{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T19:44:34Z","timestamp":1775677474376,"version":"3.50.1"},"reference-count":22,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100009954","name":"Taiho Pharmaceutical","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009954","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004337","name":"Roche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004337","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["H29-023"],"award-info":[{"award-number":["H29-023"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008349","name":"Boehringer Ingelheim","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005612","name":"Shionogi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005612","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP19ek0109268"],"award-info":[{"award-number":["JP19ek0109268"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Investigation"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.resinv.2021.03.012","type":"journal-article","created":{"date-parts":[[2021,5,7]],"date-time":"2021-05-07T02:25:12Z","timestamp":1620354312000},"page":"757-765","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Diagnostic yield and safety of bronchofiberscopy for pulmonary alveolar proteinosis"],"prefix":"10.1016","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6506-8992","authenticated-orcid":false,"given":"Koji","family":"Azuma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0740-4836","authenticated-orcid":false,"given":"Takayuki","family":"Takimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiko","family":"Kasai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1470-2460","authenticated-orcid":false,"given":"Masaki","family":"Hirose","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuyoshi","family":"Hatsuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chikatoshi","family":"Sugimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toru","family":"Arai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Akira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3994-874X","authenticated-orcid":false,"given":"Yoshikazu","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.resinv.2021.03.012_bib1","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1056\/NEJM195806052582301","article-title":"Pulmonary alveolar proteinosis","volume":"258","author":"Rosen","year":"1958","journal-title":"N Engl J Med"},{"key":"10.1016\/j.resinv.2021.03.012_bib2","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/S2213-2600(18)30043-2","article-title":"Pulmonary alveolar proteinosis in adults: pathophysiology and clinical approach","volume":"6","author":"Kumar","year":"2018","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.resinv.2021.03.012_bib3","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/s41572-019-0066-3","article-title":"Pulmonary alveolar proteinosis","volume":"5","author":"Trapnell","year":"2019","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.resinv.2021.03.012_bib4","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1164\/rccm.200708-1271OC","article-title":"Characteristics of a large cohort of patients with autoimmune pulmonary alveolar proteinosis in Japan","volume":"177","author":"Inoue","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.resinv.2021.03.012_bib5","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1084\/jem.190.6.875","article-title":"Idiopathic pulmonary alveolar proteinosis as an autoimmune disease with neutralizing antibody against granulocyte\/macrophage colony-stimulating factor","volume":"190","author":"Kitamura","year":"1999","journal-title":"J Exp Med"},{"key":"10.1016\/j.resinv.2021.03.012_bib6","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1056\/NEJMra023226","article-title":"Pulmonary alveolar proteinosis","volume":"349","author":"Trapnell","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.resinv.2021.03.012_bib7","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1164\/rccm.201001-0008OC","article-title":"Patient-derived granulocyte\/macrophage colony-stimulating factor autoantibodies reproduce pulmonary alveolar proteinosis in nonhuman primates","volume":"182","author":"Sakagami","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.resinv.2021.03.012_bib9","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1186\/s13023-020-01546-x","article-title":"Clinical significance of serum anti-granulocyte-macrophage colony-stimulating factor autoantibodies in patients with sarcoidosis and hypersensitivity pneumonitis","volume":"15","author":"Katayama","year":"2020","journal-title":"Orphanet J Rare Dis"},{"key":"10.1016\/j.resinv.2021.03.012_bib10","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1016\/j.rmed.2011.08.018","article-title":"Pulmonary alveolar proteinosis: new insights from a single-center cohort of 70 patients","volume":"105","author":"Bonella","year":"2011","journal-title":"Respir Med"},{"key":"10.1016\/j.resinv.2021.03.012_bib11","doi-asserted-by":"crossref","first-page":"544","DOI":"10.2214\/AJR.15.14982","article-title":"Pulmonary fibrosis on high-resolution CT of patients with pulmonary alveolar proteinosis","volume":"207","author":"Akira","year":"2016","journal-title":"AJR Am J Roentgenol"},{"key":"10.1016\/j.resinv.2021.03.012_bib12","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1513\/AnnalsATS.201607-574OC","article-title":"A semiquantitative computed tomographic grading system for evaluating therapeutic response in pulmonary alveolar proteinosis","volume":"14","author":"Tokura","year":"2017","journal-title":"Ann Am Thorac Soc"},{"key":"10.1016\/j.resinv.2021.03.012_bib13","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1164\/ajrccm.156.1.9612043","article-title":"Pulmonary epithelial cell injury and alveolar-capillary permeability in berylliosis","volume":"156","author":"Inoue","year":"1997","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.resinv.2021.03.012_bib14","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/resp.12210","article-title":"CYFRA 21-1 as a disease severity marker for autoimmune pulmonary alveolar proteinosis","volume":"19","author":"Arai","year":"2014","journal-title":"Respirology"},{"key":"10.1016\/j.resinv.2021.03.012_bib15","doi-asserted-by":"crossref","first-page":"2547","DOI":"10.1182\/blood-2008-05-155689","article-title":"Granulocyte\/macrophage-colony-stimulating factor autoantibodies and myeloid cell immune functions in healthy subjects","volume":"113","author":"Uchida","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.resinv.2021.03.012_bib16","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1378\/chest.114.5.1357","article-title":"Pulmonary alveolar proteinosis: clinical features and outcomes","volume":"114","author":"Goldstein","year":"1998","journal-title":"Chest"},{"key":"10.1016\/j.resinv.2021.03.012_bib17","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1164\/rccm.2109105","article-title":"Pulmonary alveolar proteinosis: progress in the first 44 years","volume":"166","author":"Seymour","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.resinv.2021.03.012_bib18","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.chest.2018.11.002","article-title":"Blood testing for differential diagnosis of pulmonary alveolar proteinosis syndrome","volume":"155","author":"McCarthy","year":"2019","journal-title":"Chest"},{"key":"10.1016\/j.resinv.2021.03.012_bib19","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1111\/resp.12309","article-title":"Lung cryobiopsies: a paradigm shift in diagnostic bronchoscopy?","volume":"19","author":"Poletti","year":"2014","journal-title":"Respirology"},{"key":"10.1016\/j.resinv.2021.03.012_bib20","doi-asserted-by":"crossref","DOI":"10.1002\/rcr2.336","article-title":"Novel application of cryobiopsy in the diagnosis of pulmonary alveolar proteinosis","volume":"6","author":"Shen","year":"2018","journal-title":"Respirol Case Rep"},{"key":"10.1016\/j.resinv.2021.03.012_bib21","doi-asserted-by":"crossref","first-page":"e54","DOI":"10.1016\/S2213-2600(18)30372-2","article-title":"Blood testing in the diagnosis of pulmonary alveolar proteinosis","volume":"6","author":"McCarthy","year":"2018","journal-title":"The Lancet Respir Med"},{"key":"10.1016\/j.resinv.2021.03.012_bib22","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1111\/j.1440-1843.2010.01848.x","article-title":"Alveolar proteinosis with hypersensitivity pneumonitis: a new clinical phenotype","volume":"15","author":"Verma","year":"2010","journal-title":"Respirology"},{"key":"10.1016\/j.resinv.2021.03.012_bib23","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.2169\/internalmedicine.3853-19","article-title":"Autoimmune pulmonary alveolar proteinosis complicated with sarcoidosis: the clinical course and serum levels of anti-granulocyte-macrophage colony-stimulating factor Autoantibody","volume":"59","author":"Arai","year":"2020","journal-title":"Intern Med"}],"container-title":["Respiratory Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212534521000733?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212534521000733?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T22:31:47Z","timestamp":1761949907000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2212534521000733"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":22,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["S2212534521000733"],"URL":"https:\/\/doi.org\/10.1016\/j.resinv.2021.03.012","relation":{},"ISSN":["2212-5345"],"issn-type":[{"value":"2212-5345","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diagnostic yield and safety of bronchofiberscopy for pulmonary alveolar proteinosis","name":"articletitle","label":"Article Title"},{"value":"Respiratory Investigation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resinv.2021.03.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Japanese Respiratory Society. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}