamp":1740119803680,"version":"3.37.3"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100017594","name":"Medical Science and Technology Project of Zhejiang Province","doi-asserted-by":"publisher","award":["2023RC002"],"award-info":[{"award-number":["2023RC002"]}],"id":[{"id":"10.13039\/501100017594","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Toxicology"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.reprotox.2024.108734","type":"journal-article","created":{"date-parts":[[2024,10,13]],"date-time":"2024-10-13T15:35:39Z","timestamp":1728833739000},"page":"108734","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Investigating the effects of COVID-19 on sperm in male smokers: A prospective integrated proteomic and metabolomic study"],"prefix":"10.1016","volume":"130","author":[{"given":"ChengLu","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JiaCheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"XiaoHua","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KeBing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.reprotox.2024.108734_bib1","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.cell.2021.01.004","article-title":"Multi-organ proteomic landscape of COVID-19 autopsies","volume":"184","author":"Nie","year":"2021","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.reprotox.2024.108734_bib2","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/andr.13098","article-title":"COVID-19 and male infertility: an update","volume":"10","author":"Aitken","year":"2022","journal-title":"Andrology"},{"issue":"1","key":"10.1016\/j.reprotox.2024.108734_bib3","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s40618-021-01628-y","article-title":"COVID-19 autopsy cases: detection of virus in endocrine tissues","volume":"45","author":"Poma","year":"2022","journal-title":"J. Endocrinol. Invest"},{"issue":"5","key":"10.1016\/j.reprotox.2024.108734_bib4","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1016\/j.euf.2020.05.009","article-title":"Pathological findings in the testes of COVID-19 patients: clinical implications","volume":"6","author":"Yang","year":"2020","journal-title":"Eur. Urol. Focus"},{"issue":"9-10","key":"10.1016\/j.reprotox.2024.108734_bib5","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1159\/000517276","article-title":"Does COVID-19 worsen the semen parameters? Early results of a tertiary healthcare center","volume":"105","author":"Koc","year":"2021","journal-title":"Urol. Int"},{"issue":"5","key":"10.1016\/j.reprotox.2024.108734_bib6","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1093\/qjmed\/hcab019","article-title":"Post-COVID-19-associated decline in long-term male fertility and embryo quality during assisted reproductive technology","volume":"114","author":"Mannur","year":"2021","journal-title":"QJM"},{"issue":"1","key":"10.1016\/j.reprotox.2024.108734_bib7","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1002\/jmv.26259","article-title":"Evaluation of sex-related hormones and semen characteristics in reproductive-aged male COVID-19 patients","volume":"93","author":"Ma","year":"2021","journal-title":"J. Med Virol."},{"issue":"4","key":"10.1016\/j.reprotox.2024.108734_bib8","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.urology.2012.07.002","article-title":"Effect of smoking on sperm vitality, DNA integrity, seminal oxidative stress, zinc in fertile men","volume":"80","author":"Taha","year":"2012","journal-title":"Urology"},{"issue":"3","key":"10.1016\/j.reprotox.2024.108734_bib9","doi-asserted-by":"crossref","first-page":"H639","DOI":"10.1152\/ajpheart.00595.2018","article-title":"Tobacco smoking induces cardiovascular mitochondrial oxidative stress, promotes endothelial dysfunction, and enhances hypertension","volume":"316","author":"Dikalov","year":"2019","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.reprotox.2024.108734_bib10","doi-asserted-by":"crossref","first-page":"45457","DOI":"10.1038\/srep45457","article-title":"Study on the short-term effects of increased alcohol and cigarette consumption in healthy young men's seminal quality","volume":"7","author":"Silva","year":"2017","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.reprotox.2024.108734_bib11","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s12978-016-0207-z","article-title":"Tobacco smoking is associated with decreased semen quality","volume":"13","author":"Asare-Anane","year":"2016","journal-title":"Reprod. Health"},{"issue":"7","key":"10.1016\/j.reprotox.2024.108734_bib12","doi-asserted-by":"crossref","first-page":"11784","DOI":"10.1002\/jcb.28458","article-title":"Deterioration of semen quality and sperm-DNA integrity as influenced by cigarette smoking in fertile and infertile human male smokers-A prospective study","volume":"120","author":"Ranganathan","year":"2019","journal-title":"J. Cell Biochem"},{"issue":"2","key":"10.1016\/j.reprotox.2024.108734_bib13","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.fertnstert.2008.02.123","article-title":"Effect of cigarette smoking on antioxidant levels and presence of leukocytospermia in infertile men: a prospective study","volume":"90","author":"Pasqualotto","year":"2008","journal-title":"Fertil. Steril."},{"issue":"3","key":"10.1016\/j.reprotox.2024.108734_bib14","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/S0022-5347(01)66968-4","article-title":"Effects of smoking on testicular function, semen quality and sperm fertilizing capacity","volume":"154","author":"Sofikitis","year":"1995","journal-title":"J. Urol."},{"issue":"11","key":"10.1016\/j.reprotox.2024.108734_bib15","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1097\/CM9.0000000000000866","article-title":"Interpretations of \"diagnosis and treatment protocol for novel coronavirus pneumonia (Trial Version 7)","volume":"133","author":"Zhao","year":"2020","journal-title":"Chin. Med J."},{"issue":"1","key":"10.1016\/j.reprotox.2024.108734_bib16","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.jviromet.2004.06.006","article-title":"Inactivation of the coronavirus that induces severe acute respiratory syndrome, SARS-CoV","volume":"121","author":"Darnell","year":"2004","journal-title":"J. Virol. Methods"},{"issue":"5","key":"10.1016\/j.reprotox.2024.108734_bib17","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/nmeth.1322","article-title":"Universal sample preparation method for proteome analysis","volume":"6","author":"Wisniewski","year":"2009","journal-title":"Nat. Methods"},{"issue":"12","key":"10.1016\/j.reprotox.2024.108734_bib18","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1038\/nprot.2016.136","article-title":"The MaxQuant computational platform for mass spectrometry-based shotgun proteomics","volume":"11","author":"Tyanova","year":"2016","journal-title":"Nat. Protoc."},{"issue":"1","key":"10.1016\/j.reprotox.2024.108734_bib19","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1038\/s41467-019-09550-x","article-title":"Metabolic reaction network-based recursive metabolite annotation for untargeted metabolomics","volume":"10","author":"Shen","year":"2019","journal-title":"Nat. Commun."},{"issue":"10","key":"10.1016\/j.reprotox.2024.108734_bib20","doi-asserted-by":"crossref","first-page":"3420","DOI":"10.1093\/nar\/gkn176","article-title":"High-throughput functional annotation and data mining with the Blast2GO suite","volume":"36","author":"Gotz","year":"2008","journal-title":"Nucleic Acids Res"},{"issue":"Web Server issue","key":"10.1016\/j.reprotox.2024.108734_bib21","doi-asserted-by":"crossref","first-page":"W116","DOI":"10.1093\/nar\/gki442","article-title":"InterProScan: protein domains identifier","volume":"33","author":"Quevillon","year":"2005","journal-title":"Nucleic Acids Res"},{"issue":"4","key":"10.1016\/j.reprotox.2024.108734_bib22","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.jmb.2015.11.006","article-title":"BlastKOALA and GhostKOALA: KEGG tools for functional characterization of genome and metagenome sequences","volume":"428","author":"Kanehisa","year":"2016","journal-title":"J. Mol. Biol."},{"issue":"7","key":"10.1016\/j.reprotox.2024.108734_bib23","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1007\/s42399-020-00341-w","article-title":"Coronavirus: why men are more vulnerable to covid-19 than women?","volume":"2","author":"Bwire","year":"2020","journal-title":"SN Compr. Clin. Med"},{"issue":"1","key":"10.1016\/j.reprotox.2024.108734_bib24","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/s13048-020-00734-4","article-title":"Incidence, clinical features, and outcomes of COVID-19 in Canada: impact of sex and age","volume":"13","author":"O'Brien","year":"2020","journal-title":"J. Ovarian Res"},{"issue":"6","key":"10.1016\/j.reprotox.2024.108734_bib25","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/j.fertnstert.2020.04.024","article-title":"No evidence of severe acute respiratory syndrome-coronavirus 2 in semen of males recovering from coronavirus disease 2019","volume":"113","author":"Pan","year":"2020","journal-title":"Fertil. Steril."},{"issue":"2","key":"10.1016\/j.reprotox.2024.108734_bib26","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.fertnstert.2020.05.028","article-title":"Assessment of SARS-CoV-2 in human semen-a cohort study","volume":"114","author":"Holtmann","year":"2020","journal-title":"Fertil. Steril."},{"issue":"1","key":"10.1016\/j.reprotox.2024.108734_bib27","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1093\/biolre\/ioaa050","article-title":"Absence of 2019 novel coronavirus in semen and testes of COVID-19 patients","volume":"103","author":"Song","year":"2020","journal-title":"Dagger, Biol. Reprod."},{"issue":"12","key":"10.1016\/j.reprotox.2024.108734_bib28","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1007\/s40618-020-01261-1","article-title":"Study of SARS-CoV-2 in semen and urine samples of a volunteer with positive naso-pharyngeal swab","volume":"43","author":"Paoli","year":"2020","journal-title":"J. Endocrinol. Invest"},{"issue":"1","key":"10.1016\/j.reprotox.2024.108734_bib29","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/andr.12848","article-title":"Absence of SARS-CoV-2 in semen of a COVID-19 patient cohort","volume":"9","author":"Guo","year":"2021","journal-title":"Andrology"},{"issue":"2","key":"10.1016\/j.reprotox.2024.108734_bib30","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.fertnstert.2021.10.022","article-title":"Sperm quality and absence of SARS-CoV-2 RNA in semen after COVID-19 infection: a prospective, observational study and validation of the SpermCOVID test","volume":"117","author":"Donders","year":"2022","journal-title":"Fertil. Steril."},{"issue":"1","key":"10.1016\/j.reprotox.2024.108734_bib31","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1186\/s12985-023-02192-y","article-title":"Evaluation of semen DNA integrity and related parameters with COVID-19 infection: a prospective cohort study","volume":"20","author":"Shi","year":"2023","journal-title":"Virol. J."},{"issue":"10","key":"10.1016\/j.reprotox.2024.108734_bib32","doi-asserted-by":"crossref","first-page":"8601","DOI":"10.1021\/acsomega.1c06551","article-title":"Semen proteomics of COVID-19 convalescent men reveals disruption of key biological pathways relevant to male reproductive function","volume":"7","author":"Ghosh","year":"2022","journal-title":"ACS Omega"},{"issue":"8","key":"10.1016\/j.reprotox.2024.108734_bib33","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1007\/s43032-024-01560-5","article-title":"Quantitative proteomics of COVID-19 recovered patients identifies long-term changes in sperm proteins leading to cellular stress in spermatozoa","volume":"31","author":"Chopra","year":"2024","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.reprotox.2024.108734_bib34","doi-asserted-by":"crossref","first-page":"1212959","DOI":"10.3389\/fphys.2023.1212959","article-title":"Semen proteomics reveals alterations in fertility-related proteins post-recovery from COVID-19","volume":"14","author":"Dash","year":"2023","journal-title":"Front Physiol."},{"issue":"4","key":"10.1016\/j.reprotox.2024.108734_bib35","first-page":"611","article-title":"a.a.o. Practice Committee of the American Society for Reproductive Medicine. Electronic address, M. Practice Committee of the American Society for Reproductive, Smoking and infertility: a committee opinion","volume":"110","year":"2018","journal-title":"Fertil. Steril."},{"issue":"6","key":"10.1016\/j.reprotox.2024.108734_bib36","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1038\/s41443-022-00605-0","article-title":"Sperm concentration and semen volume increase after smoking cessation in infertile men","volume":"34","author":"Kulaksiz","year":"2022","journal-title":"Int J. Impot Res"},{"issue":"3","key":"10.1016\/j.reprotox.2024.108734_bib37","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.ygeno.2005.09.010","article-title":"Comparative genomics of the sperm mitochondria-associated cysteine-rich protein gene","volume":"87","author":"Hawthorne","year":"2006","journal-title":"Genomics"},{"key":"10.1016\/j.reprotox.2024.108734_bib38","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.852661","article-title":"The role of testosterone in spermatogenesis: lessons from proteome profiling of human spermatozoa in testosterone deficiency","volume":"13","author":"Grande","year":"2022","journal-title":"Front Endocrinol. (Lausanne)"},{"key":"10.1016\/j.reprotox.2024.108734_bib39","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1242263","article-title":"Human immature testicular tissue organ culture: a step towards fertility preservation and restoration","volume":"14","author":"Younis","year":"2023","journal-title":"Front Endocrinol. (Lausanne)"},{"issue":"23","key":"10.1016\/j.reprotox.2024.108734_bib40","doi-asserted-by":"crossref","DOI":"10.3390\/cells11233807","article-title":"MAP4K4\/JNK signaling pathway stimulates proliferation and suppresses apoptosis of human spermatogonial stem cells and lower level of MAP4K4 is associated with male infertility","volume":"11","author":"Wan","year":"2022","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.reprotox.2024.108734_bib41","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.fertnstert.2006.11.086","article-title":"Positive expression of the immunoglobulin superfamily protein IZUMO on human sperm of severely infertile male patients","volume":"88","author":"Hayasaka","year":"2007","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.reprotox.2024.108734_bib42","doi-asserted-by":"crossref","DOI":"10.1017\/S1462399409001045","article-title":"Sperm-egg adhesion and fusion in mammals","volume":"11","author":"Sutovsky","year":"2009","journal-title":"Expert Rev. Mol. Med"},{"key":"10.1016\/j.reprotox.2024.108734_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.jri.2020.103246","article-title":"Human sperm chaperone HSPA2 distribution during in vitro capacitation","volume":"143","author":"Huerta-Retamal","year":"2021","journal-title":"J. Reprod. Immunol."},{"issue":"5","key":"10.1016\/j.reprotox.2024.108734_bib44","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/S0015-0282(02)03073-X","article-title":"Sperm maturity and treatment choice of in vitro fertilization (IVF) or intracytoplasmic sperm injection: diminished sperm HspA2 chaperone levels predict IVF failure","volume":"77","author":"Ergur","year":"2002","journal-title":"Fertil. Steril."},{"issue":"5","key":"10.1016\/j.reprotox.2024.108734_bib45","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/S1472-6483(10)61060-7","article-title":"Fertility testing and ICSI sperm selection by hyaluronic acid binding: clinical and genetic aspects","volume":"14","author":"Huszar","year":"2007","journal-title":"Reprod. Biomed. Online"},{"issue":"1","key":"10.1016\/j.reprotox.2024.108734_bib46","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.jri.2009.09.006","article-title":"Heat shock proteins on the human sperm surface","volume":"84","author":"Naaby-Hansen","year":"2010","journal-title":"J. Reprod. Immunol."},{"issue":"6","key":"10.1016\/j.reprotox.2024.108734_bib47","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1007\/s12192-019-01035-6","article-title":"MAPKAP kinase 2-mediated phosphorylation of HspA1L protects male germ cells from heat stress-induced apoptosis","volume":"24","author":"Williams","year":"2019","journal-title":"Cell Stress Chaperon-.-."},{"issue":"1","key":"10.1016\/j.reprotox.2024.108734_bib48","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.fertnstert.2015.09.013","article-title":"Decreased fecundity and sperm DNA methylation patterns","volume":"105","author":"Jenkins","year":"2016","journal-title":"Fertil. Steril."},{"issue":"5","key":"10.1016\/j.reprotox.2024.108734_bib49","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1093\/humrep\/des064","article-title":"Involvement of the prostate and testis expression (PATE)-like proteins in sperm-oocyte interaction","volume":"27","author":"Margalit","year":"2012","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.reprotox.2024.108734_bib50","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.envres.2016.03.009","article-title":"Interactions between CYP2E1, GSTZ1 and GSTT1 polymorphisms and exposure to drinking water trihalomethanes and their association with semen quality","volume":"147","author":"Yang","year":"2016","journal-title":"Environ. Res."}],"container-title":["Reproductive Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623824002016?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623824002016?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T02:48:38Z","timestamp":1733366918000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0890623824002016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":50,"alternative-id":["S0890623824002016"],"URL":"https:\/\/doi.org\/10.1016\/j.reprotox.2024.108734","relation":{},"ISSN":["0890-6238"],"issn-type":[{"type":"print","value":"0890-6238"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Investigating the effects of COVID-19 on sperm in male smokers: A prospective integrated proteomic and metabolomic study","name":"articletitle","label":"Article Title"},{"value":"Reproductive Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.reprotox.2024.108734","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"108734"}}