{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T02:46:41Z","timestamp":1788490001802,"version":"build-2803163510"},"reference-count":165,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82274572"],"award-info":[{"award-number":["82274572"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Toxicology"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.reprotox.2025.108832","type":"journal-article","created":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T07:33:59Z","timestamp":1736148839000},"page":"108832","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Exploring the impact of environmental factors on male reproductive health through epigenetics"],"prefix":"10.1016","volume":"132","author":[{"given":"Yi","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Yan","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9723-1213","authenticated-orcid":false,"given":"Zhen-Gao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.reprotox.2025.108832_bib1","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1093\/humupd\/dmn042","article-title":"Infertility and the provision of infertility medical services in developing countries","volume":"14","author":"Ombelet","year":"2008","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.reprotox.2025.108832_bib2","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s12958-015-0032-1","article-title":"A unique view on male infertility around the globe","volume":"13","author":"Agarwal","year":"2015","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.reprotox.2025.108832_bib3","doi-asserted-by":"crossref","first-page":"509","DOI":"10.2741\/s497","article-title":"Epigenetics of reproductive infertility","volume":"9","author":"Das","year":"2017","journal-title":"Front Biosci. Sch. Ed."},{"key":"10.1016\/j.reprotox.2025.108832_bib4","unstructured":"Leslie S.W., Soon-Sutton T.L., Khan M.A.B. Male Infertility. Treasure Island (FL): StatPearls Publishing; 2024."},{"key":"10.1016\/j.reprotox.2025.108832_bib5","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1093\/humupd\/dmac033","article-title":"Age-associated epigenetic changes in mammalian sperm: implications for offspring health and development","volume":"29","author":"Ashapkin","year":"2023","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.reprotox.2025.108832_bib6","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1093\/humrep\/dev053","article-title":"Aberrant DNA methylation patterns of spermatozoa in men with unexplained infertility","volume":"30","author":"Urdinguio","year":"2015","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.reprotox.2025.108832_bib7","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.3389\/fonc.2020.01024","article-title":"SERS-based assessment of MRD in acute promyelocytic leukemia?","volume":"10","author":"Turcas","year":"2020","journal-title":"Front Oncol."},{"key":"10.1016\/j.reprotox.2025.108832_bib8","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.5858\/arpa.2012-0463-RA","article-title":"Fundamentals of pyrosequencing","volume":"137","author":"Harrington","year":"2013","journal-title":"Arch. Pathol. Lab Med."},{"key":"10.1016\/j.reprotox.2025.108832_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijfoodmicro.2020.108658","article-title":"HRM and 16S rRNA gene sequencing reveal the cultivable microbiota of the European sea bass during ice storage","volume":"327","author":"Syropoulou","year":"2020","journal-title":"Int. J. Food Microbiol"},{"key":"10.1016\/j.reprotox.2025.108832_bib10","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.gpb.2021.09.003","article-title":"Defining proximity proteome of histone modifications by antibody-mediated protein A-APEX2 labeling","volume":"20","author":"Li","year":"2022","journal-title":"Genom. Proteom. Bioinforma."},{"key":"10.1016\/j.reprotox.2025.108832_bib11","doi-asserted-by":"crossref","DOI":"10.1002\/smtd.202101251","article-title":"Analysis and performance assessment of the whole genome bisulfite sequencing data workflow: currently available tools and a practical guide to advance DNA methylation studies","volume":"6","author":"Gong","year":"2022","journal-title":"Small Methods"},{"key":"10.1016\/j.reprotox.2025.108832_bib12","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/s10815-016-0682-8","article-title":"The role of epigenetics in idiopathic male infertility","volume":"33","author":"Gunes","year":"2016","journal-title":"J. Assist Reprod. Genet"},{"key":"10.1016\/j.reprotox.2025.108832_bib13","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1007\/s13238-020-00733-7","article-title":"Mapping the epigenetic modifications of DNA and RNA","volume":"11","author":"Zhao","year":"2020","journal-title":"Protein Cell"},{"key":"10.1016\/j.reprotox.2025.108832_bib14","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/s41586-018-0239-3","article-title":"Epigenetic inheritance mediated by coupling of RNAi and histone H3K9 methylation","volume":"558","author":"Yu","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.reprotox.2025.108832_bib15","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1016\/j.immuni.2023.05.008","article-title":"The SWI\/SNF chromatin remodeling complexes BAF and PBAF differentially regulate epigenetic transitions in exhausted CD8+\u2009T cells","volume":"56","author":"Baxter","year":"2023","journal-title":"Immunity"},{"key":"10.1016\/j.reprotox.2025.108832_bib16","doi-asserted-by":"crossref","first-page":"604","DOI":"10.7150\/ijbs.11218","article-title":"DNA methylation, its mediators and genome integrity","volume":"11","author":"Meng","year":"2015","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.reprotox.2025.108832_bib17","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.biopsych.2023.03.015","article-title":"DNMT1 mediates chronic pain-related depression by inhibiting GABAergic neuronal activation in the central amygdala","volume":"94","author":"Ding","year":"2023","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.reprotox.2025.108832_bib18","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/s41556-018-0087-2","article-title":"Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs","volume":"20","author":"Zhang","year":"2018","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.reprotox.2025.108832_bib19","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/nature25477","article-title":"Structural basis for DNMT3A-mediated de novo DNA methylation","volume":"554","author":"Zhang","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.reprotox.2025.108832_bib20","first-page":"145","article-title":"The application of genomic selection in pig cross breeding","volume":"42","author":"Yang","year":"2020","journal-title":"Yi Chuan"},{"key":"10.1016\/j.reprotox.2025.108832_bib21","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1093\/hmg\/10.5.467","article-title":"Increased tumour risk for BWS patients correlates with aberrant H19 and not KCNQ1OT1 methylation: occurrence of KCNQ1OT1 hypomethylation in familial cases of BWS","volume":"10","author":"Bliek","year":"2001","journal-title":"Hum. Mol. Genet"},{"key":"10.1016\/j.reprotox.2025.108832_bib22","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.78754","article-title":"Dysregulated H19\/Igf2 expression disrupts cardiac-placental axis during development of Silver-Russell syndrome-like mouse models","volume":"11","author":"Chang","year":"2022","journal-title":"Elife"},{"key":"10.1016\/j.reprotox.2025.108832_bib23","doi-asserted-by":"crossref","first-page":"3932","DOI":"10.7150\/thno.25541","article-title":"Carcinoma-associated fibroblasts promote the stemness and chemoresistance of colorectal cancer by transferring exosomal lncRNA H19","volume":"8","author":"Ren","year":"2018","journal-title":"Theranostics"},{"key":"10.1016\/j.reprotox.2025.108832_bib24","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abf4077","article-title":"An ASO therapy for Angelman syndrome that targets an evolutionarily conserved region at the start of the UBE3A-AS transcript","volume":"15","author":"Dindot","year":"2023","journal-title":"Sci. Transl. Med"},{"key":"10.1016\/j.reprotox.2025.108832_bib25","doi-asserted-by":"crossref","unstructured":"Bai S., Fu K., Yin H., et al, 2018. Sox30 initiates transcription of haploid genes during late meiosis and spermiogenesis in mouse testes [published correction appears in Development. 2019 May 21;146(10):dev179978. doi: 10.1242\/dev.179978]. Development. 145:dev164855, doi:10.1242\/dev.164855.","DOI":"10.1242\/dev.179978"},{"key":"10.1016\/j.reprotox.2025.108832_bib26","doi-asserted-by":"crossref","DOI":"10.1242\/dev.164723","article-title":"The transcription factor SOX30 is a key regulator of mouse spermiogenesis","volume":"145","author":"Zhang","year":"2018","journal-title":"Development"},{"key":"10.1016\/j.reprotox.2025.108832_bib27","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s43032-019-00025-4","article-title":"Expression and Methylation Pattern of hsa-miR-34 Family in Sperm Samples of Infertile Men","volume":"27","author":"Momeni","year":"2020","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.reprotox.2025.108832_bib28","article-title":"Hypomethylation of the DAZ3 promoter in idiopathic asthenospermia: a screening tool for liquid biopsy","volume":"10","author":"Zhang","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.reprotox.2025.108832_bib29","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.2217\/epi-2020-0253","article-title":"Association between sperm mitochondarial DNA copy number and nuclear DNA methylation","volume":"12","author":"Oluwayiose","year":"2020","journal-title":"Epigenomics"},{"key":"10.1016\/j.reprotox.2025.108832_bib30","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1111\/andr.12499","article-title":"Parabens generate reactive oxygen species in human spermatozoa","volume":"6","author":"Samarasinghe","year":"2018","journal-title":"Andrology"},{"key":"10.1016\/j.reprotox.2025.108832_bib31","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s10815-009-9346-2","article-title":"Oxidative DNA damage impairs global sperm DNA methylation in infertile men","volume":"26","author":"Tunc","year":"2009","journal-title":"J. Assist Reprod. Genet"},{"key":"10.1016\/j.reprotox.2025.108832_bib32","first-page":"78","article-title":"Formaldehyde induces DNA strand breaks on spermatozoa and lymphocytes of Wistar rats","volume":"51","author":"Jimenez-Villarreal","year":"2017","journal-title":"Tsitol Genet"},{"key":"10.1016\/j.reprotox.2025.108832_bib33","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.tig.2020.12.005","article-title":"Histone ubiquitination: an integrative signaling platform in genome stability","volume":"37","author":"Mattiroli","year":"2021","journal-title":"Trends Genet"},{"key":"10.1016\/j.reprotox.2025.108832_bib34","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1016\/j.molcel.2023.04.017","article-title":"LKB1 controls inflammatory potential through CRTC2-dependent histone acetylation","volume":"83","author":"Compton","year":"2023","journal-title":"Mol. Cell"},{"key":"10.1016\/j.reprotox.2025.108832_bib35","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1093\/nar\/gkac077","article-title":"H3K36 methylation and DNA-binding both promote Ioc4 recruitment and Isw1b remodeler function","volume":"50","author":"Li","year":"2022","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.reprotox.2025.108832_bib36","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1016\/j.tig.2022.04.010","article-title":"RNAPII driven post-translational modifications of nucleosomal histones","volume":"38","author":"Chan","year":"2022","journal-title":"Trends Genet"},{"key":"10.1016\/j.reprotox.2025.108832_bib37","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/s41586-019-1534-3","article-title":"The histone mark H3K36me2 recruits DNMT3A and shapes the intergenic DNA methylation landscape","volume":"573","author":"Weinberg","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.reprotox.2025.108832_bib38","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.semcancer.2021.03.015","article-title":"Coordinated methyl readers: functional communications in cancer","volume":"83","author":"Park","year":"2022","journal-title":"Semin Cancer Biol."},{"key":"10.1016\/j.reprotox.2025.108832_bib39","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1038\/s41422-023-00794-3","article-title":"H3K4me2\/3 modulate the stability of RNA polymerase II pausing","volume":"33","author":"Hu","year":"2023","journal-title":"Cell Res."},{"key":"10.1016\/j.reprotox.2025.108832_bib40","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/nature19362","article-title":"Distinct features of H3K4me3 and H3K27me3 chromatin domains in pre-implantation embryos","volume":"537","author":"Liu","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.reprotox.2025.108832_bib41","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1111\/j.1745-7262.2008.00415.x","article-title":"Sperm nuclear histone H2B: correlation with sperm DNA denaturation and DNA stainability","volume":"10","author":"Zini","year":"2008","journal-title":"Asian J. Androl."},{"key":"10.1016\/j.reprotox.2025.108832_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107617","article-title":"Abnormal histone replacement following BPA exposure affects spermatogenesis and fertility sequentially","volume":"170","author":"Ryu","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.reprotox.2025.108832_bib43","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1126\/science.adh0037","article-title":"Histone removal in sperm protects paternal chromosomes from premature division at fertilization","volume":"382","author":"Dubruille","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.reprotox.2025.108832_bib44","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1038\/s41467-023-38199-w","article-title":"Single-cell RNA-seq uncovers dynamic processes orchestrated by RNA-binding protein DDX43 in chromatin remodeling during spermiogenesis","volume":"14","author":"Tan","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.reprotox.2025.108832_bib45","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1101\/gad.290916.116","article-title":"Thioredoxin-dependent disulfide bond reduction is required for protamine eviction from sperm chromatin","volume":"30","author":"Emelyanov","year":"2016","journal-title":"Genes Dev."},{"key":"10.1016\/j.reprotox.2025.108832_bib46","doi-asserted-by":"crossref","first-page":"4288","DOI":"10.1016\/j.bpj.2023.10.003","article-title":"Protamine folds DNA into flowers and loop stacks","volume":"122","author":"McMillan","year":"2023","journal-title":"Biophys. J."},{"key":"10.1016\/j.reprotox.2025.108832_bib47","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.tig.2015.10.007","article-title":"Lateral thinking: how histone modifications regulate gene expression","volume":"32","author":"Lawrence","year":"2016","journal-title":"Trends Genet"},{"key":"10.1016\/j.reprotox.2025.108832_bib48","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.sbi.2020.05.019","article-title":"Histone chaperone FACT FAcilitates chromatin transcription: mechanistic and structural insights","volume":"65","author":"Zhou","year":"2020","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.reprotox.2025.108832_bib49","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1016\/j.cell.2023.01.007","article-title":"Recycling of modified H2A-H2B provides short-term memory of chromatin states","volume":"186","author":"Flury","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.reprotox.2025.108832_bib50","doi-asserted-by":"crossref","first-page":"3410","DOI":"10.1016\/j.molcel.2021.06.006","article-title":"Extended and dynamic linker histone-DNA Interactions control chromatosome compaction","volume":"81","author":"Rudnizky","year":"2021","journal-title":"Mol. Cell"},{"key":"10.1016\/j.reprotox.2025.108832_bib51","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.rbmo.2013.05.004","article-title":"Small human sperm vacuoles observed under high magnification are pocket-like nuclear concavities linked to chromatin condensation failure","volume":"27","author":"Boitrelle","year":"2013","journal-title":"Reprod. Biomed. Online"},{"key":"10.1016\/j.reprotox.2025.108832_bib52","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1080\/19396368.2019.1666435","article-title":"H3K4me2 accompanies chromatin immaturity in human spermatozoa: an epigenetic marker for sperm quality assessment","volume":"66","author":"\u0160tiavnick\u00e1","year":"2020","journal-title":"Syst. Biol. Reprod. Med."},{"key":"10.1016\/j.reprotox.2025.108832_bib53","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1016\/j.cell.2020.02.020","article-title":"Initiation of parental genome reprogramming in fertilized oocyte by splicing kinase SRPK1-catalyzed protamine phosphorylation","volume":"180","author":"Gou","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.reprotox.2025.108832_bib54","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1038\/ng.3945","article-title":"LINE-1 activation after fertilization regulates global chromatin accessibility in the early mouse embryo","volume":"49","author":"Jachowicz","year":"2017","journal-title":"Nat. Genet"},{"key":"10.1016\/j.reprotox.2025.108832_bib55","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1126\/science.abn7478","article-title":"Zygotic genome activation by the totipotency pioneer factor Nr5a2","volume":"378","author":"Gassler","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.reprotox.2025.108832_bib56","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202009045","article-title":"LNCcation: lncRNA localization and function","volume":"220","author":"Bridges","year":"2021","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.reprotox.2025.108832_bib57","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/s12943-017-0683-y","article-title":"Nano-based delivery of RNAi in cancer therapy","volume":"16","author":"Xin","year":"2017","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.reprotox.2025.108832_bib58","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/s12864-018-4491-6","article-title":"Systematic comparison of small RNA library preparation protocols for next-generation sequencing","volume":"19","author":"Dard-Dascot","year":"2018","journal-title":"BMC Genom."},{"key":"10.1016\/j.reprotox.2025.108832_bib59","doi-asserted-by":"crossref","first-page":"587","DOI":"10.2164\/jandrol.111.013060","article-title":"Identification of microRNAs and application of RNA interference for gene targeting in vivo in the rat epididymis","volume":"32","author":"Zhang","year":"2011","journal-title":"J. Androl."},{"key":"10.1016\/j.reprotox.2025.108832_bib60","doi-asserted-by":"crossref","first-page":"31","DOI":"10.17305\/bjbms.2018.3477","article-title":"MicroRNAs: Recent insights towards their role in male infertility and reproductive cancers","volume":"19","author":"Khawar","year":"2019","journal-title":"Bosn. J. Basic Med. Sci."},{"key":"10.1016\/j.reprotox.2025.108832_bib61","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/j.cell.2017.04.034","article-title":"Ubiquitination-deficient mutations in human piwi cause male infertility by impairing histone-to-protamine exchange during spermiogenesis","volume":"169","author":"Gou","year":"2017","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.reprotox.2025.108832_bib62","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1093\/biolre\/ioy230","article-title":"A novel testis-specific long noncoding RNA, Tesra, activates the Prss42\/Tessp-2 gene during mouse spermatogenesis","volume":"100","author":"Satoh","year":"2019","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.reprotox.2025.108832_bib63","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aao7232","article-title":"Dephosphorylation of protamine 2 at serine 56 is crucial for murine sperm maturation in vivo","volume":"12","author":"Itoh","year":"2019","journal-title":"Sci. Signal"},{"key":"10.1016\/j.reprotox.2025.108832_bib64","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1093\/humupd\/dml009","article-title":"Protamines and male infertility","volume":"12","author":"Oliva","year":"2006","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.reprotox.2025.108832_bib65","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s43032-019-00025-4","article-title":"Expression and methylation pattern of hsa-mir-34 family in sperm samples of infertile men","volume":"27","author":"Momeni","year":"2020","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.reprotox.2025.108832_bib66","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00438-018-1492-8","article-title":"The influence of paternal diet on sncRNA-mediated epigenetic inheritance","volume":"294","author":"Klastrup","year":"2019","journal-title":"Mol. Genet Genom."},{"key":"10.1016\/j.reprotox.2025.108832_bib67","doi-asserted-by":"crossref","DOI":"10.1126\/science.aau6977","article-title":"The biology, function, and biomedical applications of exosomes","volume":"367","author":"Kalluri","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.reprotox.2025.108832_bib68","doi-asserted-by":"crossref","first-page":"117","DOI":"10.4103\/1008-682X.168684","article-title":"Global methylation status of sperm DNA in carriers of chromosome structural aberrations","volume":"19","author":"Olszewska","year":"2017","journal-title":"Asian J. Androl."},{"issue":"1","key":"10.1016\/j.reprotox.2025.108832_bib69","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5534\/wjmh.2014.32.1.1","article-title":"Effect of oxidative stress on male reproduction","volume":"32","author":"Agarwal","year":"2014","journal-title":"World J. Mens. Health"},{"issue":"9-10","key":"10.1016\/j.reprotox.2025.108832_bib70","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s10815-009-9346-2","article-title":"Oxidative DNA damage impairs global sperm DNA methylation in infertile men","volume":"26","author":"Tunc","year":"2009","journal-title":"J. Assist Reprod. Genet"},{"key":"10.1016\/j.reprotox.2025.108832_bib71","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.canlet.2008.02.026","article-title":"Oxidative stress, DNA methylation and carcinogenesis","volume":"266","author":"Franco","year":"2008","journal-title":"Cancer Lett."},{"key":"10.1016\/j.reprotox.2025.108832_bib72","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s10815-009-9346-2","article-title":"Oxidative DNA damage impairs global sperm DNA methylation in infertile men","volume":"26","author":"Tunc","year":"2009","journal-title":"J. Assist Reprod. Genet"},{"key":"10.1016\/j.reprotox.2025.108832_bib73","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s00018-019-03253-8","article-title":"Oxidative stress and male infertility: current knowledge of pathophysiology and role of antioxidant therapy in disease management","volume":"77","author":"Barati","year":"2020","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.reprotox.2025.108832_bib74","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1071\/RD15325","article-title":"Causes and consequences of oxidative stress in spermatozoa","volume":"28","author":"Aitken","year":"2016","journal-title":"Reprod. Fertil. Dev."},{"key":"10.1016\/j.reprotox.2025.108832_bib75","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1471-2490-12-6","article-title":"Impact of seminal trace element and glutathione levels on semen quality of Tunisian infertile men","volume":"12","author":"Atig","year":"2012","journal-title":"BMC Urol."},{"issue":"4","key":"10.1016\/j.reprotox.2025.108832_bib76","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1007\/s10528-020-09965-y","article-title":"Smoking-related DNA methylation is differentially associated with cadmium concentration in blood","volume":"58","author":"Lee","year":"2020","journal-title":"Biochem Genet"},{"key":"10.1016\/j.reprotox.2025.108832_bib77","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2022.119252","article-title":"Occupational lead exposure on genome-wide DNA methylation and DNA damage","volume":"304","author":"Meng","year":"2022","journal-title":"Environ. Pollut."},{"issue":"9","key":"10.1016\/j.reprotox.2025.108832_bib78","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1093\/molehr\/3.9.763","article-title":"Autometallographic demonstration of zinc ions in rat sperm cells","volume":"3","author":"Stoltenberg","year":"1997","journal-title":"Mol. Hum. Reprod."},{"issue":"4","key":"10.1016\/j.reprotox.2025.108832_bib79","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1095\/biolreprod21.4.873","article-title":"Electrophoretic evidence for the identity of the major zinc-binding polypeptides in the rat sperm tail","volume":"21","author":"Calvin","year":"1979","journal-title":"Biol. Reprod."},{"issue":"4","key":"10.1016\/j.reprotox.2025.108832_bib80","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1002\/ar.1092270408","article-title":"Immunocytochemical localization of proteins utilized in the formation of outer dense fibers and fibrous sheath in rat spermatids: an electron microscope study","volume":"227","author":"Clermont","year":"1990","journal-title":"Anat. Rec."},{"issue":"5","key":"10.1016\/j.reprotox.2025.108832_bib81","first-page":"280","article-title":"Elimination of zinc from the flagella of spermatozoa during epididymal transit is important for motility","volume":"10","author":"Henkel","year":"2001","journal-title":"Reprod. Technol."},{"key":"10.1016\/j.reprotox.2025.108832_bib82","doi-asserted-by":"crossref","first-page":"7796","DOI":"10.3390\/ijms21207796","article-title":"The role of zinc in male fertility","volume":"21","author":"Allouche-Fitoussi","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.reprotox.2025.108832_bib83","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1006\/cyto.1996.0102","article-title":"Stimulation of human peripheral blood mononuclear cells by zinc and related cations","volume":"8","author":"Wellinghausen","year":"1996","journal-title":"Cytokine"},{"key":"10.1016\/j.reprotox.2025.108832_bib84","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1095\/biolreprod61.1.76","article-title":"Roles of bicarbonate, cAMP, and protein tyrosine phosphorylation on capacitation and the spontaneous acrosome reaction of hamster sperm","volume":"61","author":"Visconti","year":"1999","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.reprotox.2025.108832_bib85","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/1471-2156-15-83","article-title":"SPE-8, a protein-tyrosine kinase, localizes to the spermatid cell membrane through interaction with other members of the SPE-8 group spermatid activation signaling pathway in C. elegans","volume":"15","author":"Muhlrad","year":"2014","journal-title":"BMC Genet"},{"key":"10.1016\/j.reprotox.2025.108832_bib86","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1146\/annurev.biochem.69.1.373","article-title":"Protein tyrosine kinase structure and function","volume":"69","author":"Hubbard","year":"2000","journal-title":"Annu Rev. Biochem"},{"key":"10.1016\/j.reprotox.2025.108832_bib87","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0012-1606(89)90088-2","article-title":"Initiation of spermiogenesis in C. elegans: a pharmacological and genetic analysis","volume":"134","author":"Shakes","year":"1989","journal-title":"Dev. Biol."},{"key":"10.1016\/j.reprotox.2025.108832_bib88","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1242\/dev.091025","article-title":"The micronutrient element zinc modulates sperm activation through the SPE-8 pathway in Caenorhabditis elegans","volume":"140","author":"Liu","year":"2013","journal-title":"Development"},{"issue":"6","key":"10.1016\/j.reprotox.2025.108832_bib89","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.2005069","article-title":"The zinc transporter ZIPT-7.1 regulates sperm activation in nematodes","volume":"16","author":"Zhao","year":"2018","journal-title":"PLoS Biol."},{"key":"10.1016\/j.reprotox.2025.108832_bib90","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/0024-3205(73)90372-X","article-title":"New aspects in the biological role of zinc: a stabilizer of macromolecules and biological membranes","volume":"13","author":"Chvapil","year":"1973","journal-title":"Life Sci."},{"key":"10.1016\/j.reprotox.2025.108832_bib91","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.3390\/ijerph7041342","article-title":"The essential toxin: impact of zinc on human health","volume":"7","author":"Plum","year":"2010","journal-title":"Int J. Environ. Res. Public Health"},{"key":"10.1016\/j.reprotox.2025.108832_bib92","doi-asserted-by":"crossref","first-page":"6082","DOI":"10.3390\/ijms23116082","article-title":"Prenatal zinc deficient mice as a model for autism spectrum disorders","volume":"23","author":"Sauer","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.reprotox.2025.108832_bib93","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.cmrp.2017.02.006","article-title":"Zinc: An element of extensive medical importance","volume":"7","author":"Wani","year":"2017","journal-title":"Curr. Med. Res. Pract."},{"key":"10.1016\/j.reprotox.2025.108832_bib94","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0890-6238(01)00113-7","article-title":"The impact of calcium, magnesium, zinc, and copper in blood and seminal plasma on semen parameters in men","volume":"15","author":"Wong","year":"2001","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.reprotox.2025.108832_bib95","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.2006204","article-title":"Zinc: A small molecule with a big impact on sperm function","volume":"16","author":"Chu","year":"2018","journal-title":"PLoS Biol."},{"key":"10.1016\/j.reprotox.2025.108832_bib96","doi-asserted-by":"crossref","first-page":"7796","DOI":"10.3390\/ijms21207796","article-title":"The role of zinc in male fertility","volume":"21","author":"Allouche-Fitoussi","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.reprotox.2025.108832_bib97","first-page":"485","article-title":"The relationship between seminal plasma zinc levels and high molecular weight zinc binding protein and sperm motility in Iraqi infertile men","volume":"30","author":"OF","year":"2009","journal-title":"Saudi Med. J."},{"issue":"2","key":"10.1016\/j.reprotox.2025.108832_bib98","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.ydbio.2014.10.009","article-title":"Zn2+\u2009-stimulation of sperm capacitation and of the acrosome reaction is mediated by EGFR activation","volume":"396","author":"Michailov","year":"2014","journal-title":"Dev. Biol."},{"key":"10.1016\/j.reprotox.2025.108832_bib99","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/j.1365-2605.1992.tb01343.x","article-title":"Effect of zinc on human sperm motility and the acrosome reaction","volume":"15","author":"Riffo","year":"1992","journal-title":"Int. J. Androl."},{"issue":"1","key":"10.1016\/j.reprotox.2025.108832_bib100","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1159\/000477113","article-title":"Exposure to cadmium impairs sperm functions by reducing catsper in mice","volume":"42","author":"Wang","year":"2017","journal-title":"Cell Physiol. Biochem"},{"issue":"1","key":"10.1016\/j.reprotox.2025.108832_bib101","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s12958-016-0177-6","article-title":"Sperm motility and morphology changes in rats exposed to cadmium and diazinon","volume":"14","author":"Adamkovicova","year":"2016","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.reprotox.2025.108832_bib102","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1093\/toxsci\/kfab002","article-title":"Chronic exposure to cadmium induces differential methylation in mice spermatozoa","volume":"180","author":"Saintilnord","year":"2021","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.reprotox.2025.108832_bib103","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.chemosphere.2017.11.159","article-title":"In utero single low-dose exposure of cadmium induces rat fetal Leydig cell dysfunction","volume":"194","author":"Li","year":"2018","journal-title":"Chemosphere"},{"key":"10.1016\/j.reprotox.2025.108832_bib104","doi-asserted-by":"crossref","first-page":"4","DOI":"10.3389\/fendo.2018.00004","article-title":"Aldosterone blocks rat stem leydig cell development in vitro","volume":"9","author":"Zhang","year":"2018","journal-title":"Front Endocrinol."},{"key":"10.1016\/j.reprotox.2025.108832_bib105","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1080\/10937404.2020.1860842","article-title":"Potential protective roles of curcumin against cadmium-induced toxicity and oxidative stress","volume":"24","author":"Park","year":"2021","journal-title":"J. Toxicol. Environ. Health B Crit. Rev."},{"key":"10.1016\/j.reprotox.2025.108832_bib106","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/s41401-020-0396-4","article-title":"Zinc as a countermeasure for cadmium toxicity","volume":"42","author":"Yu","year":"2021","journal-title":"Acta Pharm. Sin."},{"key":"10.1016\/j.reprotox.2025.108832_bib107","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1016\/j.biochi.2006.07.003","article-title":"Toxic metal accumulation, responses to exposure and mechanisms of tolerance in plants","volume":"88","author":"Clemens","year":"2006","journal-title":"Biochimie"},{"key":"10.1016\/j.reprotox.2025.108832_bib108","doi-asserted-by":"crossref","first-page":"2504","DOI":"10.4315\/0362-028X-71.12.2504","article-title":"A chain modeling approach to estimate the impact of soil cadmium pollution on human dietary exposure","volume":"71","author":"Franz","year":"2008","journal-title":"J. Food Prot."},{"key":"10.1016\/j.reprotox.2025.108832_bib109","unstructured":"Evaluation of certain food additives and contaminants, 1989. Thirty-third Report of the Joint FAO\/WHO Expert Committee on Food Additives. World Health Organ Tech Rep Ser. 776:1\u201364."},{"key":"10.1016\/j.reprotox.2025.108832_bib110","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0105687","article-title":"Sertoli cells maintain Leydig cell number and peritubular myoid cell activity in the adult mouse testis","volume":"9","author":"Rebourcet","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.reprotox.2025.108832_bib111","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1002\/tox.22522","article-title":"Exposure to cadmium during gestation and lactation affects development and function of Leydig cells in male offspring","volume":"33","author":"Tian","year":"2018","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.reprotox.2025.108832_bib112","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.22823","article-title":"Effects of heavy metals on reproduction owing to infertility","volume":"35","author":"Bhardwaj","year":"2021","journal-title":"J. Biochem Mol. Toxicol."},{"key":"10.1016\/j.reprotox.2025.108832_bib113","series-title":"Handbook on the Toxicology of Metals","first-page":"565","article-title":"Effects of metallic elements on reproduction and development","author":"De Palma","year":"2022"},{"key":"10.1016\/j.reprotox.2025.108832_bib114","doi-asserted-by":"crossref","first-page":"265","DOI":"10.18466\/cbayarfbe.540544","article-title":"Sodium arsenic alters the gene expression of some steroidogenic genes in TM3 leydig cell","volume":"15","author":"Ta\u015f\u00e7i","year":"2019","journal-title":"Celal Bayar \u00dcniversitesi Fen. Bilim. Derg."},{"key":"10.1016\/j.reprotox.2025.108832_bib115","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.lfs.2018.09.045","article-title":"Review on molecular and biochemical insights of arsenic-mediated male reproductive toxicity","volume":"212","author":"Renu","year":"2018","journal-title":"Life Sci."},{"key":"10.1016\/j.reprotox.2025.108832_bib116","first-page":"129","volume":"26","author":"Ilieva","year":"2020","journal-title":"Rev. Artic. Expr. Specif. Mitochondrial Proteins Germ Cells Spermatogenesis"},{"issue":"6","key":"10.1016\/j.reprotox.2025.108832_bib117","doi-asserted-by":"crossref","first-page":"3055","DOI":"10.1007\/s10653-022-01394-7","article-title":"Paternal exposure to arsenic and sperm DNA methylation of imprinting gene Meg3 in reproductive-aged men","volume":"45","author":"Lu","year":"2023","journal-title":"Environ. Geochem Health"},{"issue":"1","key":"10.1016\/j.reprotox.2025.108832_bib118","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1186\/s12958-022-01028-8","article-title":"Poor semen parameters are associated with abnormal methylation of imprinted genes in sperm DNA","volume":"20","author":"Song","year":"2022","journal-title":"Reprod. Biol. Endocrinol."},{"issue":"2","key":"10.1016\/j.reprotox.2025.108832_bib119","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1002\/jat.1649","article-title":"Arsenic: toxicity, oxidative stress and human disease","volume":"31","author":"Jomova","year":"2011","journal-title":"J. Appl. Toxicol."},{"issue":"10","key":"10.1016\/j.reprotox.2025.108832_bib120","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1093\/humrep\/dez153","article-title":"Paternal impacts on development: identification of genomic regions vulnerable to oxidative DNA damage in human spermatozoa","volume":"34","author":"Xavier","year":"2019","journal-title":"Hum. Reprod."},{"issue":"1","key":"10.1016\/j.reprotox.2025.108832_bib121","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/molehr\/gap059","article-title":"On the possible origins of DNA damage in human spermatozoa","volume":"16","author":"Aitken","year":"2010","journal-title":"Mol. Hum. Reprod."},{"issue":"10","key":"10.1016\/j.reprotox.2025.108832_bib122","doi-asserted-by":"crossref","DOI":"10.1111\/and.12783","article-title":"Oxidative stress and motility impairment in the semen of fertile males","volume":"49","author":"Dobrakowski","year":"2017","journal-title":"Andrologia"},{"issue":"4","key":"10.1016\/j.reprotox.2025.108832_bib123","doi-asserted-by":"crossref","first-page":"593","DOI":"10.3390\/antiox10040593","article-title":"Oxidative stress is associated with telomere interaction impairment and chromatin condensation defects in spermatozoa of infertile males","volume":"10","author":"Berby","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.reprotox.2025.108832_bib124","doi-asserted-by":"crossref","first-page":"667","DOI":"10.2174\/138920011796504536","article-title":"L-carnitine--metabolic functions and meaning in humans life","volume":"12","author":"Pekala","year":"2011","journal-title":"Curr. Drug Metab."},{"key":"10.1016\/j.reprotox.2025.108832_bib125","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.128957","article-title":"Copper and cadmium impair sperm performance, fertilization and hatching of oocytes from Amazonian fish Colossoma macropomum","volume":"266","author":"Pinto","year":"2021","journal-title":"Chemosphere"},{"key":"10.1016\/j.reprotox.2025.108832_bib126","doi-asserted-by":"crossref","first-page":"168","DOI":"10.5001\/omj.2010.51","article-title":"Association between seminal plasma copper and magnesium levels with oxidative stress in iraqi infertile men","volume":"25","author":"Abdul-Rasheed","year":"2010","journal-title":"Oman Med. J."},{"key":"10.1016\/j.reprotox.2025.108832_bib127","doi-asserted-by":"crossref","first-page":"94","DOI":"10.3390\/toxics8040094","article-title":"Effects of cadmium, lead, and mercury on the structure and function of reproductive organs","volume":"8","author":"Mass\u00e1nyi","year":"2020","journal-title":"Toxics"},{"key":"10.1016\/j.reprotox.2025.108832_bib128","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1007\/s11356-017-0624-8","article-title":"Testicular toxicity and sperm quality following copper exposure in Wistar albino rats: ameliorative potentials of L-carnitine","volume":"25","author":"Khushboo","year":"2018","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.reprotox.2025.108832_bib129","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.128957","article-title":"Copper and cadmium impair sperm performance, fertilization and hatching of oocytes from Amazonian fish Colossoma macropomum","volume":"266","author":"Pinto","year":"2021","journal-title":"Chemosphere"},{"key":"10.1016\/j.reprotox.2025.108832_bib130","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1002\/tox.22545","article-title":"Lead exposure reduces sperm quality and DNA integrity in mice","volume":"33","author":"Li","year":"2018","journal-title":"Environ. Toxicol."},{"issue":"39","key":"10.1016\/j.reprotox.2025.108832_bib131","doi-asserted-by":"crossref","first-page":"54647","DOI":"10.1007\/s11356-021-14486-1","article-title":"Evaluation of toxic effects induced by arsenic trioxide or\/and antimony on autophagy and apoptosis in testis of adult mice","volume":"28","author":"Wu","year":"2021","journal-title":"Environ. Sci. Pollut. Res Int"},{"key":"10.1016\/j.reprotox.2025.108832_bib132","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113181","article-title":"Involvement of Ca2+\u2009and ROS signals in nickel-impaired human sperm function","volume":"231","author":"Chen","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.reprotox.2025.108832_bib133","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1007\/s10695-020-00875-9","article-title":"Effect of age on the mercury sensitivity of zebrafish (Danio rerio) sperm","volume":"47","author":"Pataki","year":"2021","journal-title":"Fish. Physiol. Biochem"},{"key":"10.1016\/j.reprotox.2025.108832_bib134","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.114158","article-title":"The emerging risk of exposure to nano(micro)plastics on endocrine disturbance and reproductive toxicity: from a hypothetical scenario to a global public health challenge","volume":"261","author":"Amereh","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.reprotox.2025.108832_bib135","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.envint.2015.07.005","article-title":"Phthalate exposure and reproductive parameters in young men from the general Swedish population","volume":"85","author":"Axelsson","year":"2015","journal-title":"Environ. Int."},{"key":"10.1016\/j.reprotox.2025.108832_bib136","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.114104","article-title":"Polystyrene nanoparticles enhance the adverse effects of di-(2-ethylhexyl) phthalate on male reproductive system in mice","volume":"245","author":"Li","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.reprotox.2025.108832_bib137","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.envint.2015.06.005","article-title":"Could exposure to phthalates speed up or delay pubertal onset and development? A 1.5-year follow-up of a school-based population","volume":"83","author":"Zhang","year":"2015","journal-title":"Environ. Int."},{"key":"10.1016\/j.reprotox.2025.108832_bib138","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.118390","article-title":"Lycopene mitigates DEHP-induced hepatic mitochondrial quality control disorder via regulating SIRT1\/PINK1\/mitophagy axis and mitochondrial unfolded protein response","volume":"292","author":"Zhao","year":"2022","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.reprotox.2025.108832_bib139","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2022.115249","article-title":"Lipophilic phthalic acid esters impair human sperm acrosomal reaction through the likely inhibition of phospholipase A2-signaling pathway","volume":"205","author":"Cosci","year":"2022","journal-title":"Biochem Pharm."},{"key":"10.1016\/j.reprotox.2025.108832_bib140","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.etap.2015.08.024","article-title":"Cytotoxic effect of nanosilver particles on testicular tissue: Evidence for biochemical stress and Hsp70-2 protein expression","volume":"40","author":"Rezazadeh-Reyhani","year":"2015","journal-title":"Environ. Toxicol. Pharm."},{"key":"10.1016\/j.reprotox.2025.108832_bib141","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.117944","article-title":"Transcriptome and in silico approaches provide new insights into the mechanism of male reproductive toxicity induced by chronic exposure to DEHP","volume":"289","author":"Ma","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.reprotox.2025.108832_bib142","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.envpol.2015.12.052","article-title":"Semen phthalate metabolites, semen quality parameters and serum reproductive hormones: a cross-sectional study in China","volume":"211","author":"Wang","year":"2016","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.reprotox.2025.108832_bib143","doi-asserted-by":"crossref","first-page":"3676","DOI":"10.1021\/acs.est.0c07008","article-title":"Risk assessment of agricultural plastic films based on release kinetics of phthalate acid esters","volume":"55","author":"Wang","year":"2021","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.reprotox.2025.108832_bib144","unstructured":"British Medical Association Board of Science and Education, 2021. Mobile phones and health: an interim report. BMA Policy Report. 1\u201315."},{"key":"10.1016\/j.reprotox.2025.108832_bib145","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.fertnstert.2007.01.166","article-title":"Effect of cell phone usage on semen analysis in men attending infertility clinic: an observational study","volume":"89","author":"Agarwal","year":"2008","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.reprotox.2025.108832_bib146","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1098\/rsbl.2005.0324","article-title":"Image content influences men's semen quality","volume":"1","author":"Kilgallon","year":"2005","journal-title":"Biol. Lett."},{"key":"10.1016\/j.reprotox.2025.108832_bib147","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/s12958-018-0431-1","article-title":"Radiations and male fertility","volume":"16","author":"Kesari","year":"2018","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.reprotox.2025.108832_bib148","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/1477-7827-7-114","article-title":"Pathophysiology of cell phone radiation: oxidative stress and carcinogenesis with focus on male reproductive system","volume":"7","author":"Desai","year":"2009","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.reprotox.2025.108832_bib149","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0015770","article-title":"The molecular chaperone Hsp90\u03b1 is required for meiotic progression of spermatocytes beyond pachytene in the mouse","volume":"5","author":"Grad","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.reprotox.2025.108832_bib150","doi-asserted-by":"crossref","first-page":"2904","DOI":"10.1074\/jbc.M410397200","article-title":"Association of NASP with HSP90 in mouse spermatogenic cells: stimulation of ATPase activity and transport of linker histones into nuclei","volume":"280","author":"Alekseev","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.reprotox.2025.108832_bib151","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1046\/j.1432-0436.2002.700207.x","article-title":"Non-thermal activation of the hsp27\/p38MAPK stress pathway by mobile phone radiation in human endothelial cells: molecular mechanism for cancer- and blood-brain barrier-related effects","volume":"70","author":"Leszczynski","year":"2002","journal-title":"Differentiation"},{"key":"10.1016\/j.reprotox.2025.108832_bib152","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1093\/humupd\/dmx006","article-title":"Dietary patterns, foods and nutrients in male fertility parameters and fecundability: a systematic review of observational studies","volume":"23","author":"Salas-Huetos","year":"2017","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.reprotox.2025.108832_bib153","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1111\/j.2047-2927.2014.00205.x","article-title":"Association between mobile phone use and semen quality: a systemic review and meta-analysis","volume":"2","author":"Liu","year":"2014","journal-title":"Andrology"},{"key":"10.1016\/j.reprotox.2025.108832_bib154","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/brv.12569","article-title":"Post-ejaculatory modifications to sperm (PEMS)","volume":"95","author":"Pitnick","year":"2020","journal-title":"Biol. Rev. Camb. Philos. Soc."},{"key":"10.1016\/j.reprotox.2025.108832_bib155","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1126\/science.147.3659.727.b","article-title":"Mammalian reproduction: the biochemistry of semen and of the male reproductive tract","volume":"147","author":"Salisbury","year":"1965","journal-title":"Science"},{"key":"10.1016\/j.reprotox.2025.108832_bib156","doi-asserted-by":"crossref","first-page":"514","DOI":"10.24272\/j.issn.2095-8137.2021.041","article-title":"Melatonin relieves heat-induced spermatocyte apoptosis in mouse testes by inhibition of ATF6 and PERK signaling pathways","volume":"42","author":"Qin","year":"2021","journal-title":"Zool. Res."},{"key":"10.1016\/j.reprotox.2025.108832_bib157","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.tox.2016.06.002","article-title":"Ebselen alters cellular oxidative status and induces endoplasmic reticulum stress in rat hippocampal astrocytes","volume":"357-358","author":"Santofimia-Casta\u00f1o","year":"2016","journal-title":"Toxicology"},{"key":"10.1016\/j.reprotox.2025.108832_bib158","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1002\/mrd.20367","article-title":"Immunolocalization of heat shock protein 70 (Hsp 70) in boar spermatozoa and its role during fertilization","volume":"72","author":"Spinaci","year":"2005","journal-title":"Mol. Reprod. Dev."},{"key":"10.1016\/j.reprotox.2025.108832_bib159","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0115841","article-title":"Heat shock protein 90 has roles in intracellular calcium homeostasis, protein tyrosine phosphorylation regulation, and progesterone-responsive sperm function in human sperm","volume":"9","author":"Li","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.reprotox.2025.108832_bib160","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s11259-017-9689-6","article-title":"Relative abundance of heat shock proteins and clusterin transcripts in spermatozoa collected from boar routinely utilised in an artificial insemination centre: preliminary results","volume":"41","author":"Zannoni","year":"2017","journal-title":"Vet. Res. Commun."},{"key":"10.1016\/j.reprotox.2025.108832_bib161","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.cryobiol.2013.05.007","article-title":"Effect of cryopreservation on human sperm messenger RNAs crucial for fertilization and early embryo development","volume":"67","author":"Valcarce","year":"2013","journal-title":"Cryobiology"},{"key":"10.1016\/j.reprotox.2025.108832_bib162","article-title":"Global DNA methylation changes in nile tilapia gonads during high temperature-induced masculinization","volume":"11","author":"Sun","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.reprotox.2025.108832_bib163","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/nature05915","article-title":"The complex language of chromatin regulation during transcription","volume":"447","author":"Berger","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.reprotox.2025.108832_bib164","doi-asserted-by":"crossref","first-page":"2973","DOI":"10.1038\/s41467-018-05445-5","article-title":"A critical view on transgenerational epigenetic inheritance in humans","volume":"9","author":"Horsthemke","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.reprotox.2025.108832_bib165","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1146\/annurev-genet-120417-031404","article-title":"Transgenerational epigenetic inheritance","volume":"52","author":"Bo\u0161kovi\u0107","year":"2018","journal-title":"Annu Rev. Genet."}],"container-title":["Reproductive Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623825000036?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623825000036?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T06:34:47Z","timestamp":1751524487000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0890623825000036"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":165,"alternative-id":["S0890623825000036"],"URL":"https:\/\/doi.org\/10.1016\/j.reprotox.2025.108832","relation":{},"ISSN":["0890-6238"],"issn-type":[{"value":"0890-6238","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exploring the impact of environmental factors on male reproductive health through epigenetics","name":"articletitle","label":"Article Title"},{"value":"Reproductive Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.reprotox.2025.108832","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"108832"}}