{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T00:19:48Z","timestamp":1782605988880,"version":"3.54.5"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Toxicology"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.reprotox.2025.109114","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T02:44:11Z","timestamp":1763693051000},"page":"109114","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Uncovering the molecular network of nicotine induced erectile dysfunction through network toxicology and mendelian randomization"],"prefix":"10.1016","volume":"139","author":[{"given":"Zhiqiang","family":"Dai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boyi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailin","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.reprotox.2025.109114_bib1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1146\/annurev.pharmtox.48.113006.094742","article-title":"Pharmacology of nicotine: addiction, smoking-induced disease, and therapeutics","volume":"49","author":"Benowitz","year":"2009","journal-title":"Annu Rev. Pharm. Toxicol."},{"issue":"5","key":"10.1016\/j.reprotox.2025.109114_bib2","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/nrn3939","article-title":"The dopamine theory of addiction: 40 years of highs and lows","volume":"16","author":"Nutt","year":"2015","journal-title":"Nat. Rev. Neurosci."},{"issue":"9","key":"10.1016\/j.reprotox.2025.109114_bib3","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1248\/bpb.b18-00134","article-title":"Impact of Nicotine Transport across the Blood-Brain Barrier: Carrier-Mediated Transport of Nicotine and Interaction with Central Nervous System Drugs","volume":"41","author":"Tega","year":"2018","journal-title":"Biol. Pharm. Bull."},{"issue":"9","key":"10.1016\/j.reprotox.2025.109114_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2024.107626","article-title":"Nicotine inhalation and metabolism triggers AOX-mediated superoxide generation with oxidative lung injury","volume":"300","author":"Zweier","year":"2024","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.reprotox.2025.109114_bib5","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1111\/j.1440-1681.2008.04896.x","article-title":"New insights into the sympathetic, endothelial and coronary effects of nicotine","volume":"35","author":"Adamopoulos","year":"2008","journal-title":"Clin. Exp. Pharm. Physiol."},{"issue":"24","key":"10.1016\/j.reprotox.2025.109114_bib6","doi-asserted-by":"crossref","first-page":"2807","DOI":"10.1016\/S0024-3205(02)02135-5","article-title":"Nicotine's oxidative and antioxidant properties in CNS","volume":"71","author":"Newman","year":"2002","journal-title":"Life Sci."},{"issue":"5","key":"10.1016\/j.reprotox.2025.109114_bib7","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/j.urology.2014.01.006","article-title":"Nicotine acutely inhibits erectile tumescence by altering heart rate variability","volume":"83","author":"Harte","year":"2014","journal-title":"Urology"},{"issue":"1","key":"10.1016\/j.reprotox.2025.109114_bib8","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.sxmr.2021.01.003","article-title":"E-Cigarette-Associated Endothelial Damage: A Potential Mechanism for Erectile Dysfunction","volume":"10","author":"Pincus","year":"2022","journal-title":"Sex. Med Rev."},{"issue":"4","key":"10.1016\/j.reprotox.2025.109114_bib9","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1111\/andr.13170","article-title":"Exposure to polycyclic aromatic hydrocarbons and nicotine, and associations with sperm DNA fragmentation","volume":"10","author":"Axelsson","year":"2022","journal-title":"Andrology"},{"issue":"3","key":"10.1016\/j.reprotox.2025.109114_bib10","doi-asserted-by":"crossref","first-page":"221","DOI":"10.5603\/EP.a2023.0034","article-title":"The influence of various endocrine disruptors on the reproductive system","volume":"74","author":"Czarnywojtek","year":"2023","journal-title":"Endokrynol. Pol."},{"key":"10.1016\/j.reprotox.2025.109114_bib11","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.12688\/f1000research.20062.1","article-title":"Cardiovascular, carcinogenic and reproductive effects of nicotine exposure: A narrative review of the scientific literature","volume":"8","author":"Price","year":"2019","journal-title":"F1000Res"},{"issue":"9861","key":"10.1016\/j.reprotox.2025.109114_bib12","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0140-6736(12)60520-0","article-title":"Erectile dysfunction","volume":"381","author":"Shamloul","year":"2013","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.reprotox.2025.109114_bib13","first-page":"149","article-title":"[Erectile dysfunction after nerve-sparing radical prostatectomy]","author":"Akhvlediani","year":"2017","journal-title":"Urologiia"},{"issue":"2","key":"10.1016\/j.reprotox.2025.109114_bib14","doi-asserted-by":"crossref","first-page":"163","DOI":"10.2174\/1570161114666151202205950","article-title":"Is Erectile Dysfunction an Example of Abnormal Endothelial Function?","volume":"14","author":"Blick","year":"2016","journal-title":"Curr. Vasc. Pharm."},{"issue":"6","key":"10.1016\/j.reprotox.2025.109114_bib15","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1097\/YCO.0000000000000097","article-title":"Diagnosis of erectile dysfunction","volume":"27","author":"Glina","year":"2014","journal-title":"Curr. Opin. Psychiatry"},{"issue":"8","key":"10.1016\/j.reprotox.2025.109114_bib16","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1007\/s40618-022-01788-5","article-title":"Erectile dysfunction as a marker of endocrine and glycemic disorders","volume":"45","author":"Mazzilli","year":"2022","journal-title":"J. Endocrinol. Invest"},{"issue":"10","key":"10.1016\/j.reprotox.2025.109114_bib17","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1111\/and.12393","article-title":"Effects of cigarette smoking on erectile dysfunction","volume":"47","author":"Kovac","year":"2015","journal-title":"Andrologia"},{"issue":"1","key":"10.1016\/j.reprotox.2025.109114_bib18","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.euf.2015.01.003","article-title":"The Link Between Cigarette Smoking and Erectile Dysfunction: A Systematic Review","volume":"1","author":"Verze","year":"2015","journal-title":"Eur. Urol. Focus"},{"issue":"1","key":"10.1016\/j.reprotox.2025.109114_bib19","article-title":"Genetic prediction of modifiable lifestyle factors for erectile dysfunction","volume":"12","author":"Xi","year":"2024","journal-title":"Sex. Med"},{"issue":"12","key":"10.1016\/j.reprotox.2025.109114_bib20","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1016\/j.jsxm.2021.09.016","article-title":"Erectile Dysfunction is a Modifiable Risk Factor for Major Depressive Disorder: Analysis of a Federated Research Network","volume":"18","author":"Nackeeran","year":"2021","journal-title":"J. Sex. Med"},{"issue":"4","key":"10.1016\/j.reprotox.2025.109114_bib21","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.sxmr.2016.05.001","article-title":"Male Sexual Function and Smoking","volume":"4","author":"Biebel","year":"2016","journal-title":"Sex. Med Rev."},{"issue":"5","key":"10.1016\/j.reprotox.2025.109114_bib22","doi-asserted-by":"crossref","DOI":"10.1093\/bib\/bbaf533","article-title":"Computational toxicology in drug discovery: applications of artificial intelligence in ADMET and toxicity prediction","volume":"26","author":"Zhang","year":"2025","journal-title":"Brief. Bioinform"},{"key":"10.1016\/j.reprotox.2025.109114_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.119480","article-title":"Application and development trends of network toxicology in the safety assessment of traditional Chinese medicine","volume":"343","author":"Li","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.reprotox.2025.109114_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.reprotox.2025.108918","article-title":"Integrating network toxicology and Mendelian randomization to uncover the role of AHR in linking air pollution to male reproductive health","volume":"135","author":"Li","year":"2025","journal-title":"Reprod. Toxicol."},{"issue":"D1","key":"10.1016\/j.reprotox.2025.109114_bib25","doi-asserted-by":"crossref","first-page":"D955","DOI":"10.1093\/nar\/gkw1118","article-title":"PubChem BioAssay: 2017 update","volume":"45","author":"Wang","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.reprotox.2025.109114_bib26","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s13321-016-0130-x","article-title":"Improving chemical similarity ensemble approach in target prediction","volume":"8","author":"Wang","year":"2016","journal-title":"J. Chemin.."},{"issue":"3","key":"10.1016\/j.reprotox.2025.109114_bib27","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1093\/bioinformatics\/btab733","article-title":"TargetNet: functional microRNA target prediction with deep neural networks","volume":"38","author":"Min","year":"2022","journal-title":"Bioinformatics"},{"key":"10.1016\/j.reprotox.2025.109114_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.reprotox.2024.108749","article-title":"Assessing male reproductive toxicity of environmental pollutant di-ethylhexyl phthalate with network toxicology and molecular docking strategy","volume":"130","author":"Hong","year":"2024","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.reprotox.2025.109114_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2025.119010","article-title":"Integration of network toxicology, machine learning and single-cell sequencing reveals the effects of soil pollutants on prostate cancer","volume":"303","author":"Liu","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.reprotox.2025.109114_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.reprotox.2025.109026","article-title":"Identification of key genes involved in phthalate-induced male erectile dysfunction: Insights from network toxicology and bioinformatics analyses","volume":"137","author":"Li","year":"2025","journal-title":"Reprod. Toxicol."},{"issue":"1","key":"10.1016\/j.reprotox.2025.109114_bib31","article-title":"Identification and validation of new fatty acid metabolism-related mechanisms and biomarkers for erectile dysfunction","volume":"12","author":"He","year":"2024","journal-title":"Sex. Med"},{"issue":"1","key":"10.1016\/j.reprotox.2025.109114_bib32","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/s13098-025-01700-0","article-title":"Protective effect of antidiabetic drugs against male infertility: evidence from Mendelian randomization","volume":"17","author":"Li","year":"2025","journal-title":"Diabetol. Metab. Syndr."},{"key":"10.1016\/j.reprotox.2025.109114_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.reprotox.2025.108999","article-title":"IGF1R as a protective target in antidiabetic drug-mediated prevention of erectile dysfunction: Insights from genetics","volume":"137","author":"Li","year":"2025","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.reprotox.2025.109114_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2025.117966","article-title":"Air pollution and prostate cancer: Unraveling the connection through network toxicology and machine learning","volume":"292","author":"Li","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"1","key":"10.1016\/j.reprotox.2025.109114_bib35","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.coph.2011.01.011","article-title":"5-HT(3) receptors: potential of individual isoforms for personalised therapy","volume":"11","author":"Niesler","year":"2011","journal-title":"Curr. Opin. Pharm."},{"issue":"13","key":"10.1016\/j.reprotox.2025.109114_bib36","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22136838","article-title":"5-HT3 Signaling Alters Development of Sacral Neural Crest Derivatives That Innervate the Lower Urinary Tract","volume":"22","author":"Ritter","year":"2021","journal-title":"Int J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.reprotox.2025.109114_bib37","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.neuropharm.2008.08.003","article-title":"The 5-HT3 receptor--the relationship between structure and function","volume":"56","author":"Barnes","year":"2009","journal-title":"Neuropharmacology"},{"issue":"3","key":"10.1016\/j.reprotox.2025.109114_bib38","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1159\/000107959","article-title":"Serotonin induces a biphasic response in rabbit cavernosal smooth muscle: relevance to the erectile process","volume":"79","author":"Lau","year":"2007","journal-title":"Urol. Int"},{"key":"10.1016\/j.reprotox.2025.109114_bib39","doi-asserted-by":"crossref","first-page":"690","DOI":"10.3389\/fnins.2017.00690","article-title":"Serotonin Receptor 5-HT3A Affects Development of Bladder Innervation and Urinary Bladder Function","volume":"11","author":"Ritter","year":"2017","journal-title":"Front Neurosci."},{"key":"10.1016\/j.reprotox.2025.109114_bib40","article-title":"Epigenetic Alterations of Serotonergic but not Dopaminergic Signalling in Compulsive Sexual Behaviour Disorder","author":"Androvi\u010dov\u00e1","year":"2025","journal-title":"Behav. Brain Res115872"},{"key":"10.1016\/j.reprotox.2025.109114_bib41","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jpsychires.2021.11.042","article-title":"Serotonin system-associated genetic and epigenetic changes in pedophilia and child sexual offending","volume":"145","author":"Jahn","year":"2022","journal-title":"J. Psychiatr. Res"},{"issue":"4","key":"10.1016\/j.reprotox.2025.109114_bib42","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s00439-013-1412-2","article-title":"SLC6A4 polymorphism, population genetics, and psychiatric traits","volume":"133","author":"Gelernter","year":"2014","journal-title":"Hum. Genet"},{"issue":"3","key":"10.1016\/j.reprotox.2025.109114_bib43","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.neuropharm.2011.01.012","article-title":"Irving Page Lecture: 5-HT(2A) serotonin receptor biology: interacting proteins, kinases and paradoxical regulation","volume":"61","author":"Roth","year":"2011","journal-title":"Neuropharmacology"},{"issue":"10","key":"10.1016\/j.reprotox.2025.109114_bib44","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/nrn4004","article-title":"Endocannabinoid signalling in reward and addiction","volume":"16","author":"Parsons","year":"2015","journal-title":"Nat. Rev. Neurosci."}],"container-title":["Reproductive Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623825002850?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623825002850?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T16:38:02Z","timestamp":1764952682000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0890623825002850"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":44,"alternative-id":["S0890623825002850"],"URL":"https:\/\/doi.org\/10.1016\/j.reprotox.2025.109114","relation":{},"ISSN":["0890-6238"],"issn-type":[{"value":"0890-6238","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Uncovering the molecular network of nicotine induced erectile dysfunction through network toxicology and mendelian randomization","name":"articletitle","label":"Article Title"},{"value":"Reproductive Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.reprotox.2025.109114","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109114"}}