{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T09:04:20Z","timestamp":1778663060636,"version":"3.51.4"},"reference-count":49,"publisher":"Elsevier BV","issue":"2-3","license":[{"start":{"date-parts":[[2005,4,1]],"date-time":"2005-04-01T00:00:00Z","timestamp":1112313600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,4,1]],"date-time":"2005-04-01T00:00:00Z","timestamp":1112313600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Physiology &amp; Neurobiology"],"published-print":{"date-parts":[[2005,4]]},"DOI":"10.1016\/j.resp.2004.11.012","type":"journal-article","created":{"date-parts":[[2005,1,11]],"date-time":"2005-01-11T07:38:59Z","timestamp":1105429139000},"page":"125-134","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Glutamatergic receptors of the rostral ventrolateral medulla are involved in the ventilatory response to hypoxia"],"prefix":"10.1016","volume":"146","author":[{"given":"Patricia M.","family":"de Paula","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz G.S.","family":"Branco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.resp.2004.11.012_bib1","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0014-2999(93)90851-8","article-title":"Cardiorespiratory effects produced by blockade of excitatory amino acid receptors in cats","volume":"238","author":"Abrahams","year":"1993","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.resp.2004.11.012_bib2","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1002\/(SICI)1096-9861(19960909)373:1<62::AID-CNE6>3.0.CO;2-B","article-title":"Monosynaptic projections from the nucleus tractus solitarii to C1 adrenergic neurons in the rostral ventrolateral medulla: comparison with input from the caudal ventrolateral medulla","volume":"373","author":"Aicher","year":"1996","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.resp.2004.11.012_bib3","first-page":"R281","article-title":"Guiding principles for research involving animals and human beings","volume":"283","year":"2002","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.resp.2004.11.012_bib4","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1152\/jappl.1992.72.4.1480","article-title":"Role of glutamate as the central neurotransmitter in the hypoxic ventilatory response","volume":"72","author":"Ang","year":"1992","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2004.11.012_bib5","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/0034-5687(70)90056-3","article-title":"Control of breathing in experimental anemia","volume":"10","author":"Bartlett","year":"1970","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2004.11.012_bib6","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/0014-2999(88)90814-X","article-title":"Kynurenate and FG9041 have both competitive and non-competitive antagonist actions at excitatory amino acid receptors","volume":"151","author":"Birch","year":"1988","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.resp.2004.11.012_bib7","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0006-8993(91)91751-L","article-title":"Reciprocal connections between rostral ventrolateral medulla and inspiration-related medullary areas in the cat","volume":"565","author":"Bongianni","year":"1991","journal-title":"Brain Res."},{"key":"10.1016\/j.resp.2004.11.012_bib8","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0034-5687(95)00045-F","article-title":"Neurotransmitters in the CNS control of breathing","volume":"101","author":"Bonham","year":"1995","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2004.11.012_bib9","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0034-5687(00)00153-5","article-title":"Neurotransmitters in central respiratory control","volume":"122","author":"Burton","year":"2000","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2004.11.012_bib10","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0014-2999(01)01219-5","article-title":"NMDA receptors are involved in dithiothreitol-induced hypothermia","volume":"426","author":"Canini","year":"2001","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.resp.2004.11.012_bib11","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.neuroscience.2004.03.013","article-title":"Medullary pathways mediating specific sympathetic responses to activation of dorsomedial hypothalamus","volume":"126","author":"Cao","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.resp.2004.11.012_bib12","first-page":"R730","article-title":"Mechanisms of pressor and bradycardic responses to l-glutamate microinjected into the NTS of conscious rats","volume":"266","author":"Colombari","year":"1994","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.resp.2004.11.012_bib13","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1146\/annurev.pharmtox.37.1.205","article-title":"Pharmacology and functions of metabotropic glutamate receptors","volume":"37","author":"Conn","year":"1997","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.resp.2004.11.012_bib14","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/j.1651-2227.1958.tb07879.x","article-title":"The gaseous metabolism of the newborn infant breathing 15% oxygen","volume":"47","author":"Cross","year":"1958","journal-title":"Acta Paediatr."},{"key":"10.1016\/j.resp.2004.11.012_bib15","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1590\/S0100-879X2004001000019","article-title":"Glutamatergic neurotransmission modulates hypoxia-induced hyperventilation but not anapyrexia","volume":"37","author":"de Paula","year":"2004","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.resp.2004.11.012_bib16","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0006-8993(85)90004-6","article-title":"Cardiorespiratory effects produced by application of l-glutamic and kainic acid to the ventral surface of the cat hindbrain","volume":"330","author":"Gatti","year":"1985","journal-title":"Brain Res."},{"key":"10.1016\/j.resp.2004.11.012_bib17","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1152\/jappl.1996.81.2.521","article-title":"Interactions among metabolic rate, hypoxia and control of breathing","volume":"81","author":"Gautier","year":"1996","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2004.11.012_bib18","first-page":"R120","article-title":"Comparative effects of hypoxia on behavioral thermoregulation in rats, hamsters and mice","volume":"260","author":"Gordon","year":"1991","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.resp.2004.11.012_bib19","first-page":"226","article-title":"Respiratory-sympathetic integration in the medulla oblongata","volume":"vol. II","author":"Guyenet","year":"1992"},{"key":"10.1016\/j.resp.2004.11.012_bib20","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0034-5687(00)00125-0","article-title":"Neural structures that mediate sympathoexcitation during hypoxia","volume":"121","author":"Guyenet","year":"2000","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2004.11.012_bib21","first-page":"R69","article-title":"Sympathoexcitatory neurotransmission of the chemoreflex in the NTS of awake rats","volume":"276","author":"Haibara","year":"1999","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.resp.2004.11.012_bib22","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/S0306-4522(97)00111-5","article-title":"Hypoxia-induced Fos expression in neurons projecting to the pressor region in the rostral ventrolateral medulla","volume":"80","author":"Hirooka","year":"1997","journal-title":"Neuroscience"},{"key":"10.1016\/j.resp.2004.11.012_bib23","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1146\/annurev.ne.17.030194.000335","article-title":"Cloned glutamate receptors","volume":"17","author":"Hollmann","year":"1994","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.resp.2004.11.012_bib24","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/S0028-3908(01)00120-4","article-title":"Involvement of brain glutamate release in pyrogenic fever","volume":"41","author":"Huang","year":"2001","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.resp.2004.11.012_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/jappl.1991.70.1.1","article-title":"Glutamic acid and gamma-aminobutyric acid neurotransmitters in central control of breathing","volume":"70","author":"Kazemi","year":"1991","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2004.11.012_bib26","first-page":"R1273","article-title":"NTS neurons with carotid chemoreceptor input arborize in the rostral ventrolateral medulla","volume":"270","author":"Koshiya","year":"1996","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.resp.2004.11.012_bib27","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1152\/jappl.1996.80.5.1759","article-title":"Effect of N-methyl-d-aspartate receptor blockade on hypoxic ventilatory response in unanesthetized piglets","volume":"80","author":"Lin","year":"1996","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2004.11.012_bib28","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0306-4522(01)00415-8","article-title":"Distribution and amino acid content of enkephalin-immunoreactive inputs onto juxtacellularly-labeled bulbospinal barosensitive neurons in rat rostral ventrolateral medulla","volume":"108","author":"Llewellyn-Smith","year":"2001","journal-title":"Neuroscience"},{"key":"10.1016\/j.resp.2004.11.012_bib29","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1146\/annurev.physiol.63.1.259","article-title":"Cellular mechanisms of oxygen sensing","volume":"63","author":"L\u00f3pez-Barneo","year":"2001","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.resp.2004.11.012_bib30","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/0034-5687(73)90108-4","article-title":"Ventilation measured by body plethysmography in hibernating mammals and in poikilotherms","volume":"17","author":"Malan","year":"1973","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2004.11.012_bib31","doi-asserted-by":"crossref","first-page":"2384","DOI":"10.1523\/JNEUROSCI.06-08-02384.1986","article-title":"Respiratory motoneuronal activity is altered by injections of picomoles of glutamate into cat brain stem","volume":"6","author":"McCrimmon","year":"1986","journal-title":"J. Neurosci."},{"key":"10.1016\/j.resp.2004.11.012_bib32","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/0014-2999(95)00203-W","article-title":"Respiratory effects produced by microinjection of l-glutamate an uptake inhibitor of l-glutamate into the caudal subretrofacial area of the medulla","volume":"280","author":"McManigle","year":"1995","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.resp.2004.11.012_bib33","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1152\/jappl.1989.67.5.1814","article-title":"Respiratory effects of N-methyl-d-aspartate on the ventrolateral medullary surface","volume":"67","author":"Mitra","year":"1989","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2004.11.012_bib34","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1113\/jphysiol.1994.sp020229","article-title":"In vivo release of glutamate in nucleus tractus solitarii of the rat during hypoxia","volume":"478","author":"Mizusawa","year":"1994","journal-title":"J. Physiol. London"},{"key":"10.1016\/j.resp.2004.11.012_bib35","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1046\/j.1440-1681.2001.03406.x","article-title":"Differential regulation of brown adipose and splanchnic sympathetic outflows in rat: roles of raphe and rostral ventrolateral medulla neurons","volume":"28","author":"Morrison","year":"2001","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.resp.2004.11.012_bib36","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1146\/annurev.bb.23.060194.001535","article-title":"Molecular diversity and functions of glutamate receptors","volume":"23","author":"Nakanishi","year":"1994","journal-title":"Annu. Rev. Biophys. Biomol. Struct."},{"key":"10.1016\/j.resp.2004.11.012_bib37","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0165-3806(99)00010-3","article-title":"The distribution of FOS-immunoreactive neurons in the brainstem, midbrain and diencephalons of fetal sheep in response to acute hypoxia in mid and late gestation","volume":"114","author":"Nitsos","year":"1999","journal-title":"Brain Res. Dev. Brain Res."},{"key":"10.1016\/j.resp.2004.11.012_bib38","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1152\/jappl.1998.84.3.853","article-title":"NMDA receptors mediate peripheral chemoreceptor afferent input in the conscious rat","volume":"84","author":"Ohtake","year":"1998","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2004.11.012_bib39","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1152\/japplphysiol.00291.2002","article-title":"Role of l-glutamate in systemic AVP-induced hypotermia","volume":"94","author":"Paro","year":"2003","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2004.11.012_bib40","series-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos","year":"1998"},{"key":"10.1016\/j.resp.2004.11.012_bib41","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/0028-3908(89)90175-5","article-title":"Comparison of the effects of the acute administration of dexoxadrol, levoxadrol MK-801 and phencyclidine on body temperature in the rat","volume":"28","author":"Pechnick","year":"1989","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.resp.2004.11.012_bib42","series-title":"Central Regulation of Autonomic Functions","first-page":"189","article-title":"Cardiorespiratory control","author":"Richter","year":"1990"},{"key":"10.1016\/j.resp.2004.11.012_bib43","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1111\/j.1469-7793.1999.567ae.x","article-title":"Neurotransmitters and neuromodulators controlling the hypoxic respiratory response in anaesthetized cats","volume":"514","author":"Richter","year":"1999","journal-title":"J. Physiol. London"},{"key":"10.1016\/j.resp.2004.11.012_bib44","first-page":"1113","article-title":"Central amino acid neurotransmitters and the hypoxic ventilatory response","volume":"151","author":"Soto-Arape","year":"1995","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.resp.2004.11.012_bib45","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1146\/annurev.physiol.64.081501.155856","article-title":"Hypoxia-induced anapyrexia: implications and putative mediators","volume":"64","author":"Steiner","year":"2002","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.resp.2004.11.012_bib46","first-page":"R245","article-title":"Hypoxia selectively excites vasomotor neurons of rostral ventrolateral medulla in rats","volume":"266","author":"Sun","year":"1994","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.resp.2004.11.012_bib47","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1152\/physrev.1999.79.3.855","article-title":"Central control of cardiovascular and respiratory systems and their interactions in vertebrates","volume":"79","author":"Taylor","year":"1999","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.resp.2004.11.012_bib48","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0165-1838(88)90080-X","article-title":"Evidence for a sympathoexcitatory pathway from the nucleus tractus solitarii to the ventrolateral medullary pressor area","volume":"23","author":"Urbanski","year":"1988","journal-title":"J. Auton. Nerv. Syst."},{"key":"10.1016\/j.resp.2004.11.012_bib49","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0006-8993(93)91702-T","article-title":"Sympathetic nerve activity after discrete hypothalamic injection of l-glutamate","volume":"601","author":"Yoshimatsu","year":"1993","journal-title":"Brain Res."}],"container-title":["Respiratory Physiology &amp; Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904804003295?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904804003295?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T22:08:48Z","timestamp":1761602928000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569904804003295"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,4]]},"references-count":49,"journal-issue":{"issue":"2-3","published-print":{"date-parts":[[2005,4]]}},"alternative-id":["S1569904804003295"],"URL":"https:\/\/doi.org\/10.1016\/j.resp.2004.11.012","relation":{},"ISSN":["1569-9048"],"issn-type":[{"value":"1569-9048","type":"print"}],"subject":[],"published":{"date-parts":[[2005,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Glutamatergic receptors of the rostral ventrolateral medulla are involved in the ventilatory response to hypoxia","name":"articletitle","label":"Article Title"},{"value":"Respiratory Physiology & Neurobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resp.2004.11.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}