{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T14:57:02Z","timestamp":1775141822697,"version":"3.50.1"},"reference-count":44,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T00:00:00Z","timestamp":1700611200000},"content-version":"vor","delay-in-days":2396,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"French Agence nationale de la Recherche (ANR)","doi-asserted-by":"publisher","award":["ANR-12-ADAP-0018"],"award-info":[{"award-number":["ANR-12-ADAP-0018"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002661","name":"National Fund for Scientific Research (FNRS)","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002661","name":"FNRS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005041","name":"Universit\u00e9 catholique de Louvain","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005041","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Research in Microbiology"],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.1016\/j.resmic.2016.10.008","type":"journal-article","created":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T16:04:58Z","timestamp":1478016298000},"page":"331-344","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["Comparative genomics of extrachromosomal elements in Bacillus thuringiensis subsp. israelensis"],"prefix":"10.1016","volume":"168","author":[{"given":"Alexandre","family":"Bolotin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6735-3359","authenticated-orcid":false,"given":"Annika","family":"Gillis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Sanchis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Nielsen-LeRoux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques","family":"Mahillon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Didier","family":"Lereclus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexei","family":"Sorokin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.resmic.2016.10.008_bib1","series-title":"Bacillus thuringiensis biotechnology","first-page":"3","article-title":"Discovery and description of Bacillus thuringiensis","author":"Sansinenea","year":"2012"},{"key":"10.1016\/j.resmic.2016.10.008_bib2","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.3390\/toxins6041222","article-title":"Bacillus thuringiensis subsp. israelensis and its dipteran-specific toxins","volume":"6","author":"Ben-Dov","year":"2014","journal-title":"Toxins"},{"key":"10.1016\/j.resmic.2016.10.008_bib3","doi-asserted-by":"crossref","first-page":"e5107","DOI":"10.1371\/journal.pone.0005107","article-title":"Microbial larvicide application by a large-scale, community-based program reduces malaria infection prevalence in urban Dar es Salaam, Tanzania","volume":"4","author":"Geissbuhler","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.resmic.2016.10.008_bib4","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1006\/plas.1996.0035","article-title":"Mobilization of \u201cnonmobilizable\u201d plasmids by the aggregation-mediated conjugation system of Bacillus thuringiensis","volume":"36","author":"Andrup","year":"1996","journal-title":"Plasmid"},{"key":"10.1016\/j.resmic.2016.10.008_bib5","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1128\/JB.01700-08","article-title":"Plasmid capture by the Bacillus thuringiensis conjugative plasmid pXO16","volume":"191","author":"Timmery","year":"2009","journal-title":"J\u00a0Bacteriol"},{"key":"10.1016\/j.resmic.2016.10.008_bib6","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/0147-619X(84)90004-0","article-title":"A\u00a0large transmissible plasmid is required for crystal toxin production in Bacillus thuringiensis variety israelensis","volume":"11","author":"Gonzalez","year":"1984","journal-title":"Plasmid"},{"key":"10.1016\/j.resmic.2016.10.008_bib7","doi-asserted-by":"crossref","first-page":"2914","DOI":"10.1128\/jb.177.10.2914-2917.1995","article-title":"The genetic basis of the aggregation system in Bacillus thuringiensis subsp. israelensis is located on the large conjugative plasmid pXO16","volume":"177","author":"Jensen","year":"1995","journal-title":"J\u00a0Bacteriol"},{"key":"10.1016\/j.resmic.2016.10.008_bib8","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1007\/s002849900105","article-title":"The aggregation-mediated conjugation system of Bacillus thuringiensis subsp. israelensis: host range and kinetics of transfer","volume":"33","author":"Jensen","year":"1996","journal-title":"Curr Microbiol"},{"key":"10.1016\/j.resmic.2016.10.008_bib9","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.jip.2014.07.003","article-title":"Synergistic activity of Bacillus thuringiensis toxins against Simulium spp. larvae","volume":"121","author":"Monnerat","year":"2014","journal-title":"J\u00a0Invertebr Pathology"},{"key":"10.1016\/j.resmic.2016.10.008_bib10","first-page":"249","article-title":"Contribution of the individual components of the \u03b4-endotoxin crystal to the mosquitocidal activity of Bacillus thuringiensis subsp. israelensis","volume":"131","author":"Crickmore","year":"1995","journal-title":"FEMS Microbiol Lett"},{"key":"10.1016\/j.resmic.2016.10.008_bib11","doi-asserted-by":"crossref","first-page":"18303","DOI":"10.1073\/pnas.0505494102","article-title":"Bacillus thuringiensis subsp. israelensis Cyt1Aa synergizes Cry11Aa toxin by functioning as a membrane-bound receptor","volume":"102","author":"Perez","year":"2005","journal-title":"Proc Natl Acad Sci U. S. A"},{"key":"10.1016\/j.resmic.2016.10.008_bib12","doi-asserted-by":"crossref","first-page":"4138","DOI":"10.1128\/AEM.00912-14","article-title":"Prevalence, genetic diversity, and host range of tectiviruses among members of the Bacillus cereus group","volume":"80","author":"Gillis","year":"2014","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.resmic.2016.10.008_bib13","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/1743-422X-4-97","article-title":"Comparative genomics of Bacillus thuringiensis phage 0305phi8-36: defining patterns of descent in a novel ancient phage lineage","volume":"4","author":"Hardies","year":"2007","journal-title":"Virol J"},{"key":"10.1016\/j.resmic.2016.10.008_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/543286","article-title":"Sequence analysis of inducible prophage phIS3501 integrated into the haemolysin II gene of Bacillus thuringiensis var israelensis ATCC35646","volume":"2012","author":"Moumen","year":"2012","journal-title":"Genet Res Int"},{"key":"10.1016\/j.resmic.2016.10.008_bib15","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1099\/mic.0.26307-0","article-title":"pGIL01, a linear tectiviral plasmid prophage originating from Bacillus thuringiensis serovar israelensis","volume":"149","author":"Verheust","year":"2003","journal-title":"Microbiology"},{"key":"10.1016\/j.resmic.2016.10.008_bib16","doi-asserted-by":"crossref","first-page":"e00231","DOI":"10.1128\/genomeA.00231-14","article-title":"Genome sequence of the acrystalliferous Bacillus thuringiensis serovar israelensis strain 4Q7, widely used as a recombination host","volume":"2","author":"Jeong","year":"2014","journal-title":"Genome Announc"},{"key":"10.1016\/j.resmic.2016.10.008_bib17","doi-asserted-by":"crossref","DOI":"10.1128\/genomeA.01023-13","article-title":"Complete genome sequence of Bacillus thuringiensis serovar israelensis strain HD-789","volume":"1","author":"Doggett","year":"2013","journal-title":"Genome Announc"},{"key":"10.1016\/j.resmic.2016.10.008_bib18","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1101\/gr.134437.111","article-title":"Genomic characterization of the Bacillus cereus sensu lato species: backdrop to the evolution of Bacillus anthracis","volume":"22","author":"Zwick","year":"2012","journal-title":"Genome Res"},{"key":"10.1016\/j.resmic.2016.10.008_bib19","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.femsle.2005.07.008","article-title":"Comparative genome analysis of Bacillus cereus group genomes with Bacillus subtilis","volume":"250","author":"Anderson","year":"2005","journal-title":"FEMS Microbiol Lett"},{"key":"10.1016\/j.resmic.2016.10.008_bib20","doi-asserted-by":"crossref","first-page":"5082","DOI":"10.1128\/AEM.68.10.5082-5095.2002","article-title":"Complete sequence and organization of pBtoxis, the toxin-coding plasmid of Bacillus thuringiensis subsp. israelensis","volume":"68","author":"Berry","year":"2002","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.resmic.2016.10.008_bib21","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.plasmid.2015.03.002","article-title":"pXO16 from Bacillus thuringiensis serovar israelensis: almost 350 kb of terra incognita","volume":"80","author":"Makart","year":"2015","journal-title":"Plasmid"},{"key":"10.1016\/j.resmic.2016.10.008_bib22","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.cbi.2007.03.003","article-title":"Extending the Bacillus cereus group genomics to putative food-borne pathogens of different toxicity","volume":"171","author":"Lapidus","year":"2008","journal-title":"Chem Biol Interact"},{"key":"10.1016\/j.resmic.2016.10.008_bib23","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.plasmid.2007.11.005","article-title":"Detection of large plasmids from the Bacillus cereus group","volume":"59","author":"Andrup","year":"2008","journal-title":"Plasmid"},{"key":"10.1016\/j.resmic.2016.10.008_bib24","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1101\/gr.078212.108","article-title":"Mapping short DNA sequencing reads and calling variants using mapping quality scores","volume":"18","author":"Li","year":"2008","journal-title":"Genome Res"},{"key":"10.1016\/j.resmic.2016.10.008_bib25","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat Methods"},{"key":"10.1016\/j.resmic.2016.10.008_bib26","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/2047-217X-1-18","article-title":"SOAPdenovo2: an empirically improved memory-efficient short-read de novo assembler","volume":"1","author":"Luo","year":"2012","journal-title":"GigaScience"},{"key":"10.1016\/j.resmic.2016.10.008_bib27","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1089\/cmb.2012.0021","article-title":"SPAdes: a new genome assembly algorithm and its applications to single-cell sequencing","volume":"19","author":"Bankevich","year":"2012","journal-title":"J\u00a0Comput Biol J Comput Mol Cell Biol"},{"key":"10.1016\/j.resmic.2016.10.008_bib28","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1002\/0471223921.ch13","article-title":"Sequence assembly and finishing methods","volume":"43","author":"Staden","year":"2001","journal-title":"Methods Biochem Anal"},{"key":"10.1016\/j.resmic.2016.10.008_bib29","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1093\/bioinformatics\/btr039","article-title":"Easyfig: a genome comparison visualizer","volume":"27","author":"Sullivan","year":"2011","journal-title":"Bioinformatics"},{"key":"10.1016\/j.resmic.2016.10.008_bib30","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1128\/AEM.72.2.1569-1578.2006","article-title":"Multiple-locus sequence typing analysis of Bacillus cereus and Bacillus thuringiensis reveals separate clustering and a distinct population structure of psychrotrophic strains","volume":"72","author":"Sorokin","year":"2006","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.resmic.2016.10.008_bib31","doi-asserted-by":"crossref","first-page":"D382","DOI":"10.1093\/nar\/gkp887","article-title":"The integrated microbial genomes system: an expanding comparative analysis resource","volume":"38","author":"Markowitz","year":"2010","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.resmic.2016.10.008_bib32","doi-asserted-by":"crossref","first-page":"D461","DOI":"10.1093\/nar\/gkm877","article-title":"SuperCAT: a supertree database for combined and integrative multilocus sequence typing analysis of the Bacillus cereus group of bacteria (including B. cereus, B. anthracis and B. thuringiensis)","volume":"36","author":"Tourasse","year":"2008","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.resmic.2016.10.008_bib33","doi-asserted-by":"crossref","DOI":"10.1128\/genomeA.00151-15","article-title":"Complete genome sequences for 35 biothreat assay-relevant bacillus species","volume":"3","author":"Johnson","year":"2015","journal-title":"Genome Announc"},{"key":"10.1016\/j.resmic.2016.10.008_bib34","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1128\/aem.47.5.952-955.1984","article-title":"Larvicidal activity of Bacillus thuringiensis subsp. israelensis in the dipteran Haematobia irritans","volume":"47","author":"Temeyer","year":"1984","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.resmic.2016.10.008_bib35","doi-asserted-by":"crossref","first-page":"6792","DOI":"10.1128\/AEM.01124-08","article-title":"Molecular characterization of a variant of Bacillus anthracis-specific phage AP50 with improved bacteriolytic activity","volume":"74","author":"Sozhamannan","year":"2008","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.resmic.2016.10.008_bib36","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0147-619X(03)00015-5","article-title":"The patchwork nature of rolling-circle plasmids: comparison of six plasmids from two distinct Bacillus thuringiensis serotypes","volume":"49","author":"Andrup","year":"2003","journal-title":"Plasmid"},{"key":"10.1016\/j.resmic.2016.10.008_bib37","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1006\/plas.1999.1415","article-title":"Refined, circular restriction map of the Bacillus thuringiensis subsp. israelensis plasmid carrying the mosquito larvicidal genes","volume":"42","author":"Ben-Dov","year":"1999","journal-title":"Plasmid"},{"key":"10.1016\/j.resmic.2016.10.008_bib38","doi-asserted-by":"crossref","first-page":"6948","DOI":"10.1128\/AEM.00976-06","article-title":"Minireplicon from pBtoxis of Bacillus thuringiensis subsp. israelensis","volume":"72","author":"Tang","year":"2006","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.resmic.2016.10.008_bib39","doi-asserted-by":"crossref","first-page":"8053","DOI":"10.1128\/JB.00908-07","article-title":"Iteron-binding ORF157 and FtsZ-like ORF156 proteins encoded by pBtoxis play a role in its replication in Bacillus thuringiensis subsp. israelensis","volume":"189","author":"Tang","year":"2007","journal-title":"J\u00a0Bacteriol"},{"key":"10.1016\/j.resmic.2016.10.008_bib40","doi-asserted-by":"crossref","first-page":"5134","DOI":"10.1128\/JB.00422-09","article-title":"A\u00a0new minimal replicon of Bacillus anthracis plasmid pXO1","volume":"191","author":"Pomerantsev","year":"2009","journal-title":"J\u00a0Bacteriol"},{"key":"10.1016\/j.resmic.2016.10.008_bib41","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.plasmid.2011.12.012","article-title":"Two independent replicons can support replication of the anthrax toxin-encoding plasmid pXO1 of Bacillus anthracis","volume":"67","author":"Akhtar","year":"2012","journal-title":"Plasmid"},{"key":"10.1016\/j.resmic.2016.10.008_bib42","doi-asserted-by":"crossref","first-page":"6530","DOI":"10.1128\/jb.175.20.6530-6536.1993","article-title":"Mobilization of small plasmids in Bacillus thuringiensis subsp. israelensis is accompanied by specific aggregation","volume":"175","author":"Andrup","year":"1993","journal-title":"J\u00a0Bacteriol"},{"key":"10.1016\/j.resmic.2016.10.008_bib43","doi-asserted-by":"crossref","first-page":"e16025","DOI":"10.1371\/journal.pone.0016025","article-title":"Determination of plasmid copy number reveals the total plasmid DNA amount is greater than the chromosomal DNA amount in Bacillus thuringiensis YBT-1520","volume":"6","author":"Zhong","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.resmic.2016.10.008_bib44","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1101\/gr.2289704","article-title":"Mauve: multiple alignment of conserved genomic sequence with rearrangements","volume":"14","author":"Darling","year":"2004","journal-title":"Genome Res"}],"container-title":["Research in Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923250816301243?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923250816301243?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T05:14:02Z","timestamp":1760332442000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0923250816301243"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5]]},"references-count":44,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["S0923250816301243"],"URL":"https:\/\/doi.org\/10.1016\/j.resmic.2016.10.008","relation":{},"ISSN":["0923-2508"],"issn-type":[{"value":"0923-2508","type":"print"}],"subject":[],"published":{"date-parts":[[2017,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparative genomics of extrachromosomal elements in Bacillus thuringiensis subsp. israelensis","name":"articletitle","label":"Article Title"},{"value":"Research in Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resmic.2016.10.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Institut Pasteur. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}]}}