{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T14:12:06Z","timestamp":1778508726160,"version":"3.51.4"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T00:00:00Z","timestamp":1730246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MND-MAB-C04-111013"],"award-info":[{"award-number":["MND-MAB-C04-111013"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 110-2628-B-016-004"],"award-info":[{"award-number":["MOST 110-2628-B-016-004"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 108-2628-B-016-002"],"award-info":[{"award-number":["MOST 108-2628-B-016-002"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MND-MAB-C12-112046"],"award-info":[{"award-number":["MND-MAB-C12-112046"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 109-2628-B-016-005"],"award-info":[{"award-number":["MOST 109-2628-B-016-005"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["109\\u20132628-B-016\\u2013005"],"award-info":[{"award-number":["109\\u20132628-B-016\\u2013005"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Toxicology"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.reprotox.2024.108738","type":"journal-article","created":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T02:49:45Z","timestamp":1730256585000},"page":"108738","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Long-term subculture induces syncytialization and influent the response to bisphenol A (BPA) of placental JEG-3 cells"],"prefix":"10.1016","volume":"130","author":[{"given":"Yu-Shiuan","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ai-An","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-Jie","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung-An","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi-Kang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsin-Chieh","family":"Lan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1-2","key":"10.1016\/j.reprotox.2024.108738_bib1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/(SICI)1097-0029(19970701\/15)38:1\/2<29::AID-JEMT5>3.0.CO;2-P","article-title":"Classification of human placental stem villi: review of structural and functional aspects","volume":"38","author":"Demir","year":"1997","journal-title":"Microsc. Res Tech."},{"issue":"1","key":"10.1016\/j.reprotox.2024.108738_bib2","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1530\/rep.1.00723","article-title":"Cytotrophoblast differentiation in the first trimester of pregnancy: evidence for separate progenitors of extravillous trophoblasts and syncytiotrophoblast","volume":"130","author":"James","year":"2005","journal-title":"Reproduction"},{"issue":"6","key":"10.1016\/j.reprotox.2024.108738_bib3","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1172\/JCI200422991","article-title":"Trophoblast differentiation during embryo implantation and formation of the maternal-fetal interface","volume":"114","author":"Red-Horse","year":"2004","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.reprotox.2024.108738_bib4","doi-asserted-by":"crossref","first-page":"1107182","DOI":"10.3389\/fendo.2023.1107182","article-title":"Regulators involved in trophoblast syncytialization in the placenta of intrauterine growth restriction","volume":"14","author":"Zhou","year":"2023","journal-title":"Front Endocrinol. (Lausanne)"},{"issue":"3","key":"10.1016\/j.reprotox.2024.108738_bib5","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2017092118","article-title":"Placental trophoblast syncytialization potentiates macropinocytosis via mTOR signaling to adapt to reduced amino acid supply","volume":"118","author":"Shao","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"2","key":"10.1016\/j.reprotox.2024.108738_bib6","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s00018-015-2069-x","article-title":"Morphological changes of placental syncytium and their implications for the pathogenesis of preeclampsia","volume":"73","author":"Roland","year":"2016","journal-title":"Cell Mol. Life Sci."},{"issue":"3","key":"10.1016\/j.reprotox.2024.108738_bib7","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/aji.12436","article-title":"Cell signaling pathways involved during invasion and syncytialization of trophoblast cells","volume":"75","author":"Gupta","year":"2016","journal-title":"Am. J. Reprod. Immunol."},{"issue":"2","key":"10.1016\/j.reprotox.2024.108738_bib8","first-page":"76","article-title":"Recurrent pregnancy loss: etiology, diagnosis, and therapy","volume":"2","author":"Ford","year":"2009","journal-title":"Rev. Obstet. Gynecol."},{"issue":"2","key":"10.1016\/j.reprotox.2024.108738_bib9","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.ajog.2022.08.010","article-title":"Placental pathology is necessary to understand common pregnancy complications and achieve an improved taxonomy of obstetrical disease","volume":"228","author":"Redline","year":"2023","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"2","key":"10.1016\/j.reprotox.2024.108738_bib10","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.mce.2011.10.021","article-title":"Impact of endocrine-disrupting compounds (EDCs) on female reproductive health","volume":"355","author":"Fowler","year":"2012","journal-title":"Mol. Cell Endocrinol."},{"issue":"1","key":"10.1016\/j.reprotox.2024.108738_bib11","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1001\/jamapediatrics.2013.3699","article-title":"Environmental phthalate exposure and preterm birth","volume":"168","author":"Ferguson","year":"2014","journal-title":"JAMA Pedia"},{"key":"10.1016\/j.reprotox.2024.108738_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.127035","article-title":"Association of bisphenol A or bisphenol S exposure with oxidative stress and immune disturbance among unexplained recurrent spontaneous abortion women","volume":"257","author":"Liang","year":"2020","journal-title":"Chemosphere"},{"issue":"10","key":"10.1016\/j.reprotox.2024.108738_bib13","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1289\/EHP188","article-title":"Urinary Concentrations of bisphenol A and phthalate metabolites measured during pregnancy and risk of preeclampsia","volume":"124","author":"Cantonwine","year":"2016","journal-title":"Environ. Health Perspect."},{"issue":"6","key":"10.1016\/j.reprotox.2024.108738_bib14","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1002\/bdrb.20275","article-title":"Bisphenol A: developmental toxicity from early prenatal exposure","volume":"89","author":"Golub","year":"2010","journal-title":"Birth Defects Res B Dev. Reprod. Toxicol."},{"issue":"22","key":"10.1016\/j.reprotox.2024.108738_bib15","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1016\/S0024-3205(01)01341-8","article-title":"Evaluation of developmental toxicity in rats exposed to the environmental estrogen bisphenol A during pregnancy","volume":"69","author":"Kim","year":"2001","journal-title":"Life Sci."},{"issue":"3","key":"10.1016\/j.reprotox.2024.108738_bib16","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1262\/jrd.18171","article-title":"Effects of bisphenol A (BPA) on placentation and survival of the neonates in mice","volume":"53","author":"Tachibana","year":"2007","journal-title":"J. Reprod. Dev."},{"key":"10.1016\/j.reprotox.2024.108738_bib17","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.reprotox.2018.10.009","article-title":"Bisphenol-A impairs cellular function and alters DNA methylation of stress pathway genes in first trimester trophoblast cells","volume":"82","author":"Basak","year":"2018","journal-title":"Reprod. Toxicol."},{"issue":"2","key":"10.1016\/j.reprotox.2024.108738_bib18","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1093\/biolre\/iox162","article-title":"Low-dose bisphenol A activates the ERK signaling pathway and attenuates steroidogenic gene expression in human placental cells","volume":"98","author":"Chu","year":"2018","journal-title":"Biol. Reprod."},{"issue":"18","key":"10.1016\/j.reprotox.2024.108738_bib19","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22189675","article-title":"The impact of hypoxia in early pregnancy on placental cells","volume":"22","author":"Zhao","year":"2021","journal-title":"Int J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.reprotox.2024.108738_bib20","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1210\/endo.132.3.7679981","article-title":"Novel role of human chorionic gonadotropin in differentiation of human cytotrophoblasts","volume":"132","author":"Shi","year":"1993","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.reprotox.2024.108738_bib21","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1385\/ENDO:19:1:3","article-title":"Hormones and human trophoblast differentiation: a review","volume":"19","author":"Malassine","year":"2002","journal-title":"Endocrine"},{"issue":"8","key":"10.1016\/j.reprotox.2024.108738_bib22","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1053\/plac.1999.0423","article-title":"Oestradiol stimulates morphological and functional differentiation of human villous cytotrophoblast","volume":"20","author":"Cronier","year":"1999","journal-title":"Placenta"},{"issue":"18","key":"10.1016\/j.reprotox.2024.108738_bib23","doi-asserted-by":"crossref","first-page":"3991","DOI":"10.1016\/j.febslet.2005.06.029","article-title":"Stimulation of GCMa and syncytin via cAMP mediated PKA signaling in human trophoblastic cells under normoxic and hypoxic conditions","volume":"579","author":"Knerr","year":"2005","journal-title":"FEBS Lett."},{"issue":"5","key":"10.1016\/j.reprotox.2024.108738_bib24","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1210\/jcem-63-5-1211","article-title":"3rd, 8-Bromo-3\u2032,5\u2032-adenosine monophosphate stimulates the endocrine activity of human cytotrophoblasts in culture","volume":"63","author":"Feinman","year":"1986","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"2","key":"10.1016\/j.reprotox.2024.108738_bib25","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.placenta.2008.11.016","article-title":"Regulation of protein expression and function of octn2 in forskolin-induced syncytialization in BeWo Cells","volume":"30","author":"Huang","year":"2009","journal-title":"Placenta"},{"key":"10.1016\/j.reprotox.2024.108738_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2023.116611","article-title":"Effects of valproic acid on syncytialization in human placental trophoblast cell lines","volume":"474","author":"Ohyama","year":"2023","journal-title":"Toxicol. Appl. Pharm."},{"issue":"3","key":"10.1016\/j.reprotox.2024.108738_bib27","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1242\/dev.113.3.767","article-title":"3rd, E-cadherin expression during the differentiation of human trophoblasts","volume":"113","author":"Coutifaris","year":"1991","journal-title":"Development"},{"issue":"12","key":"10.1016\/j.reprotox.2024.108738_bib28","doi-asserted-by":"crossref","first-page":"3332","DOI":"10.1016\/j.ajpath.2014.08.006","article-title":"p63 inhibits extravillous trophoblast migration and maintains cells in a cytotrophoblast stem cell-like state","volume":"184","author":"Li","year":"2014","journal-title":"Am. J. Pathol."},{"issue":"6771","key":"10.1016\/j.reprotox.2024.108738_bib29","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/35001608","article-title":"Syncytin is a captive retroviral envelope protein involved in human placental morphogenesis","volume":"403","author":"Mi","year":"2000","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.reprotox.2024.108738_bib30","first-page":"S35","article-title":"Development and hormonal functions of the human placenta","volume":"47","author":"Guibourdenche","year":"2009","journal-title":"Folia Histochem Cytobiol."},{"key":"10.1016\/j.reprotox.2024.108738_bib31","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/1477-7827-8-102","article-title":"Biological functions of hCG and hCG-related molecules","volume":"8","author":"Cole","year":"2010","journal-title":"Reprod. Biol. Endocrinol."},{"issue":"2-3","key":"10.1016\/j.reprotox.2024.108738_bib32","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1387\/ijdb.082758ea","article-title":"Estrogen regulation of placental angiogenesis and fetal ovarian development during primate pregnancy","volume":"54","author":"Albrecht","year":"2010","journal-title":"Int J. Dev. Biol."},{"key":"10.1016\/j.reprotox.2024.108738_bib33","doi-asserted-by":"crossref","DOI":"10.1177\/09636897221145682","article-title":"Progesterone enhances the invasion of trophoblast cells by activating PI3K\/AKT signaling pathway to prevent preeclampsia","volume":"32","author":"Liu","year":"2023","journal-title":"Cell Transpl."},{"issue":"10","key":"10.1016\/j.reprotox.2024.108738_bib34","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.1093\/humrep\/del126","article-title":"Progesterone regulates HLA-G gene expression through a novel progesterone response element","volume":"21","author":"Yie","year":"2006","journal-title":"Hum. Reprod."},{"issue":"2","key":"10.1016\/j.reprotox.2024.108738_bib35","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0143-4004(85)80066-7","article-title":"Linkage of human chorionic gonadotrophin and placental lactogen biosynthesis to trophoblast differentiation and tumorigenesis","volume":"6","author":"Hoshina","year":"1985","journal-title":"Placenta"},{"issue":"1","key":"10.1016\/j.reprotox.2024.108738_bib36","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1210\/er.2010-0013","article-title":"The molecular biology, biochemistry, and physiology of human steroidogenesis and its disorders","volume":"32","author":"Miller","year":"2011","journal-title":"Endocr. Rev."},{"issue":"Pt 7","key":"10.1016\/j.reprotox.2024.108738_bib37","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1242\/jcs.111.7.995","article-title":"Cyclic AMP-dependent protein kinases and human trophoblast cell differentiation in vitro","volume":"111","author":"Keryer","year":"1998","journal-title":"J. Cell Sci."},{"issue":"Pt 2","key":"10.1016\/j.reprotox.2024.108738_bib38","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1113\/jphysiol.2005.089326","article-title":"ERK1\/2 and p38 regulate trophoblasts differentiation in human term placenta","volume":"566","author":"Daoud","year":"2005","journal-title":"J. Physiol."},{"issue":"1-2","key":"10.1016\/j.reprotox.2024.108738_bib39","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jsbmb.2009.05.003","article-title":"cAMP-dependent regulation of CYP19 gene in rabbit preovulatory granulosa cells and corpus luteum","volume":"116","author":"Andrieu","year":"2009","journal-title":"J. Steroid Biochem Mol. Biol."},{"issue":"5","key":"10.1016\/j.reprotox.2024.108738_bib40","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1093\/humupd\/dmab015","article-title":"Cell dynamics in human villous trophoblast","volume":"27","author":"Aplin","year":"2021","journal-title":"Hum. Reprod. Update"},{"issue":"13","key":"10.1016\/j.reprotox.2024.108738_bib41","doi-asserted-by":"crossref","first-page":"3979","DOI":"10.1016\/j.celrep.2018.06.043","article-title":"Fine-tuned and cell-cycle-restricted expression of fusogenic protein syncytin-2 maintains functional placental syncytia","volume":"23","author":"Lu","year":"2018","journal-title":"Cell Rep."},{"issue":"45","key":"10.1016\/j.reprotox.2024.108738_bib42","doi-asserted-by":"crossref","first-page":"E6175","DOI":"10.1073\/pnas.1507397112","article-title":"OVO-like 1 regulates progenitor cell fate in human trophoblast development","volume":"112","author":"Renaud","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"7","key":"10.1016\/j.reprotox.2024.108738_bib43","doi-asserted-by":"crossref","DOI":"10.3390\/cancers11070989","article-title":"Function of p21 (Cip1\/Waf1\/CDKN1A) in migration and invasion of cancer and trophoblastic cells","volume":"11","author":"Kreis","year":"2019","journal-title":"Cancers (Basel)"},{"issue":"15","key":"10.1016\/j.reprotox.2024.108738_bib44","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2020105972","article-title":"Molecular pathways of senescence regulate placental structure and function","volume":"39","author":"Gal","year":"2020","journal-title":"EMBO J."},{"issue":"11","key":"10.1016\/j.reprotox.2024.108738_bib45","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1093\/jmcb\/mjz084","article-title":"Tubulin detyrosination promotes human trophoblast syncytium formation","volume":"11","author":"Wang","year":"2019","journal-title":"J. Mol. Cell Biol."},{"issue":"10","key":"10.1016\/j.reprotox.2024.108738_bib46","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1053\/plac.2001.0733","article-title":"The in-vitro characterization of induced apoptosis in placental cytotrophoblasts and syncytiotrophoblasts","volume":"22","author":"Crocker","year":"2001","journal-title":"Placenta"},{"key":"10.1016\/j.reprotox.2024.108738_bib47","first-page":"9210748","article-title":"Comparative study of PPARgamma targets in human extravillous and villous cytotrophoblasts","author":"Liu","year":"2020","journal-title":"PPAR Res 2020"},{"issue":"2","key":"10.1016\/j.reprotox.2024.108738_bib48","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1093\/toxsci\/kfr132","article-title":"Characterization of novel ligands of ERalpha, Erbeta, and PPARgamma: the case of halogenated bisphenol A and their conjugated metabolites","volume":"122","author":"Riu","year":"2011","journal-title":"Toxicol. Sci."},{"issue":"9","key":"10.1016\/j.reprotox.2024.108738_bib49","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1038\/labinvest.3780334","article-title":"Characterization of human villous and extravillous trophoblasts isolated from first trimester placenta","volume":"81","author":"Tarrade","year":"2001","journal-title":"Lab Invest"},{"issue":"11","key":"10.1016\/j.reprotox.2024.108738_bib50","doi-asserted-by":"crossref","first-page":"3757","DOI":"10.1021\/acs.molpharmaceut.2c00216","article-title":"Placental nanoparticle uptake-on-a-chip: the impact of trophoblast syncytialization and shear stress","volume":"19","author":"Abostait","year":"2022","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.reprotox.2024.108738_bib51","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.placenta.2020.10.024","article-title":"The effects of high-density lipoprotein and oxidized high-density lipoprotein on forskolin-induced syncytialization of BeWo cells","volume":"103","author":"Wang","year":"2021","journal-title":"Placenta"},{"issue":"8","key":"10.1016\/j.reprotox.2024.108738_bib52","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/0002-9378(72)90185-8","article-title":"Plasma estrone, estradiol, estriol, progesterone, and 17-hydroxyprogesterone in human pregnancy. I. Normal pregnancy","volume":"112","author":"Tulchinsky","year":"1972","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"4","key":"10.1016\/j.reprotox.2024.108738_bib53","doi-asserted-by":"crossref","DOI":"10.3390\/cells12040620","article-title":"Estrogen actions in placental vascular morphogenesis and spiral artery remodeling: a comparative view between humans and mice","volume":"12","author":"Rusidze","year":"2023","journal-title":"Cells"},{"issue":"8690","key":"10.1016\/j.reprotox.2024.108738_bib54","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/0140-6736(90)90410-7","article-title":"Oestrogen receptor B-region polymorphism and spontaneous abortion in women with breast cancer","volume":"335","author":"Lehrer","year":"1990","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.reprotox.2024.108738_bib55","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1067\/mem.2000.108653","article-title":"Serum progesterone testing to predict ectopic pregnancy in symptomatic first-trimester patients","volume":"36","author":"Buckley","year":"2000","journal-title":"Ann. Emerg. Med"},{"issue":"5","key":"10.1016\/j.reprotox.2024.108738_bib56","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1203\/00006450-199811000-00001","article-title":"Regulation of uterine smooth muscle function during gestation","volume":"44","author":"Riemer","year":"1998","journal-title":"Pedia Res"},{"issue":"1-2","key":"10.1016\/j.reprotox.2024.108738_bib57","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0378-4347(99)00471-5","article-title":"Sensitive method for the determination of bisphenol-A in serum using two systems of high-performance liquid chromatography","volume":"736","author":"Sajiki","year":"1999","journal-title":"J. Chromatogr. B Biomed. Sci. Appl."},{"issue":"11","key":"10.1016\/j.reprotox.2024.108738_bib58","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.1093\/humrep\/17.11.2839","article-title":"Determination of bisphenol A concentrations in human biological fluids reveals significant early prenatal exposure","volume":"17","author":"Ikezuki","year":"2002","journal-title":"Hum. Reprod."},{"issue":"19","key":"10.1016\/j.reprotox.2024.108738_bib59","doi-asserted-by":"crossref","first-page":"E2598","DOI":"10.1073\/pnas.1601630113","article-title":"Comparison of syncytiotrophoblast generated from human embryonic stem cells and from term placentas","volume":"113","author":"Yabe","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"113","key":"10.1016\/j.reprotox.2024.108738_bib60","doi-asserted-by":"crossref","DOI":"10.3791\/54228","article-title":"Human primary trophoblast cell culture model to study the protective effects of melatonin against hypoxia\/reoxygenation-induced disruption","author":"Sagrillo-Fagundes","year":"2016","journal-title":"J. Vis. Exp."}],"container-title":["Reproductive Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623824002053?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623824002053?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T13:08:52Z","timestamp":1778504932000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0890623824002053"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":60,"alternative-id":["S0890623824002053"],"URL":"https:\/\/doi.org\/10.1016\/j.reprotox.2024.108738","relation":{},"ISSN":["0890-6238"],"issn-type":[{"value":"0890-6238","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Long-term subculture induces syncytialization and influent the response to bisphenol A (BPA) of placental JEG-3 cells","name":"articletitle","label":"Article Title"},{"value":"Reproductive Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.reprotox.2024.108738","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"108738"}}