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Physiol."},{"key":"10.1016\/j.resp.2005.05.005_bib96","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1203\/00006450-200108000-00012","article-title":"PDGF-beta receptor expression in the dorsocaudal brainstem parallels hypoxic ventilatory depression in the developing rat","volume":"50","author":"Vlasic","year":"2001","journal-title":"Pediatr. 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