{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T11:33:25Z","timestamp":1792064005509,"version":"4.4.0"},"reference-count":68,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["45\/07\/2022\/Toxi\/BMS"],"award-info":[{"award-number":["45\/07\/2022\/Toxi\/BMS"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Toxicology"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.reprotox.2024.108750","type":"journal-article","created":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T21:07:27Z","timestamp":1731704847000},"page":"108750","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Bisphenol A-induced polycystic ovary syndrome (PCOS) with hormonal and metabolic implications in rats"],"prefix":"10.1016","volume":"131","author":[{"given":"Mehjbeen","family":"Javed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Suramya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anuradha","family":"Mangla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garima","family":"Jindal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Humaira Naaz","family":"Bhutto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaesta","family":"Shahid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suraj","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheikh","family":"Raisuddin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.reprotox.2024.108750_bib1","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1210\/er.2015-1018","article-title":"Scientific statement on the diagnostic criteria, epidemiology, pathophysiology, and molecular genetics of polycystic ovary syndrome","volume":"36","author":"Dumesic","year":"2015","journal-title":"Endocr. Rev."},{"issue":"1","key":"10.1016\/j.reprotox.2024.108750_bib2","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.fertnstert.2016.05.003","article-title":"Criteria, prevalence, and phenotypes of polycystic ovary syndrome","volume":"106","author":"Lizneva","year":"2016","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.reprotox.2024.108750_bib3","first-page":"1","article-title":"A rat model of polycystic ovary syndrome with insulin resistance induced by letrozole combined with high fat diet","volume":"26","author":"Wang","year":"2020","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.reprotox.2024.108750_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/edm2.359","article-title":"Interplay between polycystic ovary syndrome and hypothyroidism on serum testosterone, oxidative stress and StAR gene expression in female rats","volume":"5","author":"Khodabandeh","year":"2022","journal-title":"Endocrinol. Diab. Metab."},{"key":"10.1016\/j.reprotox.2024.108750_bib5","doi-asserted-by":"crossref","first-page":"64025","DOI":"10.1007\/s11356-023-26820-w","article-title":"Distinct metabolic signatures in blood plasma of bisphenol A\u2013exposed women with polycystic ovarian syndrome","volume":"30","author":"Prabhu","year":"2023","journal-title":"Environ. Sci. Pollut. Res"},{"issue":"4","key":"10.1016\/j.reprotox.2024.108750_bib6","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1111\/j.1365-2265.2010.03956.x","article-title":"PCOS forum: Research in polycystic ovary syndrome today and tomorrow","volume":"74","author":"Pasquali","year":"2011","journal-title":"Clin. Endocrinol."},{"key":"10.1016\/j.reprotox.2024.108750_bib7","doi-asserted-by":"crossref","first-page":"626","DOI":"10.2174\/1871530318666180521095443","article-title":"Bisphenol A-induced endocrine toxicity and male reprotoxicopathy are modulated by the dietary iron deficiency","volume":"68","author":"Rashid","year":"2018","journal-title":"Endocr. Metab. Immune Disord. Drug Targets"},{"key":"10.1016\/j.reprotox.2024.108750_bib8","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1177\/0960327119873017","article-title":"Transgenerational effect of parental obesity and chronic parental bisphenol A exposure on hormonal profile and reproductive organs of preadolescent Wistar rats of F1 generation: a one-generation study","volume":"39","author":"Dabeer","year":"2020","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.reprotox.2024.108750_bib9","first-page":"303","article-title":"Urinary bisphenol A in women with polycystic ovary syndrome - a possible suppressive effect on steroidogenesis?","volume":"42","author":"Lazurova","year":"2021","journal-title":"Horm. Mol. Biol. Clin. Invest."},{"key":"10.1016\/j.reprotox.2024.108750_bib10","first-page":"21","article-title":"Introduction to endocrine disrupting chemicals (EDCs) - A guide for public interest organizations and policy-makers","volume":"99","author":"Gore","year":"2014","journal-title":"Endocr. Soc. J."},{"key":"10.1016\/j.reprotox.2024.108750_bib11","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.tox.2008.10.022","article-title":"Iron deficiency augments bisphenol A-induced oxidative stress in rats","volume":"256","author":"Rashid","year":"2009","journal-title":"Toxicol"},{"key":"10.1016\/j.reprotox.2024.108750_bib12","doi-asserted-by":"crossref","first-page":"2849","DOI":"10.1016\/j.fct.2011.07.062","article-title":"Melatonin ameliorates bisphenol A-induced biochemical toxicity in testicular mitochondria of mouse","volume":"49","author":"Anjum","year":"2011","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.reprotox.2024.108750_bib13","series-title":"Environment impact on reproductive health","article-title":"Cellular mechanisms of endocrine disruption","author":"Rizzo","year":"2023"},{"issue":"11","key":"10.1016\/j.reprotox.2024.108750_bib14","article-title":"Endocrine disrupting chemicals and male fertility: from physiological to molecular effects","volume":"10","author":"Lahimer","year":"2023","journal-title":"Front. Public. Health"},{"key":"10.1016\/j.reprotox.2024.108750_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2022.137463","article-title":"Exposure to bisphenol A and its analogs and polycystic ovarian syndrome in women of childbearing age: a multicenter case-control study","volume":"313","author":"Zhan","year":"2023","journal-title":"Chemosphere"},{"key":"10.1016\/j.reprotox.2024.108750_bib16","series-title":"Food Toxicology: Current Advances and Future Challenges","first-page":"199","article-title":"Endocrine-disrupting chemicals in food and their toxicological implications","author":"Raisuddin","year":"2017"},{"key":"10.1016\/j.reprotox.2024.108750_bib17","doi-asserted-by":"crossref","first-page":"3146","DOI":"10.1007\/s11356-022-22246-y","article-title":"Perinatal exposure to environmental endocrine disruptor bisphenol A aggravates the onset of non-alcoholic fatty liver disease (NAFLD) in weanling F1 offspring of obese rats","volume":"30","author":"Dabeer","year":"2023","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.reprotox.2024.108750_bib18","article-title":"Endocrine disrupting effects of bisphenol A exposure and recent advances on its removal by water treatment systems","volume":"5","author":"Ohore","year":"2019","journal-title":"A Rev. Sci. Afr."},{"key":"10.1016\/j.reprotox.2024.108750_bib19","doi-asserted-by":"crossref","first-page":"32631","DOI":"10.1007\/s11356-022-19244-5","article-title":"Review on bisphenol A and the risk of polycystic ovarian syndrome: an insight from endocrine and gene expression","volume":"29","author":"Mukhopadhyay","year":"2022","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.reprotox.2024.108750_bib20","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1289\/ehp.0901257","article-title":"Neonatal exposure to bisphenol a and reproductive and endocrine alterations resembling the polycystic ovarian syndrome in adult rats","volume":"118","author":"Fernandez","year":"2010","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.reprotox.2024.108750_bib21","first-page":"47","article-title":"Evaluation of effect of Commiphora wightii in dehydroepiandrosterone (DHEA) induced polycystic ovary syndrome (PCOS) in rats","volume":"24","author":"Kavitha","year":"2016","journal-title":"Pharm. Tutor"},{"key":"10.1016\/j.reprotox.2024.108750_bib22","doi-asserted-by":"crossref","first-page":"735","DOI":"10.3389\/fendo.2018.00735","article-title":"An improved dehydroepiandrosterone-induced rat model of polycystic ovary syndrome (PCOS): Post-pubertal improve PCOS\u2019s features","volume":"9","author":"Kim","year":"2018","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.reprotox.2024.108750_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.yrtph.2019.104544","article-title":"Berberine decreases insulin resistance in a PCOS rats by improving GLUT4: dual regulation of the PI3K\/AKT and MAPK pathways","volume":"110","author":"Zhang","year":"2020","journal-title":"Regul. Toxicol. Pharm."},{"key":"10.1016\/j.reprotox.2024.108750_bib24","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.3390\/nu15102238","article-title":"Regulation of insulin resistance, lipid profile and glucose metabolism associated with polycystic ovary syndrome by Tinospora cordifolia","volume":"15","author":"Rani","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.reprotox.2024.108750_bib25","first-page":"677","article-title":"The rat estrous cycle revisited: a quantitative and qualitative analysis","volume":"10","author":"Paccola1","year":"2013","journal-title":"Anim. Reprod."},{"issue":"5","key":"10.1016\/j.reprotox.2024.108750_bib26","first-page":"1","article-title":"Staging of the estrous cycle and induction of estrus in experimental rodents: an update","volume":"6","author":"Ajayi","year":"2020","journal-title":"Fertil. Res. Pract."},{"issue":"2","key":"10.1016\/j.reprotox.2024.108750_bib27","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1002\/bdrb.20106","article-title":"The rodent estrous cycle: characterization of vaginal cytology and its utility in toxicological studies","volume":"80","author":"Goldman","year":"2007","journal-title":"Birth Defects Res. B Dev. Reprod. Toxicol."},{"key":"10.1016\/j.reprotox.2024.108750_bib28","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1262\/jrd.2011-012","article-title":"Follicular growth and atresia in ammalian ovaries: regulation by survival and death of granulosa cells","volume":"58","author":"Matsuda","year":"2012","journal-title":"J. Reprod. Dev."},{"key":"10.1016\/j.reprotox.2024.108750_bib29","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1080\/13880209.2016.1258425","article-title":"Soy isoflavones exert beneficial effects on letrozole-induced rat polycystic ovary syndrome (PCOS) model through anti-androgenic mechanism","volume":"55","author":"Rajan","year":"2017","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.reprotox.2024.108750_bib30","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1267\/ahc.21-00081","article-title":"Histomorphological changes in a rat model of polycystic ovary syndrome and the contribution of stevia leaf extract in modulating the ovarian fibrosis, VEGF, and TGF-\u03b2 immunoexpressions: comparison with metformin","volume":"55","author":"Morsi","year":"2022","journal-title":"Acta Histochem. Cytochem."},{"issue":"1","key":"10.1016\/j.reprotox.2024.108750_bib31","first-page":"11","article-title":"Polycystic ovary syndrome and the forgotten uterus","volume":"2","author":"Hosseinzadeh","year":"2021","journal-title":"F. S. Rev."},{"issue":"92","key":"10.1016\/j.reprotox.2024.108750_bib32","first-page":"141","article-title":"Uterine contractility in the nonpregnant mouse: changes during the estrous cycle and effects of chloride channel blockade","volume":"2015","author":"Dodds","year":"2015","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.reprotox.2024.108750_bib33","article-title":"Mapping uterine calcium dynamics during the ovulatory cycle in live mice","author":"Combs","year":"2024","journal-title":"bioRxiv [Prepr. ]"},{"key":"10.1016\/j.reprotox.2024.108750_bib34","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/B978-1-4557-2758-2.00010-X","article-title":"The structure, function, and evaluation of the female reproductive tract","volume":"235","author":"Lessy","year":"2014","journal-title":"Yen Jaffe'S. Reprod. Endocrinol."},{"key":"10.1016\/j.reprotox.2024.108750_bib35","first-page":"405","article-title":"Estrogen and the endometrium: lessons learned from gene expression profiling in rodents and human","volume":"13","author":"Groothuis","year":"2007","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.reprotox.2024.108750_bib36","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/978-3-030-38474-6_8","article-title":"Hormone Therapy Effects on the Uterus","volume":"1242","author":"Deligdisch-Schor","year":"2020","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.reprotox.2024.108750_bib37","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s43032-019-00001-y","article-title":"The regulation of uterine function during parturition: an update and recent advances","volume":"27","author":"Ilicic","year":"2020","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.reprotox.2024.108750_bib38","first-page":"47","article-title":"Changes of the uterine tissue in rats with polycystic ovary syndrome induced by estradiol valerate","volume":"11","author":"Mirabolghasemi","year":"2017","journal-title":"Int. J. Fertil. Steril."},{"key":"10.1016\/j.reprotox.2024.108750_bib39","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.788772","article-title":"Research progress on the mechanism between polycystic ovary syndrome and abnormal endometrium","volume":"12","author":"Xue","year":"2021","journal-title":"Front. Physiol."},{"key":"10.1016\/j.reprotox.2024.108750_bib40","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1095\/biolreprod.115.132241","article-title":"Development and characterization of uterine glandular epithelium specific androgen receptor knockout mouse model","volume":"93","author":"Choi","year":"2015","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.reprotox.2024.108750_bib41","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1210\/en.2015-2032","article-title":"A role for androgens in epithelial proliferation and formation of glands in the mouse uterus","volume":"157","author":"Simitsidellis","year":"2016","journal-title":"Endocrinol"},{"key":"10.1016\/j.reprotox.2024.108750_bib42","doi-asserted-by":"crossref","first-page":"12026","DOI":"10.3390\/ijms241512026","article-title":"Hyperandrogenism and its possible effects on endometrial receptivity: A Review","volume":"24","author":"Yusuf","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.reprotox.2024.108750_bib43","doi-asserted-by":"crossref","DOI":"10.1093\/molehr\/gaad017","article-title":"Androgen signalling in the ovaries and endometrium","volume":"29","author":"Lissaman","year":"2023","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.reprotox.2024.108750_bib44","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.joim.2022.01.007","article-title":"Moxibustion alleviates decreased ovarian reserve in rats by restoring the PI3K\/AKT signaling pathway","volume":"20","author":"Li","year":"2022","journal-title":"J. Integr. Med."},{"key":"10.1016\/j.reprotox.2024.108750_bib45","doi-asserted-by":"crossref","first-page":"20774","DOI":"10.1038\/s41598-023-47809-y","article-title":"A rat study on the PTEN expression in ovarian tissue in PCOS and folliculogenesis","volume":"13","author":"Kalem","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.reprotox.2024.108750_bib46","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/S0301-5629(00)00219-2","article-title":"Ultrasound criteria in the diagnosis of polycystic ovary syndrome (PCOS","volume":"26","author":"Atiomo","year":"2000","journal-title":"Ultrasound Med. Biol."},{"issue":"6","key":"10.1016\/j.reprotox.2024.108750_bib47","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1093\/humupd\/dmg044","article-title":"Ultrasound assessment of the polycystic ovary: international consensus definitions","volume":"9","author":"Balen","year":"2003","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.reprotox.2024.108750_bib48","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1093\/humrep\/dei159","article-title":"Revisiting the ovarian volume as a diagnostic criterion for polycystic ovaries","volume":"20","author":"Jonard","year":"2005","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.reprotox.2024.108750_bib49","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1002\/uog.5393","article-title":"Ovarian volume and follicle number in the diagnosis of polycystic ovary syndrome in Chinese women","volume":"32","author":"Chen","year":"2008","journal-title":"Ultrasound Obstet. Gynaecol."},{"key":"10.1016\/j.reprotox.2024.108750_bib50","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1095\/biolreprod.115.131631","article-title":"A novel letrozole model recapitulates both the reproductive and metabolic phenotypes of polycystic ovary syndrome in female mice","volume":"93","author":"Kauffman","year":"2015","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.reprotox.2024.108750_bib51","doi-asserted-by":"crossref","first-page":"8229","DOI":"10.1038\/s41598-024-58064-0","article-title":"Mechanism of elevated LH\/FSH ratio in lean PCOS revisited: a path analysis","volume":"14","author":"Pratama","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.reprotox.2024.108750_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.repbio.2023.100797","article-title":"Mechanisms of DHEA-induced AMH increase in the ovarian tissues of PCOS rat","volume":"23","author":"Zhang","year":"2023","journal-title":"Reprod. Biol."},{"key":"10.1016\/j.reprotox.2024.108750_bib53","doi-asserted-by":"crossref","first-page":"57","DOI":"10.4103\/abr.abr_144_20","article-title":"The effects of zinc methionine on reproductive and thyroid hormones in rats with polycystic ovarian syndrome","volume":"9","author":"Torshizi","year":"2020","journal-title":"Adv. Biomed. Res."},{"issue":"3","key":"10.1016\/j.reprotox.2024.108750_bib54","article-title":"PCOS without hyperandrogenism is associated with higher plasma trimethylamine N-oxide levels","volume":"20","author":"Huang","year":"2020","journal-title":"BMC Endocr. Disord."},{"key":"10.1016\/j.reprotox.2024.108750_bib55","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/S0015-0282(97)80068-4","article-title":"Classification of normogonadotropic infertility: polycystic ovaries diagnosed by ultrasound versus endocrine characteristics of polycystic ovary syndrome","volume":"67","author":"Van Santbrink","year":"1997","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.reprotox.2024.108750_bib56","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1210\/er.2015-1104","article-title":"The pathogenesis of polycystic ovary syndrome (PCOS): The hypothesis of PCOS as functional ovarian hyperandrogenism revisited","volume":"37","author":"Rosenfield","year":"2016","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.reprotox.2024.108750_bib57","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1038\/s41467-021-21308-y","article-title":"The Goto-Kakizaki rat is a spontaneous prototypical rodent model of polycystic ovary syndrome","volume":"12","author":"Bourgneuf","year":"2021","journal-title":"Nat. Commun."},{"issue":"11","key":"10.1016\/j.reprotox.2024.108750_bib58","first-page":"6013","article-title":"Human P450scc gene transcription is induced by cyclic AMP and repressed by 12-O-tetradecanoylphorbol- 13-acetate and A23187 through Independent cis elements","volume":"10","author":"Moore","year":"1990","journal-title":"Mol. Cell. Biol."},{"issue":"2","key":"10.1016\/j.reprotox.2024.108750_bib59","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1210\/jc.2014-2523","article-title":"Testosterone to dihydrotestosterone ratio as a new biomarker for an adverse metabolic phenotype in the polycystic ovary syndrome","volume":"100","author":"Munzker","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"6","key":"10.1016\/j.reprotox.2024.108750_bib60","doi-asserted-by":"crossref","first-page":"186","DOI":"10.14740\/jem601","article-title":"Increased ratio of total testosterone to dihydrotestosterone may predict an adverse metabolic outcome in polycystic ovary syndrome","volume":"9","author":"Shah","year":"2019","journal-title":"J. Endocrinol. Metab."},{"key":"10.1016\/j.reprotox.2024.108750_bib61","first-page":"265","article-title":"Does the thyroid hormonal levels alter in polycystic ovarian disease? A comparative cross-sectional study","volume":"4","author":"Shirsath","year":"2015","journal-title":"Indian J. Basic Appl. Med. Res"},{"key":"10.1016\/j.reprotox.2024.108750_bib62","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.fertnstert.2012.10.006","article-title":"Subclinical hypothyroidismin young women with polycystic ovary syndrome: an analysis of clinical, hormonal, and metabolic parameters","volume":"99","author":"Benetti-Pinto","year":"2013","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.reprotox.2024.108750_bib63","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1093\/humupd\/dmu028","article-title":"Molecular basis of thyrotropin and thyroid hormone action during implantation and early development","volume":"20","author":"Colicchia","year":"2014","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.reprotox.2024.108750_bib64","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.2337\/db13-1514","article-title":"Obesity induced infertility and hyperandrogenism are corrected by deletion of the insulin receptor in the ovarian theca cell","volume":"63","author":"Wu","year":"2014","journal-title":"Diabet"},{"issue":"3","key":"10.1016\/j.reprotox.2024.108750_bib65","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1042\/BJ20082176","article-title":"Insulin resistance in polycystic ovary syndrome is associated with defective regulation of ERK1\/2 by insulin in skeletal muscle in vivo","volume":"418","author":"Rajkhowa","year":"2009","journal-title":"Biochem. J."},{"issue":"10","key":"10.1016\/j.reprotox.2024.108750_bib66","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1111\/aogs.13395","article-title":"Ovulation induction in polycystic ovary syndrome","volume":"97","author":"Tanbo","year":"2018","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"10.1016\/j.reprotox.2024.108750_bib67","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/2532935","article-title":"The effect of berberine on polycystic ovary syndrome patients with insulin resistance (PCOS-IR): a meta-analysis and systematic review","author":"Li","year":"2018","journal-title":"Evid. Based Complement Altern. Med."},{"issue":"1","key":"10.1016\/j.reprotox.2024.108750_bib68","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1089\/met.2009.0017","article-title":"Beta-cell function and insulin resistance in pregnancy and their relation to fetal development","volume":"8","author":"Das","year":"2010","journal-title":"Metab. Synd. Relat. Disord."}],"container-title":["Reproductive Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S089062382400217X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S089062382400217X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T11:34:20Z","timestamp":1733744060000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S089062382400217X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":68,"alternative-id":["S089062382400217X"],"URL":"https:\/\/doi.org\/10.1016\/j.reprotox.2024.108750","relation":{},"ISSN":["0890-6238"],"issn-type":[{"value":"0890-6238","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bisphenol A-induced polycystic ovary syndrome (PCOS) with hormonal and metabolic implications in rats","name":"articletitle","label":"Article Title"},{"value":"Reproductive Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.reprotox.2024.108750","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"108750"}}