{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T02:27:33Z","timestamp":1793932053503,"version":"4.8.0"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2022\/15364-7"],"award-info":[{"award-number":["2022\/15364-7"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Toxicology"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.reprotox.2026.109362","type":"journal-article","created":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T06:42:58Z","timestamp":1789800178000},"page":"109362","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Gestational exposure to low-dose PFOA during organogenesis induces embryofetal developmental alterations in rats"],"prefix":"10.1016","volume":"146","author":[{"given":"Ot\u00e1vio Galassi","family":"Vitale","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Luiza Giannasi de Paula","family":"Rezende","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna Ferrari","family":"Rosalem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia Vitoria Francisco","family":"de Aquino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luara","family":"Magalh\u00e3es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna Kugel","family":"Marraschi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara Tawany Caetano","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reggina Lorena Mellado","family":"Castro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livia Trippe","family":"Nagaoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Stein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"de Matos Manoel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e1rbara Campos","family":"Jorge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamilton","family":"Hisano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2373-9399","authenticated-orcid":false,"given":"Arielle Cristina","family":"Arena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.reprotox.2026.109362_bib1","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1002\/ieam.258","article-title":"Perfluoroalkyl and polyfluoroalkyl substances in the environment: terminology, classification, and origins","volume":"7","author":"Buck","year":"2011","journal-title":"Integr. Environ. Assess. Manag."},{"issue":"9","key":"10.1016\/j.reprotox.2026.109362_bib2","article-title":"Risk to human health related to the presence of perfluoroalkyl substances in food","volume":"18","author":"EFSA Panel on Contaminants in the Food Chain (EFSA CONTAM Panel)","year":"2020","journal-title":"EFSA J. Eur. Food Saf. Auth."},{"issue":"7","key":"10.1016\/j.reprotox.2026.109362_bib3","doi-asserted-by":"crossref","first-page":"168","DOI":"10.3390\/toxics9070168","article-title":"Placental transfer and composition of perfluoroalkyl substances (PFASs): a Korean birth panel of parent-infant triads","volume":"9","author":"Kang","year":"2021","journal-title":"Toxics"},{"key":"10.1016\/j.reprotox.2026.109362_bib4","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.envint.2017.06.007","article-title":"Per- and polyfluoroalkyl substances in human serum and urine samples from a residentially exposed community","volume":"106","author":"Worley","year":"2017","journal-title":"Environ. Int."},{"issue":"6","key":"10.1016\/j.reprotox.2026.109362_bib5","doi-asserted-by":"crossref","first-page":"588S","DOI":"10.1080\/07315724.2004.10719428","article-title":"The developmental origins of adult disease","volume":"23","author":"Barker","year":"2004","journal-title":"J. Am. Coll. Nutr."},{"issue":"2","key":"10.1016\/j.reprotox.2026.109362_bib6","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1097\/MOP.0000000000000191","article-title":"Developmental origins of health and disease: a paradigm for understanding disease cause and prevention","volume":"27","author":"Heindel","year":"2015","journal-title":"Curr. Opin. Pediatr."},{"issue":"6","key":"10.1016\/j.reprotox.2026.109362_bib7","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1210\/er.2015-1010","article-title":"EDC-2: The endocrine society's second scientific statement on endocrine-disrupting chemicals","volume":"36","author":"Gore","year":"2015","journal-title":"Endocr. Rev."},{"issue":"3","key":"10.1016\/j.reprotox.2026.109362_bib8","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1210\/er.2011-1050","article-title":"Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses","volume":"33","author":"Vandenberg","year":"2012","journal-title":"Endocr. Rev."},{"issue":"2","key":"10.1016\/j.reprotox.2026.109362_bib9","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1093\/toxsci\/kfj105","article-title":"Effects of perfluorooctanoic acid exposure during pregnancy in the mouse","volume":"90","author":"Lau","year":"2006","journal-title":"Toxicol. Sci. Off. J. Soc. Toxicol."},{"key":"10.1016\/j.reprotox.2026.109362_bib10","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.envres.2012.03.007","article-title":"Perfluorooctanoic acid (PFOA), an emerging drinking water contaminant: a critical review of recent literature","volume":"116","author":"Post","year":"2012","journal-title":"Environ. Res."},{"issue":"1","key":"10.1016\/j.reprotox.2026.109362_bib11","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1093\/toxsci\/kfn025","article-title":"Toxicogenomic dissection of the perfluorooctanoic acid transcript profile in mouse liver: evidence for the involvement of nuclear receptors PPAR alpha and CAR","volume":"103","author":"Rosen","year":"2008","journal-title":"Toxicol. Sci. Off. J. Soc. Toxicol."},{"issue":"9553","key":"10.1016\/j.reprotox.2026.109362_bib12","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1016\/S0140-6736(06)69665-7","article-title":"Developmental neurotoxicity of industrial chemicals","volume":"368","author":"Grandjean","year":"2006","journal-title":"Lancet (Lond. Engl. )"},{"issue":"1-2","key":"10.1016\/j.reprotox.2026.109362_bib13","first-page":"9","article-title":"Genetic toxicities of human teratogens","volume":"396","author":"Bishop","year":"1997","journal-title":"Mutat. Res."},{"issue":"5","key":"10.1016\/j.reprotox.2026.109362_bib14","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1002\/tox.23085","article-title":"Effects of benzo(a)pyrene at environmentally relevant doses on embryo-fetal development in rats","volume":"36","author":"da Silva Moreira","year":"2021","journal-title":"Environ. Toxicol."},{"issue":"2","key":"10.1016\/j.reprotox.2026.109362_bib15","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/s41370-018-0099-9","article-title":"Guideline levels for PFOA and PFOS in drinking water: the role of scientific uncertainty, risk assessment decisions, and social factors","volume":"29","author":"Cordner","year":"2019","journal-title":"J. Expo. Sci. & Environ. Epidemiol."},{"key":"10.1016\/j.reprotox.2026.109362_bib16","unstructured":"Environment and Climate Change Canada (ECCC), Health Canada (HC). (2022). State of per- and polyfluoroalkyl substances (PFAS) report."},{"issue":"2","key":"10.1016\/j.reprotox.2026.109362_bib17","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1093\/toxsci\/kfm110","article-title":"Perfluorooctanoic acid induced developmental toxicity in the mouse is dependent on expression of peroxisome proliferator activated receptor-alpha","volume":"98","author":"Abbott","year":"2007","journal-title":"Toxicol. Sci. Off. J. Soc. Toxicol."},{"key":"10.1016\/j.reprotox.2026.109362_bib18","unstructured":"U.S. Environmental Protection Agency. Human health toxicity assessment for perfluorooctanoic acid (PFOA) and related salts. Final report. Washington (DC): Office of Water, Health and Ecological Criteria Division, U.S. Environmental Protection Agency; 2024. EPA Document No.: 815-R-24-006."},{"key":"10.1016\/j.reprotox.2026.109362_bib19","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/5948936","article-title":"Teratogenic effect of usnic acid from cladonia substellata vainio during organogenesis","volume":"2017","author":"Silva","year":"2017","journal-title":"BioMed. Res. Int."},{"key":"10.1016\/j.reprotox.2026.109362_bib20","doi-asserted-by":"crossref","unstructured":"OECD. Test No. 414: Prenatal Developmental Toxicity Study. OECD Guidelines for the Testing of Chemicals, Section 4. Paris: OECD Publishing, 2018. DOI: 10.1787\/9789264070820-en.","DOI":"10.1787\/9789264070820-en"},{"key":"10.1016\/j.reprotox.2026.109362_bib21","unstructured":"Russell, W.M.S., & Burch, R.L. (1959). The Principles of Humane Experimental Technique. Methuen, London."},{"issue":"7","key":"10.1016\/j.reprotox.2026.109362_bib22","article-title":"The ARRIVE guidelines 2.0: updated guidelines for reporting animal research","volume":"18","author":"Percie du Sert","year":"2020","journal-title":"PLOS Biol."},{"issue":"6","key":"10.1016\/j.reprotox.2026.109362_bib23","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1080\/15287394.2016.1149132","article-title":"utero and lactational exposure to fipronil in female rats: pregnancy outcomes and sexual development","volume":"79","author":"de Barros","year":"2016","journal-title":"J. Toxicol. Environ. Health Part. A"},{"issue":"3","key":"10.1016\/j.reprotox.2026.109362_bib24","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1042\/CS20050028","article-title":"Modulation of lipid metabolism by n-3 polyunsaturated fatty acids in gestational diabetic rats and their macrosomic offspring","volume":"109","author":"Soulimane-Mokhtari","year":"2005","journal-title":"Clinic. Sci. (London England 1979)"},{"key":"10.1016\/j.reprotox.2026.109362_bib25","unstructured":"Wilson, M.E., & Ford, S.P. (2001). Comparative aspects of placental efficiency. Reproduction (Cambridge, England). Supplement, 58, 223\u2013232."},{"key":"10.1016\/j.reprotox.2026.109362_bib26","series-title":"Teratology: Principles and techniques","first-page":"262","article-title":"Methods for administering agents and detecting malformations in experimental animals","author":"Wilson","year":"1965"},{"issue":"3","key":"10.1016\/j.reprotox.2026.109362_bib27","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1002\/jmor.1051270303","article-title":"A rapid method for detecting malformations in rat fetuses","volume":"127","author":"Barrow","year":"1969","journal-title":"J. Morphol."},{"key":"10.1016\/j.reprotox.2026.109362_bib28","series-title":"Principles and methods of toxicology","first-page":"989","article-title":"Test methods for assessing female reproductive and developmental toxicology","author":"Manson","year":"1994"},{"issue":"3","key":"10.1016\/j.reprotox.2026.109362_bib29","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.yrtph.2008.12.007","article-title":"Effects of the polysaccharide beta-glucan on clastogenicity and teratogenicity caused by acute exposure to cyclophosphamide in mice","volume":"53","author":"Oliveira","year":"2009","journal-title":"Regulatory toxicology pharmacology RTP"},{"issue":"2","key":"10.1016\/j.reprotox.2026.109362_bib30","first-page":"61","article-title":"Refinements in rapid clearing technic in the KOH\u2013alizarin red S method for fetal bone","volume":"39","author":"Staples","year":"1964","journal-title":"Stain. Technol."},{"issue":"2","key":"10.1016\/j.reprotox.2026.109362_bib31","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1002\/tera.1420200208","article-title":"The extent of fetal ossification as an index of delayed development in teratogenic studies on the rat","volume":"20","author":"Aliverti","year":"1979","journal-title":"Teratology"},{"key":"10.1016\/j.reprotox.2026.109362_bib32","first-page":"100","article-title":"Skeletal Examination","volume":"77","author":"Taylor","year":"1986"},{"issue":"1-2","key":"10.1016\/j.reprotox.2026.109362_bib33","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jsbmb.2011.03.011","article-title":"Endocrine disrupting properties of perfluorooctanoic acid","volume":"127","author":"White","year":"2011","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"2","key":"10.1016\/j.reprotox.2026.109362_bib34","doi-asserted-by":"crossref","first-page":"27006","DOI":"10.1289\/EHP6233","article-title":"Evaluation of Maternal, Embryo, and Placental Effects in CD-1 Mice following Gestational Exposure to Perfluorooctanoic Acid (PFOA) or Hexafluoropropylene Oxide Dimer Acid (HFPO-DA or GenX)","volume":"128","author":"Blake","year":"2020","journal-title":"Environ. Health Perspect."},{"issue":"10","key":"10.1016\/j.reprotox.2026.109362_bib35","doi-asserted-by":"crossref","first-page":"3422","DOI":"10.1210\/en.2015-1227","article-title":"Sex-specific placental responses in fetal development","volume":"156","author":"Rosenfeld","year":"2015","journal-title":"Endocrinology"},{"issue":"1-2","key":"10.1016\/j.reprotox.2026.109362_bib36","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.mce.2009.02.015","article-title":"Sexual dimorphism in environmental epigenetic programming","volume":"304","author":"Gabory","year":"2009","journal-title":"Mol. Cell. Endocrinol."},{"issue":"6","key":"10.1016\/j.reprotox.2026.109362_bib37","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.cell.2006.09.003","article-title":"Making or breaking the heart: from lineage determination to morphogenesis","volume":"126","author":"Srivastava","year":"2006","journal-title":"Cell"},{"issue":"10","key":"10.1016\/j.reprotox.2026.109362_bib38","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1289\/ehp.1307893","article-title":"The Navigation Guide - evidence-based medicine meets environmental health: systematic review of human evidence for PFOA effects on fetal growth","volume":"122","author":"Johnson","year":"2014","journal-title":"Environ. Health Perspect."},{"issue":"6","key":"10.1016\/j.reprotox.2026.109362_bib39","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1289\/ehp.1510046","article-title":"Perfluoroalkyl Acids in Maternal Serum and Indices of Fetal Growth: The Aarhus Birth Cohort","volume":"124","author":"Bach","year":"2016","journal-title":"Environ. Health Perspect."},{"issue":"Pt 4","key":"10.1016\/j.reprotox.2026.109362_bib40","article-title":"Evaluating maternal exposure to an environmental per and polyfluoroalkyl substances (PFAS) mixture during pregnancy: adverse maternal and fetoplacental effects in a New Zealand White (NZW) rabbit model","volume":"838","author":"Crute","year":"2022","journal-title":"Sci. Total. Environ."},{"issue":"2","key":"10.1016\/j.reprotox.2026.109362_bib41","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1093\/toxsci\/kfac126","article-title":"Maternal exposure to perfluorobutane sulfonate (PFBS) during pregnancy: evidence of adverse maternal and fetoplacental effects in New Zealand White (NZW) rabbits","volume":"191","author":"Crute","year":"2023","journal-title":"Toxicol. Sci. Off. J. Soc. Toxicol."},{"issue":"2S","key":"10.1016\/j.reprotox.2026.109362_bib42","doi-asserted-by":"crossref","first-page":"S869","DOI":"10.1016\/j.ajog.2017.12.012","article-title":"Long-term cardiovascular consequences of fetal growth restriction: biology, clinical implications, and opportunities for prevention of adult disease","volume":"218","author":"Crispi","year":"2018","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"6","key":"10.1016\/j.reprotox.2026.109362_bib43","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1002\/bdrb.20133","article-title":"Interpretation of skeletal variations for human risk assessment: delayed ossification and wavy ribs","volume":"80","author":"Carney","year":"2007","journal-title":"Birth Defects Res. Part. B Dev. Reprod. Toxicol."},{"issue":"5","key":"10.1016\/j.reprotox.2026.109362_bib44","first-page":"388","article-title":"Skeletal variations and their role in developmental toxicity studies","volume":"92","author":"Fleeman","year":"2011","journal-title":"Birth Defects Research Part B Developmental Reproductive Toxicology"},{"issue":"5","key":"10.1016\/j.reprotox.2026.109362_bib45","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/nrg2320","article-title":"Segmental patterning of the vertebrate embryonic axis","volume":"9","author":"Dequeant","year":"2008","journal-title":"Nat. Rev. Genet."},{"issue":"4","key":"10.1016\/j.reprotox.2026.109362_bib46","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1590\/S0100-879X2005000400010","article-title":"Relationships between fetal body weight of Wistar rats at term and the extent of skeletal ossification","volume":"38","author":"Chahoud","year":"2005","journal-title":"Braz. J. Med. Biol. Res."},{"issue":"15","key":"10.1016\/j.reprotox.2026.109362_bib47","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1002\/bdr2.1350","article-title":"Bone development in laboratory mammals used in developmental toxicity studies","volume":"110","author":"DeSesso","year":"2018","journal-title":"Birth Defects Res."},{"issue":"3","key":"10.1016\/j.reprotox.2026.109362_bib48","doi-asserted-by":"crossref","first-page":"37008","DOI":"10.1289\/EHP4372","article-title":"Adverse Maternal, Fetal, and Postnatal Effects of Hexafluoropropylene Oxide Dimer Acid (GenX) from Oral Gestational Exposure in Sprague-Dawley Rats","volume":"127","author":"Conley","year":"2019","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.reprotox.2026.109362_bib49","doi-asserted-by":"crossref","DOI":"10.1177\/01926233261439119","article-title":"Placental Lesions in CD-1 Mouse Placenta Following Gestational Exposure to Perfluorooctanoic Acid (PFOA) or Hexafluoropropylene Oxide Dimer Acid (HFPO-DA or GenX)","author":"Foley","year":"2026","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.reprotox.2026.109362_bib50","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.reprotox.2014.04.006","article-title":"Perfluorooctanoate exposure and major birth defects","volume":"47","author":"Stein","year":"2014","journal-title":"Reproductive toxicology (Elmsford N. Y. )"},{"key":"10.1016\/j.reprotox.2026.109362_bib51","doi-asserted-by":"crossref","DOI":"10.3389\/fpubh.2025.1657168","article-title":"Environmental exposure to per- and polyfluoroalkyl substances and childhood congenital heart disease: a mixed analysis","volume":"13","author":"Jiao","year":"2025","journal-title":"Front. Public. Health"},{"key":"10.1016\/j.reprotox.2026.109362_bib52","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.envint.2019.01.010","article-title":"Concentrations of perfluoroalkyl substances (PFASs) in human embryonic and fetal organs from first, second, and third trimester pregnancies","volume":"124","author":"Mamsen","year":"2019","journal-title":"Environ. Int."},{"issue":"9","key":"10.1016\/j.reprotox.2026.109362_bib53","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1289\/ehp.10009","article-title":"Half-life of serum elimination of perfluorooctanesulfonate,perfluorohexanesulfonate, and perfluorooctanoate in retired fluorochemical production workers","volume":"115","author":"Olsen","year":"2007","journal-title":"Environ. Health Perspect."},{"issue":"2","key":"10.1016\/j.reprotox.2026.109362_bib54","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1093\/toxsci\/kfm128","article-title":"Perfluoroalkyl acids: a review of monitoring and toxicological findings","volume":"99","author":"Lau","year":"2007","journal-title":"Toxicol. Sci. Off. J. Soc. Toxicol."},{"issue":"3","key":"10.1016\/j.reprotox.2026.109362_bib55","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0009-2797(02)00006-6","article-title":"Sex hormone-regulated renal transport of perfluorooctanoic acid","volume":"139","author":"Kudo","year":"2002","journal-title":"Chem. -Biol. Interact."},{"issue":"8","key":"10.1016\/j.reprotox.2026.109362_bib56","first-page":"1847","article-title":"Complementing the genome with an \"exposome\": the outstanding challenge of environmental exposure measurement in molecular epidemiology","volume":"14","author":"Wild","year":"2005","journal-title":"Cancer epidemiology biomarkers & prevention a publication American Association Cancer Research cosponsored American Society Preventive Oncology"},{"issue":"6476","key":"10.1016\/j.reprotox.2026.109362_bib57","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1126\/science.aay3164","article-title":"The exposome and health: where chemistry meets biology","volume":"367","author":"Vermeulen","year":"2020","journal-title":"Science (New York N. Y. )"},{"key":"10.1016\/j.reprotox.2026.109362_bib58","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3389\/fvets.2018.00014","article-title":"The one health concept: 10\u2009years old and a long road ahead","volume":"5","author":"Destoumieux-Garz\u00f3n","year":"2018","journal-title":"Front. Vet. Sci."}],"container-title":["Reproductive Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623826002054?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623826002054?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T01:33:05Z","timestamp":1793928785000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0890623826002054"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":58,"alternative-id":["S0890623826002054"],"URL":"https:\/\/doi.org\/10.1016\/j.reprotox.2026.109362","relation":{},"ISSN":["0890-6238"],"issn-type":[{"value":"0890-6238","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gestational exposure to low-dose PFOA during organogenesis induces embryofetal developmental alterations in rats","name":"articletitle","label":"Article Title"},{"value":"Reproductive Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.reprotox.2026.109362","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"109362"}}