{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:24:07Z","timestamp":1790519047114,"version":"4.1.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Physiology & Neurobiology"],"published-print":{"date-parts":[[2004,11]]},"DOI":"10.1016\/j.resp.2004.08.004","type":"journal-article","created":{"date-parts":[[2004,9,24]],"date-time":"2004-09-24T11:56:47Z","timestamp":1096027007000},"page":"45-57","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Breathing pattern and hypoxic sensitivity during ageing in a new model of obesity-resistant rat"],"prefix":"10.1016","volume":"144","author":[{"given":"Christophe","family":"Soulage","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marc","family":"Pequignot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Perrin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.resp.2004.08.004_bib1","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1093\/gerona\/57.8.B312","article-title":"The LOU\/c\/jall rat as an animal model of healthy aging","volume":"57","author":"Alliot","year":"2002","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.resp.2004.08.004_bib2","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/0034-5687(70)90056-3","article-title":"Control of breathing in experimental anemia","volume":"10","author":"Bartlett","year":"1970","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2004.08.004_bib3","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0034-5687(75)90093-6","article-title":"The effect of varying tidal volume on the associated phrenic motoneurone output: studies of vagal and chemical feedback","volume":"25","author":"Bartoli","year":"1975","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2004.08.004_bib4","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/BF00364107","article-title":"A model of the central and reflex inhibition of inspiration in the cat","volume":"19","author":"Bradley","year":"1975","journal-title":"Biol. Cybern."},{"key":"10.1016\/j.resp.2004.08.004_bib5","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/BF00508904","article-title":"Simultaneous measurement of tyrosine and tryptophan hydroxylase activities in brain in vivo using an inhibitor of the aromatic amino acid decarboxylase","volume":"275","author":"Carlsson","year":"1972","journal-title":"Naunyn. Schmiedebergs. Arch. Pharmacol."},{"key":"10.1016\/j.resp.2004.08.004_bib6","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1113\/jphysiol.1972.sp009797","article-title":"On the regulation of depth and rate of breathing","volume":"222","author":"Clark","year":"1972","journal-title":"J. Physiol. (London)"},{"key":"10.1016\/j.resp.2004.08.004_bib7","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1038\/oby.2002.29","article-title":"Metabolic characteristics and body composition in a model of anti-obese rats (Lou\/C)","volume":"10","author":"Couturier","year":"2002","journal-title":"Obes. Res."},{"key":"10.1016\/j.resp.2004.08.004_bib8","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1152\/japplphysiol.00406.2003","article-title":"Carotid body as a model for aging studies: is there a link between oxygen and aging?","volume":"95","author":"Di Giulio","year":"2003","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2004.08.004_bib9","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1542\/peds.16.1.81","article-title":"A barometric method for measuring ventilation in newborn infants","volume":"16","author":"Drorbaugh","year":"1955","journal-title":"Pediatrics"},{"key":"10.1016\/j.resp.2004.08.004_bib10","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1139\/y99-002","article-title":"Whole-body plethysmography, does it measure tidal volume of small animals?","volume":"76","author":"Enhorning","year":"1998","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.resp.2004.08.004_bib11","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1164\/ajrccm.150.2.8049815","article-title":"Pulmonary ventilation and mechanics in morbidly obese Zucker rats","volume":"150","author":"Farkas","year":"1994","journal-title":"Am. J. Respir. Crit. Care. Med."},{"key":"10.1016\/j.resp.2004.08.004_bib12","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1677\/joe.0.1710023","article-title":"Decreased leptin uptake in hypothalamic nuclei with ageing in Wistar rats","volume":"171","author":"Fernandez-Galaz","year":"2001","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.resp.2004.08.004_bib13","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/0006-8993(92)90458-L","article-title":"The central organization of carotid body afferent projections to the brainstem of the rat","volume":"572","author":"Finley","year":"1992","journal-title":"Brain Res."},{"key":"10.1016\/j.resp.2004.08.004_bib14","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/27376","article-title":"Leptin and the regulation of body weight in mammals","volume":"395","author":"Friedman","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.resp.2004.08.004_bib15","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1007\/BF00373745","article-title":"Maintenance of ventilatory control by CO2 in the rat during growth and aging","volume":"419","author":"Fukuda","year":"1991","journal-title":"Pflugers. Arch."},{"key":"10.1016\/j.resp.2004.08.004_bib16","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1007\/BF00374827","article-title":"Changes in ventilatory response to hypoxia in the rat during growth and aging","volume":"421","author":"Fukuda","year":"1992","journal-title":"Pflugers. Arch."},{"key":"10.1016\/j.resp.2004.08.004_bib17","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1152\/physrev.1994.74.4.829","article-title":"Carotid body chemoreceptors: from natural stimuli to sensory discharges","volume":"74","author":"Gonzalez","year":"1994","journal-title":"Physiol. Rev."},{"issue":"3","key":"10.1016\/j.resp.2004.08.004_bib18","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1152\/japplphysiol.01187.2003","article-title":"The fa leptin receptor mutation and the heritability of respiratory frequency in a brown Norway and Zucker intercross","volume":"97","author":"Iyengar","year":"2004","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2004.08.004_bib19","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1093\/jn\/129.8.1593","article-title":"Energy intake and utilization vary during development in rats","volume":"129","author":"Iossa","year":"1999","journal-title":"J. Nutr."},{"key":"10.1016\/j.resp.2004.08.004_bib20","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1152\/ajpregu.00398.2001","article-title":"Dopaminergic metabolism in carotid bodies and high-altitude acclimatization in female rats","volume":"282","author":"Joseph","year":"2002","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.resp.2004.08.004_bib21","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/0034-5687(91)90054-M","article-title":"Role of alpha 2-adrenergic receptors in the carotid body response to isocapnic hypoxia","volume":"83","author":"Kou","year":"1991","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2004.08.004_bib22","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/0034-5687(73)90035-2","article-title":"Arterial acid\u2013base changes in unanaesthetized rats in acute hypoxia","volume":"19","author":"Lewis","year":"1973","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2004.08.004_bib23","first-page":"165","article-title":"Ventilatory control and the obesity hypoventilation syndrome","volume":"119","author":"Lopata","year":"1979","journal-title":"Am. Rev. Respir. Dis."},{"key":"10.1016\/j.resp.2004.08.004_bib24","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/0006-8993(82)90401-2","article-title":"Catecholamines in the carotid body of several mammalian species: effects of surgical and chemical sympathectomy","volume":"252","author":"Mir","year":"1982","journal-title":"Brain Res."},{"key":"10.1016\/j.resp.2004.08.004_bib25","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1139\/y99-001","article-title":"On the barometric method for measurements of ventilation, and its use in small animals","volume":"76","author":"Mortola","year":"1998","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.resp.2004.08.004_bib26","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0034-5687(96)00064-3","article-title":"Ventilatory response to hypoxia in rats: gender differences","volume":"106","author":"Mortola","year":"1996","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2004.08.004_bib27","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S1569-9048(02)00040-X","article-title":"Circadian patterns of breathing","volume":"131","author":"Mortola","year":"2002","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2004.08.004_bib28","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1152\/jappl.2002.92.1.25","article-title":"Dopaminergic modulation of ventilation in obese Zucker rats","volume":"92","author":"Nakano","year":"2002","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2004.08.004_bib29","first-page":"1125","article-title":"Model of spontaneous obesity in aging male Wistar rats","volume":"259","author":"Newby","year":"1990","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.resp.2004.08.004_bib30","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1164\/ajrccm.159.5.9809025","article-title":"Leptin prevents respiratory depression in obesity","volume":"159","author":"O\u2019Donnell","year":"1999","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.resp.2004.08.004_bib31","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0034-5687(99)00111-5","article-title":"Leptin, obesity, and respiratory function","volume":"119","author":"O\u2019Donnell","year":"2000","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2004.08.004_bib32","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1152\/jappl.1997.82.3.811","article-title":"Respiratory system mechanics in sedated, paralyzed, morbidly obese patients","volume":"82","author":"Pelosi","year":"1997","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2004.08.004_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.autneu.2003.08.008","article-title":"Sympathetic and brain monoaminergic regulation of energy balance in obesity-resistant rats (Lou\/C)","volume":"109","author":"Perrin","year":"2003","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.resp.2004.08.004_bib34","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1007\/s00125-003-1195-4","article-title":"Resistance to obesity in Lou\/C rats prevents ageing-associated metabolic alterations","volume":"46","author":"Perrin","year":"2003","journal-title":"Diabetologia"},{"key":"10.1016\/j.resp.2004.08.004_bib35","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1164\/ajrccm\/147.6_Pt_1.1521","article-title":"Effect of aging on metabolic respiratory control in sleeping dogs","volume":"147","author":"Phillipson","year":"1993","journal-title":"Am. Rev. Respir. Dis."},{"key":"10.1016\/j.resp.2004.08.004_bib36","first-page":"863","article-title":"Respiratory mechanics in the aging rat","volume":"21","author":"Saldiva","year":"1988","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.resp.2004.08.004_bib37","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1152\/jappl.1997.82.1.317","article-title":"Ventilation and metabolism among rat strains","volume":"82","author":"Strohl","year":"1997","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2004.08.004_bib38","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0034-5687(00)00190-0","article-title":"Ventilatory behavior and metabolism in two strains of obese rats","volume":"124","author":"Strohl","year":"2001","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2004.08.004_bib39","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/35007534","article-title":"Central nervous system control of food intake","volume":"404","author":"Schwartz","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.resp.2004.08.004_bib40","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1152\/jappl.1996.81.2.716","article-title":"Modified control of breathing in genetically obese (ob\/ob) mice","volume":"81","author":"Tankersley","year":"1996","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2004.08.004_bib41","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/0034-5687(67)90002-3","article-title":"Comparative quantitative morphology of the mammalian lung: trachea","volume":"3","author":"Tenney","year":"1967","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2004.08.004_bib42","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1007\/BF01148589","article-title":"Distribution of sympathetic nerve endings within the rabbit carotid body: a histochemical and ultrastructural study","volume":"13","author":"Verna","year":"1984","journal-title":"J. Neurocytol."},{"key":"10.1016\/j.resp.2004.08.004_bib43","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/S0031-9384(97)00304-1","article-title":"Changes in pattern of macronutrient intake during aging in male and female rats","volume":"62","author":"Veyrat-Durebex","year":"1997","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.resp.2004.08.004_bib44","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0024-3205(02)02201-4","article-title":"Hypercapnic and hypoxic ventilatory responses in long-term streptozotocin-diabetic rats during conscious and pentobarbital-induced anesthetic states","volume":"72","author":"Yamazaki","year":"2002","journal-title":"Life Sci."},{"key":"10.1016\/j.resp.2004.08.004_bib45","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0531-5565(02)00149-3","article-title":"Nutritional control of aging","volume":"38","author":"Zimmerman","year":"2003","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.resp.2004.08.004_bib46","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/0002-9343(75)90392-7","article-title":"Decreased hypoxic ventilatory drive in the obesity-hypoventilation syndrome","volume":"59","author":"Zwillich","year":"1975","journal-title":"Am. J. Med."}],"container-title":["Respiratory Physiology & Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904804002198?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904804002198?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T22:07:26Z","timestamp":1761602846000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569904804002198"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,11]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,11]]}},"alternative-id":["S1569904804002198"],"URL":"https:\/\/doi.org\/10.1016\/j.resp.2004.08.004","relation":{},"ISSN":["1569-9048"],"issn-type":[{"value":"1569-9048","type":"print"}],"subject":[],"published":{"date-parts":[[2004,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Breathing pattern and hypoxic sensitivity during ageing in a new model of obesity-resistant rat","name":"articletitle","label":"Article Title"},{"value":"Respiratory Physiology & Neurobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resp.2004.08.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}