{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:03:31Z","timestamp":1792119811322,"version":"4.4.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,6]],"date-time":"2025-07-06T00:00:00Z","timestamp":1751760000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22376004"],"award-info":[{"award-number":["22376004"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21737001"],"award-info":[{"award-number":["21737001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Toxicology"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.reprotox.2025.108986","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T19:28:36Z","timestamp":1751916516000},"page":"108986","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Perfluorooctanoic acid (PFOA) induces apoptosis by disrupting mitochondrial function via the SIRT1\/FOXO1-SOD2 pathway in human granulosa cells: Implications for PCOS"],"prefix":"10.1016","volume":"137","author":[{"given":"Yumeng","family":"Ren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumei","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.reprotox.2025.108986_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2024.142044","article-title":"Per-and polyfluoroalkyl (PFAS) eternal pollutants: sources, environmental impacts and treatment processes","volume":"358","author":"Rekik","year":"2024","journal-title":"Chemosphere"},{"key":"10.1016\/j.reprotox.2025.108986_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.envint.2012.11.004","article-title":"Industrial source identification and emission estimation of perfluorooctane sulfonate in China","volume":"52","author":"Xie","year":"2013","journal-title":"Environ. Int."},{"key":"10.1016\/j.reprotox.2025.108986_bib3","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.chemosphere.2014.11.049","article-title":"Estimating industrial and domestic environmental releases of perfluorooctanoic acid and its salts in China from 2004 to 2012","volume":"129","author":"Li","year":"2015","journal-title":"Chemosphere"},{"issue":"2","key":"10.1016\/j.reprotox.2025.108986_bib4","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/s41370-018-0094-1","article-title":"A review of the pathways of human exposure to poly- and perfluoroalkyl substances (PFASs) and present understanding of health effects","volume":"29","author":"Sunderland","year":"2019","journal-title":"J. Expo. Sci. Environ. Epidemiol."},{"issue":"Pt 2","key":"10.1016\/j.reprotox.2025.108986_bib5","article-title":"Immunotoxicity mechanisms of perfluorinated compounds PFOA and PFOS","volume":"291","author":"Liang","year":"2022","journal-title":"Chemosphere"},{"key":"10.1016\/j.reprotox.2025.108986_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2024.108914","article-title":"Developmental neurotoxicity of PFOA exposure on hiPSC-derived cortical neurons","volume":"190","author":"Wu","year":"2024","journal-title":"Environ. Int."},{"key":"10.1016\/j.reprotox.2025.108986_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2024.118485","article-title":"Reproductive toxicity of PFOA, PFOS and their substitutes: a review based on epidemiological and toxicological evidence","volume":"250","author":"Shi","year":"2024","journal-title":"Environ. Res."},{"issue":"1-2","key":"10.1016\/j.reprotox.2025.108986_bib8","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jsbmb.2011.03.011","article-title":"Endocrine disrupting properties of perfluorooctanoic acid","volume":"127","author":"White","year":"2011","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.reprotox.2025.108986_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.etap.2023.104169","article-title":"Perfluorooctanoic acid (PFOA) affects steroidogenesis and antioxidant defence in granulosa cells from swine ovary","volume":"101","author":"Basini","year":"2023","journal-title":"Environ. Toxicol. Pharmacol."},{"issue":"5","key":"10.1016\/j.reprotox.2025.108986_bib10","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1093\/humupd\/dmaa018","article-title":"Perfluoroalkyl and polyfluoroalkyl substances (PFAS) and their effects on the ovary","volume":"26","author":"Ding","year":"2020","journal-title":"Hum. Reprod. Update"},{"issue":"4","key":"10.1016\/j.reprotox.2025.108986_bib11","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/nrendo.2010.217","article-title":"Polycystic ovary syndrome: etiology, pathogenesis and diagnosis","volume":"7","author":"Goodarzi","year":"2011","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.reprotox.2025.108986_bib12","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/1472-6823-14-86","article-title":"Exploring the potential association between brominated diphenyl ethers, polychlorinated biphenyls, organochlorine pesticides, perfluorinated compounds, phthalates, and bisphenol A in polycystic ovary syndrome: a case-control study","volume":"14","author":"Vagi","year":"2014","journal-title":"BMC Endocr. Disord."},{"issue":"2","key":"10.1016\/j.reprotox.2025.108986_bib13","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.fertnstert.2014.11.015","article-title":"Oocyte environment: follicular fluid and cumulus cells are critical for oocyte health","volume":"103","author":"Dumesic","year":"2015","journal-title":"Fertil. Steril."},{"issue":"1","key":"10.1016\/j.reprotox.2025.108986_bib15","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/s12958-020-00677-x","article-title":"Growth hormone activates PI3K\/Akt signaling and inhibits ROS accumulation and apoptosis in granulosa cells of patients with polycystic ovary syndrome","volume":"18","author":"Gong","year":"2020","journal-title":"Reprod. Biol. Endocrinol."},{"issue":"2","key":"10.1016\/j.reprotox.2025.108986_bib16","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/s41580-019-0173-8","article-title":"Mitochondria as multifaceted regulators of cell death","volume":"21","author":"Bock","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"9","key":"10.1016\/j.reprotox.2025.108986_bib17","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1038\/s41556-024-01429-4","article-title":"Mitochondria and cell death","volume":"26","author":"Glover","year":"2024","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.reprotox.2025.108986_bib18","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1146\/annurev.genet.39.110304.095751","article-title":"A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine","volume":"39","author":"Wallace","year":"2005","journal-title":"Annu Rev. Genet."},{"issue":"2","key":"10.1016\/j.reprotox.2025.108986_bib19","doi-asserted-by":"crossref","first-page":"238","DOI":"10.4103\/1673-5374.244780","article-title":"Oxidative stress: the lowest common denominator of multiple diseases","volume":"14","author":"Matschke","year":"2019","journal-title":"Neural Regen. Res."},{"issue":"1","key":"10.1016\/j.reprotox.2025.108986_bib20","doi-asserted-by":"crossref","DOI":"10.3390\/antiox7010013","article-title":"Reactive oxygen species and mitochondrial dynamics: the Yin and Yang of mitochondrial dysfunction and cancer progression","volume":"7","author":"Je\u017eek","year":"2018","journal-title":"Antioxidants"},{"key":"10.1016\/j.reprotox.2025.108986_bib21","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.967151","article-title":"MiR-93-5p promotes granulosa cell apoptosis and ferroptosis by the NF-kB signaling pathway in polycystic ovary syndrome","volume":"13","author":"Tan","year":"2022","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.reprotox.2025.108986_bib22","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s13048-025-01623-4","article-title":"miR-34a-5p modulation of polycystic ovary syndrome via targeting the NOTCH signaling pathway","volume":"18","author":"Zhang","year":"2025","journal-title":"J. Ovarian Res."},{"issue":"1","key":"10.1016\/j.reprotox.2025.108986_bib23","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1186\/s13048-024-01542-w","article-title":"Follicular fluid-derived extracellular vesicles miR-34a-5p regulates granulosa cell glycolysis in polycystic ovary syndrome by targeting LDHA","volume":"17","author":"Cui","year":"2024","journal-title":"J. Ovarian Res."},{"key":"10.1016\/j.reprotox.2025.108986_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.yrtph.2021.104862","article-title":"Human Biomonitoring (HBM)-I values for perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS) - description, derivation and discussion","volume":"121","author":"H\u00f6lzer","year":"2021","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.reprotox.2025.108986_bib25","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.reprotox.2020.09.005","article-title":"Perfluorooctanoic acid (PFOA) inhibits the gap junction intercellular communication and induces apoptosis in human ovarian granulosa cells","volume":"98","author":"Zhou","year":"2020","journal-title":"Reprod. Toxicol."},{"issue":"12","key":"10.1016\/j.reprotox.2025.108986_bib26","doi-asserted-by":"crossref","first-page":"14703","DOI":"10.1096\/fj.201900782R","article-title":"SIRT1 facilitates primordial follicle recruitment independent of deacetylase activity through directly modulating Akt1 and mTOR transcription","volume":"33","author":"Zhang","year":"2019","journal-title":"FASEB J."},{"key":"10.1016\/j.reprotox.2025.108986_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.156288","article-title":"Bushen Jianpi Tiaoxue Decoction (BJTD) ameliorates oxidative stress and apoptosis induced by uterus ageing through activation of the SIRT1\/NRF2 pathway","volume":"136","author":"Zhang","year":"2025","journal-title":"Phytomedicine"},{"issue":"11","key":"10.1016\/j.reprotox.2025.108986_bib28","doi-asserted-by":"crossref","first-page":"2904","DOI":"10.1093\/humrep\/deab203","article-title":"Mitochondria-related changes and metabolic dysfunction in low prognosis patients under the POSEIDON classification","volume":"36","author":"Jiang","year":"2021","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.reprotox.2025.108986_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154945","article-title":"Mitigation of triptolide-induced testicular Sertoli cell damage by melatonin via regulating the crosstalk between SIRT1 and NRF2","volume":"118","author":"Qin","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.reprotox.2025.108986_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainresbull.2025.111404","article-title":"Vitexin alleviates cerebral ischemia\/reperfusion injury by regulating mitophagy via the SIRT1\/PINK1\/Parkin pathway","volume":"227","author":"Chen","year":"2025","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.reprotox.2025.108986_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118237","article-title":"Bu zhong Yiqi Decoction ameliorates mild cognitive impairment by improving mitochondrial oxidative stress damage via the SIRT3\/MnSOD\/OGG1 pathway","volume":"331","author":"Dong","year":"2024","journal-title":"J. Ethnopharmacol."},{"issue":"7","key":"10.1016\/j.reprotox.2025.108986_bib32","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/j.ijheh.2018.07.009","article-title":"Perfluorinated alkyl acids in the serum and follicular fluid of UK women with and without polycystic ovarian syndrome undergoing fertility treatment and associations with hormonal and metabolic parameters","volume":"221","author":"Heffernan","year":"2018","journal-title":"Int. J. Hyg. Environ. Health"},{"issue":"5","key":"10.1016\/j.reprotox.2025.108986_bib33","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s10815-011-9548-2","article-title":"The impact of environmental exposure to perfluorinated compounds on oocyte fertilization capacity","volume":"28","author":"Governini","year":"2011","journal-title":"J. Assist Reprod. Genet."},{"key":"10.1016\/j.reprotox.2025.108986_bib34","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.envint.2013.10.018","article-title":"Associations between serum perfluoroalkyl acids and LINE-1 DNA methylation","volume":"63","author":"Watkins","year":"2014","journal-title":"Environ. Int."},{"key":"10.1016\/j.reprotox.2025.108986_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107413","article-title":"Perfluorooctanoic acid (PFOA) exposure affects early embryonic development and offspring oocyte quality via inducing mitochondrial dysfunction","volume":"167","author":"Zhou","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.reprotox.2025.108986_bib36","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.tiv.2017.09.030","article-title":"Endocrine disruptor effect of perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) on porcine ovarian cell steroidogenesis","volume":"46","author":"Chaparro-Ortega","year":"2018","journal-title":"Toxicol. Vitr."},{"key":"10.1016\/j.reprotox.2025.108986_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.166954","article-title":"Perfluorooctanoic acid exposure leads to defect in follicular development through disrupting the mitochondrial electron transport chain in granulosa cells","volume":"905","author":"Zhang","year":"2023","journal-title":"Sci. Total Environ."},{"issue":"2","key":"10.1016\/j.reprotox.2025.108986_bib38","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/S1028-4559(09)60275-8","article-title":"The effects of calcium-vitamin D and metformin on polycystic ovary syndrome: a pilot study","volume":"48","author":"Rashidi","year":"2009","journal-title":"Taiwan J. Obstet. Gynecol."},{"issue":"1","key":"10.1016\/j.reprotox.2025.108986_bib39","doi-asserted-by":"crossref","DOI":"10.3390\/cells10010079","article-title":"The mitochondrial permeability transition: nexus of aging, disease and longevity","volume":"10","author":"Rottenberg","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.reprotox.2025.108986_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.115089","article-title":"Perfluorooctanoic acid-induced cell death via the dual roles of ROS-MAPK\/ERK signaling in ameloblast-lineage cells","volume":"260","author":"Fujiwara","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"1","key":"10.1016\/j.reprotox.2025.108986_bib41","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1097\/WOX.0b013e3182439613","article-title":"Oxidative stress and antioxidant defense","volume":"5","author":"Birben","year":"2012","journal-title":"World Allergy Organ J."},{"issue":"4","key":"10.1016\/j.reprotox.2025.108986_bib42","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.tibs.2014.02.003","article-title":"FOXO transcription factors: key regulators of cellular quality control","volume":"39","author":"Webb","year":"2014","journal-title":"Trends Biochem. Sci."},{"issue":"12","key":"10.1016\/j.reprotox.2025.108986_bib43","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0167869","article-title":"Oxidative stress induces mouse follicular granulosa cells apoptosis via JNK\/FoxO1 pathway","volume":"11","author":"Weng","year":"2016","journal-title":"PLOS One"},{"key":"10.1016\/j.reprotox.2025.108986_bib44","doi-asserted-by":"crossref","first-page":"8798069","DOI":"10.1155\/2019\/8798069","article-title":"Calycosin-7-O-\u03b2-D-glucoside attenuates OGD\/R-induced damage by preventing oxidative stress and neuronal apoptosis via the SIRT1\/FOXO1\/PGC-1\u03b1 pathway in HT22 cells","volume":"2019","author":"Yan","year":"2019","journal-title":"Neural Plast."},{"key":"10.1016\/j.reprotox.2025.108986_bib45","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.redox.2015.06.019","article-title":"Redox regulation of FoxO transcription factors","volume":"6","author":"Klotz","year":"2015","journal-title":"Redox Biol."},{"issue":"10","key":"10.1016\/j.reprotox.2025.108986_bib46","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1016\/j.metabol.2015.07.010","article-title":"Curcumin treatment enhances the effect of exercise on mitochondrial biogenesis in skeletal muscle by increasing cAMP levels","volume":"64","author":"Ray Hamidie","year":"2015","journal-title":"Metabolism"},{"issue":"3","key":"10.1016\/j.reprotox.2025.108986_bib47","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1152\/physrev.00026.2013","article-title":"Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release","volume":"94","author":"Zorov","year":"2014","journal-title":"Physiol. Rev."},{"issue":"6378","key":"10.1016\/j.reprotox.2025.108986_bib48","doi-asserted-by":"crossref","DOI":"10.1126\/science.aao6047","article-title":"BAK\/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis","volume":"359","author":"McArthur","year":"2018","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.reprotox.2025.108986_bib49","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1186\/s12951-024-02651-w","article-title":"Organ-on-a-chip: future of female reproductive pathophysiological models","volume":"22","author":"Deng","year":"2024","journal-title":"J. Nanobiotechnol."}],"container-title":["Reproductive Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623825001571?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623825001571?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T19:30:52Z","timestamp":1777577452000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0890623825001571"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":48,"alternative-id":["S0890623825001571"],"URL":"https:\/\/doi.org\/10.1016\/j.reprotox.2025.108986","relation":{},"ISSN":["0890-6238"],"issn-type":[{"value":"0890-6238","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Perfluorooctanoic acid (PFOA) induces apoptosis by disrupting mitochondrial function via the SIRT1\/FOXO1-SOD2 pathway in human granulosa cells: Implications for PCOS","name":"articletitle","label":"Article Title"},{"value":"Reproductive Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.reprotox.2025.108986","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"108986"}}