{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T04:23:00Z","timestamp":1793161380519,"version":"4.5.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100012835","name":"Toho University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012835","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP23K11440"],"award-info":[{"award-number":["JP23K11440"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Toxicology"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.reprotox.2026.109236","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T08:01:52Z","timestamp":1775030512000},"page":"109236","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Environmentally relevant low-dose bisphenol A enhances invasion of human extravillous trophoblasts with associated increases in MMP activity"],"prefix":"10.1016","volume":"142","author":[{"given":"Shoko","family":"Ogushi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reina","family":"Abe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takehiro","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Nakanishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5138-5882","authenticated-orcid":false,"given":"Tomoki","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.reprotox.2026.109236_bib1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1210\/er.2008-0021","article-title":"Bisphenol-A and the great divide: a review of controversies in the field of endocrine disruption","volume":"30","author":"Vandenberg","year":"2009","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.reprotox.2026.109236_bib2","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1016\/j.scitotenv.2017.10.042","article-title":"Bisphenol A distribution in serum, urine, placenta, breast milk, and umbilical cord serum in a birth panel of mother\u2013neonate pairs","volume":"626","author":"Lee","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.reprotox.2026.109236_bib3","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.3390\/ani13152439","article-title":"An overview of the health effects of bisphenol a from a one health perspective","volume":"13","author":"Molina-L\u00f3pez","year":"2023","journal-title":"Animals"},{"key":"10.1016\/j.reprotox.2026.109236_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2022.1047827","article-title":"An insight into bisphenol A, food exposure and its adverse effects on health: a review","volume":"9","author":"Manzoor","year":"2022","journal-title":"Front Nutr."},{"key":"10.1016\/j.reprotox.2026.109236_bib5","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1586\/17474108.2013.811939","article-title":"Bisphenol A and human reproductive health","volume":"8","author":"Cantonwine","year":"2013","journal-title":"Expert Rev. Obstet. Gynecol."},{"key":"10.1016\/j.reprotox.2026.109236_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107617","article-title":"Abnormal histone replacement following BPA exposure affects spermatogenesis and fertility sequentially","volume":"170","author":"Ryu","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.reprotox.2026.109236_bib7","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1477-7827-12-37","article-title":"Bisphenol A and the female reproductive tract: an overview of recent laboratory evidence and epidemiological studies","volume":"12","author":"Caserta","year":"2014","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.reprotox.2026.109236_bib8","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/35080570","article-title":"Placental development: lessons from mouse mutants","volume":"2","author":"Rossant","year":"2001","journal-title":"Nat. Rev. Genet"},{"key":"10.1016\/j.reprotox.2026.109236_bib9","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1146\/annurev-cellbio-100814-125620","article-title":"Placenta: the forgotten organ","volume":"31","author":"Maltepe","year":"2015","journal-title":"Annu Rev. Cell Dev. Biol."},{"key":"10.1016\/j.reprotox.2026.109236_bib10","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.envres.2017.11.052","article-title":"Association between prenatal bisphenol A and phthalate exposures and fetal metabolic related biomarkers: the Hokkaido study on environment and children\u2019s health","volume":"161","author":"Minatoya","year":"2018","journal-title":"Environ. Res."},{"issue":"1968","key":"10.1016\/j.reprotox.2026.109236_bib11","first-page":"1467","article-title":"Human hormone production in vitro","volume":"159","author":"Pattillo","year":"1979","journal-title":"Science"},{"key":"10.1016\/j.reprotox.2026.109236_bib12","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1002\/rmb2.12347","article-title":"Unique features and emerging in vitro models of human placental development","volume":"19","author":"Shibata","year":"2020","journal-title":"Reprod. Med Biol."},{"key":"10.1016\/j.reprotox.2026.109236_bib13","doi-asserted-by":"crossref","first-page":"51507","DOI":"10.18632\/oncotarget.17882","article-title":"Bisphenol A exposure promotes HTR-8\/SVneo cell migration and impairs mouse placentation involving upregulation of integrin-\u03b21 and MMP-9 and stimulation of MAPK and PI3K signaling pathways","volume":"8","author":"Lan","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.reprotox.2026.109236_bib14","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1006\/excr.1993.1139","article-title":"Establishment and characterization of first trimester human trophoblast cells with extended lifespan","volume":"206","author":"Graham","year":"1993","journal-title":"Exp. Cell Res"},{"key":"10.1016\/j.reprotox.2026.109236_bib15","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1093\/toxsci\/kfac118","article-title":"Cadmium inhibits differentiation of human trophoblast stem cells into extravillous trophoblasts and disrupts epigenetic changes within the promoter region of the HLA-G gene","volume":"191","author":"Ogushi","year":"2023","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.reprotox.2026.109236_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/0471142735.ima03bs111","article-title":"Trypan blue exclusion test of cell viability","volume":"111","author":"Strober","year":"2015","journal-title":"Curr. Protoc. Immunol."},{"key":"10.1016\/j.reprotox.2026.109236_bib17","doi-asserted-by":"crossref","DOI":"10.1242\/dev.148932","article-title":"PLAC8, a new marker for human interstitial extravillous trophoblast cells, promotes their invasion and migration","volume":"145","author":"Chang","year":"2018","journal-title":"Development"},{"key":"10.1016\/j.reprotox.2026.109236_bib18","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.stem.2017.11.004","article-title":"Derivation of human trophoblast stem cells","volume":"22","author":"Okae","year":"2018","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.reprotox.2026.109236_bib19","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2203071119","article-title":"The multifaceted role of GCM1 during trophoblast differentiation in the human placenta","volume":"119","author":"Jeyarajah","year":"2022","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.reprotox.2026.109236_bib20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0232565","article-title":"An image J plugin for the high throughput image analysis of in vitro scratch wound healing assays","volume":"15","author":"Suarez-Arnedo","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.reprotox.2026.109236_bib21","doi-asserted-by":"crossref","DOI":"10.3791\/54719","article-title":"Automated quantification and analysis of cell counting procedures using imageJ Plugins","author":"O\u2019Brien","year":"2016","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.reprotox.2026.109236_bib22","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.reprotox.2019.07.001","article-title":"Effects of Bisphenol A on endogenous retroviral envelopes expression and trophoblast fusion in BeWo cells","volume":"89","author":"Narciso","year":"2019","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.reprotox.2026.109236_bib23","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.tox.2009.06.023","article-title":"Induction of cells differentiation and ABC transporters expression by a myco-estrogen, zearalenone, in human choriocarcinoma cell line (BeWo)","volume":"263","author":"Prouillac","year":"2009","journal-title":"Toxicology"},{"key":"10.1016\/j.reprotox.2026.109236_bib24","first-page":"14355","article-title":"Effect of bisphenol A on invasion ability of human trophoblastic cell line BeWo","volume":"8","author":"Wang","year":"2015","journal-title":"Int J. Clin. Exp. Pathol."},{"key":"10.1016\/j.reprotox.2026.109236_bib25","doi-asserted-by":"crossref","first-page":"289","DOI":"10.3390\/ijms21010289","article-title":"Traditional and new routes of trophoblast invasion and their implications for pregnancy diseases","volume":"21","author":"Huppertz","year":"2019","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.reprotox.2026.109236_bib26","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/s44294-024-00034-y","article-title":"Biological comparisons between pre-eclampsia and placenta accreta spectrum","volume":"2","author":"Bartels","year":"2024","journal-title":"Npj Women\u2019S. Health"},{"key":"10.1016\/j.reprotox.2026.109236_bib27","doi-asserted-by":"crossref","first-page":"9722","DOI":"10.3390\/ijms25179722","article-title":"The underlying molecular mechanisms of the placenta accreta spectrum: a narrative review","volume":"25","author":"Liz\u00e1rraga-Verdugo","year":"2024","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.reprotox.2026.109236_bib28","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1093\/biolre\/ioac001","article-title":"The impact of bisphenol A on the placenta","volume":"106","author":"Adu-Gyamfi","year":"2022","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.reprotox.2026.109236_bib29","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1289\/ehp.1002512","article-title":"Combinations of physiologic estrogens with xenoestrogens alter ERK phosphorylation profiles in rat pituitary cells","volume":"119","author":"Jeng","year":"2011","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.reprotox.2026.109236_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.jenvman.2025.125708","article-title":"Exploring the toxicological impact of bisphenol a exposure on psoriasis through network toxicology, machine learning, and multi-dimensional bioinformatics analysis","volume":"385","author":"Feng","year":"2025","journal-title":"J. Environ. Manag."},{"key":"10.1016\/j.reprotox.2026.109236_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2025.151678","article-title":"Bisphenol A enhanced cell migration through Kv3.4 in MCF7 cells","volume":"760","author":"Sim","year":"2025","journal-title":"Biochem Biophys. Res Commun."},{"key":"10.1016\/j.reprotox.2026.109236_bib32","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1067661","article-title":"Insights into the immunomodulatory regulation of matrix metalloproteinase at the maternal-fetal interface during early pregnancy and pregnancy-related diseases","volume":"13","author":"Jing","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.reprotox.2026.109236_bib33","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1136\/thorax.58.9.778","article-title":"Inhibition of MMP-9 expression by PPAR\u03b3 activators in human bronchial epithelial cells","volume":"58","author":"Hetzel","year":"2003","journal-title":"Thorax"},{"key":"10.1016\/j.reprotox.2026.109236_bib34","article-title":"The molecular mechanism of bisphenol A (BPA) as an endocrine disruptor by interacting with nuclear receptors: insights from molecular dynamics (MD) simulations","volume":"10","author":"Li","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.reprotox.2026.109236_bib35","doi-asserted-by":"crossref","first-page":"640","DOI":"10.3390\/biom14060640","article-title":"Structural studies on the binding mode of bisphenols to PPAR\u03b3","volume":"14","author":"Useini","year":"2024","journal-title":"Biomolecules"},{"key":"10.1016\/j.reprotox.2026.109236_bib36","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.reprotox.2021.11.008","article-title":"Extravillous trophoblast migration and invasion: impact of environmental chemicals and pharmaceuticals","volume":"107","author":"Meakin","year":"2022","journal-title":"Reprod. Toxicol."}],"container-title":["Reproductive Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623826000791?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623826000791?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T16:35:12Z","timestamp":1776184512000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0890623826000791"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":36,"alternative-id":["S0890623826000791"],"URL":"https:\/\/doi.org\/10.1016\/j.reprotox.2026.109236","relation":{},"ISSN":["0890-6238"],"issn-type":[{"value":"0890-6238","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Environmentally relevant low-dose bisphenol A enhances invasion of human extravillous trophoblasts with associated increases in MMP activity","name":"articletitle","label":"Article Title"},{"value":"Reproductive Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.reprotox.2026.109236","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109236"}}