{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:13:12Z","timestamp":1761675192504,"version":"build-2065373602"},"reference-count":32,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2005,5,1]],"date-time":"2005-05-01T00:00:00Z","timestamp":1114905600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,5,1]],"date-time":"2005-05-01T00:00:00Z","timestamp":1114905600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Physiology & Neurobiology"],"published-print":{"date-parts":[[2005,5]]},"DOI":"10.1016\/j.resp.2005.01.005","type":"journal-article","created":{"date-parts":[[2005,2,8]],"date-time":"2005-02-08T10:16:12Z","timestamp":1107857772000},"page":"1-9","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Doxapram stimulates the carotid body via a different mechanism than hypoxic chemotransduction"],"prefix":"10.1016","volume":"147","author":[{"given":"Toru","family":"Takahashi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinobu","family":"Osanai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Nakano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinobu","family":"Ohsaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenjiro","family":"Kikuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.resp.2005.01.005_bib1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0304-3940(95)11328-T","article-title":"Doxapram stimulates dopamine release from the intact rat carotid body in vitro","volume":"187","author":"Anderson-Beck","year":"1995","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.resp.2005.01.005_bib2","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/S0959-4388(00)00214-2","article-title":"How does calcium trigger neurotransmitter release?","volume":"11","author":"Augustine","year":"2001","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.resp.2005.01.005_bib3","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.1469-7793.2000.00135.x","article-title":"An oxygen-, acid- and anaesthetic-sensitive TASK-like background potassium channel in rat arterial chemoreceptor cells","volume":"525","author":"Buckler","year":"2000","journal-title":"J. Physiol. (Lond.)"},{"key":"10.1016\/j.resp.2005.01.005_bib4","first-page":"385","article-title":"Antihypertensive and haemodynamic properties of the potassium channel activating (\u2212) enantiomer of cromakalim in animal models","volume":"41","author":"Clapham","year":"1991","journal-title":"Arzneimittelfoschung"},{"key":"10.1016\/j.resp.2005.01.005_bib5","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1152\/jappl.1992.72.2.410","article-title":"Metabolic and cardiorespiratory effects of doxapram and theophylline in sleeping newborn piglets","volume":"72","author":"Cote","year":"1992","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2005.01.005_bib6","first-page":"L36","article-title":"Interactions between hypoxia and hypercapnic acidosis on calcium signaling in carotid body type I cells","volume":"279","author":"Dasso","year":"2000","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.resp.2005.01.005_bib7","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1097\/00000542-198209000-00002","article-title":"Halothane depresses the response of carotid body chemoreceptors to hypoxia and hypercapnia in the cat","volume":"57","author":"Davies","year":"1982","journal-title":"Anesthesiology"},{"key":"10.1016\/j.resp.2005.01.005_bib8","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0006-8993(89)91186-4","article-title":"Hypoxic and hypercapnic responses of [Ca2+]o and [K+]o in the cat carotid body in vitro","volume":"482","author":"Delpiano","year":"1989","journal-title":"Brain Res."},{"key":"10.1016\/j.resp.2005.01.005_bib9","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1152\/jappl.1994.77.6.2606","article-title":"Effect of Na+ and K+ channel blockade on baseline and anoxia-induced catecholamine release from rat carotid body","volume":"77","author":"Doyle","year":"1994","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2005.01.005_bib10","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1085\/jgp.100.3.401","article-title":"Potassium channel types in arterial chemoreceptor cells and their selective modulation by oxygen","volume":"100","author":"Ganfornina","year":"1992","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.resp.2005.01.005_bib11","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1152\/physrev.1994.74.4.829","article-title":"Carotid body chemoreceptors: from natural stimuli to sensory discharges","volume":"74","author":"Gonz\u00e1lez","year":"1994","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.resp.2005.01.005_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0306-3623(89)90052-9","article-title":"Cromakalim, nicorandil and pinacidil; novel drugs which open potassium channels in smooth muscle","volume":"20","author":"Hamilton","year":"1989","journal-title":"Gen. Pharmacol."},{"key":"10.1016\/j.resp.2005.01.005_bib13","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1093\/bja\/49.10.957","article-title":"Depression of hypoxic ventilatory response by halothane, enflurane and isoflurane in dogs","volume":"49","author":"Hirshman","year":"1977","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.resp.2005.01.005_bib14","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S0006-8993(98)00276-5","article-title":"K+-current modulated by PO2 in type I cells in rat carotid body is not a chemosensor","volume":"794","author":"Lahiri","year":"1998","journal-title":"Brain Res."},{"key":"10.1016\/j.resp.2005.01.005_bib15","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/0034-5687(75)90017-1","article-title":"Stimulus interaction in the responses of carotid body chemoreceptor single afferent fibers","volume":"24","author":"Lahiri","year":"1975","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2005.01.005_bib16","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1152\/jappl.1989.67.1.232","article-title":"Stimulus interaction between CO2 and almitrine in the cat carotid chemoreceptors","volume":"67","author":"Lahiri","year":"1989","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2005.01.005_bib17","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/S1357-2725(01)00042-5","article-title":"Regulation of oxygen sensing in peripheral arterial chemoreceptors","volume":"33","author":"Lahiri","year":"2001","journal-title":"Int. J. Biochem. Cell. Biol."},{"key":"10.1016\/j.resp.2005.01.005_bib18","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1111\/j.1432-1033.1994.00967.x","article-title":"Decrease in cytosolic ATP\/ADP ratio and activation of pyruvate kinase after in vitro addition of almitrine in hepatocytes isolated from fasted rats","volume":"224","author":"Leverve","year":"1994","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.resp.2005.01.005_bib19","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1126\/science.2456613","article-title":"Chemotransduction in the carotid body","volume":"241","author":"L\u00f3pez-Barneo","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.resp.2005.01.005_bib20","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S0166-2236(96)10050-3","article-title":"Oxygen-sensing by ion channels and the regulation of cellular functions","volume":"19","author":"L\u00f3pez-Barneo","year":"1996","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.resp.2005.01.005_bib21","series-title":"Regulation of Breathing. Part 1","article-title":"Peripheral chemoreceptors. Structure\u2013function relationships of the carotid body","author":"McDonald","year":"1981"},{"key":"10.1016\/j.resp.2005.01.005_bib22","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1097\/00000542-197505000-00009","article-title":"Potencies of doxapram and hypoxia in stimulating carotid-body chemoreceptors and ventilation in anesthetized cats","volume":"42","author":"Mitchell","year":"1975","journal-title":"Anesthesiology"},{"key":"10.1016\/j.resp.2005.01.005_bib23","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1046\/j.1471-4159.1997.69010377.x","article-title":"Hypoxia-induced catecholamine release and intracellular Ca2+ increase via suppression of K+ channels in cultured rat adrenal chromaffin cells","volume":"69","author":"Mochizuki-Oda","year":"1997","journal-title":"J. Neurochem."},{"key":"10.1016\/j.resp.2005.01.005_bib24","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1152\/jappl.1982.52.5.1261","article-title":"Stimulation carotid chemoreceptors and ventilation and doxapram in the cat","volume":"52","author":"Nishino","year":"1982","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2005.01.005_bib25","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0014-2999(94)90442-1","article-title":"Selective activation of Ca2+-dependent K+ channels by novel benzimidazolone","volume":"251","author":"Olsen","year":"1994","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.resp.2005.01.005_bib26","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/0006-8993(95)01400-4","article-title":"Stimulus interaction between CO and CO2 in the cat carotid body","volume":"711","author":"Osanai","year":"1996","journal-title":"Brain Res."},{"key":"10.1016\/j.resp.2005.01.005_bib27","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/S0006-8993(96)01313-3","article-title":"Cat carotid body chemosensory discharge (in vitro) is insensitive to charybdotoxin","volume":"747","author":"Osanai","year":"1997","journal-title":"Brain Res."},{"key":"10.1016\/j.resp.2005.01.005_bib28","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1152\/jn.2000.83.3.1150","article-title":"HERG-Like potassium current regulates the resting membrane potential in glomus cells of the rabbit carotid body","volume":"83","author":"Overholt","year":"2000","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.resp.2005.01.005_bib29","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/0006-8993(91)91386-F","article-title":"Effects of doxapram on ionic currents recorded in isolated type I cells of the neonatal rat carotid body","volume":"568","author":"Peers","year":"1991","journal-title":"Brain Res."},{"key":"10.1016\/j.resp.2005.01.005_bib30","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0034-5687(00)00116-X","article-title":"PO2\u2212PCO2 stimulus interaction in [Ca2+]i and CSN activity in the adult rat carotid body","volume":"122","author":"Roy","year":"2000","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2005.01.005_bib31","doi-asserted-by":"crossref","first-page":"L221","DOI":"10.1152\/ajplung.00010.2003","article-title":"Biophysical properties and metabolic regulation of a TASK-like potassium channel in rat carotid body type 1 cells","volume":"286","author":"Williams","year":"2004","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.resp.2005.01.005_bib32","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/978-1-4615-2572-1_18","article-title":"Ca2+-activated K+-channels from isolated type I carotid body cells of the neonatal rat","volume":"360","author":"Wyatt","year":"1994","journal-title":"Adv. Exp. Med. Biol."}],"container-title":["Respiratory Physiology & Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156990480500008X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156990480500008X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T22:08:44Z","timestamp":1761602924000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S156990480500008X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,5]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,5]]}},"alternative-id":["S156990480500008X"],"URL":"https:\/\/doi.org\/10.1016\/j.resp.2005.01.005","relation":{},"ISSN":["1569-9048"],"issn-type":[{"type":"print","value":"1569-9048"}],"subject":[],"published":{"date-parts":[[2005,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Doxapram stimulates the carotid body via a different mechanism than hypoxic chemotransduction","name":"articletitle","label":"Article Title"},{"value":"Respiratory Physiology & Neurobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resp.2005.01.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}