{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T10:18:07Z","timestamp":1783160287051,"version":"3.54.6"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFC2701000"],"award-info":[{"award-number":["2021YFC2701000"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFC2701001"],"award-info":[{"award-number":["2021YFC2701001"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People&apos;s Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Toxicology"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.reprotox.2026.109254","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T06:14:51Z","timestamp":1777011291000},"page":"109254","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Mercury chloride exposure disrupts placental function and embryonic methionine metabolism leading to neural tube defects in ICR mice"],"prefix":"10.1016","volume":"143","author":[{"given":"Xin","family":"Fu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biyun","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zemin","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3254-9105","authenticated-orcid":false,"given":"Lei","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.reprotox.2026.109254_bib1","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1097\/00007632-199404000-00018","article-title":"Prevalence of incidental intraspinal lipoma of the lumbosacral spine as determined by MRI","volume":"19","author":"Brown","year":"1994","journal-title":"Spine (Philos. Pa 1976)"},{"issue":"6123","key":"10.1016\/j.reprotox.2026.109254_bib2","doi-asserted-by":"crossref","DOI":"10.1126\/science.1222002","article-title":"The continuing challenge of understanding, preventing, and treating neural tube defects","volume":"339","author":"Wallingford","year":"2013","journal-title":"Science"},{"issue":"7","key":"10.1016\/j.reprotox.2026.109254_bib3","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1007\/s00381-023-05910-7","article-title":"Neural tube defects: a review of global prevalence, causes, and primary prevention","volume":"39","author":"Kancherla","year":"2023","journal-title":"Childs Nerv. Syst."},{"issue":"26","key":"10.1016\/j.reprotox.2026.109254_bib4","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1056\/NEJM199212243272602","article-title":"Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation","volume":"327","author":"Czeizel","year":"1992","journal-title":"N. Engl. J. Med"},{"key":"10.1016\/j.reprotox.2026.109254_bib5","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1016\/j.envpol.2019.03.093","article-title":"Mercury emission from industrially contaminated soils in relation to chemical, microbial, and meteorological factors","volume":"250","author":"Osterwalder","year":"2019","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.reprotox.2026.109254_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2025.126284","article-title":"Climate change, mercury pollution, and global ecology","volume":"375","author":"Bank","year":"2025","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.reprotox.2026.109254_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2021.106425","article-title":"Total mercury concentration in placental tissue, a good biomarker of prenatal mercury exposure, is associated with risk for neural tube defects in offspring","volume":"150","author":"Tong","year":"2021","journal-title":"Environ. Int"},{"key":"10.1016\/j.reprotox.2026.109254_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2025.138088","article-title":"Exposure to a contaminated environment and its relationship with human health: mercury effect on loss of functionality and increased oxidative stress of blood cells","volume":"492","author":"Queiroz","year":"2025","journal-title":"J. Hazard Mater."},{"issue":"1","key":"10.1016\/j.reprotox.2026.109254_bib9","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s00204-016-1803-y","article-title":"Mechanisms involved in the transport of mercuric ions in target tissues","volume":"91","author":"Bridges","year":"2017","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.reprotox.2026.109254_bib10","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.tox.2015.12.005","article-title":"Mercury toxicokinetics of the healthy human term placenta involve amino acid transporters and ABC transporters","volume":"340","author":"Straka","year":"2016","journal-title":"Toxicology"},{"issue":"1","key":"10.1016\/j.reprotox.2026.109254_bib11","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s40880-018-0288-x","article-title":"Amino acid transporter SLC7A11\/xCT at the crossroads of regulating redox homeostasis and nutrient dependency of cancer","volume":"38","author":"Koppula","year":"2018","journal-title":"Cancer Commun (Lond)"},{"issue":"1","key":"10.1016\/j.reprotox.2026.109254_bib12","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1152\/physrev.00025.2013","article-title":"The organic anion transporter (OAT) family: a systems biology perspective","volume":"95","author":"Nigam","year":"2015","journal-title":"Physiol. Rev."},{"issue":"1","key":"10.1016\/j.reprotox.2026.109254_bib13","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s12011-017-1163-3","article-title":"MRP2 and the transport kinetics of cysteine conjugates of inorganic mercury","volume":"184","author":"Oliveira","year":"2018","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.reprotox.2026.109254_bib14","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.etap.2018.12.020","article-title":"Investigation of the differential transport mechanism of cinnabar and mercury containing compounds","volume":"66","author":"Wang","year":"2019","journal-title":"Environ. Toxicol. Pharm."},{"issue":"1","key":"10.1016\/j.reprotox.2026.109254_bib15","doi-asserted-by":"crossref","DOI":"10.1002\/cbf.3926","article-title":"One carbon metabolism and its implication in health and immune functions","volume":"42","author":"Dang","year":"2024","journal-title":"Cell Biochem Funct."},{"key":"10.1016\/j.reprotox.2026.109254_bib16","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.mce.2016.06.006","article-title":"One carbon metabolism in pregnancy: impact on maternal, fetal and neonatal health","volume":"435","author":"Kalhan","year":"2016","journal-title":"Mol. Cell Endocrinol."},{"issue":"17","key":"10.1016\/j.reprotox.2026.109254_bib17","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25179339","article-title":"Unveiling the therapeutic potential of folate-dependent one-carbon metabolism in cancer and neurodegeneration","volume":"25","author":"Sobral","year":"2024","journal-title":"Int J. Mol. Sci."},{"issue":"14","key":"10.1016\/j.reprotox.2026.109254_bib18","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1016\/j.devcel.2022.06.008","article-title":"A ROS-dependent mechanism promotes CDK2 phosphorylation to drive progression through S phase","volume":"57","author":"Kirova","year":"2022","journal-title":"Dev. Cell"},{"issue":"1","key":"10.1016\/j.reprotox.2026.109254_bib19","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1002\/ptr.7601","article-title":"6-Methoxydihydrosanguinarine induces apoptosis and autophagy in breast cancer MCF-7 cells by accumulating ROS to suppress the PI3K\/AKT\/mTOR signaling pathway","volume":"37","author":"Zhang","year":"2023","journal-title":"Phytother. Res"},{"issue":"1","key":"10.1016\/j.reprotox.2026.109254_bib20","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/s41392-026-02583-x","article-title":"Reactive oxygen species (ROS) in cancer: from mechanism to therapeutic implications","volume":"11","author":"Akter","year":"2026","journal-title":"Signal Transduct. Target Ther."},{"key":"10.1016\/j.reprotox.2026.109254_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2025.127121","article-title":"Experimental evidence for maternal offloading of mercury pollution via reproduction","volume":"385","author":"Beccardi","year":"2025","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.reprotox.2026.109254_bib22","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1186\/1475-2840-11-147","article-title":"Myocardial dysfunction in patients with type 2 diabetes mellitus: role of endothelial progenitor cells and oxidative stress","volume":"11","author":"Zhao","year":"2012","journal-title":"Cardiovasc Diabetol."},{"issue":"1","key":"10.1016\/j.reprotox.2026.109254_bib23","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1038\/s41467-024-46722-w","article-title":"Structural basis for autoinhibition by the dephosphorylated regulatory domain of Ycf1","volume":"15","author":"Khandelwal","year":"2024","journal-title":"Nat. Commun."},{"issue":"8","key":"10.1016\/j.reprotox.2026.109254_bib24","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1017\/S0031182012000315","article-title":"Does the acanthocephalan parasite Polymorphus minutus modify the energy reserves and antitoxic defences of its intermediate host Gammarus roeseli","volume":"139","author":"Gismondi","year":"2012","journal-title":"Parasitology"},{"issue":"5","key":"10.1016\/j.reprotox.2026.109254_bib25","doi-asserted-by":"crossref","first-page":"704","DOI":"10.3897\/folmed.63.e56110","article-title":"Evaluation of oxidative stress biomarkers in acute mercury intoxication","volume":"63","author":"Dalkiran","year":"2021","journal-title":"Folia Med (Plovdiv. )"},{"issue":"1","key":"10.1016\/j.reprotox.2026.109254_bib26","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1080\/13880209.2020.1865409","article-title":"Comparison of the antioxidant activities of nonfumigated and sulphur-fumigated Chrysanthemum morifolium cv. Hang-ju induced by oxidative stress","volume":"59","author":"Ma","year":"2021","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.reprotox.2026.109254_bib27","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.abb.2019.01.039","article-title":"Transport of cystine across xC(-) antiporter","volume":"664","author":"Ghasemitarei","year":"2019","journal-title":"Arch. Biochem Biophys."},{"issue":"10","key":"10.1016\/j.reprotox.2026.109254_bib28","first-page":"3106","article-title":"SLC7A11\/xCT in cancer: biological functions and therapeutic implications","volume":"10","author":"Lin","year":"2020","journal-title":"Am. J. Cancer Res"},{"issue":"2","key":"10.1016\/j.reprotox.2026.109254_bib29","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1007\/s004240100537","article-title":"Identification and characterisation of human xCT that co-expresses, with 4F2 heavy chain, the amino acid transport activity system xc","volume":"442","author":"Bassi","year":"2001","journal-title":"Pflug. Arch."},{"key":"10.1016\/j.reprotox.2026.109254_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2022.115241","article-title":"The amino acid transporter SLC7A11-mediated crosstalk implicated in cancer therapy and the tumor microenvironment","volume":"205","author":"He","year":"2022","journal-title":"Biochem Pharm."},{"issue":"6","key":"10.1016\/j.reprotox.2026.109254_bib31","doi-asserted-by":"crossref","DOI":"10.1093\/pnasnexus\/pgae207","article-title":"Trophoblast-specific overexpression of the LAT1 increases transplacental transport of essential amino acids and fetal growth in mice","volume":"3","author":"Rosario","year":"2024","journal-title":"PNAS Nexus"},{"issue":"7","key":"10.1016\/j.reprotox.2026.109254_bib32","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1002\/bdra.20286","article-title":"Integrity of the methylation cycle is essential for mammalian neural tube closure","volume":"76","author":"Dunlevy","year":"2006","journal-title":"Birth Defects Res A Clin. Mol. Teratol."},{"issue":"1","key":"10.1016\/j.reprotox.2026.109254_bib33","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s13072-021-00426-3","article-title":"Ethionine-mediated reduction of S-adenosylmethionine is responsible for the neural tube defects in the developing mouse embryo-mediated m6A modification and is involved in neural tube defects via modulating Wnt\/\u03b2-catenin signaling pathway","volume":"14","author":"Zhang","year":"2021","journal-title":"Epigenetics Chromatin"},{"issue":"1","key":"10.1016\/j.reprotox.2026.109254_bib34","doi-asserted-by":"crossref","DOI":"10.1002\/jcp.31452","article-title":"Ethionine-induced S-adenosylmethionine deficiency suppressed H3K27me3 and cell differentiation during neural tube development in mice","volume":"240","author":"Zhang","year":"2025","journal-title":"J. Cell Physiol."},{"issue":"5","key":"10.1016\/j.reprotox.2026.109254_bib35","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1289\/ehp.02110s5689","article-title":"Transport of toxic metals by molecular mimicry","volume":"110","author":"Ballatori","year":"2002","journal-title":"Environ. Health Perspect."}],"container-title":["Reproductive Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623826000973?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623826000973?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T09:52:52Z","timestamp":1783158772000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0890623826000973"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":35,"alternative-id":["S0890623826000973"],"URL":"https:\/\/doi.org\/10.1016\/j.reprotox.2026.109254","relation":{},"ISSN":["0890-6238"],"issn-type":[{"value":"0890-6238","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mercury chloride exposure disrupts placental function and embryonic methionine metabolism leading to neural tube defects in ICR mice","name":"articletitle","label":"Article Title"},{"value":"Reproductive Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.reprotox.2026.109254","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109254"}}