{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T12:33:22Z","timestamp":1793018002073,"version":"4.5.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010025","name":"University of Derby","doi-asserted-by":"publisher","award":["internal grant for Vice- chancellor PhD studentship"],"award-info":[{"award-number":["internal grant for Vice- chancellor PhD studentship"]}],"id":[{"id":"10.13039\/100010025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Toxicology"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.reprotox.2026.109364","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T16:48:55Z","timestamp":1790095735000},"page":"109364","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["A comprehensive meta-analysis on the impact of airborne particulate matter on trophoblast\/placental vessel related cell function In Vitro"],"prefix":"10.1016","volume":"146","author":[{"given":"Jayabharthi","family":"Thirumalazhagan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivadas","family":"Sivasubramaniam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2037-7804","authenticated-orcid":false,"given":"Vadivel","family":"Parthsarathy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.reprotox.2026.109364_bib1","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1038\/s41586-020-2902-8","article-title":"Sources of particulate-matter air pollution and its oxidative potential in Europe","volume":"587","author":"Daellenbach","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.reprotox.2026.109364_bib2","article-title":"Global air quality guidelines: particulate matter (PM\u2082, \u2085 and PM\u2081\u2080), ozone, nitrogen dioxide, sulfur dioxide and carbon monoxide","author":"Who","year":"2021","journal-title":"Exec. Summ."},{"key":"10.1016\/j.reprotox.2026.109364_bib3","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.85944","article-title":"PM2. 5 leads to adverse pregnancy outcomes by inducing trophoblast oxidative stress and mitochondrial apoptosis via KLF9\/CYP1A1 transcriptional axis","volume":"12","author":"Li","year":"2023","journal-title":"Elife"},{"key":"10.1016\/j.reprotox.2026.109364_bib4","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2020.8243","article-title":"Association of air pollution and heat exposure with preterm birth, low birth weight, and stillbirth in the US: a systematic review","volume":"3","author":"Bekkar","year":"2020","journal-title":"JAMA Netw. Open."},{"key":"10.1016\/j.reprotox.2026.109364_bib5","article-title":"Ambient and household PM2. 5 pollution and adverse perinatal outcomes: A meta-regression and analysis of attributable global burden for 204 countries and territories","volume":"18","author":"Ghosh","year":"2021","journal-title":"PLoS. Med."},{"key":"10.1016\/j.reprotox.2026.109364_bib6","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1007\/s11869-026-02034-0","article-title":"Gestational co-exposure to extreme heat and fine particulate air pollution and the risk of preterm birth: A systematic review and meta-analysis","volume":"19","author":"Parasin","year":"2026","journal-title":"Air Qual. Atmosphere & Health"},{"key":"10.1016\/j.reprotox.2026.109364_bib7","doi-asserted-by":"crossref","first-page":"3866","DOI":"10.1038\/s41467-019-11654-3","article-title":"Ambient black carbon particles reach the fetal side of human placenta","volume":"10","author":"Bov\u00e9","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.reprotox.2026.109364_bib8","doi-asserted-by":"crossref","first-page":"e804","DOI":"10.1016\/S2542-5196(22)00200-5","article-title":"Maternal exposure to ambient black carbon particles and their presence in maternal and fetal circulation and organs: an analysis of two independent population-based observational studies","volume":"6","author":"Bongaerts","year":"2022","journal-title":"Lancet Planet. Health"},{"issue":"12","key":"10.1016\/j.reprotox.2026.109364_bib9","first-page":"1955","article-title":"Redox Systems, Oxidative Stress, and Antioxidant Defences in Health and Disease","volume":"10","author":"Allegra","year":"2021","journal-title":"Antioxid. (Basel Switz. )"},{"issue":"75","key":"10.1016\/j.reprotox.2026.109364_bib10","article-title":"Urban PM2.5 Induces Cellular Toxicity, Hormone Dysregulation, Oxidative Damage, Inflammation, and Mitochondrial Interference in the HRT8 Trophoblast Cell Line","volume":"11","author":"Naav","year":"2020","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.reprotox.2026.109364_bib11","doi-asserted-by":"crossref","DOI":"10.1002\/ccr3.4138","article-title":"Carbon monoxide poisoning during pregnancy treated with hyperbaric oxygen","volume":"9","author":"Kosaki","year":"2021","journal-title":"Clin. Case Rep."},{"key":"10.1016\/j.reprotox.2026.109364_bib12","doi-asserted-by":"crossref","first-page":"453","DOI":"10.15441\/ceem.23.097","article-title":"Perinatal carbon monoxide poisoning with fetal and maternal carboxyhemoglobin measurements","volume":"10","author":"Odegard","year":"2023","journal-title":"Clin. Exp. Emerg. Med."},{"key":"10.1016\/j.reprotox.2026.109364_bib13","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1186\/s12889-024-18913-z","article-title":"Association between risk of preterm birth and long-term and short-term exposure to ambient carbon monoxide during pregnancy in chongqing, China: a study from 2016-2020","volume":"24","author":"Ming","year":"2024","journal-title":"BMC Public. Health"},{"key":"10.1016\/j.reprotox.2026.109364_bib14","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1289\/ehp.1409651","article-title":"Air pollution and preterm birth in the US State of Georgia (2002\u20132006): associations with concentrations of 11 ambient air pollutants estimated by combining Community Multiscale Air Quality Model (CMAQ) simulations with stationary monitor measurements","volume":"124","author":"Hao","year":"2016","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.reprotox.2026.109364_bib15","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1289\/ehp.1002947","article-title":"Ambient carbon monoxide and fine particulate matter in relation to preeclampsia and preterm delivery in western Washington State","volume":"119","author":"Rudra","year":"2011","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.reprotox.2026.109364_bib16","doi-asserted-by":"crossref","first-page":"291","DOI":"10.3389\/fphar.2014.00291","article-title":"Heme oxygenase-1 is critically involved in placentation, spiral artery remodeling, and blood pressure regulation during murine pregnancy","volume":"5","author":"Zenclussen","year":"2015","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.reprotox.2026.109364_bib17","doi-asserted-by":"crossref","first-page":"774","DOI":"10.2353\/ajpath.2006.060184","article-title":"Carbon monoxide inhibits hypoxia\/reoxygenation-induced apoptosis and secondary necrosis in syncytiotrophoblast","volume":"169","author":"Bainbridge","year":"2006","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.reprotox.2026.109364_bib18","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/2045-9912-2-4","article-title":"Exploring the potential of low doses carbon monoxide as therapy in pregnancy complications","volume":"2","author":"El-Mousleh","year":"2012","journal-title":"Med. Gas. Res."},{"key":"10.1016\/j.reprotox.2026.109364_bib19","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"10.1016\/j.reprotox.2026.109364_bib20","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.etap.2019.04.008","article-title":"Effects of cooking oil fume derived fine particulate matter on blood vessel formation through the VEGF\/VEGFR2\/MEK1\/2\/ERK1\/2\/mTOR pathway in human umbilical vein endothelial cells","volume":"69","author":"Zhu","year":"2019","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.reprotox.2026.109364_bib21","first-page":"10","article-title":"Uptake of Cerium Dioxide Nanoparticles and Impact on Viability, Differentiation and Functions of Primary Trophoblast Cells from Human Placenta","author":"Nedder","year":"2020","journal-title":"Nanomater. (Basel)"},{"key":"10.1016\/j.reprotox.2026.109364_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.171101","article-title":"Gestational exposure to PM(2.5) disrupts fetal development by suppressing placental trophoblast syncytialization via progranulin\/mTOR signaling","volume":"921","author":"Wang","year":"2024","journal-title":"Sci. Total. Environ."},{"key":"10.1016\/j.reprotox.2026.109364_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0218799","article-title":"Exposure of trophoblast cells to fine particulate matter air pollution leads to growth inhibition, inflammation and ER stress","volume":"14","author":"Familari","year":"2019","journal-title":"PLoS. One"},{"key":"10.1016\/j.reprotox.2026.109364_bib24","article-title":"& PEREIRA DE SOUSA, F. L. 2022. PM10 Alters Trophoblast Cell Function and Modulates miR-125b-5p Expression","author":"Chaiwangyen","year":"2022","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.reprotox.2026.109364_bib25","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1016\/j.envpol.2017.08.029","article-title":"Suppression of progesterone synthesis in human trophoblast cells by fine particulate matter primarily derived from industry","volume":"231","author":"Wang","year":"2017","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.reprotox.2026.109364_bib26","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1002\/tox.22591","article-title":"Effect of particulate matter 2.5 on gene expression profile and cell signaling in JEG-3 human placenta cells","volume":"33","author":"Kim","year":"2018","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.reprotox.2026.109364_bib27","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.reprotox.2017.08.014","article-title":"Fine particulate matter exposure induces cell cycle arrest and inhibits migration and invasion of human extravillous trophoblast, as determined by an iTRAQ-based quantitative proteomics strategy","volume":"74","author":"Qin","year":"2017","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.reprotox.2026.109364_bib28","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.placenta.2019.10.008","article-title":"Environmental pollutant induced cellular injury is reflected in exosomes from placental explants","volume":"89","author":"Sheller-Miller","year":"2020","journal-title":"Placenta"},{"key":"10.1016\/j.reprotox.2026.109364_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.reprotox.2025.108973","article-title":"Impact of particulate matter 2.5 on placental ultrastructure including mitochondrial damage through oxidative stress","author":"Lee","year":"2025","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.reprotox.2026.109364_bib30","doi-asserted-by":"crossref","first-page":"13727","DOI":"10.3390\/ijerph192113727","article-title":"Wildfire smoke exposure during pregnancy: a review of potential mechanisms of placental toxicity, impact on obstetric outcomes, and strategies to reduce exposure","volume":"19","author":"Basilio","year":"2022","journal-title":"Int. J. Environ. Res. Public. Health"},{"key":"10.1016\/j.reprotox.2026.109364_bib31","doi-asserted-by":"crossref","first-page":"59819","DOI":"10.1007\/s11356-024-35016-9","article-title":"Effect of environmental air pollutants on placental function and pregnancy outcomes: a molecular insight","volume":"31","author":"Singh","year":"2024","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.reprotox.2026.109364_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.114790","article-title":"Exposure to wood smoke particles leads to inflammation, disrupted proliferation and damage to cellular structures in a human first trimester trophoblast cell line","volume":"264","author":"Erlandsson","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.reprotox.2026.109364_bib33","doi-asserted-by":"crossref","first-page":"75","DOI":"10.3389\/fendo.2020.00075","article-title":"Urban PM2.5 Induces Cellular Toxicity, Hormone Dysregulation, Oxidative Damage, Inflammation, and Mitochondrial Interference in the HRT8 Trophoblast Cell Line","volume":"11","author":"Naav","year":"2020","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.reprotox.2026.109364_bib34","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.85944","article-title":"PM2. 5 leads to adverse pregnancy outcomes by inducing trophoblast oxidative stress and mitochondrial apoptosis via KLF9\/CYP1A1 transcriptional axis","volume":"12","author":"Li","year":"2023","journal-title":"Elife"},{"key":"10.1016\/j.reprotox.2026.109364_bib35","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1186\/s12935-023-03056-9","article-title":"Pan-cancer analysis of NFE2L2 mutations identifies a subset of lung cancers with distinct genomic and improved immunotherapy outcomes","volume":"23","author":"Wang","year":"2023","journal-title":"Cancer Cell. Int."},{"issue":"12","key":"10.1016\/j.reprotox.2026.109364_bib36","doi-asserted-by":"crossref","first-page":"7511","DOI":"10.3390\/ijerph19127511","article-title":"Recent Insights into Particulate Matter (PM2.5)-Mediated Toxicity in Humans: An Overview","volume":"19","author":"Thangavel","year":"2022","journal-title":"Int. J. Environ. Res. Public. Health"},{"key":"10.1016\/j.reprotox.2026.109364_bib37","doi-asserted-by":"crossref","DOI":"10.3389\/ftox.2021.710225","article-title":"Potential of NRF2 pathway in preventing developmental and reproductive toxicity of fine particles","volume":"3","author":"Li","year":"2021","journal-title":"Front. Toxicol."},{"key":"10.1016\/j.reprotox.2026.109364_bib38","doi-asserted-by":"crossref","DOI":"10.3389\/ijph.2024.1607683","article-title":"Long-term exposure to particulate matter and mortality: an update of the WHO global air quality guidelines systematic review and meta-analysis","volume":"69","author":"Orellano","year":"2024","journal-title":"Int. J. Public. Health"},{"key":"10.1016\/j.reprotox.2026.109364_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2025.138376","article-title":"vitro and in vivo evidence on the association of pregnant PM2.5 exposure with preterm birth and potential role of placental miRNA-21 regulating TLR4\/NF-\u03baB and activating NLRP3 inflammasome","volume":"493","author":"Ran","year":"2025","journal-title":"J. Hazard. Mater."},{"issue":"4","key":"10.1016\/j.reprotox.2026.109364_bib40","doi-asserted-by":"crossref","first-page":"C736","DOI":"10.1152\/ajpcell.00529.2009","article-title":"Airborne particulate matter selectively activates endoplasmic reticulum stress response in the lung and liver tissues","volume":"299","author":"Laing","year":"2010","journal-title":"Am. J. Physiol. Cell. Physiol."},{"key":"10.1016\/j.reprotox.2026.109364_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2019.136397","article-title":"PM2.5 induces autophagy and apoptosis through endoplasmic reticulum stress in human endothelial cells","volume":"710","author":"Wang","year":"2020","journal-title":"Sci. Total. Environ."},{"key":"10.1016\/j.reprotox.2026.109364_bib42","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.placenta.2004.06.012","article-title":"Progesterone synthesis by the human placenta","volume":"26","author":"Tuckey","year":"2005","journal-title":"Placenta"},{"key":"10.1016\/j.reprotox.2026.109364_bib43","doi-asserted-by":"crossref","first-page":"4246","DOI":"10.3390\/ijms20174246","article-title":"Preeclampsia: maternal systemic vascular disorder caused by generalized endothelial dysfunction due to placental antiangiogenic factors","volume":"20","author":"Tomimatsu","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.reprotox.2026.109364_bib44","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1021\/acs.chemrestox.6b00265","article-title":"Occurrence, biological consequences, and human health relevance of oxidative stress-induced DNA damage","volume":"29","author":"Yu","year":"2016","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.reprotox.2026.109364_bib45","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1478-811X-2-4","article-title":"Regulation of trophoblast beta1-integrin expression by contact with endothelial cells","volume":"2","author":"Thirkill","year":"2004","journal-title":"Cell. Commun. Signal."},{"issue":"4","key":"10.1016\/j.reprotox.2026.109364_bib46","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.bbrc.2013.06.016","article-title":"Trophoblast lineage cells derived from human induced pluripotent stem cells","volume":"436","author":"Chen","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"17","key":"10.1016\/j.reprotox.2026.109364_bib47","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.3390\/cells14171317","article-title":"Maternal exposure to diesel exhaust particles (DEPs) during pregnancy and adverse pregnancy outcomes: focusing on the effect of particulate matter on trophoblast, epithelial-mesenchymal transition","volume":"14","author":"Hur","year":"2025","journal-title":"Cells"}],"container-title":["Reproductive Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623826002078?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890623826002078?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T11:42:23Z","timestamp":1793014943000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0890623826002078"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":47,"alternative-id":["S0890623826002078"],"URL":"https:\/\/doi.org\/10.1016\/j.reprotox.2026.109364","relation":{},"ISSN":["0890-6238"],"issn-type":[{"value":"0890-6238","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A comprehensive meta-analysis on the impact of airborne particulate matter on trophoblast\/placental vessel related cell function In Vitro","name":"articletitle","label":"Article Title"},{"value":"Reproductive Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.reprotox.2026.109364","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"109364"}}