{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T01:16:34Z","timestamp":1782436594725,"version":"3.54.5"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["0 -302401\/2019-9"],"award-info":[{"award-number":["0 -302401\/2019-9"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Toxicology"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.reprotox.2024.108743","type":"journal-article","created":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T18:32:06Z","timestamp":1731090726000},"page":"108743","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Investigating the significance of the transgenerational impact of high and repeated doses of ivermectin: Effects on paternal testis histopathology, pups' development, and sexual behavior"],"prefix":"10.1016","volume":"130","author":[{"given":"Natalia","family":"Moreira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kassia","family":"de Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel Aur","family":"Borges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lais Coelho","family":"Cortez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"de Macedo Amado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo Augusto","family":"Foganholi da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flora","family":"Cordeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Martha","family":"Bernardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.reprotox.2024.108743_bib1","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1080\/15563650.2022.2043338","article-title":"Ivermectin: a mini-review","volume":"60","author":"Johnson-Arbor","year":"2022","journal-title":"Clin. Toxicol. (Philos. )"},{"key":"10.1016\/j.reprotox.2024.108743_bib2","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2024.1377718","article-title":"A review of moxidectin vs. other macrocyclic lactones for prevention of heartworm disease in dogs with an appraisal of two commercial formulations","volume":"11","author":"Mwacalimba","year":"2024","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.reprotox.2024.108743_bib3","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1017\/S0031182023000343","article-title":"Control of gastrointestinal helminths in small ruminants to prevent anthelmintic resistance: The Italian experience","volume":"150","author":"Maurizio","year":"2023","journal-title":"Parasitology"},{"key":"10.1016\/j.reprotox.2024.108743_bib4","doi-asserted-by":"crossref","DOI":"10.3390\/v16040593","article-title":"Antiviral chemotherapy in avian medicine\u2014a review","volume":"16","author":"Szotowska","year":"2024","journal-title":"Viruses"},{"key":"10.1016\/j.reprotox.2024.108743_bib5","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1007\/s00431-024-05535-1","article-title":"Scabies in infants and children - a narrative review","volume":"183","author":"Chiriac","year":"2024","journal-title":"Eur. J. Pedia"},{"key":"10.1016\/j.reprotox.2024.108743_bib6","doi-asserted-by":"crossref","first-page":"951","DOI":"10.4269\/ajtmh.23-0645","article-title":"High efficacy of ivermectin for strongyloidiasis treatment","volume":"110","author":"Sengthong","year":"2024","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.reprotox.2024.108743_bib7","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s40266-024-01115-y","article-title":"Rosacea in older adults and pharmacologic treatments","volume":"41","author":"Lee","year":"2024","journal-title":"Drugs Aging"},{"key":"10.1016\/j.reprotox.2024.108743_bib8","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1080\/15563650.2022.2043338","article-title":"Ivermectin: a mini-review","volume":"60","author":"Johnson-Arbor","year":"2022","journal-title":"Clin. Toxicol. (Philos. )"},{"key":"10.1016\/j.reprotox.2024.108743_bib9","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.exger.2015.02.014","article-title":"Leydig cell aging and hypogonadism","volume":"68","author":"Beattie","year":"2015","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.reprotox.2024.108743_bib10","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1477-7827-2-13","article-title":"Stimulation of TM3 Leydig cell proliferation via GABA(A) receptors: a new role for testicular GABA","volume":"2","author":"Geigerseder","year":"2004","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.reprotox.2024.108743_bib11","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1159\/000070897","article-title":"Evidence for a GABAergic system in rodent and human testis: local GABA production and GABA receptors","volume":"77","author":"Geigerseder","year":"2003","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.reprotox.2024.108743_bib12","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.rvsc.2010.07.026","article-title":"Ivermectin impairs sexual behavior in sexually na\u00efve, but not sexually experienced male rats","volume":"91","author":"Bernardi","year":"2011","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.reprotox.2024.108743_bib13","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.ntt.2014.03.003","article-title":"Ivermectin reduces sexual behavior in female rats","volume":"43","author":"Moreira","year":"2014","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.reprotox.2024.108743_bib14","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.reprotox.2017.10.002","article-title":"Ivermectin reduces motor coordination, serum testosterone, and central neurotransmitter levels but does not affect sexual motivation in male rats","volume":"74","author":"Moreira","year":"2017","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.reprotox.2024.108743_bib15","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.rvsc.2017.12.013","article-title":"Ivermectin acute administration impaired the spermatogenesis and spermiogenesis of adult rats","volume":"117","author":"Cordeiro","year":"2018","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.reprotox.2024.108743_bib16","first-page":"145","article-title":"Does a therapeutical dose of ivermectin impairs testicular homeostasis of rats via excessive apoptosis?","volume":"59","author":"Cordeiro","year":"2023","journal-title":"Vet. Ital."},{"key":"10.1016\/j.reprotox.2024.108743_bib17","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.rvsc.2010.07.026","article-title":"Ivermectin impairs sexual behavior in sexually na\u00efve, but not sexually experienced male rats","volume":"91","author":"Bernardi","year":"2011","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.reprotox.2024.108743_bib18","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.ntt.2013.07.006","article-title":"Doramectin reduces sexual behavior and penile erection in male rats","volume":"39","author":"Ferri","year":"2013","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.reprotox.2024.108743_bib19","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1111\/j.1699-0463.1988.tb05320.x","article-title":"Some new, simple and efficient stereological methods and their use in pathological research and diagnosis","volume":"96","author":"Gundersen","year":"1988","journal-title":"APMIS"},{"key":"10.1016\/j.reprotox.2024.108743_bib20","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1590\/S1519-69842002000400008","article-title":"Determination of the estrous cycle phases of rats: some helpful considerations","volume":"62","author":"Marcondes","year":"2002","journal-title":"Braz. J. Biol."},{"key":"10.1016\/j.reprotox.2024.108743_bib21","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.pbb.2005.07.002","article-title":"Perinatal maternal exposure to picrotoxin: Effects on sexual behavior in female rat offspring","volume":"81","author":"Teodorov","year":"2005","journal-title":"Pharm. Biochem Behav."},{"key":"10.1016\/j.reprotox.2024.108743_bib22","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/0031-9384(71)90120-X","article-title":"Effects of mounts without intromission upon the behavior of female rats during the onset of estrogen-induced heat","volume":"7","author":"Fitzroy Hardy","year":"1971","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.reprotox.2024.108743_bib23","article-title":"Assessment of social interaction behaviors","author":"Kaidanovich-Beilin","year":"2010","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.reprotox.2024.108743_bib24","doi-asserted-by":"crossref","DOI":"10.1002\/mrd.23739","article-title":"Fetal Leydig cells: What we know and what we don\u2019t","volume":"91","author":"Jiang","year":"2024","journal-title":"Mol. Reprod. Dev."},{"key":"10.1016\/j.reprotox.2024.108743_bib25","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/0278-6915(89)90048-3","article-title":"Effects of ivermectin on reproduction and neonatal toxicity in rats","volume":"27","author":"Lankas","year":"1989","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.reprotox.2024.108743_bib26","doi-asserted-by":"crossref","DOI":"10.3390\/ph15030332","article-title":"Assessment of Avermectins-Induced Toxicity in Animals","volume":"15","author":"Salman","year":"2022","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.reprotox.2024.108743_bib27","unstructured":"Abdel-Baset, El-Mashad, Pathological studies on effects of ivermectin on male and female rabbits, 2017. \u3008http:\/\/www.bvmj.bu.edu.eg\u3009."},{"key":"10.1016\/j.reprotox.2024.108743_bib28","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/S0041-008X(02)00074-1","article-title":"Preliminary studies of offspring exposure to phenylbutazone and ivermectin during the perinatal period in a Holstein cow-calf model","volume":"187","author":"Chamberlain","year":"2003","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.reprotox.2024.108743_bib29","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1111\/andr.12156","article-title":"Anogenital distance as a marker of androgen exposure in humans","volume":"4","author":"Thankamony","year":"2016","journal-title":"Andrology"},{"key":"10.1016\/j.reprotox.2024.108743_bib30","doi-asserted-by":"crossref","DOI":"10.1002\/bdr2.2347","article-title":"Rodent anogenital distance recommendations","volume":"116","author":"Wise","year":"2024","journal-title":"Birth Defects Res"},{"key":"10.1016\/j.reprotox.2024.108743_bib31","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/pr.2017.287","article-title":"Anogenital distance as a phenotypic signature through infancy","volume":"83","author":"Priskorn","year":"2018","journal-title":"Pedia Res."},{"key":"10.1016\/j.reprotox.2024.108743_bib32","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1080\/15287394.2013.874881","article-title":"Perinatal androgenic exposure and reproductive health effects female rat offspring","volume":"77","author":"Guerra","year":"2014","journal-title":"J. Toxicol. Environ. Health A"},{"key":"10.1016\/j.reprotox.2024.108743_bib33","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s00204-018-2350-5","article-title":"Anogenital distance as a toxicological or clinical marker for fetal androgen action and risk for reproductive disorders","volume":"93","author":"Schwartz","year":"2019","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.reprotox.2024.108743_bib34","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0018973","article-title":"The relationship between anogenital distance, fatherhood, and fertility in adult men","volume":"6","author":"Eisenberg","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.reprotox.2024.108743_bib35","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1111\/j.1365-2605.2012.01275.x","article-title":"The relationship between anogenital distance and azoospermia in adult men","volume":"35","author":"Eisenberg","year":"2012","journal-title":"Int. J. Androl."},{"key":"10.1016\/j.reprotox.2024.108743_bib36","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/s10815-014-0410-1","article-title":"Anogenital distance as a measure of human male fertility","volume":"32","author":"Eisenberg","year":"2015","journal-title":"J. Assist Reprod. Genet."},{"key":"10.1016\/j.reprotox.2024.108743_bib37","first-page":"153","article-title":"Epidermal growth factor advances some aspects of development but retards others in both rats and hamsters","volume":"11","author":"Smart","year":"1989","journal-title":"J. Dev. Physiol."},{"key":"10.1016\/j.reprotox.2024.108743_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/0006-8993(89)91387-5","article-title":"Epidermal growth factor has both growth-promoting and growth-inhibiting effects on physical and neurobehavioral development of neonatal mice","author":"Calamandrei","year":"1989","journal-title":"Brain Res."},{"key":"10.1016\/j.reprotox.2024.108743_bib39","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1196\/annals.1315.017","article-title":"Origins of growth factors: NGF and EGF","volume":"1038","author":"COHEN","year":"2004","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.reprotox.2024.108743_bib40","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1203\/00006450-198605000-00017","article-title":"Treatment of the neonatal rat with epidermal growth factor: differences in time and organ response","volume":"20","author":"Hoath","year":"1986","journal-title":"Pedia Res."}],"container-title":["Reproductive Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623824002107?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623824002107?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T13:08:46Z","timestamp":1778504926000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0890623824002107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":40,"alternative-id":["S0890623824002107"],"URL":"https:\/\/doi.org\/10.1016\/j.reprotox.2024.108743","relation":{},"ISSN":["0890-6238"],"issn-type":[{"value":"0890-6238","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Investigating the significance of the transgenerational impact of high and repeated doses of ivermectin: Effects on paternal testis histopathology, pups' development, and sexual behavior","name":"articletitle","label":"Article Title"},{"value":"Reproductive Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.reprotox.2024.108743","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"108743"}}