{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T06:17:47Z","timestamp":1773209867985,"version":"3.50.1"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Toxicology"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.reprotox.2026.109165","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T16:43:51Z","timestamp":1767977031000},"page":"109165","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["The role of adenosine triphosphate in the treatment of linezolid-induced ovarian damage and reproductive dysfunction in rats: An investigation into the pathogenesis"],"prefix":"10.1016","volume":"140","author":[{"given":"Ilhan Bahri","family":"Delibasi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bulent","family":"Yavuzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bahadir","family":"Suleyman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neset","family":"Gumusburun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taha Abdulkadir","family":"Coban","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali Sefa","family":"Mendil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elif Esra","family":"Uyar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nurinisa","family":"Yucel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Halis","family":"Suleyman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.reprotox.2026.109165_bib1","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s00228-022-03446-4","article-title":"Linezolid pharmacokinetics: a systematic review for the best clinical practice","volume":"79","author":"Heidari","year":"2023","journal-title":"Eur. J. Clin. Pharm."},{"key":"10.1016\/j.reprotox.2026.109165_bib2","unstructured":"Azzouz A., Preuss C.V.Linezolid. 2024 Mar 1. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan\u2013. PMID: 30969615."},{"key":"10.1016\/j.reprotox.2026.109165_bib3","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1016\/j.biopha.2018.09.133","article-title":"Ameliorative effect of silymarin against linezolid-induced hepatotoxicity in methicillin-resistant Staphylococcus aureus (MRSA) infected Wistar rats","volume":"108","author":"Vivekanandan","year":"2018","journal-title":"Biomed. Pharm."},{"issue":"21","key":"10.1016\/j.reprotox.2026.109165_bib4","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1056\/NEJM200511243532123","article-title":"Mitochondrial toxicity associated with linezolid","volume":"353","author":"Soriano","year":"2005","journal-title":"N. Engl. J. Med"},{"issue":"6","key":"10.1016\/j.reprotox.2026.109165_bib5","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/ja.2014.21","article-title":"Effect of linezolid on hematological and oxidative parameters in rats","volume":"67","author":"Wang","year":"2014","journal-title":"J. Antibiot."},{"key":"10.1016\/j.reprotox.2026.109165_bib6","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/3128270","article-title":"Linezolid inhibited synthesis of ATP in mitochondria: based on GC-MS metabolomics and HPLC method","volume":"2018","author":"Ye","year":"2018","journal-title":"Biomed. Res. Int."},{"issue":"3","key":"10.1016\/j.reprotox.2026.109165_bib7","doi-asserted-by":"crossref","first-page":"298","DOI":"10.5152\/TurkArchPediatr.2023.21363","article-title":"The protective effects of pyridoxine on linezolid-induced hematological toxicity, hepatotoxicity, and oxidative stress in rats","volume":"58","author":"Kendir-Demirkol","year":"2023","journal-title":"Turk. Arch. Pedia"},{"issue":"1","key":"10.1016\/j.reprotox.2026.109165_bib8","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s40261-015-0352-0","article-title":"Thrombocytopenia in patients receiving prolonged linezolid may be caused by oxidative stress","volume":"36","author":"Wang","year":"2016","journal-title":"Clin. Drug Invest."},{"key":"10.1016\/j.reprotox.2026.109165_bib9","unstructured":"Dunn J., Grider M.H. Physiology, Adenosine Triphosphate. 2023 Feb 13. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan\u2013. PMID: 31985968."},{"issue":"2","key":"10.1016\/j.reprotox.2026.109165_bib10","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1080\/14620316.2000.11511231","article-title":"Changes in ATP, ADP and pyridine nucleotide levels related to the incidence of physiological disorders in \u2018Conference\u2019 pears and \u2018Jonagold\u2019 apples during controlled atmosphere storage","volume":"75","author":"Saquet","year":"2015","journal-title":"J. Hortic. Sci. Biotechnol."},{"issue":"1","key":"10.1016\/j.reprotox.2026.109165_bib11","doi-asserted-by":"crossref","first-page":"69","DOI":"10.4196\/kjpp.2021.25.1.69","article-title":"The effect of adenosine triphosphate on propofol-induced myopathy in rats: a biochemical and histopathological evaluation","volume":"25","author":"Erdem","year":"2021","journal-title":"Korean J. Physiol. Pharm."},{"issue":"6","key":"10.1016\/j.reprotox.2026.109165_bib12","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1210\/endrev\/bnab012","article-title":"Anti-mullerian hormone in female reproduction","volume":"42","author":"di Clemente","year":"2021","journal-title":"Endocr. Rev."},{"issue":"14","key":"10.1016\/j.reprotox.2026.109165_bib13","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1001\/jama.2017.14954","article-title":"Using antimullerian hormone to predict fertility","volume":"318","author":"Santoro","year":"2017","journal-title":"JAMA"},{"issue":"7","key":"10.1016\/j.reprotox.2026.109165_bib14","article-title":"The ARRIVE guidelines 2.0: updated guidelines for reporting animal research","volume":"18","author":"Percie du Sert","year":"2020","journal-title":"PLoS Biol."},{"issue":"2 3","key":"10.1016\/j.reprotox.2026.109165_bib15","first-page":"E255","article-title":"Ethical considerations regarding animal experimentation","volume":"63","author":"Kiani","year":"2022","journal-title":"J. Prev. Med Hyg."},{"issue":"2-3","key":"10.1016\/j.reprotox.2026.109165_bib16","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0009-8981(91)90067-M","article-title":"A simple method for determination of serum catalase activity and revision of reference range","volume":"196","author":"Goth","year":"1991","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.reprotox.2026.109165_bib17","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem"},{"key":"10.1016\/j.reprotox.2026.109165_bib18","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1279610","article-title":"Effects of different volumes of ovariectomy on fertility and offspring development of rats","volume":"14","author":"Yang","year":"2023","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.reprotox.2026.109165_bib19","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.toxlet.2019.05.006","article-title":"Mercury leads to features of polycystic ovary syndrome in rats","volume":"312","author":"Merlo","year":"2019","journal-title":"Toxicol. Lett."},{"issue":"9","key":"10.1016\/j.reprotox.2026.109165_bib20","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/j.ijsu.2013.06.007","article-title":"The protective effect of curcumin on ischemia-reperfusion injury in rat ovary","volume":"11","author":"Sak","year":"2013","journal-title":"Int J. Surg."},{"key":"10.1016\/j.reprotox.2026.109165_bib21","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.jgar.2020.02.032","article-title":"Oxidative stress response in reference and clinical Staphylococcus aureus strains under Linezolid exposure","volume":"22","author":"Martinez","year":"2020","journal-title":"J. Glob. Antimicrob. Resist"},{"issue":"1","key":"10.1016\/j.reprotox.2026.109165_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5487\/TR.2011.27.1.001","article-title":"Lipid peroxidation and its toxicological implications","volume":"27","author":"Nam","year":"2011","journal-title":"Toxicol. Res."},{"issue":"16","key":"10.1016\/j.reprotox.2026.109165_bib23","doi-asserted-by":"crossref","DOI":"10.3390\/molecules28165979","article-title":"Malondialdehyde as a potential oxidative stress marker for allergy-oriented diseases: an update","volume":"28","author":"Cordiano","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.reprotox.2026.109165_bib24","doi-asserted-by":"crossref","DOI":"10.1155\/2023\/6014706","article-title":"Assessment of oxidative stress by the estimation of lipid peroxidation marker malondialdehyde (MDA) in patients with chronic periodontitis: a systematic review and meta-analysis","volume":"2023","author":"Mohideen","year":"2023","journal-title":"Int. J. Dent."},{"key":"10.1016\/j.reprotox.2026.109165_bib25","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/736837","article-title":"Glutathione homeostasis and functions: potential targets for medical interventions","volume":"2012","author":"Lushchak","year":"2012","journal-title":"J. Amino Acids"},{"issue":"1","key":"10.1016\/j.reprotox.2026.109165_bib26","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.22942","article-title":"Imbalanced GSH\/ROS and sequential cell death","volume":"36","author":"Liu","year":"2022","journal-title":"J. Biochem. Mol. Toxicol."},{"issue":"4","key":"10.1016\/j.reprotox.2026.109165_bib27","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1080\/13813455.2018.1520891","article-title":"Superoxide dismutase: a review and a modified protocol for activities measurements in rat livers","volume":"126","author":"Campos-Shimada","year":"2020","journal-title":"Arch. Physiol. Biochem."},{"issue":"5","key":"10.1016\/j.reprotox.2026.109165_bib28","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1007\/s00204-024-03696-4","article-title":"Several lines of antioxidant defense against oxidative stress: antioxidant enzymes, nanomaterials with multiple enzyme-mimicking activities, and low-molecular-weight antioxidants","volume":"98","author":"Jomova","year":"2024","journal-title":"Arch. Toxicol."},{"issue":"8","key":"10.1016\/j.reprotox.2026.109165_bib29","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1016\/j.freeradbiomed.2006.07.015","article-title":"A new paradigm: manganese superoxide dismutase influences the production of H2O2 in cells and thereby their biological state","volume":"41","author":"Buettner","year":"2006","journal-title":"Free Radic. Biol. Med."},{"issue":"1","key":"10.1016\/j.reprotox.2026.109165_bib30","doi-asserted-by":"crossref","first-page":"71","DOI":"10.4149\/gpb_2020039","article-title":"The effect of adenosine triphosphate on bevacizumab-induced ovarian damage and reproductive dysfunction in rats","volume":"40","author":"Ince","year":"2021","journal-title":"Gen. Physiol. Biophys."},{"issue":"3","key":"10.1016\/j.reprotox.2026.109165_bib31","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.31557\/APJCP.2023.24.3.1007","article-title":"Protective effect of adenosine triphosphate against 5-Fluorouracil-induced oxidative ovarian damage in vivo","volume":"24","author":"Ozer","year":"2023","journal-title":"Asian Pac. J. Cancer Prev."},{"issue":"1","key":"10.1016\/j.reprotox.2026.109165_bib32","doi-asserted-by":"crossref","first-page":"122","DOI":"10.3390\/ph16010122","article-title":"Prolactin relationship with fertility and in vitro fertilization outcomes-a review of the literature","volume":"16","author":"Iancu","year":"2023","journal-title":"Pharmaceuticals"},{"issue":"2","key":"10.1016\/j.reprotox.2026.109165_bib33","first-page":"216","article-title":"Association of tramadol-induced ovarian damage and reproductive dysfunction with adenosine triphosphate and the protective role of exogenous atp treatment","volume":"18","author":"Gumusburun","year":"2025","journal-title":"Pharm. (Basel)"},{"issue":"6","key":"10.1016\/j.reprotox.2026.109165_bib34","doi-asserted-by":"crossref","DOI":"10.3390\/bios13060643","article-title":"Oxidative stress sensing system for 8-OHdG detection based on plasma coupled electrochemistry by transparent ITO\/AuNTAs\/PtNPs electrode","volume":"13","author":"Bai","year":"2023","journal-title":"Biosensors"},{"issue":"4","key":"10.1016\/j.reprotox.2026.109165_bib35","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.5114\/aoms.2017.72406","article-title":"Etanercept protects ovarian reserve against ischemia\/reperfusion injury in a rat model","volume":"15","author":"Eken","year":"2019","journal-title":"Arch. Med. Sci."},{"issue":"6","key":"10.1016\/j.reprotox.2026.109165_bib36","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1080\/17435390.2021.1936254","article-title":"8-Hydroxy-2\u2032-deoxyguanosine (8-OHdG) as a biomarker of oxidative DNA damage induced by occupational exposure to nanomaterials: a systematic review","volume":"15","author":"Omari Shekaftik","year":"2021","journal-title":"Nanotoxicology"},{"issue":"2","key":"10.1016\/j.reprotox.2026.109165_bib37","doi-asserted-by":"crossref","first-page":"79","DOI":"10.62425\/rtpharma.1467636","article-title":"Relationship between oxidative stress and cellular adenosine triphosphate levels","volume":"2","author":"Bulut","year":"2024","journal-title":"Recent Trends Pharmacol."}],"container-title":["Reproductive Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623826000080?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623826000080?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T08:25:13Z","timestamp":1773131113000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0890623826000080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":37,"alternative-id":["S0890623826000080"],"URL":"https:\/\/doi.org\/10.1016\/j.reprotox.2026.109165","relation":{},"ISSN":["0890-6238"],"issn-type":[{"value":"0890-6238","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of adenosine triphosphate in the treatment of linezolid-induced ovarian damage and reproductive dysfunction in rats: An investigation into the pathogenesis","name":"articletitle","label":"Article Title"},{"value":"Reproductive Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.reprotox.2026.109165","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109165"}}