{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T22:30:25Z","timestamp":1790893825877,"version":"4.1.0"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","award":["CSIR UGC NET 947"],"award-info":[{"award-number":["CSIR UGC NET 947"]}],"id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Toxicology"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.reprotox.2025.108949","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T15:45:09Z","timestamp":1747237509000},"page":"108949","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Plasticizer exposure and reproductive dysfunction: Assessing bisphenol A and phthalate esters impact on ovarian reserve in women with PCOS-associated infertility"],"prefix":"10.1016","volume":"135","author":[{"given":"Jalpa","family":"Patel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiral","family":"Chaudhary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonal","family":"Panchal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rushikesh","family":"Joshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.reprotox.2025.108949_bib1","doi-asserted-by":"crossref","DOI":"10.1097\/j.pbj.0000000000000116","article-title":"Infertility management in women with polycystic ovary syndrome: a review","volume":"6","author":"Cunha","year":"2021","journal-title":"Porto Biomed. J."},{"issue":"11","key":"10.1016\/j.reprotox.2025.108949_bib2","doi-asserted-by":"crossref","first-page":"765","DOI":"10.6061\/clinics\/2015(11)09","article-title":"Treatment of infertility in women with polycystic ovary syndrome: approach to clinical practice","volume":"70","author":"Melo","year":"2015","journal-title":"Clinics"},{"issue":"1","key":"10.1016\/j.reprotox.2025.108949_bib3","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s12595-021-00412-3","article-title":"Impact of Endocrine Disrupting Chemicals (EDCs) on Reproductive Health of Human","volume":"75","author":"Ghosh","year":"2022","journal-title":"Proc. Zool. Soc. [Internet]"},{"issue":"1","key":"10.1016\/j.reprotox.2025.108949_bib4","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.fertnstert.2016.05.011","article-title":"Environmental determinants of polycystic ovary syndrome","volume":"106","author":"Merkin","year":"2016","journal-title":"Fertil. Steril. [Internet]"},{"key":"10.1016\/j.reprotox.2025.108949_bib5","article-title":"The effects of phthalate ester exposure on human health: a review","volume":"786","author":"Chang","year":"2021","journal-title":"Sci. Total Environ. [Internet]"},{"issue":"4","key":"10.1016\/j.reprotox.2025.108949_bib6","doi-asserted-by":"crossref","first-page":"e116","DOI":"10.1016\/j.fertnstert.2018.07.351","article-title":"Assessment of the endocrine disruptor bisphenol a levels in polycystic ovary syndrome","volume":"110","author":"Anik Ilhan","year":"2018","journal-title":"Fertil. Steril. [Internet]"},{"key":"10.1016\/j.reprotox.2025.108949_bib7","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.reprotox.2018.09.006","article-title":"Serum bisphenol A concentrations correlate with serum testosterone levels in women with polycystic ovary syndrome","volume":"82","author":"Konieczna","year":"2018","journal-title":"Reprod. Toxicol."},{"issue":"0123456789","key":"10.1016\/j.reprotox.2025.108949_bib8","article-title":"Connecting Bisphenol A Exposure to PCOS: Findings from a Case-Control Investigation","author":"Patel","year":"2024","journal-title":"Reprod. Sci. [Internet]"},{"issue":"8","key":"10.1016\/j.reprotox.2025.108949_bib9","doi-asserted-by":"crossref","first-page":"7069","DOI":"10.1007\/s11033-023-08583-2","article-title":"The role of endocrine disruptors in female infertility","volume":"50","author":"Silva","year":"2023","journal-title":"Mol. Biol. Rep. [Internet]"},{"issue":"5","key":"10.1016\/j.reprotox.2025.108949_bib10","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1210\/er.2009-0006","article-title":"Ovarian aging: Mechanisms and clinical consequences","volume":"30","author":"Broekmans","year":"2009","journal-title":"Endocr. Rev."},{"issue":"5","key":"10.1016\/j.reprotox.2025.108949_bib11","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1093\/humupd\/dmu020","article-title":"Anti-M\u00fcllerian hormone: Ovarian reserve testing and its potential clinical implications","volume":"20","author":"Broer","year":"2014","journal-title":"Hum. Reprod. Update"},{"issue":"12","key":"10.1016\/j.reprotox.2025.108949_bib12","first-page":"10","article-title":"Anti-mullerian hormone: a marker of ovarian reserve and its association with polycystic ovarian syndrome","volume":"10","author":"Verma","year":"2016","journal-title":"J. Clin. Diagn. Res"},{"issue":"April","key":"10.1016\/j.reprotox.2025.108949_bib13","article-title":"Persistent organic pollutants and the size of ovarian reserve in reproductive-aged women","volume":"155","author":"Bj\u00f6rvang","year":"2021","journal-title":"Environ. Int"},{"issue":"3","key":"10.1016\/j.reprotox.2025.108949_bib14","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1016\/j.fertnstert.2009.04.040","article-title":"The antral follicle count: practical recommendations for better standardization","volume":"94","author":"Broekmans","year":"2010","journal-title":"Fertil Steril."},{"issue":"February","key":"10.1016\/j.reprotox.2025.108949_bib15","article-title":"Endocrine-disrupting chemicals and hormonal profiles in PCOS women: a comparative study between urban and rural environment","volume":"125","author":"Patel","year":"2024","journal-title":"Reprod. Toxicol. [Internet]"},{"issue":"1","key":"10.1016\/j.reprotox.2025.108949_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12920-023-01654-0","article-title":"Association of FTO gene variant rs9939609 with polycystic ovary syndrome from Gujarat, India","volume":"16","author":"Chaudhary","year":"2023","journal-title":"BMC Med Genom."},{"issue":"4","key":"10.1016\/j.reprotox.2025.108949_bib17","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1089\/jwh.2014.5000","article-title":"Prevalence of infertility and use of fertility treatment in women with polycystic ovary syndrome: Data from a large community-based cohort study","volume":"24","author":"Joham","year":"2015","journal-title":"J. Women\u2019S. Heal"},{"issue":"11","key":"10.1016\/j.reprotox.2025.108949_bib18","doi-asserted-by":"crossref","first-page":"4237","DOI":"10.1210\/jc.2006-0178","article-title":"Position statement: criteria for defining polycystic ovary syndrome as a predominantly hyperandrogenic syndrome: An androgen excess society guideline","volume":"91","author":"Azziz","year":"2006","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"1","key":"10.1016\/j.reprotox.2025.108949_bib19","first-page":"1","article-title":"Assessment of gut microbial \u03b2-glucuronidase and \u03b2-glucosidase activity in women with polycystic ovary syndrome","volume":"13","author":"Patel","year":"2023","journal-title":"Sci. Rep. [Internet]"},{"issue":"APR","key":"10.1016\/j.reprotox.2025.108949_bib20","first-page":"1","article-title":"High thyroid stimulating hormone level is associated with hyperandrogenism in euthyroid polycystic ovary syndrome (PCOS) women, independent of age, BMI, and thyroid autoimmunity: A cross-sectional analysis","volume":"10","author":"Cai","year":"2019","journal-title":"Front Endocrinol. (Lausanne)"},{"issue":"1","key":"10.1016\/j.reprotox.2025.108949_bib21","doi-asserted-by":"crossref","first-page":"59.e1","DOI":"10.1016\/j.ajog.2014.02.026","article-title":"Characterization of women with elevated antim\u00fcllerian hormone levels (AMH): Correlation of AMH with polycystic ovarian syndrome phenotypes and assisted reproductive technology outcomes","volume":"211","author":"Tal","year":"2014","journal-title":"Am. J. Obstet. Gynecol. [Internet]"},{"issue":"3","key":"10.1016\/j.reprotox.2025.108949_bib22","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1210\/jc.2005-2076","article-title":"Serum anti-M\u00fcllerian hormone as a surrogate for antral follicle count for definition of the polycystic ovary syndrome","volume":"91","author":"Pigny","year":"2006","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"2","key":"10.1016\/j.reprotox.2025.108949_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3346\/jkms.2021.36.e1","article-title":"The Association of Ovarian Reserve with Exposure to Bisphenol A and Phthalate in Reproductive-aged Women","volume":"36","author":"Park","year":"2021","journal-title":"J. Korean Med Sci."},{"issue":"1","key":"10.1016\/j.reprotox.2025.108949_bib24","first-page":"6","article-title":"Bisphenol A and Ovarian reserve among infertile women with polycystic Ovarian syndrome","volume":"14","author":"Zhou","year":"2017","journal-title":"Int J. Environ. Res Public Health"},{"issue":"2","key":"10.1016\/j.reprotox.2025.108949_bib25","first-page":"27","article-title":"PREVALENCE OF POLYCYSTIC OVARIES IN GYNAECOLOGICAL POPULATION Edwar Z.Khosho 1, Ahlam Abdul-Hadi 2 & Hutham W.A. Al-Serrai 3","volume":"28","author":"Edwar Z.Khosho","year":"2010","journal-title":"Med J. Basrah Univ."},{"issue":"2","key":"10.1016\/j.reprotox.2025.108949_bib26","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1080\/19396368.2020.1860155","article-title":"Correlation between anti-Mullerian hormone levels and antral follicle counts in polycystic ovary and metabolic syndromes","volume":"67","author":"Fu","year":"2021","journal-title":"Syst. Biol. Reprod. Med [Internet]"},{"issue":"April","key":"10.1016\/j.reprotox.2025.108949_bib27","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.envint.2018.04.022","article-title":"Urinary concentrations of phthalate metabolites, bisphenols and personal care product chemical biomarkers in pregnant women in Israel","volume":"116","author":"Machtinger","year":"2018","journal-title":"Environ. Int [Internet]"},{"issue":"April","key":"10.1016\/j.reprotox.2025.108949_bib28","article-title":"The association of serum phthalate metabolites with biomarkers of ovarian reserve in women of childbearing age","volume":"242","author":"Li","year":"2022","journal-title":"Ecotoxicol. Environ. Saf. [Internet]"}],"container-title":["Reproductive Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623825001200?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623825001200?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T12:13:03Z","timestamp":1749211983000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0890623825001200"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":28,"alternative-id":["S0890623825001200"],"URL":"https:\/\/doi.org\/10.1016\/j.reprotox.2025.108949","relation":{},"ISSN":["0890-6238"],"issn-type":[{"value":"0890-6238","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Plasticizer exposure and reproductive dysfunction: Assessing bisphenol A and phthalate esters impact on ovarian reserve in women with PCOS-associated infertility","name":"articletitle","label":"Article Title"},{"value":"Reproductive Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.reprotox.2025.108949","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"108949"}}