{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T17:13:00Z","timestamp":1784913180958,"version":"3.55.0"},"reference-count":68,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001501","name":"University Grants Commission","doi-asserted-by":"publisher","award":["210510251663"],"award-info":[{"award-number":["210510251663"]}],"id":[{"id":"10.13039\/501100001501","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Toxicology"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.reprotox.2025.108921","type":"journal-article","created":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T15:49:48Z","timestamp":1744818588000},"page":"108921","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Dietary protein deficiency exacerbates perfluorohexane sulfonate (PFHxS)-induced reproductive abnormalities and metabolic disruptions in female rats"],"prefix":"10.1016","volume":"135","author":[{"family":"Suramya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehjbeen","family":"Javed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anuradha","family":"Mangla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suraj","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaesta","family":"Shahid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Humaira Naaz","family":"Bhutto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahzad","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basir","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0913-8906","authenticated-orcid":false,"given":"Sheikh","family":"Raisuddin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.reprotox.2025.108921_bib1","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.watres.2015.02.047","article-title":"Distribution of perfluorooctane sulfonate isomers and predicted risk of thyroid hormonal perturbation in drinking water","volume":"76","author":"Yu","year":"2015","journal-title":"Water Res."},{"key":"10.1016\/j.reprotox.2025.108921_bib2","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.toxrep.2024.03.012","article-title":"Emerging contaminants in food matrices: an overview of the occurrence, pathways, impacts and detection techniques of per- and polyfluoroalkyl substances","volume":"12","author":"Eze","year":"2024","journal-title":"Toxicol. Rep."},{"issue":"9","key":"10.1016\/j.reprotox.2025.108921_bib3","doi-asserted-by":"crossref","first-page":"12815","DOI":"10.1007\/s11356-024-32082-x","article-title":"PFAS: exploration of neurotoxicity and environmental impact","volume":"31","author":"Nannaware","year":"2024","journal-title":"Environ. Sci. Pollut. Res."},{"issue":"4","key":"10.1016\/j.reprotox.2025.108921_bib4","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.3390\/ijms22042148","article-title":"Endocrine disruptor potential of short- and long-chain perfluoroalkyl substances (PFASs)\u2014A synthesis of current knowledge with proposal of molecular mechanism","volume":"22","author":"Mokra","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.reprotox.2025.108921_bib5","doi-asserted-by":"crossref","DOI":"10.1186\/s12940-022-00958-5","article-title":"Consideration of pathways for immunotoxicity of per- and polyfluoroalkyl substances (PFAS)","volume":"22","author":"Ehrlich","year":"2023","journal-title":"Environ. Health"},{"key":"10.1016\/j.reprotox.2025.108921_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107408","article-title":"The PFAS-Tox Database: a systematic evidence maps of health studies on 29 per- and polyfluoroalkyl substances","volume":"167","author":"Pelch","year":"2022","journal-title":"Environ. Int."},{"issue":"11\u201312","key":"10.1016\/j.reprotox.2025.108921_bib7","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1289\/ehp.1306615","article-title":"Perfluorooctanoic acid (PFOA) exposures and incident cancers among adults living near a chemical plant","volume":"121","author":"Barry","year":"2013","journal-title":"Environ. Health Perspect."},{"issue":"7","key":"10.1016\/j.reprotox.2025.108921_bib8","doi-asserted-by":"crossref","DOI":"10.1289\/EHP6837","article-title":"Measurement of novel, drinking water-associated PFAS in blood from adults and children in Wilmington, North Carolina","volume":"128","author":"Kotlarz","year":"2020","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.reprotox.2025.108921_bib9","doi-asserted-by":"crossref","DOI":"10.3389\/ftox.2020.601149","article-title":"Diet as an exposure source and mediator of per- and polyfluoroalkyl substance (PFAS) toxicity","volume":"2","author":"Roth","year":"2020","journal-title":"Front. Toxicol."},{"issue":"7","key":"10.1016\/j.reprotox.2025.108921_bib10","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1016\/j.fct.2009.04.004","article-title":"Exposure to perfluorinated compounds in Catalonia, Spain, through consumption of various raw and cooked foodstuffs, including packaged food","volume":"47","author":"Jogsten","year":"2009","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.reprotox.2025.108921_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2019.108648","article-title":"Human exposure to per- and polyfluoroalkyl substances (PFAS) through drinking water: a review of the recent scientific literature","volume":"177","author":"Domingo","year":"2019","journal-title":"Environ. Res."},{"key":"10.1016\/j.reprotox.2025.108921_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.115663","article-title":"Environmental impacts, exposure pathways, and health effects of PFOA and PFOS","volume":"267","author":"Wee","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"ement_1","key":"10.1016\/j.reprotox.2025.108921_bib13","article-title":"Per- and polyfluoroalkyl substances serum concentrations and polycystic ovary syndrome among women attending a fertility clinic","volume":"39","author":"Zhang","year":"2024","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.reprotox.2025.108921_bib14","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.reprotox.2016.08.009","article-title":"Perfluoroalkyl substances and endometriosis in US women in NHANES 2003\u20132006","volume":"65","author":"Campbell","year":"2016","journal-title":"Reprod. Toxicol."},{"issue":"5","key":"10.1016\/j.reprotox.2025.108921_bib15","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.ijheh.2015.03.008","article-title":"Association between perfluoroalkyl substances and reproductive hormones in adolescents and young adults","volume":"218","author":"Tsai","year":"2015","journal-title":"Int. J. Hyg. Environ. Health"},{"issue":"1","key":"10.1016\/j.reprotox.2025.108921_bib16","doi-asserted-by":"crossref","DOI":"10.1186\/s12940-022-00895-3","article-title":"Perfluoroalkyl substances (PFASs) as risk factors for breast cancer: a case\u2013control study in Chinese population","volume":"21","author":"Li","year":"2022","journal-title":"Environ. Health"},{"issue":"2","key":"10.1016\/j.reprotox.2025.108921_bib17","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1159\/000449175","article-title":"The rise and fall of protein malnutrition in global health","volume":"69","author":"Semba","year":"2016","journal-title":"Ann. Nutr. Metab."},{"key":"10.1016\/j.reprotox.2025.108921_bib18","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2022.927972","article-title":"Female infertility and diet, is there a role for a personalized nutritional approach in assisted reproductive technologies? A Narrative Review","volume":"9","author":"Kohil","year":"2022","journal-title":"Front. Nutr."},{"issue":"7","key":"10.1016\/j.reprotox.2025.108921_bib19","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1080\/15376516.2024.2349538","article-title":"Obesity aggravates neuroinflammatory and neurodegenerative effects of bisphenol A in female rats","volume":"34","author":"Mangla","year":"2024","journal-title":"Toxico. Mech. Methods"},{"issue":"9","key":"10.1016\/j.reprotox.2025.108921_bib20","doi-asserted-by":"crossref","first-page":"7898","DOI":"10.3390\/ijms24097898","article-title":"Mechanisms of oxidative stress in metabolic syndrome","volume":"24","author":"Masenga","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.reprotox.2025.108921_bib21","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1079\/BJN19700047","article-title":"Incidence of protein deficiency in relation to different diets in India","volume":"24","author":"Sukhatme","year":"1970","journal-title":"Br. J. Nutr."},{"issue":"1","key":"10.1016\/j.reprotox.2025.108921_bib22","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/nyas.13365","article-title":"Protective influence of healthful nutrition on mechanisms of environmental pollutant toxicity and disease risks","volume":"1398","author":"Hoffman","year":"2017","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"10","key":"10.1016\/j.reprotox.2025.108921_bib23","doi-asserted-by":"crossref","first-page":"6410","DOI":"10.1007\/s11356-013-1549-5","article-title":"Influence of nutrition in PCB-induced vascular inflammation","volume":"21","author":"Petriello","year":"2013","journal-title":"Environ. Sci. Pollut. Res."},{"issue":"5","key":"10.1016\/j.reprotox.2025.108921_bib24","doi-asserted-by":"crossref","first-page":"838S","DOI":"10.1093\/jn\/127.5.838S","article-title":"Components of the AIN-93 diets as improvements in the AIN-76A diet","volume":"127","author":"Reeves","year":"1997","journal-title":"J. Nutr."},{"key":"10.1016\/j.reprotox.2025.108921_bib25","author":"Council","year":"1995","journal-title":"Nutr. Requir. Lab. Anim.: Fourth Revis. Ed."},{"issue":"32","key":"10.1016\/j.reprotox.2025.108921_bib26","doi-asserted-by":"crossref","first-page":"49279","DOI":"10.1007\/s11356-022-19369-7","article-title":"Environmental exposure to low-dose perfluorohexanesulfonate promotes obesity and non-alcoholic fatty liver disease in mice fed a high-fat diet","volume":"29","author":"He","year":"2022","journal-title":"Environ. Sci. Poll. Res."},{"issue":"1","key":"10.1016\/j.reprotox.2025.108921_bib27","doi-asserted-by":"crossref","first-page":"45","DOI":"10.12944\/CRNFSJ.10.1.04","article-title":"Assessment of rats fed protein-deficient diets supplemented with Moringa oleifera leaf meal","volume":"10","author":"Mhlomi","year":"2022","journal-title":"Curr. Res. Nutr. Food Sci."},{"issue":"04","key":"10.1016\/j.reprotox.2025.108921_bib28","first-page":"490","article-title":"Protein malnutrition in BALB\/c mice: an experimental model resembling clinical scenario","volume":"13","author":"D\u2019Souza","year":"2022","journal-title":"J. Allied Health Sci."},{"issue":"4","key":"10.1016\/j.reprotox.2025.108921_bib29","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1590\/S1519-69842002000400008","article-title":"Determination of the estrous cycle phases of rats: some helpful considerations","volume":"62","author":"Marcondes","year":"2002","journal-title":"Braz. J. Biol."},{"key":"10.1016\/j.reprotox.2025.108921_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.reprotox.2024.108750","article-title":"Bisphenol A-induced polycystic ovary syndrome (PCOS) with hormonal and metabolic implications in rats","volume":"131","author":"Javed","year":"2025","journal-title":"Reprod. Toxicol."},{"issue":"1","key":"10.1016\/j.reprotox.2025.108921_bib31","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.reprotox.2025.108921_bib32","first-page":"143","article-title":"Effects of 17\u03b2-Estradiol on serum hormone concentrations and estrous cycle in female CRL: CD BR rats: effects on parental and first-generation rats","volume":"44","author":"Biegel","year":"1998","journal-title":"Toxicol. Sci."},{"issue":"1","key":"10.1016\/j.reprotox.2025.108921_bib33","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.toxlet.2015.01.003","article-title":"In vitro evaluation of neurotoxicity potential and oxidative stress responses of diazinon and its degradation products in rat brain synaptosomes","volume":"233","author":"Colovic","year":"2015","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.reprotox.2025.108921_bib34","series-title":"R handbook of methods in oxygen radical research","first-page":"283","article-title":"Catalase activity. n","author":"Claiborne","year":"1985"},{"issue":"3","key":"10.1016\/j.reprotox.2025.108921_bib35","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1159\/000136485","article-title":"Bromobenzene-induced liver necrosis. protective role of glutathione and evidence for 3,4-Bromobenzene oxide as the hepatotoxic metabolite","volume":"11","author":"Jollow","year":"1974","journal-title":"Pharmacology"},{"issue":"11","key":"10.1016\/j.reprotox.2025.108921_bib36","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1016\/0006-2952(84)90353-8","article-title":"Differential distribution of glutathione and glutathione-related enzymes in rabbit kidney","volume":"33","author":"Mohandas","year":"1984","journal-title":"Biochem. Pharm."},{"issue":"1","key":"10.1016\/j.reprotox.2025.108921_bib37","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0003-2697(78)90342-1","article-title":"Determination of malonaldehyde precursor in tissues by thiobarbituric acid test","volume":"86","author":"Uchiyama","year":"1978","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.reprotox.2025.108921_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2019.108648","article-title":"Human exposure to per- and polyfluoroalkyl substances (PFAS) through drinking water: a review of the recent scientific literature","volume":"177","author":"Domingo","year":"2019","journal-title":"Environ. Res."},{"issue":"23","key":"10.1016\/j.reprotox.2025.108921_bib39","doi-asserted-by":"crossref","first-page":"14793","DOI":"10.1021\/acs.est.0c05658","article-title":"Nutritional and environmental contaminant exposure: a tale of two co-existing factors for disease risks","volume":"54","author":"Huang","year":"2020","journal-title":"Environ. Sci. Technol."},{"issue":"3\u20134","key":"10.1016\/j.reprotox.2025.108921_bib40","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.reprotox.2009.01.004","article-title":"Evaluation of potential reproductive and developmental toxicity of potassium perfluorohexanesulfonate in Sprague Dawley rats","volume":"27","author":"Butenhoff","year":"2009","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.reprotox.2025.108921_bib41","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.reprotox.2018.04.007","article-title":"Reproductive and developmental toxicity of potassium Perfluorohexanesulfonate in CD-1 mice","volume":"78","author":"Chang","year":"2018","journal-title":"Reprod. Toxicol."},{"issue":"2","key":"10.1016\/j.reprotox.2025.108921_bib42","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1093\/toxsci\/kfy055","article-title":"Perfluorohexane sulfonate (PFHxS) and a mixture of endocrine disrupters reduce thyroxine levels and cause antiandrogenic effects in rats","volume":"163","author":"Ramh\u00f8j","year":"2018","journal-title":"Toxicol. Sci."},{"issue":"5","key":"10.1016\/j.reprotox.2025.108921_bib43","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1093\/humupd\/dmaa018","article-title":"Perfluoroalkyl and polyfluoroalkyl substances (PFAS) and their effects on the ovary","volume":"26","author":"Ding","year":"2020","journal-title":"Hum. Reprod. Update"},{"issue":"1","key":"10.1016\/j.reprotox.2025.108921_bib44","doi-asserted-by":"crossref","DOI":"10.1186\/s13048-021-00903-z","article-title":"Chronic exposure to perfluorohexane sulfonate leads to a reproduction deficit by suppressing hypothalamic kisspeptin expression in mice","volume":"14","author":"Yin","year":"2021","journal-title":"J. Ovarian Res."},{"key":"10.1016\/j.reprotox.2025.108921_bib45","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.placenta.2016.01.010","article-title":"In utero perfluorooctane, sulfonate exposure causes low body weights of fetal rats: A mechanism study","volume":"39","author":"Li","year":"2016","journal-title":"Placenta"},{"issue":"1","key":"10.1016\/j.reprotox.2025.108921_bib46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1079\/BJN19770003","article-title":"Biochemical characteristics of different forms of protein-energy malnutrition: an experimental model using young rats","volume":"37","author":"Heard","year":"1977","journal-title":"Br. J. Nutr."},{"issue":"4","key":"10.1016\/j.reprotox.2025.108921_bib47","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.3390\/ijms22042148","article-title":"Endocrine disruptor potential of short- and long-chain perfluoroalkyl substances (PFASs)\u2014a synthesis of current knowledge with proposal of molecular mechanism","volume":"22","author":"Mokra","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.reprotox.2025.108921_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.repbio.2023.100768","article-title":"Perflourohexane sulfonate (PFHxS) disturbs the estrous cycle, ovulation rate, oocyte cell communication, and calcium homeostasis in mice","volume":"23","author":"Adyeni","year":"2023","journal-title":"Reprod. Biol."},{"issue":"6","key":"10.1016\/j.reprotox.2025.108921_bib49","doi-asserted-by":"crossref","DOI":"10.1289\/EHP1203","article-title":"Plasma perfluoroalkyl and polyfluoroalkyl substances concentration and menstrual cycle characteristics in preconception women","volume":"125","author":"Zhou","year":"2017","journal-title":"Environ. Health Perspect."},{"issue":"2","key":"10.1016\/j.reprotox.2025.108921_bib50","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/iep.12388","article-title":"Protein restriction during puberty alters nutritional parameters and affects ovarian and uterine histomorphometry in adulthood in rats","volume":"102","author":"De Morais Oliveira","year":"2021","journal-title":"Int. J. Exp. Pathol."},{"issue":"11","key":"10.1016\/j.reprotox.2025.108921_bib51","doi-asserted-by":"crossref","first-page":"9185","DOI":"10.3390\/nu7115460","article-title":"The role of maternal dietary proteins in the development of metabolic syndrome in offspring","volume":"7","author":"Jahan-Mihan","year":"2015","journal-title":"Nutrients"},{"issue":"10","key":"10.1016\/j.reprotox.2025.108921_bib52","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.3390\/cells8101123","article-title":"Estrogen-receptor expression and function in female reproductive disease","volume":"8","author":"Tang","year":"2019","journal-title":"Cells"},{"issue":"3","key":"10.1016\/j.reprotox.2025.108921_bib53","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1289\/EHP303","article-title":"Early-life exposure to perfluoroalkyl substances and childhood metabolic function","volume":"125","author":"Fleisch","year":"2016","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.reprotox.2025.108921_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.117857","article-title":"Characterization of PFOS toxicity on in-vivo and ex-vivo mouse pancreatic islets","volume":"289","author":"Wan","year":"2021","journal-title":"Environ. Poll."},{"issue":"1","key":"10.1016\/j.reprotox.2025.108921_bib55","doi-asserted-by":"crossref","DOI":"10.1186\/s12944-015-0073-7","article-title":"Serum lipids and associated factors of dyslipidemia in the adult population in Shenzhen","volume":"14","author":"Ni","year":"2015","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.reprotox.2025.108921_bib56","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.chemosphere.2013.10.005","article-title":"The association between PFOA, PFOS, and serum lipid levels in adolescents","volume":"98","author":"Geiger","year":"2013","journal-title":"Chemosphere"},{"issue":"11","key":"10.1016\/j.reprotox.2025.108921_bib57","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1038\/s42255-021-00493-6","article-title":"Lipolysis: cellular mechanisms for lipid mobilization from fat stores","volume":"3","author":"Grabner","year":"2021","journal-title":"Nat. Metab."},{"issue":"1","key":"10.1016\/j.reprotox.2025.108921_bib58","doi-asserted-by":"crossref","DOI":"10.1038\/srep25145","article-title":"Low protein diets produce divergent effects on energy balance","volume":"6","author":"Pezeshki","year":"2016","journal-title":"Sci. Rep."},{"issue":"7","key":"10.1016\/j.reprotox.2025.108921_bib59","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0006110","article-title":"Early low protein diet aggravates the unbalance between antioxidant enzymes leading to islet dysfunction","volume":"4","author":"Theys","year":"2009","journal-title":"PLoS ONE"},{"issue":"4","key":"10.1016\/j.reprotox.2025.108921_bib60","doi-asserted-by":"crossref","first-page":"191","DOI":"10.18782\/2320-7051.2932","article-title":"Repercussion of lipid peroxidation on ovulation cycle of female","volume":"5","author":"Lal","year":"2017","journal-title":"Int. J. Pure Appl. Biosci."},{"issue":"11","key":"10.1016\/j.reprotox.2025.108921_bib61","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1093\/humrep\/dead177","article-title":"Human ovarian aging is characterized by oxidative damage and mitochondrial dysfunction","volume":"38","author":"Smits","year":"2023","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.reprotox.2025.108921_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2021.130486","article-title":"Exposure to isomers of per- and polyfluoroalkyl substances increases the risk of diabetes and impairs glucose-homeostasis in Chinese adults: isomers of C8 health project","volume":"278","author":"Zeeshan","year":"2021","journal-title":"Chemosphere"},{"issue":"21","key":"10.1016\/j.reprotox.2025.108921_bib63","doi-asserted-by":"crossref","first-page":"8020","DOI":"10.3390\/ijerph17218020","article-title":"PFAS environmental pollution and antioxidant responses: an overview of the impact on the human field","volume":"17","author":"Bonato","year":"2020","journal-title":"Int. J. Environ. Res. Public Health"},{"issue":"4","key":"10.1016\/j.reprotox.2025.108921_bib64","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1177\/07482337221074762","article-title":"Potential toxicity of nickel nano and microparticles on the reproductive system of female rats: a comparative time-dependent study","volume":"38","author":"Singh","year":"2022","journal-title":"Toxicol. Ind. Health"},{"issue":"1\u20132","key":"10.1016\/j.reprotox.2025.108921_bib65","first-page":"7","article-title":"Iron deficiency augments bisphenol A-induced oxidative stress in rats","volume":"256","author":"Rashid","year":"2008","journal-title":"Toxicol"},{"issue":"5","key":"10.1016\/j.reprotox.2025.108921_bib66","first-page":"801","article-title":"Dietary protein and pesticide toxicity in male weanling rats. Bull World Health Organ","volume":"40","author":"Boyd","year":"1969"},{"issue":"3","key":"10.1016\/j.reprotox.2025.108921_bib67","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1002\/bdrb.20006","article-title":"Effects of protein deficient diets on the developmental toxicity of inorganic arsenic in mice","volume":"71","author":"Lammon","year":"2004","journal-title":"Birth Defects Res."},{"issue":"12","key":"10.1016\/j.reprotox.2025.108921_bib68","doi-asserted-by":"crossref","first-page":"2798","DOI":"10.1093\/jn\/137.12.2798","article-title":"Interactions between arsenic-induced toxicity and nutrition in early life","volume":"137","author":"Vahter","year":"2007","journal-title":"J. Nutr."}],"container-title":["Reproductive Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623825000929?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623825000929?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T12:12:25Z","timestamp":1749211945000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0890623825000929"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":68,"alternative-id":["S0890623825000929"],"URL":"https:\/\/doi.org\/10.1016\/j.reprotox.2025.108921","relation":{},"ISSN":["0890-6238"],"issn-type":[{"value":"0890-6238","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dietary protein deficiency exacerbates perfluorohexane sulfonate (PFHxS)-induced reproductive abnormalities and metabolic disruptions in female rats","name":"articletitle","label":"Article Title"},{"value":"Reproductive Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.reprotox.2025.108921","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"108921"}}