{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T22:27:20Z","timestamp":1773700040148,"version":"3.50.1"},"reference-count":50,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","respiratoryinvestigation.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Investigation"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1016\/j.resinv.2016.03.008","type":"journal-article","created":{"date-parts":[[2016,6,7]],"date-time":"2016-06-07T00:16:18Z","timestamp":1465258578000},"page":"407-412","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"title":["The role of necroptosis in pulmonary diseases"],"prefix":"10.1016","volume":"54","author":[{"given":"Kenji","family":"Mizumura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuichiro","family":"Maruoka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Gon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Augustine M.K.","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.resinv.2016.03.008_bib1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.semcdb.2015.02.003","article-title":"The molecular relationships between apoptosis, autophagy and necroptosis","volume":"39","author":"Lalaoui","year":"2015","journal-title":"Semin Cell Dev Biol"},{"key":"10.1016\/j.resinv.2016.03.008_bib2","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/nature14191","article-title":"Necroptosis and its role in inflammation","volume":"517","author":"Pasparakis","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.resinv.2016.03.008_bib3","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1084\/jem.187.9.1477","article-title":"Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor","volume":"187","author":"Vercammen","year":"1998","journal-title":"J Exp Med"},{"key":"10.1016\/j.resinv.2016.03.008_bib4","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1016\/j.cell.2009.05.037","article-title":"Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation","volume":"137","author":"Cho","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.resinv.2016.03.008_bib5","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.cell.2011.11.031","article-title":"Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase","volume":"148","author":"Sun","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.resinv.2016.03.008_bib6","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1056\/NEJMra1310050","article-title":"Necroptosis","volume":"370","author":"Linkermann","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1016\/j.resinv.2016.03.008_bib7","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s10557-007-6035-1","article-title":"Necrostatin: a potentially novel cardioprotective agent?","volume":"21","author":"Smith","year":"2007","journal-title":"Cardiovasc Drugs Ther"},{"key":"10.1016\/j.resinv.2016.03.008_bib8","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.celrep.2012.12.012","article-title":"A role of RIP3-mediated macrophage necrosis in atherosclerosis development","volume":"3","author":"Lin","year":"2013","journal-title":"Cell Rep"},{"key":"10.1016\/j.resinv.2016.03.008_bib9","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/ki.2011.450","article-title":"Rip1 (receptor-interacting protein kinase 1) mediates necroptosis and contributes to renal ischemia\/reperfusion injury","volume":"81","author":"Linkermann","year":"2012","journal-title":"Kidney Int"},{"key":"10.1016\/j.resinv.2016.03.008_bib10","doi-asserted-by":"crossref","first-page":"3987","DOI":"10.1172\/JCI74985","article-title":"Mitophagy-dependent necroptosis contributes to the pathogenesis of COPD","volume":"124","author":"Mizumura","year":"2014","journal-title":"J Clin Investig"},{"key":"10.1016\/j.resinv.2016.03.008_bib11","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1002\/emmm.201201283","article-title":"Sphingosine analogue drug FTY720 targets I2PP2A\/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis","volume":"5","author":"Saddoughi","year":"2013","journal-title":"EMBO Mol Med"},{"key":"10.1016\/j.resinv.2016.03.008_bib12","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nrm3028","article-title":"Mechanisms of mitophagy","volume":"12","author":"Youle","year":"2011","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.resinv.2016.03.008_bib13","doi-asserted-by":"crossref","first-page":"323","DOI":"10.3389\/fphys.2014.00323","article-title":"Necroptosis: is there a role for mitochondria?","volume":"5","author":"Marshall","year":"2014","journal-title":"Front Physiol"},{"key":"10.1016\/j.resinv.2016.03.008_bib14","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1038\/cdd.2014.76","article-title":"RIPK1 both positively and negatively regulates RIPK3 oligomerization and necroptosis","volume":"21","author":"Orozco","year":"2014","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.resinv.2016.03.008_bib15","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.immuni.2013.06.018","article-title":"The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism","volume":"39","author":"Murphy","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.resinv.2016.03.008_bib16","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/ncb2883","article-title":"Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis","volume":"16","author":"Cai","year":"2014","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.resinv.2016.03.008_bib17","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/cr.2013.171","article-title":"Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death","volume":"24","author":"Chen","year":"2014","journal-title":"Cell Res"},{"key":"10.1016\/j.resinv.2016.03.008_bib18","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1016\/j.str.2014.07.014","article-title":"A plug release mechanism for membrane permeation by MLKL","volume":"22","author":"Su","year":"2014","journal-title":"Structure"},{"key":"10.1016\/j.resinv.2016.03.008_bib19","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.molcel.2014.03.003","article-title":"Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3","volume":"54","author":"Wang","year":"2014","journal-title":"Mol Cell"},{"key":"10.1016\/j.resinv.2016.03.008_bib20","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.celrep.2014.04.026","article-title":"MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates","volume":"7","author":"Dondelinger","year":"2014","journal-title":"Cell Rep"},{"key":"10.1016\/j.resinv.2016.03.008_bib21","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/82732","article-title":"Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule","volume":"1","author":"Holler","year":"2000","journal-title":"Nat Immunol"},{"key":"10.1016\/j.resinv.2016.03.008_bib22","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1083\/jcb.200904158","article-title":"Cellular IAPs inhibit a cryptic CD95-induced cell death by limiting RIP1 kinase recruitment","volume":"187","author":"Geserick","year":"2009","journal-title":"J Cell Biol"},{"key":"10.1016\/j.resinv.2016.03.008_bib23","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1038\/cdd.2012.90","article-title":"TRAIL induces necroptosis involving RIPK1\/RIPK3-dependent PARP-1 activation","volume":"19","author":"Jouan-Lanhouet","year":"2012","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.resinv.2016.03.008_bib24","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/febs.13120","article-title":"Programmed necrosis and necroptosis signalling","volume":"282","author":"Feoktistova","year":"2015","journal-title":"FEBS J"},{"key":"10.1016\/j.resinv.2016.03.008_bib25","doi-asserted-by":"crossref","first-page":"20054","DOI":"10.1073\/pnas.1116302108","article-title":"Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3-mediated pathway","volume":"108","author":"He","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.resinv.2016.03.008_bib26","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.cell.2011.10.026","article-title":"Autophagy: renovation of cells and tissues","volume":"147","author":"Mizushima","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.resinv.2016.03.008_bib27","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/cdd.2011.96","article-title":"Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012","volume":"19","author":"Galluzzi","year":"2012","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.resinv.2016.03.008_bib28","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1038\/nrm2529","article-title":"Autophagic cell death: the story of a misnomer","volume":"9","author":"Kroemer","year":"2008","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.resinv.2016.03.008_bib29","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1056\/NEJMra1205406","article-title":"Autophagy in human health and disease","volume":"368","author":"Choi","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1016\/j.resinv.2016.03.008_bib30","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1126\/science.1096645","article-title":"Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8","volume":"304","author":"Yu","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.resinv.2016.03.008_bib31","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1172\/JCI39987","article-title":"Induction of autophagy-dependent necroptosis is required for childhood acute lymphoblastic leukemia cells to overcome glucocorticoid resistance","volume":"120","author":"Bonapace","year":"2010","journal-title":"J Clin Investig"},{"key":"10.1016\/j.resinv.2016.03.008_bib32","doi-asserted-by":"crossref","first-page":"21110","DOI":"10.1074\/jbc.M111.319129","article-title":"Inhibition of autophagy rescues palmitic acid-induced necroptosis of endothelial cells","volume":"287","author":"Khan","year":"2012","journal-title":"J Biol Chem"},{"key":"10.1016\/j.resinv.2016.03.008_bib33","doi-asserted-by":"crossref","first-page":"244","DOI":"10.3389\/fphar.2014.00244","article-title":"Emerging role of selective autophagy in human diseases","volume":"5","author":"Mizumura","year":"2014","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.resinv.2016.03.008_bib34","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/ncb2220","article-title":"During autophagy mitochondria elongate, are spared from degradation and sustain cell viability","volume":"13","author":"Gomes","year":"2011","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.resinv.2016.03.008_bib35","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1177\/1090198111402197","article-title":"Worldwide behavioral research on major global causes of mortality","volume":"38","author":"Dal-Re","year":"2011","journal-title":"Health Educ Behav"},{"key":"10.1016\/j.resinv.2016.03.008_bib36","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1038\/nchembio.1059","article-title":"Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy","volume":"8","author":"Sentelle","year":"2012","journal-title":"Nat Chem Biol"},{"key":"10.1016\/j.resinv.2016.03.008_bib37","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/nm1238","article-title":"Ceramide upregulation causes pulmonary cell apoptosis and emphysema-like disease in mice","volume":"11","author":"Petrache","year":"2005","journal-title":"Nat Med"},{"key":"10.1016\/j.resinv.2016.03.008_bib38","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1080\/15548627.2015.1017190","article-title":"PARK2-mediated mitophagy is involved in regulation of HBEC senescence in COPD pathogenesis","volume":"11","author":"Ito","year":"2015","journal-title":"Autophagy"},{"key":"10.1016\/j.resinv.2016.03.008_bib39","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.semcdb.2014.07.002","article-title":"Therapeutic exploitation of necroptosis for cancer therapy","volume":"35","author":"Fulda","year":"2014","journal-title":"Semin Cell Dev Biol"},{"key":"10.1016\/j.resinv.2016.03.008_bib40","doi-asserted-by":"crossref","first-page":"759","DOI":"10.2174\/1573406410666140327122009","article-title":"Novel selenosemicarbazone metal complexes exert anti-tumor effect via alternative, caspase-independent necroptotic cell death","volume":"10","author":"Zec","year":"2014","journal-title":"Med Chem"},{"key":"10.1016\/j.resinv.2016.03.008_bib41","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/cdd.2013.193","article-title":"The protein disulfide isomerases PDIA4 and PDIA6 mediate resistance to cisplatin-induced cell death in lung adenocarcinoma","volume":"21","author":"Tufo","year":"2014","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.resinv.2016.03.008_bib42","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s12943-015-0321-5","article-title":"Apoptosis, autophagy, necroptosis, and cancer metastasis","volume":"14","author":"Su","year":"2015","journal-title":"Mol Cancer"},{"key":"10.1016\/j.resinv.2016.03.008_bib43","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1186\/1471-2407-13-580","article-title":"The anti-tumor effect of shikonin on osteosarcoma by inducing RIP1 and RIP3 dependent necroptosis","volume":"13","author":"Fu","year":"2013","journal-title":"BMC Cancer"},{"key":"10.1016\/j.resinv.2016.03.008_bib44","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.coviro.2013.05.019","article-title":"Viral modulation of programmed necrosis","volume":"3","author":"Kaiser","year":"2013","journal-title":"Curr Opin Virol"},{"key":"10.1016\/j.resinv.2016.03.008_bib45","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.chom.2010.03.006","article-title":"Virus inhibition of RIP3-dependent necrosis","volume":"7","author":"Upton","year":"2010","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.resinv.2016.03.008_bib46","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/nri3131","article-title":"Viral infection and the evolution of caspase 8-regulated apoptotic and necrotic death pathways","volume":"12","author":"Mocarski","year":"2012","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.resinv.2016.03.008_bib47","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/ni.3206","article-title":"The diverse role of RIP kinases in necroptosis and inflammation","volume":"16","author":"Silke","year":"2015","journal-title":"Nat Immunol"},{"key":"10.1016\/j.resinv.2016.03.008_bib48","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1016\/j.immuni.2011.09.020","article-title":"RIP kinase-dependent necrosis drives lethal systemic inflammatory response syndrome","volume":"35","author":"Duprez","year":"2011","journal-title":"Immunity"},{"key":"10.1016\/j.resinv.2016.03.008_bib49","doi-asserted-by":"crossref","first-page":"R142","DOI":"10.1186\/cc13970","article-title":"Receptor-interacting protein kinase 3 deficiency inhibits immune cell infiltration and attenuates organ injury in sepsis","volume":"18","author":"Sharma","year":"2014","journal-title":"Crit Care"},{"key":"10.1016\/j.resinv.2016.03.008_bib50","doi-asserted-by":"crossref","first-page":"e1001577","DOI":"10.1371\/journal.pmed.1001577","article-title":"Circulating mitochondrial DNA in patients in the ICU as a marker of mortality: derivation and validation","volume":"10","author":"Nakahira","year":"2013","journal-title":"PLoS Med"}],"container-title":["Respiratory Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S2212534516300223?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S2212534516300223?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T05:38:36Z","timestamp":1568007516000},"score":1,"resource":{"primary":{"URL":"http:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2212534516300223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":50,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["S2212534516300223"],"URL":"https:\/\/doi.org\/10.1016\/j.resinv.2016.03.008","relation":{},"ISSN":["2212-5345"],"issn-type":[{"value":"2212-5345","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of necroptosis in pulmonary diseases","name":"articletitle","label":"Article Title"},{"value":"Respiratory Investigation","name":"journaltitle","label":"Journal Title"},{"value":"http:\/\/dx.doi.org\/10.1016\/j.resinv.2016.03.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 The Japanese Respiratory Society. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}