{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:50:05Z","timestamp":1786996205626,"version":"build-2736575974"},"reference-count":224,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Toxicology"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.reprotox.2025.109043","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T23:44:37Z","timestamp":1756856677000},"page":"109043","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Positioning nutrigenomics and nutrigenetics within the framework of male infertility exploration"],"prefix":"10.1016","volume":"137","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0961-0601","authenticated-orcid":false,"given":"Emmanuel Osei","family":"Nkansah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binbin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunzhu","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Ishraq","family":"Zafar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.reprotox.2025.109043_bib1","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1038\/s41467-023-37735-y","article-title":"ARRDC5 expression is conserved in mammalian testes and required for normal sperm morphogenesis","volume":"14","author":"Giassetti","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.reprotox.2025.109043_bib2","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/S2213-8587(16)30040-7","article-title":"Novel concepts in the aetiology of male reproductive impairment","volume":"5","author":"Tournaye","year":"2017","journal-title":"Lancet Diabetes Endocrinol."},{"key":"10.1016\/j.reprotox.2025.109043_bib3","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/s41572-023-00459-w","article-title":"Male infertility","volume":"9","author":"Eisenberg","year":"2023","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.reprotox.2025.109043_bib4","doi-asserted-by":"crossref","DOI":"10.3390\/jcm9051400","article-title":"Diet and nutritional factors in male (In)fertility-underestimated factors","volume":"9","author":"Skoracka","year":"2020","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.reprotox.2025.109043_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23052542","article-title":"Diet and Male fertility: the impact of nutrients and antioxidants on sperm energetic metabolism","volume":"23","author":"Ferramosca","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.reprotox.2025.109043_bib6","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1001\/jama.2021.4788","article-title":"Diagnosis and management of infertility: a review","volume":"326","author":"Carson","year":"2021","journal-title":"JAMA"},{"key":"10.1016\/j.reprotox.2025.109043_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2020.154229","article-title":"The effect of underweight on female and male reproduction","volume":"107","author":"Boutari","year":"2020","journal-title":"Metabolism"},{"key":"10.1016\/j.reprotox.2025.109043_bib8","doi-asserted-by":"crossref","DOI":"10.1111\/and.13617","article-title":"Obesity and male infertility: mechanisms and management","volume":"53","author":"Leisegang","year":"2021","journal-title":"Andrologia"},{"key":"10.1016\/j.reprotox.2025.109043_bib9","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/andr.12452","article-title":"Dietary habits and semen parameters: a systematic narrative review","volume":"6","author":"Ricci","year":"2018","journal-title":"Andrology"},{"key":"10.1016\/j.reprotox.2025.109043_bib10","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/s41585-018-0003-3","article-title":"Genetics of male infertility","volume":"15","author":"Krausz","year":"2018","journal-title":"Nat. Rev. Urol."},{"key":"10.1016\/j.reprotox.2025.109043_bib11","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1210\/jc.2009-1925","article-title":"Clinical review#: state of the art for genetic testing of infertile men","volume":"95","author":"McLachlan","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.reprotox.2025.109043_bib12","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1002\/ajmg.a.32500","article-title":"Genetic counseling in robertsonian translocations der(13;14): frequencies of reproductive outcomes and infertility in 101 pedigrees","volume":"146a","author":"Engels","year":"2008","journal-title":"Am. J. Med. Genet. A"},{"key":"10.1016\/j.reprotox.2025.109043_bib13","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/s10038-020-0769-z","article-title":"Novel pericentric inversion inv(9)(p23q22.3) in unrelated individuals with fertility problems in the southeast european population","volume":"65","author":"Sismani","year":"2020","journal-title":"J. Hum. Genet."},{"key":"10.1016\/j.reprotox.2025.109043_bib14","doi-asserted-by":"crossref","first-page":"5","DOI":"10.4103\/aja2021130","article-title":"Microdeletions and vertical transmission of the Y-chromosome azoospermia factor region","volume":"25","author":"Deng","year":"2023","journal-title":"Asian J. Androl."},{"key":"10.1016\/j.reprotox.2025.109043_bib15","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1038\/86927","article-title":"An abundance of X-linked genes expressed in spermatogonia","volume":"27","author":"Wang","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1016\/j.reprotox.2025.109043_bib16","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1101\/gad.1613608","article-title":"Meiotic failure in Male mice lacking an X-linked factor","volume":"22","author":"Yang","year":"2008","journal-title":"Genes Dev."},{"key":"10.1016\/j.reprotox.2025.109043_bib17","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1056\/NEJMoa1406192","article-title":"X-linked TEX11 mutations, meiotic arrest, and azoospermia in infertile men","volume":"372","author":"Yatsenko","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.reprotox.2025.109043_bib18","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.15252\/emmm.201404967","article-title":"TEX11 is mutated in infertile men with azoospermia and regulates genome-wide recombination rates in mouse","volume":"7","author":"Yang","year":"2015","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.reprotox.2025.109043_bib19","doi-asserted-by":"crossref","first-page":"4984","DOI":"10.1096\/fj.201701096RR","article-title":"Cep55 overexpression causes Male-specific sterility in mice by suppressing Foxo1 nuclear retention through sustained activation of PI3K\/Akt signaling","volume":"32","author":"Sinha","year":"2018","journal-title":"Faseb J."},{"key":"10.1016\/j.reprotox.2025.109043_bib20","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abn0968","article-title":"Loss-of-function mutations in CEP78 cause male infertility in humans and mice","volume":"8","author":"Zhang","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.reprotox.2025.109043_bib21","doi-asserted-by":"crossref","first-page":"8465","DOI":"10.1038\/s41467-024-52705-8","article-title":"CEP112 coordinates translational regulation of essential fertility genes during spermiogenesis through phase separation in humans and mice","volume":"15","author":"Zhang","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.reprotox.2025.109043_bib22","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1038\/s41467-022-29109-7","article-title":"CEP128 is involved in spermatogenesis in humans and mice","volume":"13","author":"Zhang","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.reprotox.2025.109043_bib23","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.gene.2017.08.033","article-title":"A homozygous CEP135 mutation is associated with multiple morphological abnormalities of the sperm flagella (MMAF)","volume":"633","author":"Sha","year":"2017","journal-title":"Gene"},{"key":"10.1016\/j.reprotox.2025.109043_bib24","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2221762120","article-title":"TSKS localizes to nuage in spermatids and regulates cytoplasmic elimination during spermiation","volume":"120","author":"Shimada","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.reprotox.2025.109043_bib25","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/s41467-023-44337-1","article-title":"STYXL1 regulates CCT complex assembly and flagellar tubulin folding in sperm formation","volume":"15","author":"Chen","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.reprotox.2025.109043_bib26","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1016\/j.devcel.2024.04.002","article-title":"DDX20 is required for cell-cycle reentry of prospermatogonia and establishment of spermatogonial stem cell pool during testicular development in mice","volume":"59","author":"Zou","year":"2024","journal-title":"Dev. Cell"},{"key":"10.1016\/j.reprotox.2025.109043_bib27","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1038\/s41467-023-38199-w","article-title":"Single-cell RNA-seq uncovers dynamic processes orchestrated by RNA-binding protein DDX43 in chromatin remodeling during spermiogenesis","volume":"14","author":"Tan","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.reprotox.2025.109043_bib28","doi-asserted-by":"crossref","first-page":"6637","DOI":"10.1038\/s41467-024-50930-9","article-title":"Inherited defects of piRNA biogenesis cause transposon de-repression, impaired spermatogenesis, and human Male infertility","volume":"15","author":"Stallmeyer","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.reprotox.2025.109043_bib29","doi-asserted-by":"crossref","first-page":"2704","DOI":"10.1016\/j.devcel.2024.06.017","article-title":"TDRD1 phase separation drives intermitochondrial cement assembly to promote piRNA biogenesis and fertility","volume":"59","author":"Gao","year":"2024","journal-title":"Dev. Cell"},{"key":"10.1016\/j.reprotox.2025.109043_bib30","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1038\/s41467-024-46664-3","article-title":"piRNA loading triggers MIWI translocation from the intermitochondrial cement to chromatoid body during mouse spermatogenesis","volume":"15","author":"Wei","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.reprotox.2025.109043_bib31","article-title":"HSF5 deficiency causes Male infertility involving spermatogenic arrest at meiotic prophase I in humans and mice","volume":"11","author":"Liu","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.reprotox.2025.109043_bib32","doi-asserted-by":"crossref","first-page":"3330","DOI":"10.1038\/s41467-024-47601-0","article-title":"Atypical heat shock transcription factor HSF5 is critical for male meiotic prophase under non-stress conditions","volume":"15","author":"Yoshimura","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.reprotox.2025.109043_bib33","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/ng1089","article-title":"Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals","volume":"33","author":"Jaenisch","year":"2003","journal-title":"Nat. Genet."},{"key":"10.1016\/j.reprotox.2025.109043_bib34","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1152\/physrev.00010.2017","article-title":"Dietary modulation of the epigenome","volume":"98","author":"Ideraabdullah","year":"2018","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.reprotox.2025.109043_bib35","doi-asserted-by":"crossref","first-page":"8178","DOI":"10.1038\/s41467-024-52556-3","article-title":"Nutritional vitamin B12 regulates RAS\/MAPK-mediated cell fate decisions through one-carbon metabolism","volume":"15","author":"Laranjeira","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.reprotox.2025.109043_bib36","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.ejim.2023.05.036","article-title":"How epigenetics impacts on human diseases","volume":"114","author":"Farsetti","year":"2023","journal-title":"Eur. J. Intern. Med."},{"key":"10.1016\/j.reprotox.2025.109043_bib37","first-page":"246","article-title":"Role of epigenetics in biology and human diseases","volume":"20","author":"Moosavi","year":"2016","journal-title":"Iran. Biomed. J."},{"key":"10.1016\/j.reprotox.2025.109043_bib38","doi-asserted-by":"crossref","first-page":"3375","DOI":"10.1038\/s41467-018-05778-1","article-title":"Diet and the epigenome","volume":"9","author":"Zhang","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.reprotox.2025.109043_bib39","doi-asserted-by":"crossref","DOI":"10.3390\/nu11112763","article-title":"Is an \"epigenetic diet\" for migraines justified? The case of folate and DNA methylation","volume":"11","author":"Fila","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.reprotox.2025.109043_bib40","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.aninu.2015.09.002","article-title":"Epigenetic modulation of DNA methylation by nutrition and its mechanisms in animals","volume":"1","author":"Zhang","year":"2015","journal-title":"Anim. Nutr."},{"key":"10.1016\/j.reprotox.2025.109043_bib41","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1089\/ars.2012.4554","article-title":"Folate and DNA methylation","volume":"17","author":"Ly","year":"2012","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.reprotox.2025.109043_bib42","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1079\/PNS2004383","article-title":"Folate bioavailability","volume":"63","author":"McNulty","year":"2004","journal-title":"Proc. Nutr. Soc."},{"key":"10.1016\/j.reprotox.2025.109043_bib43","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1080\/10408398.2019.1571480","article-title":"Nutrigenomics: epigenetics and cancer prevention: a comprehensive review","volume":"60","author":"Nasir","year":"2020","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.reprotox.2025.109043_bib44","first-page":"E93","article-title":"Main nutritional deficiencies","volume":"63","author":"Kiani","year":"2022","journal-title":"J. Prev. Med. Hyg."},{"key":"10.1016\/j.reprotox.2025.109043_bib45","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0065744","article-title":"Cocoa consumption alters the global DNA methylation of peripheral leukocytes in humans with cardiovascular disease risk factors: a randomized controlled trial","volume":"8","author":"Crescenti","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.reprotox.2025.109043_bib46","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1056\/NEJMra0708473","article-title":"Effect of in utero and early-life conditions on adult health and disease","volume":"359","author":"Gluckman","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.reprotox.2025.109043_bib47","doi-asserted-by":"crossref","first-page":"17046","DOI":"10.1073\/pnas.0806560105","article-title":"Persistent epigenetic differences associated with prenatal exposure to famine in humans","volume":"105","author":"Heijmans","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.reprotox.2025.109043_bib48","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1111\/j.1471-0528.2008.01822.x","article-title":"Transgenerational effects of prenatal exposure to the Dutch famine on neonatal adiposity and health in later life","volume":"115","author":"Painter","year":"2008","journal-title":"Bjog"},{"key":"10.1016\/j.reprotox.2025.109043_bib49","doi-asserted-by":"crossref","first-page":"4046","DOI":"10.1093\/hmg\/ddp353","article-title":"DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific","volume":"18","author":"Tobi","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.reprotox.2025.109043_bib50","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1093\/jn\/135.6.1382","article-title":"Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring","volume":"135","author":"Lillycrop","year":"2005","journal-title":"J. Nutr."},{"key":"10.1016\/j.reprotox.2025.109043_bib51","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0021662","article-title":"Offspring of mothers fed a high fat diet display hepatic cell cycle inhibition and associated changes in gene expression and DNA methylation","volume":"6","author":"Dudley","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.reprotox.2025.109043_bib52","doi-asserted-by":"crossref","first-page":"4148","DOI":"10.1096\/fj.14-255620","article-title":"Overweight and CpG methylation of the pomc promoter in offspring of high-fat-diet-fed dams are not \"reprogrammed\" by regular chow diet in rats","volume":"28","author":"Marco","year":"2014","journal-title":"Faseb J."},{"key":"10.1016\/j.reprotox.2025.109043_bib53","doi-asserted-by":"crossref","first-page":"4756","DOI":"10.1210\/en.2010-0505","article-title":"Maternal high-fat diet alters methylation and gene expression of dopamine and opioid-related genes","volume":"151","author":"Vucetic","year":"2010","journal-title":"Endocrinology"},{"key":"10.1016\/j.reprotox.2025.109043_bib54","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/cr.2011.22","article-title":"Regulation of chromatin by histone modifications","volume":"21","author":"Bannister","year":"2011","journal-title":"Cell Res."},{"key":"10.1016\/j.reprotox.2025.109043_bib55","doi-asserted-by":"crossref","DOI":"10.3390\/molecules25102326","article-title":"Epigallocatechin-3-gallate (EGCG) alters histone acetylation and methylation and impacts chromatin architecture profile in human endothelial cells","volume":"25","author":"Ciesielski","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.reprotox.2025.109043_bib56","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.cbi.2004.05.003","article-title":"Copper induces histone hypoacetylation through directly inhibiting histone acetyltransferase activity","volume":"148","author":"Kang","year":"2004","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.reprotox.2025.109043_bib57","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1186\/gb-2004-5-5-224","article-title":"Sirtuins: Sir2-related NAD-dependent protein deacetylases","volume":"5","author":"North","year":"2004","journal-title":"Genome Biol."},{"key":"10.1016\/j.reprotox.2025.109043_bib58","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/s41392-022-01257-8","article-title":"The sirtuin family in health and disease","volume":"7","author":"Wu","year":"2022","journal-title":"Signal Transduct. Target Ther."},{"key":"10.1016\/j.reprotox.2025.109043_bib59","doi-asserted-by":"crossref","first-page":"3169","DOI":"10.1002\/jcp.24054","article-title":"Metaboloepigenetics: interrelationships between energy metabolism and epigenetic control of gene expression","volume":"227","author":"Donohoe","year":"2012","journal-title":"J. Cell Physiol."},{"key":"10.1016\/j.reprotox.2025.109043_bib60","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1074\/mcp.M117.067553","article-title":"The landscape of histone modifications in a High-Fat Diet-Induced obese (DIO) mouse model","volume":"16","author":"Nie","year":"2017","journal-title":"Mol. Cell Proteom."},{"key":"10.1016\/j.reprotox.2025.109043_bib61","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20082022","article-title":"The impact of caloric restriction on the epigenetic signatures of aging","volume":"20","author":"Gensous","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.reprotox.2025.109043_bib62","doi-asserted-by":"crossref","first-page":"2","DOI":"10.3389\/fgene.2015.00002","article-title":"Non-coding RNA: what is functional and what is junk?","volume":"6","author":"Palazzo","year":"2015","journal-title":"Front. Genet."},{"key":"10.1016\/j.reprotox.2025.109043_bib63","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2020.583372","article-title":"The impact of diet on the involvement of non-coding RNAs, extracellular vesicles, and gut microbiome-virome in colorectal cancer initiation and progression","volume":"10","author":"Ekine-Afolabi","year":"2020","journal-title":"Front Oncol."},{"key":"10.1016\/j.reprotox.2025.109043_bib64","article-title":"Non-coding RNAs in disease: from mechanisms to therapeutics","author":"Nemeth","year":"2023","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.reprotox.2025.109043_bib65","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.cell.2013.06.020","article-title":"lincRNAs: genomics, evolution, and mechanisms","volume":"154","author":"Ulitsky","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.reprotox.2025.109043_bib66","doi-asserted-by":"crossref","DOI":"10.3390\/nu9111168","article-title":"Nutrimiromics: role of microRNAs and nutrition in modulating inflammation and chronic diseases","volume":"9","author":"Quintanilha","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.reprotox.2025.109043_bib67","doi-asserted-by":"crossref","DOI":"10.15761\/IFNM.1000293","article-title":"Crosstalk between food components and microRNAs: role in metabolism, nutrition, health and diseases","volume":"7","author":"Kaur","year":"2020","journal-title":"Integr. Food Nutr. Metab."},{"key":"10.1016\/j.reprotox.2025.109043_bib68","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/cr.2011.158","article-title":"Exogenous plant MIR168a specifically targets mammalian LDLRAP1: evidence of cross-kingdom regulation by microRNA","volume":"22","author":"Zhang","year":"2012","journal-title":"Cell Res."},{"key":"10.1016\/j.reprotox.2025.109043_bib69","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1016\/j.jaci.2015.10.028","article-title":"microRNA in native and processed cow's milk and its implication for the farm milk effect on asthma","volume":"137","author":"Kirchner","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.reprotox.2025.109043_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2023.107776","article-title":"Present and future challenges for the investigation of transgenerational epigenetic inheritance","volume":"172","author":"Fallet","year":"2023","journal-title":"Environ. Int."},{"key":"10.1016\/j.reprotox.2025.109043_bib71","doi-asserted-by":"crossref","first-page":"6673","DOI":"10.1038\/s41467-021-26909-1","article-title":"Angiogenin mediates paternal inflammation-induced metabolic disorders in offspring through sperm tsRNAs","volume":"12","author":"Zhang","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.reprotox.2025.109043_bib72","article-title":"Paternal High-Fat diet altered sperm 5'tsRNA-Gly-GCC is associated with enhanced gluconeogenesis in the offspring","volume":"9","author":"Wang","year":"2022","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.reprotox.2025.109043_bib73","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.2147\/DMSO.S248948","article-title":"microRNA expression profiles in myocardium of High-Fat Diet-Induced obesity rat","volume":"13","author":"Yang","year":"2020","journal-title":"Diab. Metab. Syndr. Obes."},{"key":"10.1016\/j.reprotox.2025.109043_bib74","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-29993-4","article-title":"Analysis of diet-induced differential methylation, expression, and interactions of lncRNA and protein-coding genes in mouse liver","volume":"8","author":"Silva","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.reprotox.2025.109043_bib75","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1146\/annurev-nutr-062220-030244","article-title":"Long noncoding RNAs that function in nutrition: Lnc-ing nutritional cues to metabolic pathways","volume":"42","author":"Lovell","year":"2022","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.reprotox.2025.109043_bib76","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jnutbio.2017.01.001","article-title":"Long noncoding RNAs and sulforaphane: a target for chemoprevention and suppression of prostate cancer","volume":"42","author":"Beaver","year":"2017","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.reprotox.2025.109043_bib77","doi-asserted-by":"crossref","first-page":"503","DOI":"10.2217\/epi.11.71","article-title":"Epigenetic diet: impact on the epigenome and cancer","volume":"3","author":"Hardy","year":"2011","journal-title":"Epigenomics"},{"key":"10.1016\/j.reprotox.2025.109043_bib78","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118028","article-title":"High fat diet impairs spermatogenesis by regulating glucose and lipid metabolism in sertoli cells","volume":"257","author":"Luo","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.reprotox.2025.109043_bib79","doi-asserted-by":"crossref","first-page":"7335","DOI":"10.1038\/s41467-022-34990-3","article-title":"Targeting APLN\/APJ restores blood-testis barrier and improves spermatogenesis in murine and human diabetic models","volume":"13","author":"Song","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.reprotox.2025.109043_bib80","doi-asserted-by":"crossref","first-page":"4226","DOI":"10.1096\/fj.12-224048","article-title":"Paternal obesity initiates metabolic disturbances in two generations of mice with incomplete penetrance to the F2 generation and alters the transcriptional profile of testis and sperm microRNA content","volume":"27","author":"Fullston","year":"2013","journal-title":"Faseb J."},{"key":"10.1016\/j.reprotox.2025.109043_bib81","doi-asserted-by":"crossref","first-page":"9444","DOI":"10.1038\/s41598-021-88981-3","article-title":"Inheritable testicular metabolic memory of high-fat diet causes transgenerational sperm defects in mice","volume":"11","author":"Cris\u00f3stomo","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.reprotox.2025.109043_bib82","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1038\/s41366-024-01562-y","article-title":"Paternal obesity induces subfertility in Male offspring by modulating the oxidative stress-related transcriptional network","volume":"48","author":"Li","year":"2024","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.reprotox.2025.109043_bib83","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1038\/s41467-024-45675-4","article-title":"Multigenerational paternal obesity enhances the susceptibility to Male subfertility in offspring via Wt1 N6-methyladenosine modification","volume":"15","author":"Xiong","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.reprotox.2025.109043_bib84","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s41110-023-00243-6","article-title":"Dietary calcium improves the reproductive functions against high-fat diet (HFD)\u2013induced testicular toxicity in Male obese rats","volume":"48","author":"Choudhuri","year":"2023","journal-title":"Nutrire"},{"key":"10.1016\/j.reprotox.2025.109043_bib85","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.molmet.2016.06.008","article-title":"Male-lineage transmission of an acquired metabolic phenotype induced by grand-paternal obesity","volume":"5","author":"Cropley","year":"2016","journal-title":"Mol. Metab."},{"key":"10.1016\/j.reprotox.2025.109043_bib86","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1126\/science.aad7977","article-title":"Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder","volume":"351","author":"Chen","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.reprotox.2025.109043_bib87","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1126\/science.aad6780","article-title":"Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals","volume":"351","author":"Sharma","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.reprotox.2025.109043_bib88","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/s41556-018-0087-2","article-title":"Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs","volume":"20","author":"Zhang","year":"2018","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.reprotox.2025.109043_bib89","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1038\/s41586-024-07472-3","article-title":"Epigenetic inheritance of diet-induced and sperm-borne mitochondrial RNAs","volume":"630","author":"Tomar","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.reprotox.2025.109043_bib90","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.maturitas.2014.02.011","article-title":"How to overcome Male infertility after 40: influence of paternal age on fertility","volume":"78","author":"Belloc","year":"2014","journal-title":"Maturitas"},{"key":"10.1016\/j.reprotox.2025.109043_bib91","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s10815-016-0663-y","article-title":"Effects of aging on the Male reproductive system","volume":"33","author":"Gunes","year":"2016","journal-title":"J. Assist. Reprod. Genet."},{"key":"10.1016\/j.reprotox.2025.109043_bib92","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1016\/j.devcel.2022.04.004","article-title":"Single-cell analysis of human testis aging and correlation with elevated body mass index","volume":"57","author":"Nie","year":"2022","journal-title":"Dev. Cell"},{"key":"10.1016\/j.reprotox.2025.109043_bib93","doi-asserted-by":"crossref","first-page":"4224","DOI":"10.1038\/s41467-025-59591-8","article-title":"Impaired ketogenesis in leydig cells drives testicular aging","volume":"16","author":"Liu","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.reprotox.2025.109043_bib94","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.arr.2014.10.007","article-title":"Consistent age-dependent declines in human semen quality: a systematic review and meta-analysis","volume":"19","author":"Johnson","year":"2015","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.reprotox.2025.109043_bib95","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0015-0282(00)01679-4","article-title":"Effects of Male age on semen quality and fertility: a review of the literature","volume":"75","author":"Kidd","year":"2001","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.reprotox.2025.109043_bib96","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.fertnstert.2018.03.016","article-title":"Impact of age, clinical conditions, and lifestyle on routine semen parameters and sperm kinematics","volume":"110","author":"Ver\u00f3n","year":"2018","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.reprotox.2025.109043_bib97","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/s12958-020-00668-y","article-title":"Advanced paternal age: effects on sperm parameters, assisted reproduction outcomes and offspring health","volume":"18","author":"Halvaei","year":"2020","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.reprotox.2025.109043_bib98","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/978-3-030-21664-1_2","article-title":"Age-Dependent de novo mutations during spermatogenesis and their consequences","volume":"1166","author":"Cioppi","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.reprotox.2025.109043_bib99","article-title":"Personalized nutrition: a review of genotype-based nutritional supplementation","volume":"9","author":"Wang","year":"2022","journal-title":"Front. Nutr."},{"issue":"1","key":"10.1016\/j.reprotox.2025.109043_bib100","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1111\/j.1439-0272.2011.01213.x","article-title":"Noninsulin-dependent diabetes mellitus: effects on sperm morphological and functional characteristics, nuclear DNA integrity and outcome of assisted reproductive technique","volume":"44","author":"Rama Raju","year":"2012","journal-title":"Andrologia"},{"issue":"1","key":"10.1016\/j.reprotox.2025.109043_bib101","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1111\/j.1439-0272.2011.01228.x","article-title":"High levels of lipid peroxidation in semen of diabetic patients","volume":"44","author":"La Vignera","year":"2012","journal-title":"Andrologia"},{"key":"10.1016\/j.reprotox.2025.109043_bib102","article-title":"Choline dehydrogenase polymorphism rs12676 is a functional variation and is associated with changes in human sperm cell function","volume":"7","author":"Johnson","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.reprotox.2025.109043_bib103","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.gene.2013.12.001","article-title":"Associations of variants in MTHFR and MTRR genes with male infertility in the Jordanian population","volume":"536","author":"Mfady","year":"2014","journal-title":"Gene"},{"key":"10.1016\/j.reprotox.2025.109043_bib104","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1177\/1933719110385135","article-title":"Relationship between genetic polymorphisms of methylenetetrahydrofolate reductase (C677T, A1298C, and G1793A) as risk factors for idiopathic Male infertility","volume":"18","author":"Safarinejad","year":"2011","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.reprotox.2025.109043_bib105","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0022277","article-title":"Strong association of 677C>T substitution in the MTHFR gene with Male infertility--a study on an Indian population and a meta-analysis","volume":"6","author":"Gupta","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.reprotox.2025.109043_bib106","doi-asserted-by":"crossref","first-page":"3162","DOI":"10.1093\/humrep\/del280","article-title":"Association study of four polymorphisms in three folate-related enzyme genes with non-obstructive male infertility","volume":"21","author":"Lee","year":"2006","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.reprotox.2025.109043_bib107","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1177\/1933719111411729","article-title":"Polymorphisms in folate-related enzyme genes in idiopathic infertile Brazilian men","volume":"18","author":"Gava","year":"2011","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.reprotox.2025.109043_bib108","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1262\/jrd.2013-058","article-title":"Vitamin a deprivation affects the progression of the spermatogenic wave and initial formation of the blood-testis barrier, resulting in irreversible testicular degeneration in mice","volume":"59","author":"Chihara","year":"2013","journal-title":"J. Reprod. Dev."},{"key":"10.1016\/j.reprotox.2025.109043_bib109","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1095\/biolreprod.110.086157","article-title":"Vitamin a deficiency results in meiotic failure and accumulation of undifferentiated spermatogonia in prepubertal mouse Testis1","volume":"84","author":"Li","year":"2010","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.reprotox.2025.109043_bib110","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004541","article-title":"Retinoic acid activates two pathways required for meiosis in mice","volume":"10","author":"Koubova","year":"2014","journal-title":"PLoS Genet."},{"key":"10.1016\/j.reprotox.2025.109043_bib111","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.21037\/tau-20-592","article-title":"Nutrition, genetic variation and male fertility","volume":"10","author":"Vanderhout","year":"2021","journal-title":"Transl. Androl. Urol."},{"key":"10.1016\/j.reprotox.2025.109043_bib112","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.nut.2012.12.025","article-title":"Glutathione S-transferase M1 and T1 gene polymorphisms with consumption of high fruit-juice and vegetable diet affect antioxidant capacity in healthy adults","volume":"29","author":"Yuan","year":"2013","journal-title":"Nutrition"},{"key":"10.1016\/j.reprotox.2025.109043_bib113","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.3945\/ajcn.2009.28327","article-title":"Functional genetic variants of glutathione S-transferase protect against serum ascorbic acid deficiency","volume":"90","author":"Cahill","year":"2009","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.reprotox.2025.109043_bib114","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1177\/0897190015585876","article-title":"Genetic variation in CYP2R1 and GC genes associated with vitamin d deficiency status","volume":"30","author":"Slater","year":"2017","journal-title":"J. Pharm. Pract."},{"key":"10.1016\/j.reprotox.2025.109043_bib115","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1111\/j.1365-2605.2012.01256.x","article-title":"Expression of the vitamin d metabolizing enzyme CYP24A1 at the annulus of human spermatozoa May serve as a novel marker of semen quality","volume":"35","author":"Blomberg Jensen","year":"2012","journal-title":"Int. J. Androl."},{"key":"10.1016\/j.reprotox.2025.109043_bib116","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/BF01450873","article-title":"Immunohistochemical detection and distribution of the 1,25-dihydroxyvitamin D3 receptor in rat reproductive tissues","volume":"105","author":"Johnson","year":"1996","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.reprotox.2025.109043_bib117","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1093\/humrep\/dew152","article-title":"Vitamin d deficiency and low ionized calcium are linked with semen quality and sex steroid levels in infertile men","volume":"31","author":"Blomberg Jensen","year":"2016","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.reprotox.2025.109043_bib118","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.2337\/db20-0573","article-title":"The role of TCF7L2 in type 2 diabetes","volume":"70","author":"Del Bosque-Plata","year":"2021","journal-title":"Diabetes"},{"key":"10.1016\/j.reprotox.2025.109043_bib119","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.clnu.2019.01.014","article-title":"Interaction analysis of gene variants of TCF7L2 and body mass index and waist circumference on type 2 diabetes","volume":"39","author":"Li","year":"2020","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.reprotox.2025.109043_bib120","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/1741-7015-9-71","article-title":"FTO gene polymorphisms and obesity risk: a meta-analysis","volume":"9","author":"Peng","year":"2011","journal-title":"BMC Med"},{"key":"10.1016\/j.reprotox.2025.109043_bib121","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.gene.2018.09.053","article-title":"The FTO rs9939609 \"A\" allele is associated with impaired fasting glucose and insulin resistance in Emirati population","volume":"681","author":"Saber-Ayad","year":"2019","journal-title":"Gene"},{"key":"10.1016\/j.reprotox.2025.109043_bib122","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/S0140-6736(10)60588-0","article-title":"Common genetic determinants of vitamin d insufficiency: a genome-wide association study","volume":"376","author":"Wang","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.reprotox.2025.109043_bib123","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.gene.2017.09.008","article-title":"Association of vitamin d and vitamin d binding protein (DBP) gene polymorphism with susceptibility of type 2 diabetes mellitus in Bangladesh","volume":"636","author":"Rahman","year":"2017","journal-title":"Gene"},{"key":"10.1016\/j.reprotox.2025.109043_bib124","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0098-2997(00)00006-6","article-title":"The roles of iron in health and disease","volume":"22","author":"Lieu","year":"2001","journal-title":"Mol. Asp. Med."},{"key":"10.1016\/j.reprotox.2025.109043_bib125","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0140-6736(20)32594-0","article-title":"Iron deficiency","volume":"397","author":"Pasricha","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.reprotox.2025.109043_bib126","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1182\/blood-2009-07-232496","article-title":"A genome-wide association analysis of serum iron concentrations","volume":"115","author":"Tanaka","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.reprotox.2025.109043_bib127","doi-asserted-by":"crossref","first-page":"626","DOI":"10.3945\/ajcn.111.025684","article-title":"Association of TMPRSS6 polymorphisms with ferritin, hemoglobin, and type 2 diabetes risk in a Chinese han population","volume":"95","author":"Gan","year":"2012","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.reprotox.2025.109043_bib128","doi-asserted-by":"crossref","first-page":"147","DOI":"10.2174\/1573399810666140606111745","article-title":"Diabetes mellitus induced impairment of Male reproductive functions: a review","volume":"10","author":"Jangir","year":"2014","journal-title":"Curr. Diabetes Rev."},{"key":"10.1016\/j.reprotox.2025.109043_bib129","doi-asserted-by":"crossref","first-page":"948","DOI":"10.4103\/1008-682X.150844","article-title":"The effects of diabetes on Male fertility and epigenetic regulation during spermatogenesis","volume":"17","author":"Ding","year":"2015","journal-title":"Asian J. Androl."},{"key":"10.1016\/j.reprotox.2025.109043_bib130","first-page":"1377","article-title":"Healthful eating, the Western style diet and chronic","volume":"387","author":"Varani","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.reprotox.2025.109043_bib131","first-page":"296","article-title":"The impact of obesity on the Male reproductive axis","volume":"7","author":"Mihalca","year":"2014","journal-title":"J. Med. Life"},{"key":"10.1016\/j.reprotox.2025.109043_bib132","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.mce.2014.08.005","article-title":"Sperm glucose transport and metabolism in diabetic individuals","volume":"396","author":"Dias","year":"2014","journal-title":"Mol. Cell Endocrinol."},{"key":"10.1016\/j.reprotox.2025.109043_bib133","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1210\/jc.2009-2354","article-title":"Testosterone therapy in men with androgen deficiency syndromes: an endocrine society clinical practice guideline","volume":"95","author":"Bhasin","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.reprotox.2025.109043_bib134","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1477-7827-12-34","article-title":"Obesity is associated with increased seminal insulin and leptin alongside reduced fertility parameters in a controlled Male cohort","volume":"12","author":"Leisegang","year":"2014","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.reprotox.2025.109043_bib135","first-page":"215","article-title":"Association between adherence to the Mediterranean diet and semen quality parameters in Male partners of couples attempting fertility","volume":"32","author":"Karayiannis","year":"2017","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.reprotox.2025.109043_bib136","doi-asserted-by":"crossref","first-page":"2807","DOI":"10.1093\/humrep\/des247","article-title":"Dietary intake of antioxidant nutrients is associated with semen quality in young university students","volume":"27","author":"M\u00ednguez-Alarc\u00f3n","year":"2012","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.reprotox.2025.109043_bib137","doi-asserted-by":"crossref","first-page":"3328","DOI":"10.1093\/humrep\/des311","article-title":"Intake of food groups and idiopathic asthenozoospermia: a case-control study","volume":"27","author":"Eslamian","year":"2012","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.reprotox.2025.109043_bib138","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.fct.2014.03.017","article-title":"The effects of bioactive compounds from plant foods on mitochondrial function: a focus on apoptotic mechanisms","volume":"68","author":"Forbes-Hern\u00e1ndez","year":"2014","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.reprotox.2025.109043_bib139","doi-asserted-by":"crossref","first-page":"4146","DOI":"10.3748\/wjg.v23.i23.4146","article-title":"Antioxidant dietary approach in treatment of fatty liver: new insights and updates","volume":"23","author":"Ferramosca","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.reprotox.2025.109043_bib140","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1017\/S0954422419000210","article-title":"Crosstalk between mitochondrial metabolism and oxidoreductive homeostasis: a new perspective for understanding the effects of bioactive dietary compounds","volume":"33","author":"Di Giacomo","year":"2020","journal-title":"Nutr. Res. Rev."},{"key":"10.1016\/j.reprotox.2025.109043_bib141","doi-asserted-by":"crossref","DOI":"10.3390\/antiox10020217","article-title":"Modulation of human sperm mitochondrial respiration efficiency by plant polyphenols","volume":"10","author":"Ferramosca","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.reprotox.2025.109043_bib142","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1111\/andr.12348","article-title":"Dietary fatty acids influence sperm quality and function","volume":"5","author":"Ferramosca","year":"2017","journal-title":"Andrology"},{"key":"10.1016\/j.reprotox.2025.109043_bib143","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0013457","article-title":"Hypercholesterolemia impaired sperm functionality in rabbits","volume":"5","author":"Saez Lancellotti","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.reprotox.2025.109043_bib144","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.ejogrb.2016.05.043","article-title":"Food intake diet and sperm characteristics in a blue zone: a loma linda study","volume":"203","author":"Orzylowska","year":"2016","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.reprotox.2025.109043_bib145","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/S0015-0282(02)04389-3","article-title":"Role of environmental estrogens in the deterioration of Male factor fertility","volume":"78","author":"Rozati","year":"2002","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.reprotox.2025.109043_bib146","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.reprotox.2019.08.005","article-title":"The effects of perfluorooctanoic acid (PFOA) on fetal and adult rat testis","volume":"90","author":"Eggert","year":"2019","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.reprotox.2025.109043_bib147","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s11154-019-09521-z","article-title":"Endocrine disrupting chemicals: exposure, effects on human health, mechanism of action, models for testing and strategies for prevention","volume":"21","author":"Yilmaz","year":"2020","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"10.1016\/j.reprotox.2025.109043_bib148","doi-asserted-by":"crossref","first-page":"445","DOI":"10.2478\/10004-1254-61-2010-2024","article-title":"Dioxins and human toxicity","volume":"61","author":"Marinkovi\u0107","year":"2010","journal-title":"Arh. Hig. Rada Toksikol."},{"key":"10.1016\/j.reprotox.2025.109043_bib149","doi-asserted-by":"crossref","DOI":"10.1289\/EHP5200","article-title":"Evidence for bisphenol b endocrine properties: scientific and regulatory perspectives","volume":"127","author":"Serra","year":"2019","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.reprotox.2025.109043_bib150","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1007\/s11224-020-01664-z","article-title":"Endocrine-disrupting potential of polybrominated diphenyl ethers (PBDEs) on androgen receptor signaling: a structural insight","volume":"32","author":"Sheikh","year":"2020","journal-title":"Struct. Chem."},{"key":"10.1016\/j.reprotox.2025.109043_bib151","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph17165655","article-title":"Critical review on the presence of phthalates in food and evidence of their biological impact","volume":"17","author":"Giuliani","year":"2020","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.reprotox.2025.109043_bib152","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/j.chemosphere.2019.01.001","article-title":"A review of environmental and health effects of organochlorine pesticide residues in Africa","volume":"220","author":"Taiwo","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.reprotox.2025.109043_bib153","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.envint.2007.09.005","article-title":"Environmental levels, toxicity and human exposure to tributyltin (TBT)-contaminated marine environment. A review. b_antizar@hotmail.com","volume":"34","author":"Antizar-Ladislao","year":"2008","journal-title":"Environ. Int."},{"key":"10.1016\/j.reprotox.2025.109043_bib154","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph18073794","article-title":"Perfluoroalkyl chemicals and Male reproductive health: do PFOA and PFOS increase risk for Male infertility?","volume":"18","author":"Tarapore","year":"2021","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.reprotox.2025.109043_bib155","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.scitotenv.2017.06.146","article-title":"Occurrence survey and spatial distribution of perfluoroalkyl and polyfluoroalkyl surfactants in groundwater, surface water, and sediments from tropical environments","volume":"607-608","author":"Munoz","year":"2017","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.reprotox.2025.109043_bib156","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2020.152633","article-title":"Perfluoroheptanoic acid induces leydig cell hyperplasia but inhibits spermatogenesis in rats after pubertal exposure","volume":"448","author":"Li","year":"2021","journal-title":"Toxicology"},{"key":"10.1016\/j.reprotox.2025.109043_bib157","article-title":"Exposure to perfluorooctane sulfonate in utero reduces testosterone production in rat fetal leydig cells","volume":"9","author":"Zhao","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.reprotox.2025.109043_bib158","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1093\/humrep\/des425","article-title":"PFOS (perfluorooctanesulfonate) in serum is negatively associated with testosterone levels, but not with semen quality, in healthy men","volume":"28","author":"Joensen","year":"2013","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.reprotox.2025.109043_bib159","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1038\/s41598-017-01016-8","article-title":"Perfluorooctanesulfonate (PFOS)-induced sertoli cell injury through a disruption of F-actin and microtubule organization is mediated by Akt1\/2","volume":"7","author":"Gao","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.reprotox.2025.109043_bib160","article-title":"Perfluorohexane sulfonic acid disrupts the immune microenvironment for spermatogenesis by damaging the structure of the Blood-Testis barrier in mice","volume":"12","author":"Zhang","year":"2025","journal-title":"Adv. Sci."},{"key":"10.1016\/j.reprotox.2025.109043_bib161","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1097\/MOU.0b013e32834b7e7c","article-title":"Estrogens and phytoestrogens in male infertility","volume":"21","author":"Giwercman","year":"2011","journal-title":"Curr. Opin. Urol."},{"key":"10.1016\/j.reprotox.2025.109043_bib162","doi-asserted-by":"crossref","first-page":"495","DOI":"10.3889\/oamjms.2019.086","article-title":"Phytoestrogens and their health effect","volume":"7","author":"Desmawati","year":"2019","journal-title":"Open Access Maced. J. Med. Sci."},{"key":"10.1016\/j.reprotox.2025.109043_bib163","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1111\/andr.12858","article-title":"Phytoestrogen intake and other dietary risk factors for low motile sperm count and poor sperm morphology","volume":"8","author":"Povey","year":"2020","journal-title":"Andrology"},{"key":"10.1016\/j.reprotox.2025.109043_bib164","doi-asserted-by":"crossref","DOI":"10.1111\/and.12143","article-title":"Evolution of sperm quality in men living in the vicinity of a municipal solid waste incinerator possibly correlated with decreasing dioxins emission levels","volume":"46","author":"Faure","year":"2014","journal-title":"Andrologia"},{"key":"10.1016\/j.reprotox.2025.109043_bib165","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1111\/1541-4337.12388","article-title":"Bisphenol A: food exposure and impact on human health","volume":"17","author":"Almeida","year":"2018","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"10.1016\/j.reprotox.2025.109043_bib166","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1111\/and.12182","article-title":"Sperm impairments in adult vesper mice (Calomys laucha) caused by in utero exposure to bisphenol a","volume":"46","author":"Vilela","year":"2014","journal-title":"Andrologia"},{"key":"10.1016\/j.reprotox.2025.109043_bib167","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1210\/en.2011-1308","article-title":"Neonatal exposure to estradiol\/bisphenol a alters promoter methylation and expression of Nsbp1 and Hpcal1 genes and transcriptional programs of Dnmt3a\/b and Mbd2\/4 in the rat prostate gland throughout life","volume":"153","author":"Tang","year":"2012","journal-title":"Endocrinology"},{"key":"10.1016\/j.reprotox.2025.109043_bib168","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2020.109531","article-title":"Exposure pathways, levels and toxicity of polybrominated diphenyl ethers in humans: a review","volume":"187","author":"Wu","year":"2020","journal-title":"Environ. Res."},{"key":"10.1016\/j.reprotox.2025.109043_bib169","doi-asserted-by":"crossref","DOI":"10.1289\/EHP522","article-title":"A Case-Control study of maternal polybrominated diphenyl ether (PBDE) exposure and cryptorchidism in Canadian populations","volume":"125","author":"Goodyer","year":"2017","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.reprotox.2025.109043_bib170","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s12263-017-0555-5","article-title":"Food components and contaminants as (anti)androgenic molecules","volume":"12","author":"Marcoccia","year":"2017","journal-title":"Genes Nutr."},{"key":"10.1016\/j.reprotox.2025.109043_bib171","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.marpolbul.2005.08.008","article-title":"Striped weakfish (Cynoscion guatucupa): a biomonitor of organochlorine pesticides in estuarine and near-coastal zones","volume":"52","author":"Lanfranchi","year":"2006","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.reprotox.2025.109043_bib172","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e18140","article-title":"Origin, dietary exposure, and toxicity of endocrine-disrupting food chemical contaminants: a comprehensive review","volume":"9","author":"Peivasteh-Roudsari","year":"2023","journal-title":"Heliyon"},{"key":"10.1016\/j.reprotox.2025.109043_bib173","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1177\/1933719114522519","article-title":"Apolipoprotein e induction in Syrian hamster testis following tributyltin exposure: a potential mechanism of Male infertility","volume":"21","author":"Kanimozhi","year":"2014","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.reprotox.2025.109043_bib174","doi-asserted-by":"crossref","first-page":"4021","DOI":"10.1002\/jcb.26564","article-title":"Molecular mechanisms of tributyltin-induced alterations in cholesterol homeostasis and steroidogenesis in hamster testis: in vivo and in vitro studies","volume":"119","author":"Kanimozhi","year":"2018","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.reprotox.2025.109043_bib175","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1108\/00070700810918036","article-title":"Functional foods: a conceptual definition","volume":"110","author":"Doyon","year":"2008","journal-title":"Br. Food J."},{"key":"10.1016\/j.reprotox.2025.109043_bib176","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1002\/mrc.5257","article-title":"The NMR added value to the Green foodomics perspective: advances by machine learning to the holistic view on food and nutrition","volume":"60","author":"Picone","year":"2022","journal-title":"Magn. Reson. Chem."},{"key":"10.1016\/j.reprotox.2025.109043_bib177","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.tifs.2016.12.010","article-title":"An integrated strategy between food chemistry, biology, nutrition, pharmacology, and statistics in the development of functional foods: a proposal","volume":"62","author":"Granato","year":"2017","journal-title":"Trends Food Sci. Technol."},{"key":"10.1016\/j.reprotox.2025.109043_bib178","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2022.957516","article-title":"A rational definition for functional foods: a perspective","volume":"9","author":"Temple","year":"2022","journal-title":"Front. Nutr."},{"key":"10.1016\/j.reprotox.2025.109043_bib179","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1146\/annurev-food-032519-051708","article-title":"Functional foods: product development, technological trends, efficacy testing, and safety","volume":"11","author":"Granato","year":"2020","journal-title":"Annu. Rev. Food Sci. Technol."},{"key":"10.1016\/j.reprotox.2025.109043_bib180","doi-asserted-by":"crossref","DOI":"10.1016\/j.jclepro.2022.134491","article-title":"A critical review of superfoods from a holistic nutritional and environmental approach","author":"Fern\u00e1ndez-R\u00edos","year":"2022","journal-title":"J. Clean. Prod."},{"key":"10.1016\/j.reprotox.2025.109043_bib181","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.microc.2013.05.016","article-title":"Characterization and comparison of the chemical composition of exotic superfoods","volume":"110","author":"Llorent-Mart\u00ednez","year":"2013","journal-title":"Microchem. J."},{"key":"10.1016\/j.reprotox.2025.109043_bib182","doi-asserted-by":"crossref","DOI":"10.12944\/CRNFSJ.6.3.02","article-title":"Superfoods: recent data on their role in the prevention of diseases","author":"Proestos","year":"2018","journal-title":"Curr. Res. Nutr. Food Sci. J."},{"key":"10.1016\/j.reprotox.2025.109043_bib183","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1111\/and.12180","article-title":"The micronutrient supplements, zinc sulphate and folic acid, did not ameliorate sperm functional parameters in oligoasthenoteratozoospermic men","volume":"46","author":"Raigani","year":"2014","journal-title":"Andrologia"},{"key":"10.1016\/j.reprotox.2025.109043_bib184","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S0015-0282(01)03229-0","article-title":"Effects of folic acid and zinc sulfate on Male factor subfertility: a double-blind, randomized, placebo-controlled trial","volume":"77","author":"Wong","year":"2002","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.reprotox.2025.109043_bib185","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s42000-023-00431-z","article-title":"Dietary trends and the decline in Male reproductive health","volume":"22","author":"Whittaker","year":"2023","journal-title":"Hormones"},{"key":"10.1016\/j.reprotox.2025.109043_bib186","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1590\/S1677-5538.IBJU.2015.02.07","article-title":"The effect of adjuvant vitamin c after varicocele surgery on sperm quality and quantity in infertile men: a double blind placebo controlled clinical trial","volume":"41","author":"Cyrus","year":"2015","journal-title":"Int. Braz. J. Urol."},{"key":"10.1016\/j.reprotox.2025.109043_bib187","first-page":"4069","article-title":"The effect of folate and folate plus zinc supplementation on endocrine parameters and sperm characteristics in Sub-Fertile men: a systematic review and Meta-Analysis","volume":"14","author":"Irani","year":"2017","journal-title":"Urol. J."},{"key":"10.1016\/j.reprotox.2025.109043_bib188","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1007\/s00394-019-02091-5","article-title":"A randomized placebo-controlled trial to investigate the effect of lactolycopene on semen quality in healthy males","volume":"59","author":"Williams","year":"2020","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.reprotox.2025.109043_bib189","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1002\/ptr.5998","article-title":"Curcumin nanomicelle improves semen parameters, oxidative stress, inflammatory biomarkers, and reproductive hormones in infertile men: a randomized clinical trial","volume":"32","author":"Alizadeh","year":"2018","journal-title":"Phytother. Res."},{"key":"10.1016\/j.reprotox.2025.109043_bib190","doi-asserted-by":"crossref","first-page":"e23","DOI":"10.1016\/j.fertnstert.2020.08.092","article-title":"Walnuts improve semen quality in infertile men: a randomized control dietary intervention trial","volume":"114","author":"Masterson","year":"2020","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.reprotox.2025.109043_bib191","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1093\/ajcn\/nqy181","article-title":"Effect of nut consumption on semen quality and functionality in healthy men consuming a Western-style diet: a randomized controlled trial","volume":"108","author":"Salas-Huetos","year":"2018","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.reprotox.2025.109043_bib192","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.phymed.2014.02.006","article-title":"Effects of nigella sativa L. Seed oil on abnormal semen quality in infertile men: a randomized, double-blind, placebo-controlled clinical trial","volume":"21","author":"Kolahdooz","year":"2014","journal-title":"Phytomedicine"},{"key":"10.1016\/j.reprotox.2025.109043_bib193","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s40104-016-0113-9","article-title":"Antioxidant efficiency of lycopene on oxidative stress - induced damage in bovine spermatozoa","volume":"7","author":"Tvrd\u00e1","year":"2016","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"10.1016\/j.reprotox.2025.109043_bib194","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1002\/ptr.6627","article-title":"Effect of fenugreek extract supplement on testosterone levels in Male: a meta-analysis of clinical trials","volume":"34","author":"Mansoori","year":"2020","journal-title":"Phytother. Res."},{"key":"10.1016\/j.reprotox.2025.109043_bib195","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12889-020-08547-2","article-title":"The association between iodine intake and semen quality among fertile men in China","volume":"20","author":"Sun","year":"2020","journal-title":"BMC Public Health"},{"key":"10.1016\/j.reprotox.2025.109043_bib196","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/S2468-1253(21)00303-4","article-title":"Roles of the gut virome and mycobiome in faecal microbiota transplantation","volume":"7","author":"Lam","year":"2022","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"10.1016\/j.reprotox.2025.109043_bib197","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41575-021-00499-1","article-title":"The promise of the gut microbiome as part of individualized treatment strategies","volume":"19","author":"Schupack","year":"2022","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.reprotox.2025.109043_bib198","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1136\/gutjnl-2021-324690","article-title":"Intestinal microbiota defines the GUT-TESTIS axis","volume":"71","author":"Martinot","year":"2022","journal-title":"Gut"},{"key":"10.1016\/j.reprotox.2025.109043_bib199","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1136\/gutjnl-2020-320766","article-title":"Small intestinal bacterial overgrowth (SIBO) as a potential cause of impaired spermatogenesis","volume":"69","author":"Tremellen","year":"2020","journal-title":"Gut"},{"key":"10.1016\/j.reprotox.2025.109043_bib200","article-title":"Gut-Derived exosomes mediate the microbiota Dysbiosis-Induced spermatogenesis impairment by targeting meioc in mice","volume":"11","author":"Chen","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.reprotox.2025.109043_bib201","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.ijmm.2009.08.005","article-title":"Mechanisms of probiotic actions - a review","volume":"300","author":"Oelschlaeger","year":"2010","journal-title":"Int. J. Med. Microbiol."},{"key":"10.1016\/j.reprotox.2025.109043_bib202","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1097\/MCG.0b013e3182549092","article-title":"World gastroenterology organisation global guidelines: probiotics and prebiotics October 2011","volume":"46","author":"Guarner","year":"2012","journal-title":"J. Clin. Gastroenterol."},{"key":"10.1016\/j.reprotox.2025.109043_bib203","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1007\/s12011-018-1261-x","article-title":"Probiotics as a complementary therapy in the model of cadmium chloride toxicity: crosstalk of \u03b2-Catenin, BDNF, and StAR signaling pathways","volume":"185","author":"Kadry","year":"2018","journal-title":"Biol. Trace Elem. Res"},{"key":"10.1016\/j.reprotox.2025.109043_bib204","doi-asserted-by":"crossref","DOI":"10.3390\/nu14040902","article-title":"The use of probiotics for management and improvement of reproductive eubiosis and function","volume":"14","author":"Hashem","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.reprotox.2025.109043_bib205","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/978-3-030-89340-8_9","article-title":"Oxidative stress and idiopathic male infertility","volume":"1358","author":"Sengupta","year":"2022","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.reprotox.2025.109043_bib206","doi-asserted-by":"crossref","first-page":"193","DOI":"10.3920\/BM2016.0122","article-title":"Probiotic administration improves sperm quality in asthenozoospermic human donors","volume":"8","author":"Valcarce","year":"2017","journal-title":"Benef. Microbes"},{"key":"10.1016\/j.reprotox.2025.109043_bib207","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1080\/14647273.2020.1824080","article-title":"Probiotic effects on sperm parameters, oxidative stress index, inflammatory factors and sex hormones in infertile men","volume":"25","author":"Helli","year":"2022","journal-title":"Hum. Fertil."},{"key":"10.1016\/j.reprotox.2025.109043_bib208","doi-asserted-by":"crossref","DOI":"10.3390\/nu9091021","article-title":"Effects of probiotics, prebiotics, and synbiotics on human health","volume":"9","author":"Markowiak","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.reprotox.2025.109043_bib209","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/andr.12336","article-title":"The association of a probiotic with a prebiotic (Flortec, Bracco) to improve the quality\/quantity of spermatozoa in infertile patients with idiopathic oligoasthenoteratospermia: a pilot study","volume":"5","author":"Maretti","year":"2017","journal-title":"Andrology"},{"key":"10.1016\/j.reprotox.2025.109043_bib210","first-page":"1","article-title":"Probiotics, prebiotics, and synbiotics","volume":"111","author":"de Vrese","year":"2008","journal-title":"Adv. Biochem. Eng. Biotechnol."},{"key":"10.1016\/j.reprotox.2025.109043_bib211","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1189\/jlb.1109753","article-title":"Probiotics, prebiotics, and synbiotics: impact on the gut immune system and allergic reactions","volume":"89","author":"Gourbeyre","year":"2011","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.reprotox.2025.109043_bib212","first-page":"235","article-title":"Synbiotic (FamiLact) administration in idiopathic Male infertility enhances sperm quality, DNA integrity, and chromatin status: a triple-blinded randomized clinical trial","volume":"19","author":"Abbasi","year":"2021","journal-title":"Int. J. Reprod. Biomed."},{"key":"10.1016\/j.reprotox.2025.109043_bib213","doi-asserted-by":"crossref","DOI":"10.3390\/antiox13020193","article-title":"Redox homeostasis and Nrf2-Regulated mechanisms are relevant to Male infertility","volume":"13","author":"Signorini","year":"2024","journal-title":"Antioxidants"},{"key":"10.1016\/j.reprotox.2025.109043_bib214","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/s10815-014-0425-7","article-title":"Contemporary evidence on the physiological role of reactive oxygen species in human sperm function","volume":"32","author":"Du Plessis","year":"2015","journal-title":"J. Assist. Reprod. Genet."},{"key":"10.1016\/j.reprotox.2025.109043_bib215","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s00018-019-03253-8","article-title":"Oxidative stress and Male infertility: current knowledge of pathophysiology and role of antioxidant therapy in disease management","volume":"77","author":"Barati","year":"2020","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.reprotox.2025.109043_bib216","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.pharep.2015.07.005","article-title":"Nuclear factor E2-related factor-2 (Nrf2) expression and regulation in Male reproductive tract","volume":"68","author":"Wajda","year":"2016","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.reprotox.2025.109043_bib217","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1016\/j.freeradbiomed.2010.07.019","article-title":"Knockout of the transcription factor NRF2 disrupts spermatogenesis in an age-dependent manner","volume":"49","author":"Nakamura","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.reprotox.2025.109043_bib218","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.taap.2014.06.009","article-title":"Protection by sulforaphane from type 1 diabetes-induced testicular apoptosis is associated with the up-regulation of Nrf2 expression and function","volume":"279","author":"Jiang","year":"2014","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.reprotox.2025.109043_bib219","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1530\/REP-23-0097","article-title":"Obesity induces Male mice infertility via oxidative stress, apoptosis, and glycolysis","volume":"166","author":"Han","year":"2023","journal-title":"Reproduction"},{"key":"10.1016\/j.reprotox.2025.109043_bib220","doi-asserted-by":"crossref","DOI":"10.3390\/antiox10101534","article-title":"Redox balance in Male infertility: excellence through Moderation-\"\u039c\u03ad\u03c4\u03c1\u03bf\u03bd \u1f04\u03c1\u03b9\u03c3\u03c4\u03bf\u03bd\"","volume":"10","author":"Symeonidis","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.reprotox.2025.109043_bib221","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1146\/annurev.nu.16.070196.000341","article-title":"Antioxidants in human health and disease","volume":"16","author":"Halliwell","year":"1996","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.reprotox.2025.109043_bib222","doi-asserted-by":"crossref","DOI":"10.3390\/antiox10071067","article-title":"The effect of antioxidant supplementation on operated or non-operated varicocele-associated infertility: a systematic review and meta-analysis","volume":"10","author":"Pyrgidis","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.reprotox.2025.109043_bib223","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1038\/s41591-024-03000-y","article-title":"The evolution of personalized nutrition","volume":"30","author":"Neu","year":"2024","journal-title":"Nat. Med."},{"key":"10.1016\/j.reprotox.2025.109043_bib224","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/s41430-022-01146-x","article-title":"Opportunities to integrate nutrigenomics into clinical practice and patient counseling","volume":"77","author":"Roosan","year":"2023","journal-title":"Eur. J. Clin. Nutr."}],"container-title":["Reproductive Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S089062382500214X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S089062382500214X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T13:07:56Z","timestamp":1757768876000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S089062382500214X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":224,"alternative-id":["S089062382500214X"],"URL":"https:\/\/doi.org\/10.1016\/j.reprotox.2025.109043","relation":{},"ISSN":["0890-6238"],"issn-type":[{"value":"0890-6238","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Positioning nutrigenomics and nutrigenetics within the framework of male infertility exploration","name":"articletitle","label":"Article Title"},{"value":"Reproductive Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.reprotox.2025.109043","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109043"}}