{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T03:14:28Z","timestamp":1778987668745,"version":"3.51.4"},"reference-count":48,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T00:00:00Z","timestamp":1713830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004192","name":"National Science and Technology Development Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004192","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Investigation"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.resinv.2024.04.012","type":"journal-article","created":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T02:56:55Z","timestamp":1713927415000},"page":"558-565","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["The bioflavonoid hispidulin effectively attenuates T helper type 2-driven allergic lung inflammation in the ovalbumin-induced allergic asthma mouse model"],"prefix":"10.1016","volume":"62","author":[{"given":"Chaiphichit","family":"Phayangkhe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pornpimon","family":"Ek-eudomsuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kitipong","family":"Soontrapa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"10258","key":"10.1016\/j.resinv.2024.04.012_bib1","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/S0140-6736(20)30925-9","article-title":"Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019","volume":"396","year":"2020","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.resinv.2024.04.012_bib2","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/ni.3049","article-title":"The immunology of asthma","volume":"16","author":"Lambrecht","year":"2015","journal-title":"Nat Immunol"},{"key":"10.1016\/j.resinv.2024.04.012_bib3","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1097\/MCP.0b013e3280108757","article-title":"Asthma: new developments concerning immune mechanisms, diagnosis and treatment","volume":"13","author":"Effros","year":"2007","journal-title":"Curr Opin Pulm Med"},{"key":"10.1016\/j.resinv.2024.04.012_bib4","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1126\/science.287.5460.2013","article-title":"Prostaglandin D2 as a mediator of allergic asthma","volume":"287","author":"Matsuoka","year":"2000","journal-title":"Science."},{"key":"10.1016\/j.resinv.2024.04.012_bib5","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1146\/annurev.physiol.010908.163200","article-title":"Immunobiology of asthma","volume":"71","author":"Hamid","year":"2009","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.resinv.2024.04.012_bib6","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/S0140-6736(10)61054-9","article-title":"Management of severe asthma in children","volume":"376","author":"Bush","year":"2010","journal-title":"Lancet."},{"key":"10.1016\/j.resinv.2024.04.012_bib7","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/S0140-6736(06)69289-1","article-title":"Pharmacological management of mild or moderate persistent asthma","volume":"368","author":"O'Byrne","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.resinv.2024.04.012_bib8","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0378-8741(86)90001-2","article-title":"Ethnobotanical review of medicinal plants from Thai traditional books, Part I: plants with anti-inflammatory, anti-asthmatic and antihypertensive properties","volume":"18","author":"Panthong","year":"1986","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.resinv.2024.04.012_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109319","article-title":"Moore: the therapeutic potential of phytochemicals, hispidulin, vanillic acid, verbascoside, and apigenin","volume":"118","author":"Brimson","year":"2019","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.resinv.2024.04.012_bib10","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/0306-3623(88)90164-4","article-title":"Effects of hispidulin, a flavone isolated from Inula viscosa, on isolated Guinea-pig smooth muscle","volume":"19","author":"Abdalla","year":"1988","journal-title":"Gen Pharmacol"},{"key":"10.1016\/j.resinv.2024.04.012_bib11","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0378-8741(01)00320-8","article-title":"Isolation of a bronchodilator flavonoid from the Thai medicinal plant Clerodendrum petasites","volume":"78","author":"Hazekamp","year":"2001","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.resinv.2024.04.012_bib12","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.jep.2015.02.043","article-title":"Bioassay-guided isolation and mechanistic action of anti-inflammatory agents from Clerodendrum inerme leaves","volume":"165","author":"Srisook","year":"2015","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.resinv.2024.04.012_bib13","article-title":"Hispidulin inhibits mast cell-mediated allergic inflammation through down-regulation of histamine release and inflammatory cytokines","volume":"24","author":"Kim","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.resinv.2024.04.012_bib14","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1186\/s12906-019-2689-z","article-title":"Immunosuppressive effect of hispidulin in allergic contact dermatitis","volume":"19","author":"Thitilertdecha","year":"2019","journal-title":"BMC Compl Alternative Med"},{"key":"10.1016\/j.resinv.2024.04.012_bib15","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.ejphar.2015.03.037","article-title":"Translational value of animal models of asthma: challenges and promises","volume":"759","author":"Sagar","year":"2015","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.resinv.2024.04.012_bib16","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1242\/dmm.000323","article-title":"Mouse models of allergic asthma: acute and chronic allergen challenge","volume":"1","author":"Nials","year":"2008","journal-title":"Dis Model Mech"},{"key":"10.1016\/j.resinv.2024.04.012_bib17","doi-asserted-by":"crossref","first-page":"10","DOI":"10.4168\/aair.2009.1.1.10","article-title":"Understanding asthma using animal models","volume":"1","author":"Shin","year":"2009","journal-title":"Allergy Asthma Immunol Res"},{"key":"10.1016\/j.resinv.2024.04.012_bib18","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/rr40","article-title":"Th2 cytokines and asthma \u2014 interleukin-4: its role in the pathogenesis of asthma, and targeting it for asthma treatment with interleukin-4 receptor antagonists","volume":"2","author":"Steinke","year":"2001","journal-title":"Respir Res"},{"key":"10.1016\/j.resinv.2024.04.012_bib19","doi-asserted-by":"crossref","first-page":"25555","DOI":"10.1074\/jbc.271.41.25555","article-title":"Interleukin-4-induced STAT6 recognizes and activates a target site in the promoter of the interleukin-4 receptor gene","volume":"271","author":"Kotanides","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/j.resinv.2024.04.012_bib20","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.cyto.2015.05.010","article-title":"T helper 2 (Th2) cell differentiation, type 2 innate lymphoid cell (ILC2) development and regulation of interleukin-4 (IL-4) and IL-13 production","volume":"75","author":"Zhu","year":"2015","journal-title":"Cytokine"},{"key":"10.1016\/j.resinv.2024.04.012_bib21","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1084\/jem.167.1.43","article-title":"Purified interleukin 5 supports the terminal differentiation and proliferation of murine eosinophilic precursors","volume":"167","author":"Yamaguchi","year":"1988","journal-title":"J Exp Med"},{"key":"10.1016\/j.resinv.2024.04.012_bib22","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1067\/mai.2001.118600","article-title":"IL-13 induces eosinophil recruitment into the lung by an IL-5- and eotaxin-dependent mechanism","volume":"108","author":"Pope","year":"2001","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.resinv.2024.04.012_bib23","doi-asserted-by":"crossref","first-page":"3101","DOI":"10.1182\/blood.V79.12.3101.bloodjournal79123101","article-title":"Interleukin-5, eosinophils, and disease","volume":"79","author":"Sanderson","year":"1992","journal-title":"Blood"},{"key":"10.1016\/j.resinv.2024.04.012_bib24","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1111\/j.1365-2222.2004.1954.x","article-title":"Induction of eotaxin production by interleukin-4, interleukin-13 and lipopolysaccharide by nasal fibroblasts","volume":"34","author":"Nonaka","year":"2004","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.resinv.2024.04.012_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0039673","article-title":"IL-4 engagement of the type I IL-4 receptor complex enhances mouse eosinophil migration to eotaxin-1 in vitro","volume":"7","author":"Heller","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.resinv.2024.04.012_bib26","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1172\/JCI5909","article-title":"Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production","volume":"103","author":"Zhu","year":"1999","journal-title":"J Clin Invest"},{"key":"10.1016\/j.resinv.2024.04.012_bib27","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1111\/j.1365-2222.2007.02871.x","article-title":"Modulation of mucus production by interleukin-13 receptor alpha2 in the human airway epithelium","volume":"38","author":"Tanabe","year":"2008","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.resinv.2024.04.012_bib28","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.4049\/jimmunol.167.3.1683","article-title":"IL-13 induces airways hyperreactivity independently of the IL-4R\u03b1 chain in the allergic lung","volume":"167","author":"Mattes","year":"2001","journal-title":"J Immunol"},{"key":"10.1016\/j.resinv.2024.04.012_bib29","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.4049\/jimmunol.141.7.2335","article-title":"IL-4 is required to generate and sustain in vivo IgE responses","volume":"141","author":"Finkelman","year":"1988","journal-title":"J Immunol"},{"key":"10.1016\/j.resinv.2024.04.012_bib30","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/362248a0","article-title":"interleukin-13 is a new human lymphokine regulating inflammatory and immune responses","volume":"362","author":"Minty","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.resinv.2024.04.012_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1440-1592.2003.00275.x","article-title":"Regulatory mechanisms of human Ige synthesis","volume":"52","author":"Yanagihara","year":"2003","journal-title":"Allergol Int"},{"key":"10.1016\/j.resinv.2024.04.012_bib32","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S1074-7613(00)80439-2","article-title":"Stat6 is required for mediating responses to IL-4 and for development of Th2 cells","volume":"4","author":"Kaplan","year":"1996","journal-title":"Immunity"},{"key":"10.1016\/j.resinv.2024.04.012_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2009.06.047","article-title":"Induction of long-lived allergen-specific plasma cells by mucosal allergen challenge","volume":"124","author":"Luger","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.resinv.2024.04.012_bib34","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.00715","article-title":"Non-classical B cell memory of allergic IgE responses","volume":"10","author":"Saunders","year":"2019","journal-title":"Front Immunol"},{"issue":"3","key":"10.1016\/j.resinv.2024.04.012_bib35","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.jtcme.2016.11.003","article-title":"Medicinal importance, pharmacological activities, and analytical aspects of hispidulin: a concise report","volume":"7","author":"Patel","year":"2017","journal-title":"J Tradit Complement Med"},{"issue":"2","key":"10.1016\/j.resinv.2024.04.012_bib36","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1002\/ptr.6862","article-title":"Hispidulin: a novel natural compound with therapeutic potential against human cancers","volume":"35","author":"Ashaq","year":"2021","journal-title":"Phytother Res"},{"issue":"5","key":"10.1016\/j.resinv.2024.04.012_bib37","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1111\/cas.13575","article-title":"Hispidulin suppresses cell growth and metastasis by targeting PIM1 through JAK2\/STAT3 signaling in colorectal cancer","volume":"109","author":"Liu","year":"2018","journal-title":"Cancer Sci"},{"issue":"4","key":"10.1016\/j.resinv.2024.04.012_bib38","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.biocel.2004.11.005","article-title":"The serine\/threonine kinase Pim-1","volume":"37","author":"Bachmann","year":"2005","journal-title":"Int J Biochem Cell Biol"},{"issue":"4","key":"10.1016\/j.resinv.2024.04.012_bib39","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.4049\/jimmunol.168.4.1524","article-title":"Cutting edge: transcriptional activity of NFATc1 is enhanced by the Pim-1 kinase","volume":"168","author":"Rainio","year":"2002","journal-title":"J Immunol"},{"issue":"7","key":"10.1016\/j.resinv.2024.04.012_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112663","article-title":"NFAT and NF-\u03baB dynamically coregulate TCR and CAR signaling responses in human T cells","volume":"42","author":"Huang","year":"2023","journal-title":"Cell Rep"},{"issue":"1","key":"10.1016\/j.resinv.2024.04.012_bib41","doi-asserted-by":"crossref","DOI":"10.1111\/cbdd.14367","article-title":"Study of hispidulin in the treatment of uric acid nephropathy based on NF-\u03baB signaling pathway","volume":"103","author":"Li","year":"2024","journal-title":"Chem Biol Drug Des"},{"issue":"1\u20133","key":"10.1016\/j.resinv.2024.04.012_bib42","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.ejphar.2013.06.002","article-title":"Hispidulin attenuates bone resorption and osteoclastogenesis via the RANKL-induced NF-\u03baB and NFATc1 pathways","volume":"715","author":"Nepal","year":"2013","journal-title":"Eur J Pharmacol"},{"issue":"18","key":"10.1016\/j.resinv.2024.04.012_bib43","doi-asserted-by":"crossref","DOI":"10.3390\/molecules28186717","article-title":"Hispidulin inhibits the vascular inflammation triggered by Porphyromonas gingivalis lipopolysaccharide","volume":"28","author":"Kim","year":"2023","journal-title":"Molecules"},{"issue":"5","key":"10.1016\/j.resinv.2024.04.012_bib44","first-page":"3597","article-title":"In vivo and in vitro anti-allergic and anti-inflammatory effects of Dryopteris crassirhizoma through the modulation of the NF-\u0138B signaling pathway in an ovalbumin-induced allergic asthma mouse model","volume":"22","author":"Piao","year":"2020","journal-title":"Mol Med Rep"},{"issue":"2","key":"10.1016\/j.resinv.2024.04.012_bib45","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1055\/s-2003-37712","article-title":"Constituents of sage (Salvia officinalis) with in vitro affinity to human brain benzodiazepine receptor","volume":"69","author":"Kavvadias","year":"2003","journal-title":"Planta Med"},{"issue":"5","key":"10.1016\/j.resinv.2024.04.012_bib46","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1038\/sj.bjp.0705828","article-title":"The flavone hispidulin, a benzodiazepine receptor ligand with positive allosteric properties, traverses the blood\u2013brain barrier and exhibits anticonvulsive effects","volume":"142","author":"Kavvadias","year":"2004","journal-title":"Br J Pharmacol"},{"issue":"5","key":"10.1016\/j.resinv.2024.04.012_bib47","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0251632","article-title":"Activation of GABA(A) receptors inhibits T-cell proliferation","volume":"16","author":"Sparrow","year":"2021","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.resinv.2024.04.012_bib48","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1080\/09168451.2018.1444467","article-title":"Flavonoid metabolism: the interaction of metabolites and gut microbiota","volume":"82","author":"Murota","year":"2018","journal-title":"Biosci Biotechnol Biochem"}],"container-title":["Respiratory Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212534524000662?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212534524000662?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,2]],"date-time":"2024-11-02T08:03:02Z","timestamp":1730534582000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2212534524000662"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":48,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["S2212534524000662"],"URL":"https:\/\/doi.org\/10.1016\/j.resinv.2024.04.012","relation":{},"ISSN":["2212-5345"],"issn-type":[{"value":"2212-5345","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The bioflavonoid hispidulin effectively attenuates T helper type 2-driven allergic lung inflammation in the ovalbumin-induced allergic asthma mouse model","name":"articletitle","label":"Article Title"},{"value":"Respiratory Investigation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resinv.2024.04.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier B.V. on behalf of The Japanese Respiratory Society.","name":"copyright","label":"Copyright"}]}}