{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T20:18:14Z","timestamp":1788293894465,"version":"build-2803163510"},"reference-count":97,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["401510"],"award-info":[{"award-number":["401510"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Toxicology"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.reprotox.2026.109270","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T16:08:08Z","timestamp":1779984488000},"page":"109270","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["miR-to-miR interactions: Investigating the effects of miR-21 down-regulation and bisphenol exposure in COCs, arrested 8-cell embryos and blastocysts"],"prefix":"10.1016","volume":"143","author":[{"given":"Fiona K.","family":"McIlhargey-Larkin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmine E.","family":"Vandervelden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reem","family":"Sabry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5757-568X","authenticated-orcid":false,"given":"Laura A.","family":"Favetta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.reprotox.2026.109270_bib1","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.3390\/biomedicines10071689","article-title":"An interplay between epigenetics and translation in oocyte maturation and embryo development: assisted reproduction perspective","volume":"10","author":"Dvoran","year":"2022","journal-title":"Biomedicines"},{"issue":"3","key":"10.1016\/j.reprotox.2026.109270_bib2","article-title":"A descriptive analysis of a fertility services waitlist in Eastern Canada","volume":"5","author":"Murphy","year":"2025","journal-title":"AJOG Glob. Rep."},{"issue":"3","key":"10.1016\/j.reprotox.2026.109270_bib3","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1093\/humrep\/der465","article-title":"Estimating the prevalence of infertility in Canada","volume":"27","author":"Bushnik","year":"2012","journal-title":"Hum. Reprod. Oxf. Engl."},{"issue":"1","key":"10.1016\/j.reprotox.2026.109270_bib4","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1001\/jama.2021.4788","article-title":"Diagnosis and management of infertility","volume":"326","author":"Carson","year":"2021","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/j.reprotox.2026.109270_bib5","doi-asserted-by":"crossref","first-page":"237","DOI":"10.3390\/biomedicines12010237","article-title":"Genetic and epigenetic profiles of polycystic ovarian syndrome and in vitro bisphenol exposure in a human granulosa cell model","volume":"12","author":"Sabry","year":"2024","journal-title":"Biomedicines"},{"issue":"2","key":"10.1016\/j.reprotox.2026.109270_bib6","article-title":"Identification and validation of genes involved in energy metabolism in polycystic ovary syndrome","volume":"23","author":"Zhang","year":"2025","journal-title":"Iran. J. Biotechnol."},{"issue":"1","key":"10.1016\/j.reprotox.2026.109270_bib7","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s13238-020-00757-z","article-title":"Insights into epigenetic patterns in mammalian early embryos","volume":"12","author":"Xu","year":"2021","journal-title":"Protein Cell."},{"issue":"42","key":"10.1016\/j.reprotox.2026.109270_bib8","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1146\/annurev-environ-102016-061111","article-title":"Marked for life: epigenetic effects of endocrine disrupting chemicals","volume":"42","author":"Jacobs","year":"2017","journal-title":"Annu. Rev. Environ. Resour."},{"key":"10.1016\/j.reprotox.2026.109270_bib9","series-title":"Human Reproductive and Prenatal Genetics","first-page":"173","article-title":"Chapter 8 - Epigenetic Control of Oocyte Development","author":"Viveiros","year":"2019"},{"key":"10.1016\/j.reprotox.2026.109270_bib10","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.7892.1","article-title":"Oocyte maturation and development","volume":"5","author":"Verlhac","year":"2016","journal-title":"F1000Research"},{"issue":"6","key":"10.1016\/j.reprotox.2026.109270_bib11","doi-asserted-by":"crossref","first-page":"121","DOI":"10.3390\/diseases12060121","article-title":"Oocyte maturation and miRNAs: studying a complicate interaction to reveal possible biomarkers for female infertility","volume":"12","author":"Nazou","year":"2024","journal-title":"Diseases"},{"key":"10.1016\/j.reprotox.2026.109270_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2024.114941","article-title":"Oocyte maturation, blastocyst and embryonic development are mediated and enhanced via hormesis","volume":"192","author":"Calabrese","year":"2024","journal-title":"Food Chem. Toxicol."},{"issue":"12","key":"10.1016\/j.reprotox.2026.109270_bib13","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1016\/j.stem.2023.09.010","article-title":"Epigenetic regulation of early human embryo development","volume":"30","author":"Wilkinson","year":"2023","journal-title":"Cell. Stem Cell."},{"issue":"1","key":"10.1016\/j.reprotox.2026.109270_bib14","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.tcb.2023.05.009","article-title":"miRNA dosage control in development and human disease","volume":"34","author":"Cui","year":"2024","journal-title":"Trends Cell. Biol."},{"issue":"11","key":"10.1016\/j.reprotox.2026.109270_bib15","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.5713\/ajas.19.0707","article-title":"MicroRNAs regulate granulosa cells apoptosis and follicular development \u2014 A review","volume":"33","author":"Gong","year":"2020","journal-title":"Asian-Australas. J. Anim. Sci."},{"key":"10.1016\/j.reprotox.2026.109270_bib16","article-title":"MicroRNA mediating networks in granulosa cells associated with ovarian follicular development","volume":"2017","author":"Zhang","year":"2017","journal-title":"BioMed. Res. Int. Vol."},{"issue":"3","key":"10.1016\/j.reprotox.2026.109270_bib17","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.cub.2009.12.044","article-title":"MicroRNA function is globally suppressed in mouse oocytes and early embryos","volume":"20","author":"Suh","year":"2010","journal-title":"Curr. Biol."},{"issue":"3","key":"10.1016\/j.reprotox.2026.109270_bib18","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1080\/15476286.2015.1017238","article-title":"Unveiling the principle of microRNA-mediated redundancy in cellular pathway regulation","volume":"12","author":"Fischer","year":"2015","journal-title":"RNA Biol."},{"issue":"4","key":"10.1016\/j.reprotox.2026.109270_bib19","doi-asserted-by":"crossref","first-page":"dmm047662","DOI":"10.1242\/dmm.047662","article-title":"miRNA interplay: mechanisms and consequences in cancer","volume":"14","author":"Hill","year":"2021","journal-title":"Dis. Model. Mech."},{"issue":"12","key":"10.1016\/j.reprotox.2026.109270_bib20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.0030215","article-title":"Most Caenorhabditis elegans microRNAs are individually not essential for development or viability","volume":"3","author":"Miska","year":"2007","journal-title":"PLoS. Genet."},{"issue":"21","key":"10.1016\/j.reprotox.2026.109270_bib21","doi-asserted-by":"crossref","first-page":"6284","DOI":"10.1093\/nar\/gkh968","article-title":"Substrate requirements for let-7 function in the developing zebrafish embryo","volume":"32","author":"Kloosterman","year":"2004","journal-title":"Nucleic Acids Res."},{"issue":"7","key":"10.1016\/j.reprotox.2026.109270_bib22","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.4161\/rna.24955","article-title":"The human transcriptome is enriched for miRNA-binding sites located in cooperativity-permitting distance","volume":"10","author":"Rinck","year":"2013","journal-title":"RNA Biol."},{"key":"10.1016\/j.reprotox.2026.109270_bib23","doi-asserted-by":"crossref","unstructured":"D. Pati\u00f1o-Garc\u00eda, L. Cruz-Fernandes, J. Bu\u00f1ay, R. Orellana, and R.D. Moreno, \u201cDaily exposure to phthalates and alkylphenols alters miR biogenesis and expression in mice ovaries,\u201d Nov. 2020, doi: 10.1530\/JME-20-0149.","DOI":"10.1530\/JME-20-0149"},{"issue":"15","key":"10.1016\/j.reprotox.2026.109270_bib24","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23158276","article-title":"BPA Decreases PDCD4 in Bovine Granulosa Cells Independently of miR-21 Inhibition","volume":"23","author":"Sabry","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.reprotox.2026.109270_bib25","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.fertnstert.2014.11.005","article-title":"A new chapter in the bisphenol A story: bisphenol S and bisphenol F are not safe alternatives to this compound","volume":"103","author":"Eladak","year":"2015","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.reprotox.2026.109270_bib26","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.taap.2018.02.011","article-title":"Bisphenol A alters oocyte maturation by prematurely closing gap junctions in the cumulus cell-oocyte complex","volume":"344","author":"Acu\u00f1a-Hern\u00e1ndez","year":"2018","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.reprotox.2026.109270_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2025.112555","article-title":"Impact of BPA and its analogs on sperm hyperactivity, acrosome reaction, epigenetic profiles and in vitro embryo development","volume":"604","author":"Davis","year":"2025","journal-title":"Mol. Cell. Endocrinol."},{"issue":"2","key":"10.1016\/j.reprotox.2026.109270_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.repbio.2025.101026","article-title":"Are BPA effects on Connexins and key downstream microRNAs in bovine COCs correlated to miR-21 expression?","volume":"25","author":"Goncalves","year":"2025","journal-title":"Reprod. Biol."},{"key":"10.1016\/j.reprotox.2026.109270_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2022.111574","article-title":"BPA and its analogs increase oxidative stress levels in in vitro cultured granulosa cells by altering anti-oxidant enzymes expression","volume":"545","author":"Sabry","year":"2022","journal-title":"Mol. Cell. Endocrinol."},{"issue":"15","key":"10.1016\/j.reprotox.2026.109270_bib30","doi-asserted-by":"crossref","DOI":"10.3390\/ani13152439","article-title":"An overview of the health effects of bisphenol a from a one health perspective","volume":"13","author":"Molina-L\u00f3pez","year":"2023","journal-title":"Animals"},{"key":"10.1016\/j.reprotox.2026.109270_bib31","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/s12958-021-00773-6","article-title":"BPA and BPS affect the expression of anti-Mullerian hormone (AMH) and its receptor during bovine oocyte maturation and early embryo development","volume":"19","author":"Saleh","year":"2021","journal-title":"Reprod. Biol. Endocrinol. RBE"},{"key":"10.1016\/j.reprotox.2026.109270_bib32","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.reprotox.2015.12.002","article-title":"BPA exposure during in vitro oocyte maturation results in dose-dependent alterations to embryo development rates, apoptosis rate, sex ratio and gene expression","volume":"59","author":"Ferris","year":"2016","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.reprotox.2026.109270_bib33","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.reprotox.2020.12.001","article-title":"Effects of bisphenol A and bisphenol S on microRNA expression during bovine (Bos taurus) oocyte maturation and early embryo development","volume":"99","author":"Sabry","year":"2021","journal-title":"Reprod. Toxicol."},{"issue":"3","key":"10.1016\/j.reprotox.2026.109270_bib34","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0032754","article-title":"Endocrine Disruptor Regulation of MicroRNA Expression in Breast Carcinoma Cells","volume":"7","author":"Tilghman","year":"2012","journal-title":"PLOS ONE"},{"key":"10.1016\/j.reprotox.2026.109270_bib35","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2023.1294541","article-title":"The relationship between miR-21, DNA methylation, and bisphenol a in bovine COCs and granulosa cells","volume":"11","author":"Sabry","year":"2023","journal-title":"Front. Cell. Dev. Biol."},{"key":"10.1016\/j.reprotox.2026.109270_bib36","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ydbio.2021.08.008","article-title":"MicroRNA-21 is involved in oocyte maturation, blastocyst formation, and pre-implantation embryo development","volume":"480","author":"Dehghan","year":"2021","journal-title":"Dev. Biol."},{"issue":"11","key":"10.1016\/j.reprotox.2026.109270_bib37","doi-asserted-by":"crossref","first-page":"5363","DOI":"10.3390\/ijms26115363","article-title":"Exosomal communication between cumulus\u2013oocyte complexes and granulosa cells: a new molecular axis for oocyte competence in human-assisted reproduction","volume":"26","author":"Voros","year":"2025","journal-title":"Int. J. Mol. Sci."},{"issue":"10","key":"10.1016\/j.reprotox.2026.109270_bib38","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1002\/mrd.23641","article-title":"MicroRNA21 inhibition affects porcine oocyte maturation and alters protein expression critical for metabolic pathway function","volume":"89","author":"Li","year":"2022","journal-title":"Mol. Reprod. Dev."},{"issue":"1","key":"10.1016\/j.reprotox.2026.109270_bib39","doi-asserted-by":"crossref","DOI":"10.1289\/EHP14888","article-title":"Impact of maternal BPA exposure during pregnancy on obesity in male offspring: a mechanistic mouse study of adipose-derived exosomal miRNA","volume":"133","author":"Huang","year":"2025","journal-title":"Environ. Health Perspect."},{"issue":"1","key":"10.1016\/j.reprotox.2026.109270_bib40","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/1477-7827-12-117","article-title":"Usefulness of bovine and porcine IVM\/IVF models for reproductive toxicology","volume":"12","author":"Santos","year":"2014","journal-title":"Reprod. Biol. Endocrinol."},{"issue":"6","key":"10.1016\/j.reprotox.2026.109270_bib41","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1093\/molehr\/gat006","article-title":"Evolutionary conservation of the oocyte transcriptome among vertebrates and its implications for understanding human reproductive function","volume":"19","author":"Sylvestre","year":"2013","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.reprotox.2026.109270_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2024.148703","article-title":"Role of miRNAs in assisted reproductive technology","volume":"927","author":"Nadri","year":"2024","journal-title":"Gene"},{"issue":"1","key":"10.1016\/j.reprotox.2026.109270_bib43","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.anireprosci.2014.05.016","article-title":"Genome activation in bovine embryos: Review of the literature and new insights from RNA sequencing experiments","volume":"149","author":"Graf","year":"2014","journal-title":"Anim. Reprod. Sci."},{"issue":"9","key":"10.1016\/j.reprotox.2026.109270_bib44","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1093\/molehr\/gas015","article-title":"Analysis of microRNAs and their precursors in bovine early embryonic development","volume":"18","author":"Mondou","year":"2012","journal-title":"MHR Basic. Sci. Reprod. Med."},{"issue":"22","key":"10.1016\/j.reprotox.2026.109270_bib45","doi-asserted-by":"crossref","first-page":"32554","DOI":"10.18632\/oncotarget.8689","article-title":"The toxic effects and possible mechanisms of Bisphenol A on oocyte maturation of porcine in vitro","volume":"7","author":"Wang","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.reprotox.2026.109270_bib46","article-title":"Roles of miR-10a-5p and miR-103a-3p, Regulators of BDNF Expression in Follicular Fluid, in the Outcomes of IVF-ET","volume":"12","author":"Zhang","year":"2021","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.reprotox.2026.109270_bib47","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.mod.2016.12.004","article-title":"MicroRNA-224 delays oocyte maturation through targeting Ptx3 in cumulus cells","volume":"143","author":"Li","year":"2017","journal-title":"Mech. Dev."},{"issue":"3","key":"10.1016\/j.reprotox.2026.109270_bib48","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1093\/biolre\/ioaa098","article-title":"MiRNA-155 regulates cumulus cells function, oocyte maturation, and blastocyst formation","volume":"103","author":"Dehghan","year":"2020","journal-title":"Biol. Reprod."},{"issue":"6","key":"10.1016\/j.reprotox.2026.109270_bib49","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/s41419-018-0713-8","article-title":"Placental exosome-mediated Bta-miR-499-Lin28B\/let-7 axis regulates inflammatory bias during early pregnancy","volume":"9","author":"Zhao","year":"2018","journal-title":"Cell. Death Dis."},{"issue":"6","key":"10.1016\/j.reprotox.2026.109270_bib50","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/s41419-021-03831-4","article-title":"Long non-coding RNA Xist regulates oocyte loss via suppressing miR-23b-3p\/miR-29a-3p maturation and upregulating STX17 in perinatal mouse ovaries","volume":"12","author":"Zhou","year":"2021","journal-title":"Cell. Death Dis."},{"key":"10.1016\/j.reprotox.2026.109270_bib51","doi-asserted-by":"crossref","first-page":"17777","DOI":"10.1038\/s41598-020-74961-6","article-title":"vitro maturation in the presence of Leukemia Inhibitory Factor modulates gene and miRNA expression in bovine oocytes and embryos","volume":"10","author":"Vendrell-Flotats","year":"2020","journal-title":"Sci. Rep."},{"issue":"11","key":"10.1016\/j.reprotox.2026.109270_bib52","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1007\/s10815-009-9368-9","article-title":"Does first polar body morphology predict oocyte performance during ICSI treatment?","volume":"26","author":"Younis","year":"2009","journal-title":"J. Assist. Reprod. Genet."},{"issue":"4","key":"10.1016\/j.reprotox.2026.109270_bib53","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1373\/clinchem.2008.112797","article-title":"The MIQE Guidelines: Minimum Information for Publication of Quantitative Real-Time PCR Experiments","volume":"55","author":"Bustin","year":"2009","journal-title":"Clin. Chem."},{"key":"10.1016\/j.reprotox.2026.109270_bib54","unstructured":"A. Hooper, \u201cMicroRNA Regulation of Ovarian Angiogenesis and Folliculogenesis in Bovine Cystic Ovarian Disease,\u201d University of Guelph, 2018. Accessed: Apr. 06, 2025. [Online]. Available: \u3008http:\/\/hdl.handle.net\/10214\/13920\u3009."},{"issue":"5","key":"10.1016\/j.reprotox.2026.109270_bib55","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.febslet.2007.01.081","article-title":"Identification and characterization of microRNAs from the bovine adipose tissue and mammary gland","volume":"581","author":"Gu","year":"2007","journal-title":"FEBS Lett."},{"issue":"11","key":"10.1016\/j.reprotox.2026.109270_bib56","doi-asserted-by":"crossref","DOI":"10.1177\/1010428317717140","article-title":"Normalizers for microRNA quantification in plasma of patients with vulvar intraepithelial neoplasia lesions and vulvar carcinoma","volume":"39","author":"Zalewski","year":"2017","journal-title":"Tumor Biol."},{"issue":"1","key":"10.1016\/j.reprotox.2026.109270_bib57","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1186\/s12964-022-00992-3","article-title":"Role of miRNAs interference on ovarian functions and premature ovarian failure","volume":"20","author":"Nouri","year":"2022","journal-title":"Cell. Commun. Signal."},{"key":"10.1016\/j.reprotox.2026.109270_bib58","article-title":"MicroRNA-146b negatively affects bovine embryo development and quality","author":"Pavani","year":"2023","journal-title":"Reproduction"},{"key":"10.1016\/j.reprotox.2026.109270_bib59","doi-asserted-by":"crossref","first-page":"611","DOI":"10.3389\/fimmu.2014.00611","article-title":"\u201cThe Role of microRNAs in Bovine Infection and Immunity,\u201d","volume":"5","author":"Lawless","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.reprotox.2026.109270_bib60","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.3959","article-title":"Comparative analysis of the microRNA transcriptome between yak and cattle provides insight into high-altitude adaptation","volume":"5","author":"Guan","year":"2017","journal-title":"PeerJ"},{"issue":"1","key":"10.1016\/j.reprotox.2026.109270_bib61","doi-asserted-by":"crossref","first-page":"dvab011","DOI":"10.1093\/eep\/dvab011","article-title":"Different bisphenols induce non-monotonous changes in miRNA expression and LINE-1 methylation in two cell lines","volume":"7","author":"Oldenburg","year":"2021","journal-title":"Environ. Epigenetics"},{"issue":"8","key":"10.1016\/j.reprotox.2026.109270_bib62","doi-asserted-by":"crossref","first-page":"2584","DOI":"10.1093\/nar\/gkp117","article-title":"Estradiol downregulates miR-21 expression and increases miR-21 target gene expression in MCF-7 breast cancer cells","volume":"37","author":"Wickramasinghe","year":"2009","journal-title":"Nucleic Acids Res."},{"issue":"14","key":"10.1016\/j.reprotox.2026.109270_bib63","doi-asserted-by":"crossref","first-page":"4850","DOI":"10.1093\/nar\/gkp500","article-title":"Estradiol-regulated microRNAs control estradiol response in breast cancer cells","volume":"37","author":"Bhat-Nakshatri","year":"2009","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.reprotox.2026.109270_bib64","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1093\/toxsci\/kfu030","article-title":"Are structural analogues to bisphenol a safe alternatives?","volume":"139","author":"Rosenmai","year":"2014","journal-title":"Toxicol. Sci."},{"issue":"7","key":"10.1016\/j.reprotox.2026.109270_bib65","doi-asserted-by":"crossref","first-page":"362","DOI":"10.3390\/metabo14070362","article-title":"miR-21\/SMAD2 is involved in the decrease in progesterone synthesis caused by lipopolysaccharide exposure in follicular granulosa cells of laying goose","volume":"14","author":"Guo","year":"2024","journal-title":"Metabolites"},{"issue":"5","key":"10.1016\/j.reprotox.2026.109270_bib66","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1007\/s13770-017-0080-z","article-title":"Profile of MicroRNA expression in endometrial cell during in vitro culture according to progesterone concentration","volume":"14","author":"Kim","year":"2017","journal-title":"Tissue Eng. Regen. Med."},{"issue":"1","key":"10.1016\/j.reprotox.2026.109270_bib67","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1471-213X-8-41","article-title":"Cloning and characterization of microRNAs from rainbow trout (Oncorhynchus mykiss): Their expression during early embryonic development","volume":"8","author":"Ramachandra","year":"2008","journal-title":"BMC Dev. Biol."},{"issue":"7","key":"10.1016\/j.reprotox.2026.109270_bib68","doi-asserted-by":"crossref","first-page":"2828","DOI":"10.3390\/ijms26072828","article-title":"Role of miRNAs in bovine oocyte maturation and reproductive regulation","volume":"26","author":"Yang","year":"2025","journal-title":"Int. J. Mol. Sci."},{"issue":"11","key":"10.1016\/j.reprotox.2026.109270_bib69","doi-asserted-by":"crossref","first-page":"R519","DOI":"10.1016\/j.cub.2024.04.044","article-title":"The maternal-to-zygotic transition","volume":"34","author":"Brantley","year":"2024","journal-title":"Curr. Biol."},{"key":"10.1016\/j.reprotox.2026.109270_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2025.109299","article-title":"The protection of bisphenol A-modulated miRNAs and targets by natural products","volume":"196","author":"Chuang","year":"2025","journal-title":"Environ. Int."},{"issue":"3","key":"10.1016\/j.reprotox.2026.109270_bib71","doi-asserted-by":"crossref","first-page":"396","DOI":"10.3390\/ijms17030396","article-title":"MicroRNA Expression during Bovine Oocyte Maturation and Fertilization","volume":"17","author":"Gilchrist","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.reprotox.2026.109270_bib72","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.theriogenology.2022.02.019","article-title":"MiRNA-155 inhibition enhances porcine embryo preimplantation developmental competence by upregulating ZEB2 and downregulating ATF4","volume":"183","author":"Tanga","year":"2022","journal-title":"Theriogenology"},{"issue":"15","key":"10.1016\/j.reprotox.2026.109270_bib73","doi-asserted-by":"crossref","first-page":"eabn4935","DOI":"10.1126\/sciadv.abn4935","article-title":"A developmentally programmed splicing failure contributes to DNA damage response attenuation during mammalian zygotic genome activation","volume":"8","author":"Wyatt","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.reprotox.2026.109270_bib74","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3389\/fgene.2018.00175","article-title":"miR-155 and miR-122 Expression of Spermatozoa in Obese Subjects","volume":"9","author":"L\u00f3pez","year":"2018","journal-title":"Front. Genet."},{"issue":"1","key":"10.1016\/j.reprotox.2026.109270_bib75","first-page":"89","article-title":"MicroRNA-21 and microRNA-155 promote the progression of Burkitt\u2019s lymphoma by the PI3K\/AKT signaling pathway","volume":"13","author":"Han","year":"2020","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.reprotox.2026.109270_bib76","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/1477-7827-12-85","article-title":"MicroRNA-34 family expression in bovine gametes and preimplantation embryos","volume":"12","author":"Tscherner","year":"2014","journal-title":"Reprod. Biol. Endocrinol. RBE"},{"issue":"2","key":"10.1016\/j.reprotox.2026.109270_bib77","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1073\/pnas.1110368109","article-title":"Sperm-borne microRNA-34c is required for the first cleavage division in mouse","volume":"109","author":"Liu","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"7","key":"10.1016\/j.reprotox.2026.109270_bib78","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0132767","article-title":"miR-34 and p53: new insights into a complex functional relationship","volume":"10","author":"Navarro","year":"2015","journal-title":"PLOS ONE"},{"issue":"2","key":"10.1016\/j.reprotox.2026.109270_bib79","doi-asserted-by":"crossref","first-page":"3148","DOI":"10.3390\/ijms16023148","article-title":"The Regulation and Function of miR-21-FOXO3a-miR-34b\/c Signaling in Breast Cancer","volume":"16","author":"Liu","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.reprotox.2026.109270_bib80","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s12958-023-01089-3","article-title":"Sperm-borne microRNA-34c regulates maternal mRNA degradation and preimplantation embryonic development in mice","volume":"21","author":"Cui","year":"2023","journal-title":"Reprod. Biol. Endocrinol. RBE"},{"issue":"18","key":"10.1016\/j.reprotox.2026.109270_bib81","doi-asserted-by":"crossref","first-page":"2712","DOI":"10.3390\/ani15182712","article-title":"Reproductive effects of endocrine disruptors in domestic ruminants: integrating in vitro and in vivo evidence","volume":"15","author":"Sapanidou","year":"2025","journal-title":"Animals"},{"issue":"6","key":"10.1016\/j.reprotox.2026.109270_bib82","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1016\/j.fertnstert.2014.08.005","article-title":"Molecular characterization of exosomes and their microRNA cargo in human follicular fluid: bioinformatic analysis reveals that exosomal microRNAs control pathways involved in follicular maturation","volume":"102","author":"Santonocito","year":"2014","journal-title":"Fertil. Steril."},{"issue":"6","key":"10.1016\/j.reprotox.2026.109270_bib83","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1095\/biolreprod.116.142711","article-title":"MicroRNAs are stored in human mii oocyte and their expression profile changes in reproductive Aging1","volume":"95","author":"Battaglia","year":"2016","journal-title":"Biol. Reprod."},{"issue":"1","key":"10.1016\/j.reprotox.2026.109270_bib84","doi-asserted-by":"crossref","first-page":"24976","DOI":"10.1038\/srep24976","article-title":"Circulating microRNAs in follicular fluid, powerful tools to explore in vitro fertilization process","volume":"6","author":"Scalici","year":"2016","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.reprotox.2026.109270_bib85","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1007\/s12020-010-9345-1","article-title":"Follicle-stimulating hormone regulation of microRNA expression on progesterone production in cultured rat granulosa cells","volume":"38","author":"Yao","year":"2010","journal-title":"Endocrine"},{"issue":"1","key":"10.1016\/j.reprotox.2026.109270_bib86","doi-asserted-by":"crossref","DOI":"10.3390\/genes13010142","article-title":"Effects of BPA, BPS, and BPF on Oxidative Stress and Antioxidant Enzyme Expression in Bovine Oocytes and Spermatozoa","volume":"13","author":"Nguyen","year":"2022","journal-title":"Genes"},{"issue":"1","key":"10.1016\/j.reprotox.2026.109270_bib87","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1093\/biolre\/ioaa058","article-title":"MicroRNA-21 as a regulator of human cumulus cell viability and its potential influence on the developmental potential of the oocyte","volume":"103","author":"Bartolucci","year":"2020","journal-title":"Biol. Reprod."},{"issue":"1","key":"10.1016\/j.reprotox.2026.109270_bib88","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s12958-016-0152-2","article-title":"MicroRNA-21 and PDCD4 expression during in vitro oocyte maturation in pigs","volume":"14","author":"Wright","year":"2016","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.reprotox.2026.109270_bib89","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.661155","article-title":"Bisphenol A exposure disrupts organelle distribution and functions during mouse oocyte maturation","volume":"9","author":"Pan","year":"2021","journal-title":"Front. Cell. Dev. Biol."},{"issue":"1","key":"10.1016\/j.reprotox.2026.109270_bib90","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s12958-024-01217-7","article-title":"Effect of cytoplasmic fragmentation on embryo development, quality, and pregnancy outcome: a systematic review of the literature","volume":"22","author":"Yazdani","year":"2024","journal-title":"Reprod. Biol. Endocrinol."},{"issue":"2","key":"10.1016\/j.reprotox.2026.109270_bib91","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.fertnstert.2014.10.031","article-title":"Fragmentation of human cleavage-stage embryos is related to the progression through meiotic and mitotic cell cycles","volume":"103","author":"Stensen","year":"2015","journal-title":"Fertil. Steril."},{"issue":"2","key":"10.1016\/j.reprotox.2026.109270_bib92","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1093\/molehr\/2.2.93","article-title":"Programmed cell death and human embryo fragmentation","volume":"2","author":"Jurisicova","year":"1996","journal-title":"Mol. Hum. Reprod."},{"issue":"4","key":"10.1016\/j.reprotox.2026.109270_bib93","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/j.fertnstert.2010.11.033","article-title":"Pathogenesis, developmental consequences, and clinical correlations of human embryo fragmentation","volume":"95","author":"Fujimoto","year":"2011","journal-title":"Fertil. Steril."},{"issue":"2","key":"10.1016\/j.reprotox.2026.109270_bib94","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1002\/em.22072","article-title":"Induction of oxidative stress by bisphenol A and its pleiotropic effects","volume":"58","author":"Gassman","year":"2017","journal-title":"Environ. Mol. Mutagen."},{"issue":"4","key":"10.1016\/j.reprotox.2026.109270_bib95","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1534\/genetics.120.303577","article-title":"Counteracting environmental chemicals with coenzyme q10: an educational primer for use with \u2018antioxidant CoQ10 restores fertility by rescuing bisphenol a-induced oxidative dna damage in the caenorhabditis elegans germline","volume":"216","author":"Bradford","year":"2020","journal-title":"Genetics"},{"issue":"2","key":"10.1016\/j.reprotox.2026.109270_bib96","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1534\/genetics.119.302939","article-title":"Antioxidant CoQ10 restores fertility by rescuing bisphenol A-Induced Oxidative DNA damage in the caenorhabditis elegans germline","volume":"214","author":"Hornos Carneiro","year":"2020","journal-title":"Genetics"},{"issue":"10","key":"10.1016\/j.reprotox.2026.109270_bib97","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1007\/s10815-020-01906-3","article-title":"Does coenzyme Q10 supplementation improve fertility outcomes in women undergoing assisted reproductive technology procedures? A systematic review and meta-analysis of randomized-controlled trials","volume":"37","author":"Florou","year":"2020","journal-title":"J. Assist. Reprod. Genet."}],"container-title":["Reproductive Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623826001139?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623826001139?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T05:12:41Z","timestamp":1783141961000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0890623826001139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":97,"alternative-id":["S0890623826001139"],"URL":"https:\/\/doi.org\/10.1016\/j.reprotox.2026.109270","relation":{},"ISSN":["0890-6238"],"issn-type":[{"value":"0890-6238","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"miR-to-miR interactions: Investigating the effects of miR-21 down-regulation and bisphenol exposure in COCs, arrested 8-cell embryos and blastocysts","name":"articletitle","label":"Article Title"},{"value":"Reproductive Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.reprotox.2026.109270","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"109270"}}