{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:55:25Z","timestamp":1792000525822,"version":"4.4.0"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002336","name":"Daiichi Sankyo Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002336","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Toxicology"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.reprotox.2026.109176","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T16:53:17Z","timestamp":1769619197000},"page":"109176","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Reduced food consumption triggers abortion in antibiotic-treated pregnant rabbits: Insights from a pair-feeding study"],"prefix":"10.1016","volume":"140","author":[{"given":"Toshiki","family":"Matsuoka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiko","family":"Ohshima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumi","family":"Honda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Shirai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Sakurai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiharu","family":"Kuwata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.reprotox.2026.109176_bib1","unstructured":"ICH S5 Guidance on Reproductive Toxicology and Male Fertility: Detection of Toxicity to Reproduction for Medicinal Products. Fed Reg 1994;59:48746\u201348752."},{"key":"10.1016\/j.reprotox.2026.109176_bib2","first-page":"342","article-title":"Enigma of antibiotic-induced diarrhea in the laboratory rabbit","volume":"8","author":"Gray","year":"1966","journal-title":"Toxicol. Appl. Pharm."},{"key":"10.1016\/j.reprotox.2026.109176_bib3","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/0272-0590(86)90157-0","article-title":"Association between adverse maternal and embryo-fetal effects in norfloxacin-treated and food-deprived rabbits","volume":"7","author":"Clark","year":"1986","journal-title":"Fund. Appl. Toxicol."},{"key":"10.1016\/j.reprotox.2026.109176_bib4","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/0300-483X(81)90088-3","article-title":"Dietary deprivation induces fetal loss and abortion in rabbits","volume":"22","author":"Matsuzawa","year":"1981","journal-title":"Toxicology"},{"key":"10.1016\/j.reprotox.2026.109176_bib5","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1006\/faat.1993.1128","article-title":"Food restriction during organogenesis in rabbits: effects on reproduction and the offspring","volume":"21","author":"Petrere","year":"1993","journal-title":"Fundam. Appl. Toxicol."},{"key":"10.1016\/j.reprotox.2026.109176_bib6","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1002\/bdrb.20058","article-title":"Effects of feed restriction during organogenesis on embryo-fetal development in rabbit","volume":"74","author":"Cappon","year":"2005","journal-title":"Birth Defects Res. B"},{"key":"10.1016\/j.reprotox.2026.109176_bib7","doi-asserted-by":"crossref","first-page":"169","DOI":"10.2131\/jts.31.169","article-title":"Effects of stage and degree of restricted feeding on pregnancy outcome in rabbits","volume":"31","author":"Matsuoka","year":"2006","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.reprotox.2026.109176_bib8","doi-asserted-by":"crossref","first-page":"129","DOI":"10.2131\/jts.34.129","article-title":"Effects of restricted feeding on blood parameters in pregnant rabbits","volume":"34","author":"Matsuoka","year":"2009","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.reprotox.2026.109176_bib9","first-page":"e55","article-title":"American College of Obstetricians and Gynecologists' Committee on Practice Bulletins: Practice Bulletin. Anemia in Pregnancy","volume":"138","year":"2021","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.reprotox.2026.109176_bib10","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/0010-7824(93)90027-5","article-title":"Termination of early pregnancy in the rat, rabbit, and hamster with RU 486 and anordrin","volume":"47","author":"Chang","year":"1993","journal-title":"Contraception"},{"key":"10.1016\/j.reprotox.2026.109176_bib11","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/j.ajog.2004.11.061","article-title":"Dose response of RU486 in a novel rabbit model of noninfectious preterm birth: Comparative efficacy of 3 routes of administration","volume":"192","author":"Gorenberg","year":"2005","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.reprotox.2026.109176_bib12","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/S0022-2275(20)40127-0","article-title":"Aberrant hypothalamic-pituitary-ovarian axis in the Watanabe heritable hyperlipidemic rabbit","volume":"35","author":"Robins","year":"1994","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.reprotox.2026.109176_bib13","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1530\/REP-10-0378","article-title":"The effects of a high-fat, high-cholesterol diet on markers of uterine contractility during parturition in the rat","volume":"141","author":"Elmes","year":"2011","journal-title":"Reproduction"},{"key":"10.1016\/j.reprotox.2026.109176_bib14","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/S0022-2275(20)36712-2","article-title":"Cholesterol catabolism in the rabbit in fasted and fed states","volume":"16","author":"Klauda","year":"1975","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.reprotox.2026.109176_bib15","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1177\/0192623312466452","article-title":"Interpreting stress responses during routine toxicity studies: a review of the biology, impact, and assessment","volume":"41","author":"Everds","year":"2013","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.reprotox.2026.109176_bib16","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1071\/RD10298","article-title":"Acute fasting before conception affects metabolic and endocrine status without impacting follicle and oocyte development and embryo gene expression in the rabbit","volume":"23","author":"Garcia-Garcia","year":"2011","journal-title":"Reprod. Fertil. Dev."},{"key":"10.1016\/j.reprotox.2026.109176_bib17","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.jhep.2004.10.012","article-title":"The impact of intestinal microflora on serum bilirubin levels","volume":"42","author":"V\u00edtek","year":"2005","journal-title":"J. Hepatol."},{"key":"10.1016\/j.reprotox.2026.109176_bib18","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1097\/01.shk.0000111828.07309.26","article-title":"Antibiotic treatment in a murine model of sepsis: impact on cytokines and endotoxin release","volume":"21","author":"Vianna","year":"2004","journal-title":"Shock"},{"key":"10.1016\/j.reprotox.2026.109176_bib19","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1016\/0002-9378(90)90777-5","article-title":"A rabbit model for bacteria-induced preterm pregnancy loss","volume":"163","author":"Dombroski","year":"1990","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.reprotox.2026.109176_bib20","first-page":"222","article-title":"Bacteria-induced or bacterial product-induced preterm parturition in mice and rabbits is preceded by a significant fall in serum progesterone concentrations","volume":"7","author":"Fidel","year":"1998","journal-title":"J. Matern. Fetal Med."}],"container-title":["Reproductive Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623826000195?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623826000195?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T07:37:44Z","timestamp":1776152264000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0890623826000195"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":20,"alternative-id":["S0890623826000195"],"URL":"https:\/\/doi.org\/10.1016\/j.reprotox.2026.109176","relation":{},"ISSN":["0890-6238"],"issn-type":[{"value":"0890-6238","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reduced food consumption triggers abortion in antibiotic-treated pregnant rabbits: Insights from a pair-feeding study","name":"articletitle","label":"Article Title"},{"value":"Reproductive Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.reprotox.2026.109176","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109176"}}