{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T12:33:32Z","timestamp":1790426012026,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"4-5","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T00:00:00Z","timestamp":1700611200000},"content-version":"vor","delay-in-days":570,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001677","name":"INSERM","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007525","name":"Universit\u00e9 de Rennes 1","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007525","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Research in Microbiology"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.resmic.2022.103941","type":"journal-article","created":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T16:22:40Z","timestamp":1649175760000},"page":"103941","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Small RNA-mediated regulation of the tet(M) resistance gene expression in Enterococcus faecium"],"prefix":"10.1016","volume":"173","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1323-8715","authenticated-orcid":false,"given":"Killian","family":"Le Neindre","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loren","family":"Dejoies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Reissier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Gu\u00e9rin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brice","family":"Felden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4026-9912","authenticated-orcid":false,"given":"Vincent","family":"Cattoir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.resmic.2022.103941_bib1","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1086\/533452","article-title":"Federal funding for the study of antimicrobial resistance in nosocomial pathogens: No ESKAPE","volume":"197","author":"Rice","year":"2008","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.resmic.2022.103941_bib2","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/2475067","article-title":"Mechanisms of antimicrobial resistance in ESKAPE pathogens","volume":"2016","author":"Santajit","year":"2016","journal-title":"BioMed Res Int"},{"key":"10.1016\/j.resmic.2022.103941_bib3","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/nrmicro2761","article-title":"The rise of the Enterococcus: beyond vancomycin resistance","volume":"10","author":"Arias","year":"2012","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.resmic.2022.103941_bib4","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00534-13","article-title":"Emergence of epidemic multidrug-resistant Enterococcus faecium from animal and commensal strains","volume":"4","author":"Lebreton","year":"2013","journal-title":"mBio"},{"key":"10.1016\/j.resmic.2022.103941_bib5","article-title":"Antimicrobial-resistant CC17 Enterococcus faecium: the past, the present and the future","volume":"16","author":"Lee","year":"2019","journal-title":"J\u00a0Glob Antimicrob Resist"},{"key":"10.1016\/j.resmic.2022.103941_bib6","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1111\/j.1469-0691.2010.03226.x","article-title":"Mobile genetic elements and their contribution to the emergence of antimicrobial resistant Enterococcus faecalis and Enterococcus faecium","volume":"16","author":"Hegstad","year":"2010","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.resmic.2022.103941_bib7","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1186\/s12864-019-5975-8","article-title":"Comparative genomic analysis revealed great plasticity and environmental adaptation of the genomes of Enterococcus faecium","volume":"20","author":"Zhong","year":"2019","journal-title":"BMC Genom"},{"key":"10.1016\/j.resmic.2022.103941_bib8","doi-asserted-by":"crossref","DOI":"10.1128\/MMBR.00008-19","article-title":"Adaptation to adversity: the intermingling of stress tolerance and pathogenesis in enterococci","volume":"83","author":"Gaca","year":"2019","journal-title":"Microbiol Mol Biol Rev"},{"key":"10.1016\/j.resmic.2022.103941_bib9","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1042\/BC20070137","article-title":"Small regulatory non-coding RNAs in bacteria: physiology and mechanistic aspects","volume":"101","author":"Repoila","year":"2009","journal-title":"Biol Cell"},{"key":"10.1016\/j.resmic.2022.103941_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2017.00803","article-title":"Roles of regulatory RNAs for antibiotic resistance in bacteria and their potential value as novel drug targets","volume":"8","author":"Dersch","year":"2017","journal-title":"Front Microbiol"},{"key":"10.1016\/j.resmic.2022.103941_bib11","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1128\/AAC.36.4.769","article-title":"Characterization of the tet(M) determinant of Tn916: evidence for regulation by transcription attenuation","volume":"36","author":"Su","year":"1992","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.resmic.2022.103941_bib12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0116254","article-title":"Transcriptional attenuation controls macrolide inducible efflux and resistance in Streptococcus pneumoniae and in other Gram-positive bacteria containing mef\/mel(msr(D)) elements","volume":"10","author":"Chancey","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.resmic.2022.103941_bib13","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1128\/mr.60.2.366-385.1996","article-title":"Ribosome regulation by the nascent peptide","volume":"60","author":"Lovett","year":"1996","journal-title":"Microbiol Rev"},{"key":"10.1016\/j.resmic.2022.103941_bib14","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/S0167-4781(02)00455-4","article-title":"Transcription attenuation","volume":"1577","author":"Gollnick","year":"2002","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.resmic.2022.103941_bib15","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.1128\/JB.00259-12","article-title":"Comparative Analysis of the first complete Enterococcus faecium genome","volume":"194","author":"Lam","year":"2012","journal-title":"J\u00a0Bacteriol"},{"key":"10.1016\/j.resmic.2022.103941_bib16","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-11265-2","article-title":"Small RNAs in vancomycin-resistant Enterococcus faecium involved in daptomycin response and resistance","volume":"7","author":"Sinel","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.resmic.2022.103941_bib17","doi-asserted-by":"crossref","first-page":"2872","DOI":"10.1016\/S0021-9258(18)49928-0","article-title":"Purification and characterization of Tet(M), a protein that renders ribosomes resistant to tetracycline","volume":"266","author":"Burdett","year":"1991","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.resmic.2022.103941_bib18","doi-asserted-by":"crossref","first-page":"4089","DOI":"10.1128\/JB.180.16.4089-4092.1998","article-title":"Binding interaction between Tet(M) and the ribosome: requirements for binding","volume":"180","author":"Dantley","year":"1998","journal-title":"J\u00a0Bacteriol"},{"key":"10.1016\/j.resmic.2022.103941_bib19","doi-asserted-by":"crossref","first-page":"16900","DOI":"10.1073\/pnas.1208037109","article-title":"Structural basis for TetM-mediated tetracycline resistance","volume":"109","author":"D\u00f6nh\u00f6fer","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.resmic.2022.103941_bib20","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a025387","article-title":"Tetracycline antibiotics and resistance","volume":"6","author":"Grossman","year":"2016","journal-title":"Cold Spring Harb Perspect Med"},{"key":"10.1016\/j.resmic.2022.103941_bib21","doi-asserted-by":"crossref","first-page":"6137","DOI":"10.1093\/nar\/18.20.6137","article-title":"Nucleotide sequence of the tet(M) gene of Tn916","volume":"18","author":"Burdett","year":"1990","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.resmic.2022.103941_bib22","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1128\/AAC.42.8.1871","article-title":"Tn916 family conjugative transposons and dissemination of antimicrobial resistance determinants","volume":"42","author":"Rice","year":"1998","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.resmic.2022.103941_bib23","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1111\/j.1574-6976.2011.00283.x","article-title":"Tn916-like genetic elements: a diverse group of modular mobile elements conferring antibiotic resistance","volume":"35","author":"Roberts","year":"2011","journal-title":"FEMS Microbiol Rev"},{"key":"10.1016\/j.resmic.2022.103941_bib24","series-title":"Bacterial integrative mobile genetic elements","first-page":"153","article-title":"The Tn916\/Tn1545 family of conjugative transposons","author":"Ciric","year":"2013"},{"key":"10.1016\/j.resmic.2022.103941_bib25","doi-asserted-by":"crossref","first-page":"2585","DOI":"10.1093\/molbev\/msv133","article-title":"Rampant parasexuality evolves in a hospital pathogen during antibiotic selection","volume":"32","author":"Beabout","year":"2015","journal-title":"Mol Biol Evol"},{"key":"10.1016\/j.resmic.2022.103941_bib26","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1046\/j.1365-2958.1998.00778.x","article-title":"Circularization of Tn916 is required for expression of the transposon-encoded transfer functions: characterization of long tetracycline-inducible transcripts reading through the attachment site","volume":"28","author":"Celli","year":"1998","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.resmic.2022.103941_bib27","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1111\/j.1462-2920.2010.02355.x","article-title":"A\u00a0genetic element present on megaplasmids allows Enterococcus faecium to use raffinose as carbon source","volume":"13","author":"Zhang","year":"2011","journal-title":"Environ Microbiol"},{"key":"10.1016\/j.resmic.2022.103941_bib28","doi-asserted-by":"crossref","first-page":"4296","DOI":"10.1093\/nar\/18.14.4296","article-title":"A\u00a0pair of mobilizable shuttle vectors conferring resistance to spectinomycin for molecular cloning in Escherichia coli and in Gram-positive bacteria","volume":"18","author":"Trieu-Cuot","year":"1990","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.resmic.2022.103941_bib29","doi-asserted-by":"crossref","first-page":"4565","DOI":"10.1038\/s41598-017-04786-3","article-title":"sRNA and cis-antisense sRNA identification in Staphylococcus aureus highlights an unusual sRNA gene cluster with one encoding a secreted peptide","volume":"7","author":"Bronsard","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.resmic.2022.103941_bib30","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.celrep.2014.03.012","article-title":"Dual toxic-peptide-coding Staphylococcus aureus RNA under antisense regulation targets host cells and bacterial rivals unequally","volume":"7","author":"Pinel-Marie","year":"2014","journal-title":"Cell Rep"},{"key":"10.1016\/j.resmic.2022.103941_bib31","doi-asserted-by":"crossref","DOI":"10.21769\/BioProtoc.3072","article-title":"mRNA stability assay using transcription inhibition by actinomycin D in mouse pluripotent stem cells","volume":"8","author":"Ratnadiwakara","year":"2018","journal-title":"Bio Protoc"},{"key":"10.1016\/j.resmic.2022.103941_bib32","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1093\/nar\/gky1256","article-title":"Functionality and cross-regulation of the four SprG\/SprF type I toxin-antitoxin systems in Staphylococcus aureus","volume":"47","author":"Riffaud","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.resmic.2022.103941_bib33","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1128\/AAC.01864-15","article-title":"Diversity and evolution of the Tn5801-tet(M)-like integrative and conjugative elements among Enterococcus, Streptococcus, and Staphylococcus","volume":"60","author":"Le\u00f3n-Sampedro","year":"2016","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.resmic.2022.103941_bib34","doi-asserted-by":"crossref","first-page":"719977","DOI":"10.3389\/fmicb.2021.719977","article-title":"Diversity and versatility in small RNA-mediated regulation in bacterial pathogens","volume":"12","author":"Felden","year":"2021","journal-title":"Front Microbiol"},{"key":"10.1016\/j.resmic.2022.103941_bib35","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1128\/jb.184.4.889-894.2002","article-title":"Tetracycline induces stabilization of mRNA in Bacillus subtilis","volume":"184","author":"Wei","year":"2002","journal-title":"J\u00a0Bacteriol"},{"issue":"1","key":"10.1016\/j.resmic.2022.103941_bib36","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/nsmb.2193","article-title":"A\u00a0cis-antisense RNA acts in trans in Staphylococcus aureus to control translation of a human cytolytic peptide","volume":"19","author":"Sayed","year":"2011","journal-title":"Nat Struct Mol Biol"},{"key":"10.1016\/j.resmic.2022.103941_bib37","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1101\/pdb.prot077180","article-title":"Toeprinting","volume":"2013","author":"Nilsen","year":"2013","journal-title":"Cold Spring Harb Protoc"},{"key":"10.1016\/j.resmic.2022.103941_bib38","doi-asserted-by":"crossref","first-page":"2722","DOI":"10.1093\/jac\/dkx202","article-title":"Inducibility of Tn916 conjugative transfer in Enterococcus faecalis by subinhibitory concentrations of ribosome-targeting antibiotics","volume":"72","author":"Scornec","year":"2017","journal-title":"J\u00a0Antimicrob Chemother"},{"key":"10.1016\/j.resmic.2022.103941_bib39","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1038\/ja.2015.145","article-title":"Interaction of the tetracyclines with double-stranded RNAs of random base sequence: new perspectives on the target and mechanism of action","volume":"69","author":"Chukwudi","year":"2016","journal-title":"J\u00a0Antibiot"},{"key":"10.1016\/j.resmic.2022.103941_bib40","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1093\/jac\/dkt370","article-title":"Effect of subinhibitory concentrations of four commonly used biocides on the conjugative transfer of Tn916 in Bacillus subtilis","volume":"69","author":"Seier-Petersen","year":"2014","journal-title":"J\u00a0Antimicrob Chemother"},{"issue":"1","key":"10.1016\/j.resmic.2022.103941_bib41","doi-asserted-by":"crossref","first-page":"11","DOI":"10.4161\/rna.8.1.13346","article-title":"ARNold: a web tool for the prediction of Rho-independent transcription terminators","volume":"8","author":"Naville","year":"2011","journal-title":"RNA Biol"}],"container-title":["Research in Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923250822000225?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923250822000225?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T05:17:56Z","timestamp":1760332676000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0923250822000225"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":41,"journal-issue":{"issue":"4-5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["S0923250822000225"],"URL":"https:\/\/doi.org\/10.1016\/j.resmic.2022.103941","relation":{},"ISSN":["0923-2508"],"issn-type":[{"value":"0923-2508","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Small RNA-mediated regulation of the tet(M) resistance gene expression in Enterococcus faecium","name":"articletitle","label":"Article Title"},{"value":"Research in Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resmic.2022.103941","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Institut Pasteur. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"103941"}}