{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T22:33:36Z","timestamp":1788561216708,"version":"build-2803163510"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T00:00:00Z","timestamp":1661904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009109","name":"Pharmaceuticals Bayer","doi-asserted-by":"publisher","award":["20267"],"award-info":[{"award-number":["20267"]}],"id":[{"id":"10.13039\/501100009109","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009647","name":"Ministry of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009647","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Medicine and Research"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.resmer.2022.100945","type":"journal-article","created":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T12:34:24Z","timestamp":1671626064000},"page":"100945","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Risk stratification, prognosis, and survival in a pulmonary arterial hypertension cohort in Latin America. A multicenter study"],"prefix":"10.1016","volume":"83","author":[{"given":"Mirta","family":"Diez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7112-9640","authenticated-orcid":false,"given":"Jorge","family":"C\u00e1neva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Diez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo R.","family":"Perna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Aimone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Bosio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilia Lobo","family":"M\u00e1rquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela Garc\u00eda","family":"Brasca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norberto","family":"Vulcano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Daghero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucrecia Mar\u00eda","family":"Burgos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliana","family":"Favaloro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Pablo","family":"Escalante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Lorena","family":"Coronel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayel\u00e9n","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngel","family":"Ch\u00e1vez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucrecia","family":"Secco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.resmer.2022.100945_bib0001","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1056\/NEJMra040291","article-title":"Treatment of pulmonary arterial hypertension","volume":"351","author":"Humbert","year":"2004","journal-title":"N Engl J Med"},{"issue":"3","key":"10.1016\/j.resmer.2022.100945_bib0002","first-page":"363","article-title":"World health organization group I pulmonary hypertension: epidemiology and pathophysiology","volume":"34","author":"Prins","year":"2016","journal-title":"Cardiol Clin"},{"key":"10.1016\/j.resmer.2022.100945_bib0003","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1183\/13993003.01032-2015","article-title":"2015 ESC\/ERS guidelines for the diagnosis and treatment of pulmonary hypertension: the joint task force for the diagnosis and treatment of pulmonary hypertension of the european society of cardiology (ESC) and the European respiratory society (ERS)","volume":"46","author":"Gali\u00e8","year":"2015","journal-title":"Eur Respir J"},{"key":"10.1016\/j.resmer.2022.100945_bib0004","doi-asserted-by":"crossref","first-page":"343","DOI":"10.7326\/0003-4819-115-5-343","article-title":"Survival in patients with primary pulmonary hypertension. Results from a national prospective registry","volume":"115","author":"D'Alonzo","year":"1991","journal-title":"Ann Intern Med"},{"issue":"123","key":"10.1016\/j.resmer.2022.100945_bib0005","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1183\/09059180.00008211","article-title":"REVEAL: a contemporary US pulmonary arterial hypertension registry","volume":"21","author":"McGoon","year":"2012","journal-title":"Eur Respir Rev"},{"key":"10.1016\/j.resmer.2022.100945_bib0006","doi-asserted-by":"crossref","first-page":"D51","DOI":"10.1016\/j.jacc.2013.10.023","article-title":"Pulmonary arterial hypertension: epidemiology and registries","volume":"62","author":"McGoon","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.resmer.2022.100945_bib0007","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1161\/CIRCULATIONAHA.109.911818","article-title":"Survival in patients with idiopathic, familial, and anorexigen-associated pulmonary arterial hypertension in the modern management era","volume":"122","author":"Humbert","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.resmer.2022.100945_bib0008","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.1016\/j.jacc.2011.06.068","article-title":"Progressive right ventricular dysfunction in patients with pulmonary arterial hypertension responding to therapy","volume":"58","author":"Van de Veerdonk","year":"2011","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"10.1016\/j.resmer.2022.100945_bib0009","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00740-2017","article-title":"Mortality in pulmonary arterial hypertension: prediction by the 2015 European pulmonary hypertension guidelines risk stratification model","volume":"50","author":"Hoeper","year":"2017","journal-title":"Eur Respir J"},{"issue":"47","key":"10.1016\/j.resmer.2022.100945_bib0010","doi-asserted-by":"crossref","first-page":"4175","DOI":"10.1093\/eurheartj\/ehx257","article-title":"A comprehensive risk stratification at early follow-up determines prognosis in pulmonary arterial hypertension","volume":"39","author":"Kylhammar","year":"2018","journal-title":"Eur Heart J"},{"issue":"2","key":"10.1016\/j.resmer.2022.100945_bib0011","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00889-2017","article-title":"Risk assessment, prognosis and guideline implementation in pulmonary arterial hypertension","volume":"50","author":"Boucly","year":"2017","journal-title":"Eur Respir J"},{"issue":"1","key":"10.1016\/j.resmer.2022.100945_bib0012","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1186\/s12890-018-0667-8","article-title":"Pulmonary arterial hypertension in Latin America: epidemiological data from local studies","volume":"18","author":"Valverde","year":"2018","journal-title":"BMC Pulm Med"},{"issue":"Suppl S1","key":"10.1016\/j.resmer.2022.100945_bib0013","first-page":"319","article-title":"First collaborative registry of pulmonary hypertension in Argentina (RECOPILAR). Epidemiology, clinical profile and management of pulmonary arterial hypertension","volume":"20","author":"Echazarreta","year":"2018","journal-title":"Eur J Heart Fail"},{"issue":"2","key":"10.1016\/j.resmer.2022.100945_bib0014","first-page":"144","article-title":"Hipertensi\u00f3n arterial pulmonar: registro de un centro de referencia en Argentina","volume":"14","author":"L","year":"2014","journal-title":"Revista Americana de Medicina Respiratoria"},{"key":"10.1016\/j.resmer.2022.100945_bib0015","first-page":"180","article-title":"Collaborative registry of pulmonary hypertension in Argentina (RECOPILAR). Final analysis","volume":"81","author":"Echazarreta","year":"2021","journal-title":"Medicina (B Aires)"},{"key":"10.1016\/j.resmer.2022.100945_bib0016","article-title":"External validation of a refined 4-strata risk assessment score from the French pulmonary hypertension Registry","author":"Boucly","year":"2021","journal-title":"Eur Respir J"},{"issue":"11","key":"10.1016\/j.resmer.2022.100945_bib0017","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/j.healun.2012.08.009","article-title":"Validation of the registry to evaluate early and long-term pulmonary arterial hypertension disease management (REVEAL) pulmonary hypertension prediction model in a unique population and utility in the prediction of long-term survival","volume":"31","author":"Cogswell","year":"2012","journal-title":"J Heart Lung Transplant"},{"issue":"3","key":"10.1016\/j.resmer.2022.100945_bib0018","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.healun.2014.09.016","article-title":"Prognostic implications of serial risk score assessments in patients with pulmonary arterial hypertension: a registry to evaluate early and long-term pulmonary arterial hypertension disease management (REVEAL) analysis","volume":"34","author":"Benza","year":"2015","journal-title":"J Heart Lung Transplant"},{"issue":"2","key":"10.1016\/j.resmer.2022.100945_bib0019","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.ijcard.2012.10.026","article-title":"Elderly patients diagnosed with idiopathic pulmonary arterial hypertension: results from the COMPERA registry","volume":"168","author":"Hoeper","year":"2013","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.resmer.2022.100945_bib0020","doi-asserted-by":"crossref","first-page":"3105","DOI":"10.1161\/CIRCULATIONAHA.104.488486","article-title":"Long-term response to calcium channel blockers in idiopathic pulmonary arterial hypertension","volume":"111","author":"Sitbon","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.resmer.2022.100945_bib0021","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.ijcard.2019.11.139","article-title":"Current status of long-term prognosis among all subtypes of pulmonary hypertension in Japan","volume":"300","author":"Kozu","year":"2020","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.resmer.2022.100945_bib0022","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.ijcard.2018.08.082","article-title":"Targeted therapy of pulmonary arterial hypertension: updated recommendations from the cologne consensus conference 2018","author":"Hoeper","year":"2018","journal-title":"Int J Cardiol"}],"container-title":["Respiratory Medicine and Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590041222000617?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590041222000617?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:57:34Z","timestamp":1762909054000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590041222000617"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":22,"alternative-id":["S2590041222000617"],"URL":"https:\/\/doi.org\/10.1016\/j.resmer.2022.100945","relation":{},"ISSN":["2590-0412"],"issn-type":[{"value":"2590-0412","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Risk stratification, prognosis, and survival in a pulmonary arterial hypertension cohort in Latin America. A multicenter study","name":"articletitle","label":"Article Title"},{"value":"Respiratory Medicine and Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resmer.2022.100945","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"100945"}}