{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T02:04:50Z","timestamp":1792029890051,"version":"4.4.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Investigation"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.resinv.2024.08.007","type":"journal-article","created":{"date-parts":[[2024,8,24]],"date-time":"2024-08-24T15:03:36Z","timestamp":1724511816000},"page":"942-950","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Multidisciplinary team discussion based on etiological treatment improves refractory chronic cough outcomes"],"prefix":"10.1016","volume":"62","author":[{"given":"Yicong","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanting","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danruo","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangying","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaoyan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaqiong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.resinv.2024.08.007_bib1","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1016\/S0140-6736(08)60595-4","article-title":"Prevalence, pathogenesis, and causes of chronic cough","volume":"371","author":"Chung","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.resinv.2024.08.007_bib2","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1183\/09031936.00218714","article-title":"The global epidemiology of chronic cough in adults: a systematic review and meta-analysis","volume":"45","author":"Song","year":"2015","journal-title":"Eur Respir J"},{"key":"10.1016\/j.resinv.2024.08.007_bib3","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01136-2019","article-title":"ERS guidelines on the diagnosis and treatment of chronic cough in adults and children","volume":"55","author":"Morice","year":"2020","journal-title":"Eur Respir J"},{"key":"10.1016\/j.resinv.2024.08.007_bib4","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1378\/chest.127.5.1710","article-title":"Chronic idiopathic cough: a discrete clinical entity?","volume":"127","author":"Haque","year":"2005","journal-title":"Chest"},{"key":"10.1016\/j.resinv.2024.08.007_bib5","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1378\/chest.15-1496","article-title":"Treatment of unexplained chronic cough: CHEST guideline and expert panel report","volume":"149","author":"Gibson","year":"2016","journal-title":"Chest"},{"key":"10.1016\/j.resinv.2024.08.007_bib6","doi-asserted-by":"crossref","DOI":"10.1378\/chest.114.2_Supplement.133S","article-title":"Managing cough as a defense mechanism and as a symptom. A consensus panel report of the American College of Chest Physicians","volume":"114","author":"Irwin","year":"1998","journal-title":"Chest"},{"key":"10.1016\/j.resinv.2024.08.007_bib7","first-page":"143","article-title":"[Guidelines of the German respiratory society for diagnosis and treatment of adults suffering from acute, subacute and chronic cough]","volume":"73","author":"Kardos","year":"2019","journal-title":"Pneumologie"},{"key":"10.1016\/j.resinv.2024.08.007_bib8","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.resinv.2021.01.007","article-title":"The Japanese respiratory society guidelines for the management of cough and sputum (digest edition)","volume":"59","author":"Mukae","year":"2021","journal-title":"Respir Investig"},{"key":"10.1016\/j.resinv.2024.08.007_bib9","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1378\/chest.12-0441","article-title":"A prospective, multicenter survey on causes of chronic cough in China","volume":"143","author":"Lai","year":"2013","journal-title":"Chest"},{"key":"10.1016\/j.resinv.2024.08.007_bib10","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/S0140-6736(21)02348-5","article-title":"Efficacy and safety of gefapixant, a P2X(3) receptor antagonist, in refractory chronic cough and unexplained chronic cough (COUGH-1 and COUGH-2): results from two double-blind, randomised, parallel-group, placebo-controlled, phase 3 trials","volume":"399","author":"McGarvey","year":"2022","journal-title":"Lancet"},{"key":"10.1016\/j.resinv.2024.08.007_bib11","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1136\/thorax.58.4.339","article-title":"Development of a symptom specific health status measure for patients with chronic cough: Leicester Cough Questionnaire (LCQ)","volume":"58","author":"Birring","year":"2003","journal-title":"Thorax"},{"key":"10.1016\/j.resinv.2024.08.007_bib12","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/s00408-015-9701-2","article-title":"The impact of chronic cough: a cross-sectional European survey","volume":"193","author":"Chamberlain","year":"2015","journal-title":"Lung"},{"key":"10.1016\/j.resinv.2024.08.007_bib13","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1378\/chest.14-1485","article-title":"Overview of the management of cough: CHEST guideline and expert panel report","volume":"146","author":"Irwin","year":"2014","journal-title":"Chest"},{"key":"10.1016\/j.resinv.2024.08.007_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0225712","article-title":"Direct costs of illness of patients with chronic cough in rural Malawi-Experiences from Dowa and Ntchisi districts","volume":"14","author":"Sichali","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.resinv.2024.08.007_bib15","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1016\/S0140-6736(12)60776-4","article-title":"Gabapentin for refractory chronic cough: a randomised, double-blind, placebo-controlled trial","volume":"380","author":"Ryan","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.resinv.2024.08.007_bib16","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1016\/j.jaip.2019.03.030","article-title":"An update on speech pathology management of chronic refractory cough","volume":"7","author":"Vertigan","year":"2019","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.resinv.2024.08.007_bib17","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/S0140-6736(21)02438-7","article-title":"Gefapixant for chronic cough","volume":"399","author":"Thomas","year":"2022","journal-title":"Lancet"},{"key":"10.1016\/j.resinv.2024.08.007_bib18","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1378\/chest.15-1271","article-title":"Pregabalin and speech pathology combination therapy for refractory chronic cough: a randomized controlled trial","volume":"149","author":"Vertigan","year":"2016","journal-title":"Chest"},{"key":"10.1016\/j.resinv.2024.08.007_bib19","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.21037\/tlcr.2019.11.33","article-title":"Multidisciplinary team care in advanced lung cancer","volume":"9","author":"Kowalczyk","year":"2020","journal-title":"Transl Lung Cancer Res"},{"key":"10.1016\/j.resinv.2024.08.007_bib20","first-page":"1887","article-title":"Multidisciplinary team intervention associated with improved survival for patients with colorectal adenocarcinoma with liver or lung metastasis","volume":"8","author":"Chen","year":"2018","journal-title":"Am J Cancer Res"},{"key":"10.1016\/j.resinv.2024.08.007_bib21","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.e2718","article-title":"Effects of multidisciplinary team working on breast cancer survival: retrospective, comparative, interventional cohort study of 13 722 women","volume":"344","author":"Kesson","year":"2012","journal-title":"BMJ"},{"key":"10.1016\/j.resinv.2024.08.007_bib22","doi-asserted-by":"crossref","first-page":"815","DOI":"10.2147\/JMDH.S295478","article-title":"The role of the multidisciplinary health care team in the management of patients with systemic sclerosis","volume":"15","author":"Farina","year":"2022","journal-title":"J Multidiscip Healthc"},{"key":"10.1016\/j.resinv.2024.08.007_bib23","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.chest.2017.10.016","article-title":"Classification of cough as a symptom in adults and management algorithms: CHEST guideline and expert panel report","volume":"153","author":"Irwin","year":"2018","journal-title":"Chest"},{"key":"10.1016\/j.resinv.2024.08.007_bib24","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1001\/archinte.1997.00440380091009","article-title":"Interpretation of positive results of a methacholine inhalation challenge and 1 week of inhaled bronchodilator use in diagnosing and treating cough-variant asthma","volume":"157","author":"Irwin","year":"1997","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.resinv.2024.08.007_bib25","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1164\/rccm.201209-1686OC","article-title":"A longitudinal assessment of acute cough","volume":"187","author":"Lee","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.resinv.2024.08.007_bib26","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/S0892-1997(02)00097-8","article-title":"Validity and reliability of the reflux symptom index (RSI)","volume":"16","author":"Belafsky","year":"2002","journal-title":"J Voice"},{"key":"10.1016\/j.resinv.2024.08.007_bib27","doi-asserted-by":"crossref","DOI":"10.1378\/chest.129.1_suppl.116S","article-title":"Chronic cough due to nonasthmatic eosinophilic bronchitis: ACCP evidence-based clinical practice guidelines","volume":"129","author":"Brightling","year":"2006","journal-title":"Chest"},{"key":"10.1016\/j.resinv.2024.08.007_bib28","doi-asserted-by":"crossref","first-page":"63S","DOI":"10.1378\/chest.129.1_suppl.63S","article-title":"Chronic upper airway cough syndrome secondary to rhinosinus diseases (previously referred to as postnasal drip syndrome): ACCP evidence-based clinical practice guidelines","volume":"129","author":"Pratter","year":"2006","journal-title":"Chest"},{"key":"10.1016\/j.resinv.2024.08.007_bib29","doi-asserted-by":"crossref","DOI":"10.1378\/chest.129.1_suppl.75S","article-title":"Chronic cough due to asthma: ACCP evidence-based clinical practice guidelines","volume":"129","author":"Dicpinigaitis","year":"2006","journal-title":"Chest"},{"key":"10.1016\/j.resinv.2024.08.007_bib30","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1016\/j.chest.2016.08.1458","article-title":"Chronic cough due to gastroesophageal reflux in adults: CHEST guideline and expert panel report","volume":"150","author":"Kahrilas","year":"2016","journal-title":"Chest"},{"key":"10.1016\/j.resinv.2024.08.007_bib31","first-page":"13","volume":"45","year":"2021","journal-title":"Zhonghua Jiehe He Huxi Zazhi"},{"key":"10.1016\/j.resinv.2024.08.007_bib32","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1378\/chest.07-2541","article-title":"Exhaled nitric oxide measurement is useful for the exclusion of nonasthmatic eosinophilic bronchitis in patients with chronic cough","volume":"134","author":"Oh","year":"2008","journal-title":"Chest"},{"key":"10.1016\/j.resinv.2024.08.007_bib33","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/j.jclinepi.2009.09.015","article-title":"A prospective global measure, the Punum Ladder, provides more valid assessments of quality of life than a retrospective transition measure","volume":"63","author":"Fletcher","year":"2010","journal-title":"J Clin Epidemiol"},{"key":"10.1016\/j.resinv.2024.08.007_bib34","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1183\/09031936.05.00140803","article-title":"Investigation and management of chronic cough using a probability-based algorithm","volume":"25","author":"Kastelik","year":"2005","journal-title":"Eur Respir J"},{"key":"10.1016\/j.resinv.2024.08.007_bib35","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.anai.2022.08.993","article-title":"Referrals, etiology, prevalence, symptoms, and treatments of chronic cough","volume":"129","author":"Prenner","year":"2022","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.resinv.2024.08.007_bib36","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2021-054832","article-title":"Burden and impact of chronic cough in UK primary care: a dataset analysis","volume":"11","author":"Hull","year":"2021","journal-title":"BMJ Open"},{"key":"10.1016\/j.resinv.2024.08.007_bib37","doi-asserted-by":"crossref","first-page":"2300","DOI":"10.21037\/jtd-22-1435","article-title":"Worldwide prevalence, risk factors and burden of chronic cough in the general population: a narrative review","volume":"15","author":"Yang","year":"2023","journal-title":"J Thorac Dis"},{"key":"10.1016\/j.resinv.2024.08.007_bib38","article-title":"Advances in the diagnosis and management of gastroesophageal reflux disease","volume":"371","author":"Katzka","year":"2020","journal-title":"BMJ"},{"key":"10.1016\/j.resinv.2024.08.007_bib39","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1053\/j.gastro.2022.05.055","article-title":"Vonoprazan triple and dual therapy for Helicobacter pylori infection in the United States and Europe: randomized clinical trial","volume":"163","author":"Chey","year":"2022","journal-title":"Gastroenterology"},{"key":"10.1016\/j.resinv.2024.08.007_bib40","doi-asserted-by":"crossref","first-page":"871","DOI":"10.4168\/aair.2019.11.6.871","article-title":"Age and sex distribution of Chinese chronic cough patients and their relationship with capsaicin cough sensitivity","volume":"11","author":"Lai","year":"2019","journal-title":"Allergy Asthma Immunol Res"},{"key":"10.1016\/j.resinv.2024.08.007_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.rmed.2021.106726","article-title":"Distribution of chronic cough phenotypes in the general population: a cross-sectional analysis of the LEAD cohort in Austria","volume":"192","author":"Abozid","year":"2022","journal-title":"Respir Med"},{"key":"10.1016\/j.resinv.2024.08.007_bib42","doi-asserted-by":"crossref","first-page":"336","DOI":"10.2500\/aap.2008.29.3122","article-title":"Systematic evaluation and treatment of chronic cough in a community setting","volume":"29","author":"Levine","year":"2008","journal-title":"Allergy Asthma Proc"},{"key":"10.1016\/j.resinv.2024.08.007_bib43","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1080\/07853890.2022.2074535","article-title":"Global, regional and national burden of gastroesophageal reflux disease, 1990-2019: update from the GBD 2019 study","volume":"54","author":"Zhang","year":"2022","journal-title":"Ann Med"},{"key":"10.1016\/j.resinv.2024.08.007_bib44","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1186\/s12889-023-15272-z","article-title":"Burden of gastroesophageal reflux disease in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of disease study 2019","volume":"23","author":"Li","year":"2023","journal-title":"BMC Publ Health"},{"key":"10.1016\/j.resinv.2024.08.007_bib45","doi-asserted-by":"crossref","DOI":"10.3346\/jkms.2022.37.e275","article-title":"Effectiveness and safety of codeine and levodropropizine in patients with chronic cough","volume":"37","author":"Lee","year":"2022","journal-title":"J Korean Med Sci"},{"key":"10.1016\/j.resinv.2024.08.007_bib46","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1124\/pr.111.005116","article-title":"Antitussive drugs--past, present, and future","volume":"66","author":"Dicpinigaitis","year":"2014","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.resinv.2024.08.007_bib47","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1745-9974-4-2","article-title":"Intra-abdominal pressures during voluntary and reflex cough","volume":"4","author":"Addington","year":"2008","journal-title":"Cough"},{"key":"10.1016\/j.resinv.2024.08.007_bib48","article-title":"Gastroesophageal reflux disease and chronic cough: a possible mechanism elucidated by ambulatory pH\u2010impedance\u2010pressure monitoring","volume":"31","author":"Li","year":"2019","journal-title":"Neuro Gastroenterol Motil"},{"key":"10.1016\/j.resinv.2024.08.007_bib49","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/S0140-6736(20)30566-3","article-title":"Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study","volume":"395","author":"Zhou","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.resinv.2024.08.007_bib50","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.21037\/jtd-21-876","article-title":"Prevalence and risk factors for postinfectious cough in discharged patients with coronavirus disease 2019 (COVID-19)","volume":"14","author":"Chen","year":"2022","journal-title":"J Thorac Dis"}],"container-title":["Respiratory Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221253452400128X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221253452400128X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T08:50:41Z","timestamp":1732092641000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S221253452400128X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":50,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["S221253452400128X"],"URL":"https:\/\/doi.org\/10.1016\/j.resinv.2024.08.007","relation":{},"ISSN":["2212-5345"],"issn-type":[{"value":"2212-5345","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multidisciplinary team discussion based on etiological treatment improves refractory chronic cough outcomes","name":"articletitle","label":"Article Title"},{"value":"Respiratory Investigation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resinv.2024.08.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Japanese Respiratory Society. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}