{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T20:59:15Z","timestamp":1793393955697,"version":"4.5.0"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100024586","name":"Human Resource Development Centre, Council of Scientific And Industrial Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100024586","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Toxicology"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.reprotox.2025.109068","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T12:51:03Z","timestamp":1758631863000},"page":"109068","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Melatonin alleviates Di-2-ethylhexyl phthalate induced male reproductive toxicity through inhibition of endoplasmic reticulum stress: Behavioral, biochemical, and morphological evidences"],"prefix":"10.1016","volume":"138","author":[{"given":"Jiten","family":"Singh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9693-0338","authenticated-orcid":false,"given":"Ashok","family":"Jangra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sapana","family":"Kushwaha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itishree","family":"Dubey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinesh","family":"Dhingra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinesh","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.reprotox.2025.109068_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.reprotox.2024.108628","article-title":"Melatonin and resveratrol alleviate molecular and metabolic toxicity induced by bisphenol a in endometrial organoids","volume":"128","author":"Abady","year":"2024","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.reprotox.2025.109068_bib2","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.fct.2016.02.003","article-title":"Mechanism of diethylhexylphthalate (DEHP) induced testicular damage and of grape seed extract-induced protection in the rat","volume":"90","author":"Abdel-Kawi","year":"2016","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.reprotox.2025.109068_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2024.119476","article-title":"Developmental exposure to environmentally relevant doses of phthalates alters the neural control of Male and female reproduction in mice","volume":"258","author":"Adam","year":"2024","journal-title":"Environ. Res."},{"key":"10.1016\/j.reprotox.2025.109068_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2024.122936","article-title":"Protective role of melatonin against diclofenac-induced acute kidney injury","volume":"353","author":"Agaty","year":"2024","journal-title":"Life Sci."},{"issue":"1","key":"10.1016\/j.reprotox.2025.109068_bib5","doi-asserted-by":"crossref","DOI":"10.1186\/s40360-025-00863-w","article-title":"Melatonin protect against pregabalin-induced gonadotoxicity via anti-oxidative, anti-inflammatory, anti-apoptotic, enzymatic and hormonal regulatory mechanisms in rats","volume":"26","author":"Ajayi","year":"2025","journal-title":"BMC Pharmacol. Toxicol."},{"key":"10.1016\/j.reprotox.2025.109068_bib6","article-title":"Combination of low doses of mirtazapine plus venlafaxine produces antidepressant-like effects in rats, without affecting Male or female sexual behavior","author":"\u00c1lvarez-Silva","year":"2024","journal-title":"Psychopharmacology"},{"issue":"1","key":"10.1016\/j.reprotox.2025.109068_bib7","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/0018-506X(85)90002-9","article-title":"Oxytocin improves Male copulatory performance in rats","volume":"19","author":"Arletti","year":"1985","journal-title":"Horm. Behav."},{"key":"10.1016\/j.reprotox.2025.109068_bib8","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.envint.2015.07.005","article-title":"Phthalate exposure and reproductive parameters in young men from the general Swedish population","volume":"85","author":"Axelsson","year":"2015","journal-title":"Environ. Int."},{"key":"10.1016\/j.reprotox.2025.109068_bib9","first-page":"882","article-title":"Improved method for the determination of blood glutathione","volume":"61","author":"Beutler","year":"1963","journal-title":"J. Lab. Clin. Med."},{"key":"10.1016\/j.reprotox.2025.109068_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.toxlet.2016.12.004","article-title":"Urban fine particulate matter exposure causes Male reproductive injury through destroying blood-testis barrier (BTB) integrity","volume":"266","author":"Cao","year":"2017","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.reprotox.2025.109068_bib11","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.trsl.2025.02.005","article-title":"Caspase-12 exhibits non-redundant functions in response to endoplasmic reticulum stress to promote GSDMD-mediated NETosis, leading to thoracic aortic dissection","volume":"278","author":"Chen","year":"2025","journal-title":"Transl. Res."},{"issue":"2","key":"10.1016\/j.reprotox.2025.109068_bib12","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1002\/tox.24029","article-title":"Protective effects of melatonin on DEHP-induced apoptosis and oxidative stress in prepubertal testes via the PI3K\/AKT pathway","volume":"39","author":"Chen","year":"2024","journal-title":"Environ. Toxicol."},{"issue":"11","key":"10.1016\/j.reprotox.2025.109068_bib13","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.2460\/javma.23.02.0067","article-title":"Gabapentin, melatonin, and acepromazine combination prior to hospital visits decreased stress scores in aggressive and anxious dogs in a prospective clinical trial","volume":"261","author":"Costa","year":"2023","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"10.1016\/j.reprotox.2025.109068_bib14","article-title":"Sulforaphane substantially impedes testicular ferroptosis in adult rats exposed to di-2-ethylhexyl phthalate through activation of NRF-2\/SLC7A11\/GPX-4 trajectory","author":"Elseweidy","year":"2024","journal-title":"NaunynSchmiede \u2019S. Arch. Pharmacol."},{"issue":"1","key":"10.1016\/j.reprotox.2025.109068_bib15","doi-asserted-by":"crossref","DOI":"10.1038\/s42003-023-05685-2","article-title":"Multiple ageing effects on testicular\/epididymal germ cells lead to decreased Male fertility in mice","volume":"7","author":"Endo","year":"2024","journal-title":"Commun. Biol."},{"issue":"7","key":"10.1016\/j.reprotox.2025.109068_bib16","article-title":"Melatonin receptors: a key mediator in animal reproduction","volume":"9","author":"Gao","year":"2022","journal-title":"Vet. Sci."},{"issue":"1","key":"10.1016\/j.reprotox.2025.109068_bib17","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0003-2697(82)90118-X","article-title":"Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids","volume":"126","author":"Green","year":"1982","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.reprotox.2025.109068_bib18","article-title":"Di-(2-ethylhexyl) phthalate exposure induces developmental toxicity in the mouse fetal heart via mitochondrial dysfunction","author":"Guo","year":"2024","journal-title":"Cardiovasc. Toxicol."},{"issue":"12","key":"10.1016\/j.reprotox.2025.109068_bib19","doi-asserted-by":"crossref","DOI":"10.1002\/bdr2.2423","article-title":"Melatonin attenuates PFOS-Induced reproductive toxicity of pregnant mice due to placental damage via antioxidant, Anti-Aging and Anti-Inflammatory pathways","volume":"116","author":"Han","year":"2024","journal-title":"Birth Defects Res."},{"key":"10.1016\/j.reprotox.2025.109068_bib20","first-page":"433","article-title":"Aberrations of miR-126-3p, miR-181a and sirtuin1 network mediate Di-(2-ethylhexyl) phthalate-induced testicular damage in rats: the protective role of hesperidin","author":"Helmy","year":"2020","journal-title":"Toxicology"},{"issue":"2","key":"10.1016\/j.reprotox.2025.109068_bib21","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.gendis.2023.02.030","article-title":"X-box binding protein 1 caused an imbalance in pyroptosis and mitophagy in immature rats with di-(2-ethylhexyl) phthalate-induced testis toxicity","volume":"11","author":"Hong","year":"2024","journal-title":"Genes Dis."},{"issue":"34","key":"10.1016\/j.reprotox.2025.109068_bib22","doi-asserted-by":"crossref","first-page":"5835","DOI":"10.1039\/D4AY01092B","article-title":"Phthalate content in toy samples available on the market of the republic of Serbia","volume":"16","author":"Ivanovic","year":"2024","journal-title":"Anal. Methods"},{"issue":"1","key":"10.1016\/j.reprotox.2025.109068_bib23","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s10571-016-0344-5","article-title":"Sodium phenylbutyrate and edaravone abrogate chronic restraint Stress-Induced behavioral deficits: implication of Oxido-Nitrosative, endoplasmic reticulum stress cascade, and neuroinflammation","volume":"37","author":"Jangra","year":"2017","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.reprotox.2025.109068_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.neubiorev.2022.104818","article-title":"Targeting endoplasmic reticulum stress using natural products in neurological disorders","volume":"141","author":"Jangra","year":"2022","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"1","key":"10.1016\/j.reprotox.2025.109068_bib25","first-page":"17","article-title":"Interlinkage between inflammation, oxidative stress, and endoplasmic reticulum stress in bisphenols-induced testicular steroidogenesis disturbance: a mini review","volume":"23","author":"Jefferi","year":"2025","journal-title":"Int. J. Reprod. Biomed."},{"issue":"9","key":"10.1016\/j.reprotox.2025.109068_bib26","doi-asserted-by":"crossref","DOI":"10.3390\/biom14091171","volume":"14","author":"Justin Margret","year":"2024","journal-title":"Biomolecules"},{"issue":"8","key":"10.1016\/j.reprotox.2025.109068_bib27","doi-asserted-by":"crossref","first-page":"3808","DOI":"10.1210\/jcem.87.8.8763","article-title":"Compound heterozygous mutations in the cholesterol Side-Chain cleavage enzyme gene (CYP11A) cause congenital adrenal insufficiency in humans","volume":"87","author":"Katsumata","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"2","key":"10.1016\/j.reprotox.2025.109068_bib28","doi-asserted-by":"crossref","first-page":"85","DOI":"10.14715\/cmb\/2025.71.2.13","article-title":"Prenatal DEHP exposure induces hippocampal neurotoxicity in Male offspring via PTEN dysregulation and impaired Akt\/mTOR and NMDA signaling","volume":"71","author":"Kiknadze","year":"2025","journal-title":"Cell. Mol. Biol."},{"issue":"5","key":"10.1016\/j.reprotox.2025.109068_bib29","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.70294","article-title":"Morin hydrate improves kidney functions in DEHP-Intoxicated mice via NF-kB\/TNF\u03b1\/Oxidative Stress\/Apoptosis pathway","volume":"39","author":"Kumar","year":"2025","journal-title":"J. Biochem. Mol. Toxicol."},{"issue":"1","key":"10.1016\/j.reprotox.2025.109068_bib30","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.mrgentox.2013.04.013","article-title":"Telmisartan ameliorates germ cell toxicity in the STZ-induced diabetic rat: studies on possible molecular mechanisms","volume":"755","author":"Kushwaha","year":"2013","journal-title":"Mutat. Res. Genet. Toxicol. Environ. Mutagen."},{"issue":"2","key":"10.1016\/j.reprotox.2025.109068_bib31","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1093\/toxsci\/kfae064","article-title":"Single-cell insights into mouse testicular toxicity under peripubertal exposure to di(2-ethylhexyl) phthalate","volume":"200","author":"Li","year":"2024","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.reprotox.2025.109068_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2023.110575","article-title":"Mechanism of testicular injury induced by Di-ethylhexyl phthalate and its protective agents","volume":"381","author":"Lin","year":"2023","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.reprotox.2025.109068_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2024.116816","article-title":"Long-term exposure to the mixture of phthalates induced Male reproductive toxicity in rats and the alleviative effects of quercetin","volume":"483","author":"Liu","year":"2024","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.reprotox.2025.109068_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2024.111310","article-title":"Exploring the nephrotoxicity and molecular mechanisms of Di-2-ethylhexyl phthalate: a comprehensive review","volume":"405","author":"Liu","year":"2025","journal-title":"Chem. Biol. Interact."},{"issue":"2","key":"10.1016\/j.reprotox.2025.109068_bib35","first-page":"220","article-title":"Protein measurement with the folin phenol reagent","volume":"217","author":"Lowry","year":"1994","journal-title":"Anal. Biochem."},{"issue":"20","key":"10.1016\/j.reprotox.2025.109068_bib36","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242015056","article-title":"The role of melatonin to ameliorate oxidative stress in sperm cells","volume":"24","author":"Makris","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.reprotox.2025.109068_bib37","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1002\/tox.24425","article-title":"Se-Methylselenocysteine ameliorates DEHP-Induced ferroptosis in testicular sertoli cells via the Nrf2\/GPX4 axis","volume":"40","author":"Mao","year":"2025","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.reprotox.2025.109068_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.reprotox.2023.108368","article-title":"The protective role of melatonin in citalopram-induced reproductive toxicity via modulating nitro-oxidative stress and apoptosis in Male mice","volume":"118","author":"Moradi","year":"2023","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.reprotox.2025.109068_bib39","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.exger.2015.06.022","article-title":"Melatonin membrane receptor (MT1R) expression and nitro-oxidative stress in testis of golden hamster, mesocricetus auratus: an age-dependent study","volume":"69","author":"Mukherjee","year":"2015","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.reprotox.2025.109068_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.reprotox.2024.108535","article-title":"Protective role of hesperidin in finasteride-induced testicular toxicity in adult Male wistar rats: insights into oxidative stress, apoptosis, and ultrastructure of seminiferous tubules","volume":"124","author":"Nabil","year":"2024","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.reprotox.2025.109068_bib41","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.biopha.2017.04.077","article-title":"Alcohol aggravates stress-induced cognitive deficits and hippocampal neurotoxicity: protective effect of melatonin","volume":"91","author":"Rajput","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.reprotox.2025.109068_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2025.117314","article-title":"Melatonin ameliorates PM2.5-induced airway inflammation and apoptosis by PERK\/eIF2\u03b1\/ATF4\/CHOP in chronic obstructive pulmonary disease mice","volume":"499","author":"Shi","year":"2025","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.reprotox.2025.109068_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2024.141922","article-title":"Recent advances in toxicological research of di-(2-ethylhexyl)-phthalate: focus on endoplasmic reticulum stress pathway","volume":"356","author":"Singh","year":"2024","journal-title":"Chemosphere"},{"key":"10.1016\/j.reprotox.2025.109068_bib44","doi-asserted-by":"crossref","DOI":"10.1007\/s43032-025-01825-7","article-title":"Beta(\u03b2)-sitosterol attenuates chronic unpredictable stress (CUS) induced testicular damage in the experimental rat model","author":"Singh","year":"2025","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.reprotox.2025.109068_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.tice.2025.102910","article-title":"Vitamin d alleviates chronic stress-induced testicular steroidogenesis disruption in wistar rats","volume":"95","author":"Srivastava","year":"2025","journal-title":"Tissue Cell"},{"issue":"3","key":"10.1016\/j.reprotox.2025.109068_bib46","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26031036","article-title":"Prenatal constant light exposure induces behavioral deficits in Male and female rat offspring: effects of prenatal melatonin treatment","volume":"26","author":"Stoyanova","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.reprotox.2025.109068_bib47","doi-asserted-by":"crossref","unstructured":"Tolulope, D., Samuel, O., Oluwatoyin, L., & Folorunsho, A. (2025). Pharmacological Research - Reports Vitamin D 3 supplementation improve sexual behaviors of male wistar rats treated with flunitrazepam. 3(January), 0\u20132.","DOI":"10.1016\/j.prerep.2025.100028"},{"key":"10.1016\/j.reprotox.2025.109068_bib48","unstructured":"U.S. Department of Health and Human Services. (2021). 15th Report on Carcinogens. Encyclopedia of Toxicology, 364\u2013365."},{"key":"10.1016\/j.reprotox.2025.109068_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2024.153956","article-title":"Di-(2-ethylhexyl) phthalate induces prepubertal testicular injury through MAM-related mitochondrial calcium overload in leydig and sertoli cell apoptosis","volume":"509","author":"Wang","year":"2024","journal-title":"Toxicology"},{"key":"10.1016\/j.reprotox.2025.109068_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2022.113315","article-title":"Microplastics and di (2-ethylhexyl) phthalate synergistically induce apoptosis in mouse pancreas through the GRP78\/CHOP\/Bcl-2 pathway activated by oxidative stress","volume":"167","author":"Wang","year":"2022","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.reprotox.2025.109068_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2025.112462","article-title":"GSTA2 overexpression alleviates bis (2-ethylhexyl) phthalate (DEHP)-induced Male reproductive disorders by inhibiting oxidative stress-mediated cell apoptosis via the activated PI3K\/AKT signaling pathway","volume":"599","author":"Wei","year":"2025","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.reprotox.2025.109068_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2022.137216","article-title":"Di-2-ethylhexyl phthalate (DEHP) exposure induces sperm quality and functional defects in mice","volume":"312","author":"XueXia","year":"2023","journal-title":"Chemosphere"},{"issue":"6","key":"10.1016\/j.reprotox.2025.109068_bib53","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1093\/biolre\/ioab046","article-title":"Melatonin promotes Male reproductive performance and increases testosterone synthesis in mammalian leydig cells","volume":"104","author":"Yang","year":"2021","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.reprotox.2025.109068_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2024.125503","article-title":"DEHP-mediated oxidative stress leads to impaired testosterone synthesis in leydig cells through the cAMP\/PKA\/SF-1\/StAR pathway","volume":"366","author":"Yang","year":"2025","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.reprotox.2025.109068_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.115711","article-title":"Mitochondrial dysfunction and endoplasmic reticulum stress induced by activation of PPAR\u03b1 leaded testicular to apoptosis in SD rats explored to di-(2-ethylhexyl) phthalate (DEHP)","volume":"268","author":"Zhang","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.reprotox.2025.109068_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.118390","article-title":"Lycopene mitigates DEHP-induced hepatic mitochondrial quality control disorder via regulating SIRT1\/PINK1\/mitophagy axis and mitochondrial unfolded protein response","volume":"292","author":"Zhao","year":"2022","journal-title":"Environ. Pollut."}],"container-title":["Reproductive Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623825002394?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623825002394?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T20:31:10Z","timestamp":1762201870000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0890623825002394"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":56,"alternative-id":["S0890623825002394"],"URL":"https:\/\/doi.org\/10.1016\/j.reprotox.2025.109068","relation":{},"ISSN":["0890-6238"],"issn-type":[{"value":"0890-6238","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Melatonin alleviates Di-2-ethylhexyl phthalate induced male reproductive toxicity through inhibition of endoplasmic reticulum stress: Behavioral, biochemical, and morphological evidences","name":"articletitle","label":"Article Title"},{"value":"Reproductive Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.reprotox.2025.109068","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109068"}}