{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T17:18:53Z","timestamp":1791566333259,"version":"4.3.4"},"reference-count":49,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin City","doi-asserted-by":"publisher","award":["19JCZDJC33800"],"award-info":[{"award-number":["19JCZDJC33800"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31870139"],"award-info":[{"award-number":["31870139"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32070145"],"award-info":[{"award-number":["32070145"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873961"],"award-info":[{"award-number":["81873961"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Research in Microbiology"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.resmic.2022.103996","type":"journal-article","created":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T18:56:54Z","timestamp":1667242614000},"page":"103996","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Atg8 and Ire1 in combination regulate the autophagy-related endoplasmic reticulum stress response in Candida albicans"],"prefix":"10.1016","volume":"174","author":[{"given":"Jiawen","family":"Du","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengsen","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixuan","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianrong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qilin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingchun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.resmic.2022.103996_bib1","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/bs.aambs.2014.12.002","article-title":"Candida survival strategies","volume":"91","author":"Polke","year":"2015","journal-title":"Adv Appl Microbiol"},{"key":"10.1016\/j.resmic.2022.103996_bib2","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/nature17041","article-title":"Protein misfolding in the endoplasmic reticulum as a conduit to human disease","volume":"529","author":"Wang","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.resmic.2022.103996_bib3","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.pharmthera.2012.02.003","article-title":"Stress management at the ER: regulators of ER stress-induced apoptosis","volume":"134","author":"Gorman","year":"2012","journal-title":"Pharmacol Therapeut"},{"key":"10.1016\/j.resmic.2022.103996_bib4","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1038\/ncb0805-766","article-title":"ERAD: the long road to destruction","volume":"7","author":"Meusser","year":"2005","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.resmic.2022.103996_bib5","doi-asserted-by":"crossref","first-page":"210","DOI":"10.3390\/biomedicines8070210","article-title":"Endoplasmic reticulum stress in macrophages: the vicious circle of lipid accumulation and pro-inflammatory response","volume":"8","author":"Sukhorukov","year":"2020","journal-title":"Biomedicines"},{"key":"10.1016\/j.resmic.2022.103996_bib6","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1146\/annurev.cellbio.21.122303.120200","article-title":"Intracellular signaling by the unfolded protein response","volume":"22","author":"Bernales","year":"2006","journal-title":"Annu Rev Cell Dev Biol"},{"key":"10.1016\/j.resmic.2022.103996_bib7","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1126\/science.1209038","article-title":"The unfolded protein response: from stress pathway to homeostatic regulation","volume":"334","author":"Walter","year":"2011","journal-title":"Science (New York, NY)"},{"key":"10.1016\/j.resmic.2022.103996_bib8","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S0955-0674(00)00219-2","article-title":"Intracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammals","volume":"13","author":"Patil","year":"2001","journal-title":"Curr Opin Cell Biol"},{"key":"10.1016\/j.resmic.2022.103996_bib9","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.mrfmmm.2004.06.056","article-title":"ER stress and the unfolded protein response","volume":"569","author":"Schr\u00f6der","year":"2005","journal-title":"Mutat Res"},{"key":"10.1016\/j.resmic.2022.103996_bib10","doi-asserted-by":"crossref","first-page":"56","DOI":"10.3390\/cells7060056","article-title":"Unfolding the endoplasmic reticulum of a social amoeba: Dictyostelium discoideum as a new model for the study of endoplasmic reticulum stress","volume":"7","author":"Dom\u00ednguez-Mart\u00edn","year":"2018","journal-title":"Cells"},{"key":"10.1016\/j.resmic.2022.103996_bib11","doi-asserted-by":"crossref","DOI":"10.1128\/MCB.00054-18","article-title":"IreA controls endoplasmic reticulum stress-induced autophagy and survival through homeostasis recovery","volume":"38","author":"Dom\u00ednguez-Mart\u00edn","year":"2018","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.resmic.2022.103996_bib12","article-title":"Divergence and conservation of the major UPR branch IRE1-bZIP signaling pathway across eukaryotes","volume":"6","author":"Zhang","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.resmic.2022.103996_bib13","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/35014014","article-title":"Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response","volume":"2","author":"Bertolotti","year":"2000","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.resmic.2022.103996_bib14","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.ijmm.2018.03.004","article-title":"Stress-associated endoplasmic reticulum protein 1 (SERP1) and Atg8 synergistically regulate unfolded protein response (UPR) that is independent on autophagy in Candida albicans","volume":"308","author":"Li","year":"2018","journal-title":"IJMM Int J Med Microbiol"},{"key":"10.1016\/j.resmic.2022.103996_bib15","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1006\/bbrc.2000.3987","article-title":"Dissociation of Kar2p\/BiP from an ER sensory molecule, Ire1p, triggers the unfolded protein response in yeast","volume":"279","author":"Okamura","year":"2000","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.resmic.2022.103996_bib16","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.fgb.2015.02.008","article-title":"Candida albicans autophagy, no longer a bystander: its role in tolerance to ER stress-related antifungal drugs","volume":"81","author":"Yu","year":"2015","journal-title":"Fungal Genet Biol"},{"key":"10.1016\/j.resmic.2022.103996_bib17","doi-asserted-by":"crossref","first-page":"106","DOI":"10.3390\/cells7080106","article-title":"The unfolded protein response pathway in the yeast Kluyveromyces lactis. A comparative view among yeast species","volume":"7","author":"Hern\u00e1ndez-Elvira","year":"2018","journal-title":"Cells"},{"key":"10.1016\/j.resmic.2022.103996_bib18","doi-asserted-by":"crossref","DOI":"10.1111\/cmi.13307","article-title":"The protein kinase Ire1 impacts pathogenicity of Candida albicans by regulating homeostatic adaptation to endoplasmic reticulum stress","volume":"23","author":"Sircaik","year":"2021","journal-title":"Cell Microbiol"},{"key":"10.1016\/j.resmic.2022.103996_bib19","doi-asserted-by":"crossref","first-page":"5396","DOI":"10.1074\/jbc.R117.804641","article-title":"Transcriptional and post-transcriptional regulation of autophagy in the yeast Saccharomyces cerevisiae","volume":"293","author":"Delorme-Axford","year":"2018","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.resmic.2022.103996_bib20","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1146\/annurev-genet-102808-114910","article-title":"Regulation mechanisms and signaling pathways of autophagy","volume":"43","author":"He","year":"2009","journal-title":"Annu Rev Genet"},{"key":"10.1016\/j.resmic.2022.103996_bib21","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1089\/ars.2013.5371","article-title":"An overview of autophagy: morphology, mechanism, and regulation","volume":"20","author":"Parzych","year":"2014","journal-title":"Antioxidants Redox Signal"},{"key":"10.1016\/j.resmic.2022.103996_bib22","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.jmb.2019.07.016","article-title":"Selective autophagy: ATG8 family proteins, LIR motifs and cargo receptors","volume":"432","author":"Johansen","year":"2020","journal-title":"J\u00a0Mol Biol"},{"key":"10.1016\/j.resmic.2022.103996_bib23","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.tibs.2020.12.013","article-title":"ER-phagy, ER homeostasis, and ER quality control: implications for disease","volume":"46","author":"Ferro-Novick","year":"2021","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.resmic.2022.103996_bib24","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1007\/s00018-012-1173-4","article-title":"Stress-induced self-cannibalism: on the regulation of autophagy by endoplasmic reticulum stress","volume":"70","author":"Deegan","year":"2013","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.resmic.2022.103996_bib25","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.tibs.2015.01.002","article-title":"UPR, autophagy, and mitochondria crosstalk underlies the ER stress response","volume":"40","author":"Senft","year":"2015","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.resmic.2022.103996_bib26","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1128\/JB.181.6.1868-1874.1999","article-title":"Rapid hypothesis testing with Candida albicans through gene disruption with short homology regions","volume":"181","author":"Wilson","year":"1999","journal-title":"J\u00a0Bacteriol"},{"key":"10.1016\/j.resmic.2022.103996_bib27","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.bbrc.2019.03.146","article-title":"Vph2 is required for protection against a reductive stress in Candida albicans","volume":"512","author":"Jia","year":"2019","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.resmic.2022.103996_bib28","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1111\/j.1742-4658.2007.06202.x","article-title":"Mammalian Gup1, a homolog of Saccharomyces cerevisiae glycerol uptake\/transporter 1, acts as a negative regulator for N-terminal palmitoylation of Sonic hedgehog","volume":"275","author":"Abe","year":"2008","journal-title":"FEBS J"},{"key":"10.1016\/j.resmic.2022.103996_bib29","doi-asserted-by":"crossref","first-page":"5701","DOI":"10.1038\/s41467-020-19532-z","article-title":"The auxin-inducible degron 2 technology provides sharp degradation control in yeast, mammalian cells, and mice","volume":"11","author":"Yesbolatova","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.resmic.2022.103996_bib30","doi-asserted-by":"crossref","first-page":"4584","DOI":"10.1128\/AAC.00551-15","article-title":"The monoterpene carvacrol generates endoplasmic reticulum stress in the pathogenic fungus Candida albicans","volume":"59","author":"Chaillot","year":"2015","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.resmic.2022.103996_bib31","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.3390\/s17061201","article-title":"The effects of dithiothreitol on DNA","volume":"17","author":"Fjelstrup","year":"2017","journal-title":"Sensors"},{"key":"10.1016\/j.resmic.2022.103996_bib32","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1038\/s41429-019-0200-1","article-title":"Tunicamycin: chemical synthesis and biosynthesis","volume":"72","author":"Yamamoto","year":"2019","journal-title":"J\u00a0Antibiot (Tokyo)"},{"key":"10.1016\/j.resmic.2022.103996_bib33","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.ymeth.2005.03.001","article-title":"ER stress signaling by regulated splicing: IRE1\/HAC1\/XBP1","volume":"35","author":"Back","year":"2005","journal-title":"Methods (San Diego, CA, U S)"},{"key":"10.1016\/j.resmic.2022.103996_bib34","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nrm2199","article-title":"Signal integration in the endoplasmic reticulum unfolded protein response","volume":"8","author":"Ron","year":"2007","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.resmic.2022.103996_bib35","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/j.celrep.2014.09.016","article-title":"Ire1 has distinct catalytic mechanisms for XBP1\/HAC1 splicing and RIDD","volume":"9","author":"Tam","year":"2014","journal-title":"Cell Rep"},{"key":"10.1016\/j.resmic.2022.103996_bib36","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/j.fgb.2008.06.001","article-title":"Impact of the unfolded protein response upon genome-wide expression patterns, and the role of Hac1 in the polarized growth, of Candida albicans","volume":"45","author":"Wimalasena","year":"2008","journal-title":"Fungal Genet Biol"},{"key":"10.1016\/j.resmic.2022.103996_bib37","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202051869","article-title":"Atg1 kinase regulates autophagosome-vacuole fusion by controlling SNARE bundling","volume":"21","author":"Barz","year":"2020","journal-title":"EMBO Rep"},{"key":"10.1016\/j.resmic.2022.103996_bib38","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.devcel.2013.10.014","article-title":"Homotypic vacuole fusion in yeast requires organelle acidification and not the V-ATPase membrane domain","volume":"27","author":"Coonrod","year":"2013","journal-title":"Dev Cell"},{"key":"10.1016\/j.resmic.2022.103996_bib39","article-title":"Assessing lysosomal alkalinization in the intestine of live Caenorhabditis elegans","volume":"134","author":"Baxi","year":"2018","journal-title":"JoVE"},{"key":"10.1016\/j.resmic.2022.103996_bib40","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1016\/j.febslet.2014.06.015","article-title":"Regulation of autophagy: modulation of the size and number of autophagosomes","volume":"588","author":"Jin","year":"2014","journal-title":"FEBS (Fed Eur Biochem Soc) Lett"},{"key":"10.1016\/j.resmic.2022.103996_bib41","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1016\/j.cub.2014.04.048","article-title":"Transcriptional regulation by Pho23 modulates the frequency of autophagosome formation","volume":"24","author":"Jin","year":"2014","journal-title":"CB (Curr Biol)"},{"key":"10.1016\/j.resmic.2022.103996_bib42","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.3389\/fimmu.2019.02825","article-title":"ER stress and the UPR in shaping intestinal tissue homeostasis and immunity","volume":"10","author":"Coleman","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.resmic.2022.103996_bib43","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1016\/j.cell.2017.10.040","article-title":"A\u00a0J-protein co-chaperone recruits BiP to monomerize Ire1 and repress the unfolded protein response","volume":"171","author":"Amin-Wetzel","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.resmic.2022.103996_bib44","doi-asserted-by":"crossref","first-page":"190","DOI":"10.3389\/fncel.2019.00190","article-title":"Endoplasmic reticulum stress is involved in stress-induced hypothalamic neuronal injury in Rats via the PERK-ATF4-CHOP and IRE1-ASK1-JNK pathways","volume":"13","author":"Yi","year":"2019","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.resmic.2022.103996_bib45","first-page":"fnx153","article-title":"Autophagy participates in the unfolded protein response in Toxoplasma gondii","volume":"364","author":"Nguyen","year":"2017","journal-title":"FEMS (Fed Eur Microbiol Soc) Microbiol Lett"},{"key":"10.1016\/j.resmic.2022.103996_bib46","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/nature12599","article-title":"Paneth cells as a site of origin for intestinal inflammation","volume":"503","author":"Adolph","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.resmic.2022.103996_bib47","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.cell.2007.05.021","article-title":"Atg8, a ubiquitin-like protein required for autophagosome formation, mediates membrane tethering and hemifusion","volume":"130","author":"Nakatogawa","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.resmic.2022.103996_bib48","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1093\/genetics\/162.4.1573","article-title":"Candida albicans Mds3p, a conserved regulator of pH responses and virulence identified through insertional mutagenesis","volume":"162","author":"Davis","year":"2002","journal-title":"Genetics"},{"key":"10.1016\/j.resmic.2022.103996_bib49","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1099\/mic.0.27663-0","article-title":"Yeast wall protein 1 of Candida albicans","volume":"151","author":"Granger","year":"2005","journal-title":"Microbiology (Reading, U K)"}],"container-title":["Research in Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923250822000778?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923250822000778?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T05:17:45Z","timestamp":1760332665000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0923250822000778"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":49,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["S0923250822000778"],"URL":"https:\/\/doi.org\/10.1016\/j.resmic.2022.103996","relation":{},"ISSN":["0923-2508"],"issn-type":[{"value":"0923-2508","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Atg8 and Ire1 in combination regulate the autophagy-related endoplasmic reticulum stress response in Candida albicans","name":"articletitle","label":"Article Title"},{"value":"Research in Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resmic.2022.103996","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Institut Pasteur. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"103996"}}