{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T22:37:25Z","timestamp":1761950245159,"version":"build-2065373602"},"reference-count":18,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,7]],"date-time":"2023-07-07T00:00:00Z","timestamp":1688688000000},"content-version":"am","delay-in-days":371,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Investigation"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.resinv.2022.03.003","type":"journal-article","created":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T07:51:09Z","timestamp":1649749869000},"page":"570-577","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Hierarchical cluster analysis based on disease-associated manifestations of patients with lymphangioleiomyomatosis: An analysis of the national database of designated intractable diseases of Japan"],"prefix":"10.1016","volume":"60","author":[{"given":"Mie","family":"Hayashida","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takumi","family":"Kinjo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3349-2980","authenticated-orcid":false,"given":"Yosuke","family":"Wada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3922-4082","authenticated-orcid":false,"given":"Yoshiaki","family":"Kitaguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Hanaoka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.resinv.2022.03.003_bib1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1146\/annurev-med-050715-104245","article-title":"Lymphangioleiomyomatosis: a monogenic model of malignancy","volume":"68","author":"Krymskaya","year":"2017","journal-title":"Annu Rev Med"},{"key":"10.1016\/j.resinv.2022.03.003_bib2","doi-asserted-by":"crossref","first-page":"3807","DOI":"10.1172\/JCI58709","article-title":"Lymphangioleiomyomatosis - a wolf in sheep's clothing","volume":"122","author":"Henske","year":"2012","journal-title":"J Clin Invest"},{"key":"10.1016\/j.resinv.2022.03.003_bib3","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s00408-012-9419-3","article-title":"Clinical predictors of mortality and cause of death in lymphangioleiomyomatosis: a population-based registry","volume":"191","author":"Oprescu","year":"2013","journal-title":"Lung"},{"key":"10.1016\/j.resinv.2022.03.003_bib4","doi-asserted-by":"crossref","first-page":"249","DOI":"10.2147\/CLEP.S50780","article-title":"Clinical features, epidemiology, and therapy of lymphangioleiomyomatosis","volume":"7","author":"Taveira-DaSilva","year":"2015","journal-title":"Clin Epidemiol"},{"key":"10.1016\/j.resinv.2022.03.003_bib5","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1378\/chest.126.6.1867","article-title":"Decline in lung function in patients with lymphangioleiomyomatosis treated with or without progesterone","volume":"126","author":"Taveira-DaSilva","year":"2004","journal-title":"Chest"},{"key":"10.1016\/j.resinv.2022.03.003_bib6","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1164\/ajrccm.160.2.9901027","article-title":"Decline in lung function in lymphangioleiomyomatosis: relation to menopause and progesterone treatment","volume":"160","author":"Johnson","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.resinv.2022.03.003_bib7","doi-asserted-by":"crossref","first-page":"1802066","DOI":"10.1183\/13993003.02066-2018","article-title":"Analysis of the MILES cohort reveals determinants of disease progression and treatment response in lymphangioleiomyomatosis","volume":"53","author":"Gupta","year":"2019","journal-title":"Eur Respir J"},{"key":"10.1016\/j.resinv.2022.03.003_bib8","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.rmed.2003.11.013","article-title":"Groupe d'etudes et de recherche sur les maladies \"Orphelines\" pulmonaires. Low initial KCO predicts rapid FEV1 decline in pulmonary lymphangioleiomyomatosis","volume":"98","author":"Lazor","year":"2004","journal-title":"Respir Med"},{"key":"10.1016\/j.resinv.2022.03.003_bib9","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.resinv.2015.11.003","article-title":"Reductions in pulmonary function detected\u00a0in patients with lymphangioleiomyomatosis: an analysis of the Japanese national research project on intractable diseases database","volume":"54","author":"Hayashida","year":"2016","journal-title":"Respir Investig"},{"key":"10.1016\/j.resinv.2022.03.003_bib10","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1089\/lrb.2006.4.143","article-title":"Vascular endothelial growth factor-D is increased in serum of patients with lymphangioleiomyomatosis","volume":"4","author":"Seyama","year":"2006","journal-title":"Lymphatic Res Biol"},{"key":"10.1016\/j.resinv.2022.03.003_bib11","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1378\/chest.08-1160","article-title":"Serum vascular endothelial growth factor-D levels in patients with lymphangioleiomyomatosis reflect lymphatic involvement","volume":"135","author":"Glasgow","year":"2009","journal-title":"Chest"},{"key":"10.1016\/j.resinv.2022.03.003_bib12","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S2213-2600(13)70090-0","article-title":"Serum VEGF-D a concentration as a biomarker of lymphangioleiomyomatosis severity and treatment response: a prospective analysis of the multicenter international lymphangioleiomyomatosis efficacy of sirolimus (MILES) trial","volume":"1","author":"Young","year":"2013","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.resinv.2022.03.003_bib13","doi-asserted-by":"crossref","first-page":"2003036","DOI":"10.1183\/13993003.03036-2020","article-title":"Machine learning can predict disease manifestations and outcomes in lymphangioleiomyomatosis","volume":"57","author":"Chernbumroong","year":"2021","journal-title":"Eur Respir J"},{"key":"10.1016\/j.resinv.2022.03.003_bib14","doi-asserted-by":"crossref","first-page":"106093","DOI":"10.1016\/j.rmed.2020.106093","article-title":"COPD phenotypes and machine learning cluster analysis: a systematic review and future research agenda","volume":"171","author":"Nikolaou","year":"2020","journal-title":"Respir Med"},{"key":"10.1016\/j.resinv.2022.03.003_bib15","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.resinv.2014.03.003","article-title":"Reference values for spirometry, including vital capacity, in Japanese adults calculated with the LMS method and compared with previous values","volume":"52","author":"Kubota","year":"2014","journal-title":"Respir Investig"},{"key":"10.1016\/j.resinv.2022.03.003_bib16","first-page":"941","article-title":"[Pulmonary function in healthy subjects and its prediction. 5. Pulmonary diffusing capacity in adults (author's transl)]","volume":"24","author":"Nishida","year":"1976","journal-title":"Rinsho Byori"},{"key":"10.1016\/j.resinv.2022.03.003_bib17","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1089\/lrb.2009.0024","article-title":"The natural history of lymphangioleiomyomatosis: markers of severity, rate of progression and prognosis","volume":"8","author":"Taveira-DaSilva","year":"2010","journal-title":"Lymphatic Res Biol"},{"key":"10.1016\/j.resinv.2022.03.003_bib18","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1164\/rccm.201607-1384ST","article-title":"Official American thoracic society\/Japanese respiratory society clinical practice guidelines: lymphangioleiomyomatosis diagnosis and management","volume":"194","author":"McCormack","year":"2016","journal-title":"Am J Respir Crit Care Med"}],"container-title":["Respiratory Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212534522000284?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212534522000284?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T22:32:57Z","timestamp":1761949977000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2212534522000284"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["S2212534522000284"],"URL":"https:\/\/doi.org\/10.1016\/j.resinv.2022.03.003","relation":{},"ISSN":["2212-5345"],"issn-type":[{"type":"print","value":"2212-5345"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hierarchical cluster analysis based on disease-associated manifestations of patients with lymphangioleiomyomatosis: An analysis of the national database of designated intractable diseases of Japan","name":"articletitle","label":"Article Title"},{"value":"Respiratory Investigation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resinv.2022.03.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Japanese Respiratory Society. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}