{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:58:21Z","timestamp":1791280701171,"version":"4.1.0"},"reference-count":128,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T00:00:00Z","timestamp":1151712000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T00:00:00Z","timestamp":1151712000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Physiology &amp; Neurobiology"],"published-print":{"date-parts":[[2006,7]]},"DOI":"10.1016\/j.resp.2006.02.014","type":"journal-article","created":{"date-parts":[[2008,4,23]],"date-time":"2008-04-23T05:11:09Z","timestamp":1208927469000},"page":"282-297","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":51,"title":["Regulation of cough by secondary sensory inputs"],"prefix":"10.1016","volume":"152","author":[{"given":"Jan","family":"Hanacek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milos","family":"Tatar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Widdicombe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.resp.2006.02.014_bib1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0034-5687(00)00210-3","article-title":"Neurogenic inflammation in the airways","volume":"125","author":"Barnes","year":"2001","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2006.02.014_bib2","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1152\/ajplegacy.1952.171.3.522","article-title":"Intestine in reflex chemical control of breathing","volume":"171","author":"Bean","year":"1952","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.resp.2006.02.014_bib3","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1136\/gut.46.6.762","article-title":"Cough threshold in reflux oesophagitis: influence of acid and of laryngeal and oesophageal damage","volume":"46","author":"Benini","year":"2000","journal-title":"Gut"},{"key":"10.1016\/j.resp.2006.02.014_bib4","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1152\/jappl.1964.19.2.224","article-title":"Reflex control of abdominal muscles during positive pressure breathing","volume":"19","author":"Bishop","year":"1964","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2006.02.014_bib5","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S0306-4522(99)00547-3","article-title":"Acute effects of capsaicin on gastrointestinal vagal afferents","volume":"96","author":"Blackshaw","year":"2000","journal-title":"Neuroscience"},{"key":"10.1016\/j.resp.2006.02.014_bib6","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1006\/pupt.2002.0361","article-title":"Functional organization of the central cough generation mechanism","volume":"15","author":"Bolser","year":"2002","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.resp.2006.02.014_bib7","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1152\/jappl.1999.86.3.1017","article-title":"Influence of central antitussive drugs on the cough motor pattern","volume":"86","author":"Bolser","year":"1999","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2006.02.014_bib8","doi-asserted-by":"crossref","unstructured":"Bolser, D.C., Poliacek, I., Jakus, J., Davenport, P.W., 2006. Neurogenesis of cough, other airway defensive behaviours and breathing: a holonarchical supersystem? Respir. Physiol. Neurobiol., doi:10.1016\/j.resp.2006.01.008, in press.","DOI":"10.1016\/j.resp.2006.01.008"},{"key":"10.1016\/j.resp.2006.02.014_bib9","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.pupt.2004.09.008","article-title":"Plasticity of central mechanisms for cough","volume":"17","author":"Bonham","year":"2004","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.resp.2006.02.014_bib10","doi-asserted-by":"crossref","first-page":"529","DOI":"10.33549\/physiolres.930205","article-title":"Effects of hyperoxia and allergic airway inflammation on cough reflex intensity in guinea pigs","volume":"51","author":"Brozmanova","year":"2002","journal-title":"Physiol. Res."},{"key":"10.1016\/j.resp.2006.02.014_bib11","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0031-6997(25)07376-4","article-title":"Pathophysiology and pharmacology of cough","volume":"10","author":"Bucher","year":"1958","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.resp.2006.02.014_bib12","unstructured":"Canning, B., Mazzone, S., 2006. Sensory receptors for cough. Respir. Physiol. Neurobiol., this issue."},{"key":"10.1016\/j.resp.2006.02.014_bib13","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.pupt.2004.09.020","article-title":"Plasticity of vagal afferent fibres mediating cough","volume":"17","author":"Carr","year":"2004","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.resp.2006.02.014_bib14","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/0034-5687(84)90098-7","article-title":"Stimulus\u2013response curve of the lung inflation cardio-depressor reflex","volume":"57","author":"Cassidy","year":"1984","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2006.02.014_bib15","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0034-5687(70)90107-6","article-title":"Hypoxia and hypercapnia as respiratory stimulants and depressants","volume":"11","author":"Cherniack","year":"1970","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2006.02.014_bib16","series-title":"Cough \u2013 Causes, Mechanisms and Therapy","first-page":"304","year":"2003"},{"key":"10.1016\/j.resp.2006.02.014_bib17","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1164\/ajrccm\/138.2.305","article-title":"Cough and the common cold","volume":"138","author":"Curley","year":"1988","journal-title":"Am. Rev. Respir. Dis."},{"key":"10.1016\/j.resp.2006.02.014_bib18","first-page":"859","article-title":"The reflex effects of inflation of the lungs on the heart rate and hind limb vascular resistence in the cat","volume":"11","author":"Daly","year":"1983","journal-title":"IRCS Med. Sci. Libr. Compend."},{"key":"10.1016\/j.resp.2006.02.014_bib19","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0034-5687(78)90050-6","article-title":"Lung reflexes in rabbits during lung stretch receptors block by sulphur dioxide","volume":"84","author":"Davies","year":"1978","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2006.02.014_bib20","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1152\/physrev.1954.34.2.167","article-title":"Chemoreceptors from the heart and lungs","volume":"34","author":"Dawes","year":"1954","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.resp.2006.02.014_bib21","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/j.1748-1716.1981.tb06910.x","article-title":"Positive feedback facilitation of external intercostal and phrenic inspiratory activity by pulmonary stretch receptors","volume":"113","author":"DiMarco","year":"1981","journal-title":"Acta Physiol. Scand."},{"key":"10.1016\/j.resp.2006.02.014_bib22","first-page":"411","article-title":"Pontine projections of pulmonary slowly adapting receptors relay neurons in the cat","volume":"9","author":"Ezure","year":"1998","journal-title":"Neurol. Rep."},{"key":"10.1016\/j.resp.2006.02.014_bib23","first-page":"1709","article-title":"Lung inflation inhibits slowly adapting receptor relay neurons","volume":"11","author":"Ezure","year":"2000","journal-title":"Neurol. Rep."},{"key":"10.1016\/j.resp.2006.02.014_bib24","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1164\/ajrccm.160.5.9901093","article-title":"Coughing in laryngectomized patients","volume":"160","author":"Fontana","year":"1999","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.resp.2006.02.014_bib25","series-title":"Cough \u2013 Causes, Mechanisms and Therapy","first-page":"193","article-title":"Motor mechanisms and the mechanics of cough","author":"Fontana","year":"2003"},{"key":"10.1016\/j.resp.2006.02.014_bib26","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.pupt.2004.09.001","article-title":"Physiological down-regulation of cough","volume":"17","author":"Fontana","year":"2004","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.resp.2006.02.014_bib27","first-page":"34P","article-title":"Effect of partial laryngeal denervation on irritant-induced cough and bronchoconstriction in conscious guinea pigs","volume":"422","author":"Forsberg","year":"1990","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2006.02.014_bib28","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1152\/jappl.1986.60.6.2048","article-title":"Effect of pulmonary artery PCO2 on slowly adapting stretch receptors","volume":"60","author":"Green","year":"1986","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2006.02.014_bib29","first-page":"169","article-title":"Modification of the intensity of the expiration reflex during short-term inflation of the lung in rabbits","volume":"31","author":"Hanacek","year":"1982","journal-title":"Physiol. Bohemoslov."},{"key":"10.1016\/j.resp.2006.02.014_bib30","first-page":"33","article-title":"The role of the vagus nerve in mechanisms of expiration reflex increase by lung inflation","volume":"19","author":"Hanacek","year":"1983","journal-title":"Bull. Eur. Physiopathol. Respir."},{"key":"10.1016\/j.resp.2006.02.014_bib31","first-page":"45","article-title":"Relation between the airway receptors and the defensive reflexes of the respiratory tract","volume":"10","author":"Hanacek","year":"1984","journal-title":"Fol. Med. Mart."},{"key":"10.1016\/j.resp.2006.02.014_bib32","first-page":"227","article-title":"Influence of sulphur dioxide breathing on defensive reflexes of the airways","volume":"70","author":"Hanacek","year":"1987","journal-title":"Acta Physiol. Hung."},{"key":"10.1016\/j.resp.2006.02.014_bib33","series-title":"Proceedings of 1st High Tatras International Health Symposium, Health and Quality of Life in Changing Europe in the Year 2000","first-page":"272","article-title":"Cough reflex changes in cats after sulphur dioxide breathing","author":"Hanacek","year":"1992"},{"key":"10.1016\/j.resp.2006.02.014_bib34","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1159\/000194614","article-title":"Influence of lung stretch receptors on the cough reflex in rabbit","volume":"45","author":"Hanacek","year":"1984","journal-title":"Respiration"},{"key":"10.1016\/j.resp.2006.02.014_bib35","first-page":"444","article-title":"Changes in the intensity of cough in non-anaesthetized cats with inflammation of the respiratory organs induced by croton oil","volume":"85","author":"Hanacek","year":"1986","journal-title":"Bratisl. Lek. Listy"},{"key":"10.1016\/j.resp.2006.02.014_bib36","first-page":"251","article-title":"Functional and morphological changes of the respiratory organs in cats after long-term exposure to pure normobaric oxygen","volume":"97","author":"Hanacek","year":"1996","journal-title":"Bratisl. Lek. Listy"},{"key":"10.1016\/j.resp.2006.02.014_bib37","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1006\/pulp.1996.0049","article-title":"Effect of long-term high oxygen concentration breathing on defensive respiratory reflexes in guinea pigs","volume":"9","author":"Hanacek","year":"1996","journal-title":"Pulm. Pharmacol."},{"issue":"12","key":"10.1016\/j.resp.2006.02.014_bib38","first-page":"259","article-title":"Reflex inputs to cough","volume":"85","author":"Hanacek","year":"2002","journal-title":"Eur. Respir. Rev."},{"key":"10.1016\/j.resp.2006.02.014_bib39","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1152\/jappl.1986.60.2.376","article-title":"Abnormal pulmonary slowly adapting receptors in canine acrylamide neuropathy","volume":"60","author":"Hersh","year":"1986","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2006.02.014_bib40","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1164\/ajrccm\/140.1.58","article-title":"The cough response to ultrasonically nebulized distilled water in heart\u2013lung transplantation patients","volume":"140","author":"Higenbottam","year":"1989","journal-title":"Am. Rev. Respir. Dis."},{"key":"10.1016\/j.resp.2006.02.014_bib41","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1164\/ajrccm.152.1.7599827","article-title":"The Breuer\u2013Hering reflex in humans: effect of pulmonary denervation and hypocapnia","volume":"152","author":"Iber","year":"1995","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.resp.2006.02.014_bib42","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1164\/ajrccm.149.1.8111576","article-title":"Pathogenesis of chronic persistent cough associated with gastroesophageal reflux","volume":"149","author":"Ing","year":"1994","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.resp.2006.02.014_bib43","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1378\/chest.114.2_Supplement.133S","article-title":"Managing cough as a defense mechanism and as a symptom: a consensus panel report of the American College of Chest Physicians","volume":"114","author":"Irwin","year":"1998","journal-title":"Chest"},{"key":"10.1016\/j.resp.2006.02.014_bib44","first-page":"540","article-title":"Rhinolith\u2014a rare cause of chronic cough","volume":"7","author":"Ishrat-Husain","year":"1967","journal-title":"Can. Med. Assoc. J."},{"key":"10.1016\/j.resp.2006.02.014_bib45","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1113\/expphysiol.1994.sp003821","article-title":"Defensive reflexes of the repiratory system in anaesthetized rabbits during high frequency jet ventilation","volume":"79","author":"Javorka","year":"1994","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.resp.2006.02.014_bib46","first-page":"612","article-title":"Effect of increased intrapulmonary pressure on defensive reflexes of the respiratory tract","volume":"77","author":"Javorka","year":"1982","journal-title":"Bratisl. Lek. Listy"},{"key":"10.1016\/j.resp.2006.02.014_bib47","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1111\/j.1469-7793.1997.635bg.x","article-title":"Nitric oxide contributes to substance P-induced increase in lung rapidly adapting receptors activity in guinea pigs","volume":"503","author":"Joad","year":"1997","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2006.02.014_bib48","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1006\/pupt.1999.0207","article-title":"Pharmacological regulation of the cough reflex \u2013 from experimental model to antitussive effect in man","volume":"12","author":"Karlson","year":"1999","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.resp.2006.02.014_bib49","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1152\/jappl.1988.65.3.1007","article-title":"Afferent neural pathways in cough and reflex bronchoconstriction","volume":"65","author":"Karlsson","year":"1988","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2006.02.014_bib50","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1152\/ajplegacy.1946.147.1.100","article-title":"Unitary analysis of pulmonary volume receptors","volume":"147","author":"Knowlton","year":"1946","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.resp.2006.02.014_bib51","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/BF00176891","article-title":"Heterogenous activity of pulmonary vagal receptors during high-frequency oscillation ventilation","volume":"173","author":"Kohl","year":"1995","journal-title":"Lung"},{"key":"10.1016\/j.resp.2006.02.014_bib52","first-page":"101","article-title":"The effect of chemical stimulation of esophageal mucosa on citric acid induced cough and specific airway resistance in guinea pig","volume":"106","author":"Kollarik","year":"2005","journal-title":"Bratisl. Lek. Listy"},{"key":"10.1016\/j.resp.2006.02.014_bib53","unstructured":"Kollarik, M., Undem, B., 2006. Membrane receptors and channels on \u2018sensory cough receptors\u2019. Respir. Physiol. Neurobiol., this issue."},{"key":"10.1016\/j.resp.2006.02.014_bib54","doi-asserted-by":"crossref","first-page":"341","DOI":"10.2170\/jjphysiol.48.341","article-title":"An increase in the threshold of citric acid-induced cough during chest wall vibration in healthy humans","volume":"48","author":"Kondo","year":"1998","journal-title":"Jpn. J. Physiol."},{"key":"10.1016\/j.resp.2006.02.014_bib55","first-page":"677","article-title":"Differentiation of the expiration and the cough reflex","volume":"21","author":"Korpas","year":"1972","journal-title":"Physiol. Bohemoslov."},{"key":"10.1016\/j.resp.2006.02.014_bib56","series-title":"Cough and Other Respiratory Reflexes","author":"Korpas","year":"1979"},{"issue":"Suppl. 10","key":"10.1016\/j.resp.2006.02.014_bib57","first-page":"63","article-title":"Cough reflex in hypercapnia","volume":"23","author":"Kulik","year":"1987","journal-title":"Bull. Eur. Physiopathol. Respir."},{"key":"10.1016\/j.resp.2006.02.014_bib58","first-page":"25","article-title":"Cough reflex in laryngectomized patients","volume":"7","author":"Lavorini","year":"1994","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.resp.2006.02.014_bib59","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1152\/jappl.1995.79.4.1082","article-title":"Capsazepine inhibits cough induced by capsaicin and citric acid and by hypertonic saline in guinea pigs","volume":"79","author":"Lalloo","year":"1995","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2006.02.014_bib60","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0034-5687(92)90039-Y","article-title":"Effect of single breath of cigarette smoke on slowly adapting receptors in canine lungs","volume":"88","author":"Lee","year":"1992","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2006.02.014_bib61","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1006\/pupt.2002.0338","article-title":"Hypersensitivity of bronchopulmonary C-fibres induced by airway mucosal inflammation: cellular mechanism","volume":"15","author":"Lee","year":"2002","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.resp.2006.02.014_bib62","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.pupt.2004.09.025","article-title":"Ionotropic and metabolotropic receptor mediated airway sensory nerve activation","volume":"17","author":"Lee","year":"2004","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.resp.2006.02.014_bib63","series-title":"Respiratory Defence Mechanisms. Part II","first-page":"545","article-title":"Cough","author":"Leith","year":"1977"},{"key":"10.1016\/j.resp.2006.02.014_bib64","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1113\/jphysiol.1987.sp016545","article-title":"Lung reflexes and nasal vascular resistance in the anaesthetized dog","volume":"386","author":"Lung","year":"1987","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2006.02.014_bib65","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1183\/09031936.99.13350899","article-title":"Cough frequency and cough receptor sensitivity to citric acid challenge during simulated ascent to extreme altitude","volume":"13","author":"Mason","year":"1999","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.resp.2006.02.014_bib66","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.pupt.2004.09.021","article-title":"Sensory regulation of the cough reflex","volume":"17","author":"Mazzone","year":"2004","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.resp.2006.02.014_bib67","first-page":"236","article-title":"Plasticity of the cough reflex","volume":"12","author":"Mazzone","year":"2002","journal-title":"Eur. Respir. Rev."},{"key":"10.1016\/j.resp.2006.02.014_bib68","series-title":"Cough: Causes, Mechanisms and Therapy","first-page":"161","article-title":"Sensory pathways for the cough reflex","author":"Mazzone","year":"2003"},{"key":"10.1016\/j.resp.2006.02.014_bib69","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1113\/jphysiol.2005.093153","article-title":"Synergistic interactions between airway afferent nerve subtypes regulating the cough reflex in guinea-pigs","volume":"569","author":"Mazzone","year":"2005","journal-title":"J. Physiol. Lond."},{"key":"10.1016\/j.resp.2006.02.014_bib70","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1006\/phrs.1996.0122","article-title":"Actions of moguisteine on cough and pulmonary rapidly adapting receptors in the guinea pig","volume":"35","author":"Morikawa","year":"1997","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.resp.2006.02.014_bib71","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.1152\/jappl.1989.66.6.2642","article-title":"Inhibitory effects of CO2 on airway defensive reflexes in enflurane-anesthetized humans","volume":"66","author":"Nishino","year":"1989","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2006.02.014_bib72","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1152\/jappl.1989.67.3.954","article-title":"Influence of CPAP on reflex responses to tracheal irritation in anaesthetized humans","volume":"67","author":"Nishino","year":"1989","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2006.02.014_bib73","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1097\/00000542-199601000-00008","article-title":"Differences in respiratory reflex responses from the larynx, the trachea, and the bronchi in anaesthetized female subject","volume":"84","author":"Nishino","year":"1996","journal-title":"Anesthesiology"},{"key":"10.1016\/j.resp.2006.02.014_bib74","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1164\/ajrccm.150.2.8049818","article-title":"Capsaicin cough sensitivity decreases with successful treatment of chronic cough","volume":"150","author":"O\u2019Connell","year":"1996","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.resp.2006.02.014_bib75","first-page":"89","article-title":"Impulses in vagal afferent fibers from specific pulmonary deflation receptors. The response of these receptors to phenyl diguanide, potato starch, 5-hydroxytryptamine and nicotine and their role in respiratory and cardiovascular reflexes","volume":"40","author":"Paintal","year":"1955","journal-title":"Q. J. Physiol."},{"key":"10.1016\/j.resp.2006.02.014_bib76","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1152\/jappl.1989.67.4.1428","article-title":"Reflex responses to capsaicin: intravenous, aerosol and intratracheal administration","volume":"67","author":"Palacek","year":"1989","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2006.02.014_bib77","first-page":"25","article-title":"Cough sensitivity in localized sclerodermia with no clinical symptoms from lower airways","volume":"54","author":"Pecova","year":"2003","journal-title":"J. Physiol. Pharmacol."},{"key":"10.1016\/j.resp.2006.02.014_bib78","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S1094-5539(02)00214-6","article-title":"Cough sensitivity in atopic dermatitis","volume":"16","author":"Pecova","year":"2003","journal-title":"Pulm. Pharmacol. Ther."},{"issue":"Suppl. 4","key":"10.1016\/j.resp.2006.02.014_bib79","first-page":"171","article-title":"Cough sensitivity in allergic rhinitis","volume":"56","author":"Pecova","year":"2005","journal-title":"J. Physiol. Pharmacol."},{"key":"10.1016\/j.resp.2006.02.014_bib80","first-page":"3","article-title":"The effect of intensified nasal breathing on the cough reflex intensity in guinea pigs with ovalbumin induced rhinitis","volume":"4","author":"Plevkova","year":"2004","journal-title":"Acta Med. Mart."},{"issue":"Suppl. 3","key":"10.1016\/j.resp.2006.02.014_bib81","first-page":"101","article-title":"Effects of intranasal capsaicin challenge on cough reflex in healthy human volunteers","volume":"55","author":"Plevkova","year":"2004","journal-title":"J. Physiol. Pharmacol."},{"key":"10.1016\/j.resp.2006.02.014_bib82","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.resp.2004.06.006","article-title":"Modulation of experimentally-induced cough reflex by the stimulation of nasal mucosa in cats and guinea pigs","volume":"142","author":"Plevkova","year":"2004","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2006.02.014_bib83","doi-asserted-by":"crossref","first-page":"21","DOI":"10.55782\/ane-1997-1207","article-title":"The role of pulmonary stretch receptors during cough in dogs","volume":"57","author":"Romaniuk","year":"1997","journal-title":"Acta Neurobiol. Exp."},{"key":"10.1016\/j.resp.2006.02.014_bib84","first-page":"99","article-title":"Sensory neurophysiology of airways","volume":"115","author":"Sampson","year":"1977","journal-title":"Am. Rev. Respir. Dis."},{"key":"10.1016\/j.resp.2006.02.014_bib85","first-page":"954","article-title":"Airway receptors in cough","volume":"45","author":"Sant Ambrogio","year":"1984","journal-title":"Bull. Eur. Physiopathol. Respir."},{"key":"10.1016\/j.resp.2006.02.014_bib86","series-title":"The Lung: Scientific Foundations","first-page":"1383","article-title":"Reflexes from the airway, lung, chest wall, and limbs","author":"Sant Ambrogio","year":"1991"},{"key":"10.1016\/j.resp.2006.02.014_bib87","series-title":"Pathophysiology of the Gut and Airways","first-page":"89","article-title":"Coughing: an airway defensive reflex","author":"Sant Ambrogio","year":"1993"},{"key":"10.1016\/j.resp.2006.02.014_bib88","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1164\/ajrccm.155.2.9032206","article-title":"Activation of intrinsic laryngeal muscles during cough","volume":"155","author":"Sant Ambrogio","year":"1997","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.resp.2006.02.014_bib89","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1164\/ajrccm\/151.3_Pt_1.815","article-title":"Role of substance P in cough during bronchoconstriction in awake guinea-pigs","volume":"151","author":"Sekizawa","year":"1995","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.resp.2006.02.014_bib90","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0034-5687(94)90104-X","article-title":"Nasal receptors responding to noxious chemical irritants","volume":"96","author":"Sekizawa","year":"1994","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2006.02.014_bib91","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/j.1469-7793.2000.00207.x","article-title":"Functional connectivity among ventrolateral medullary neurons and responses during fictive cough in the cat","volume":"525","author":"Shannon","year":"2000","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2006.02.014_bib92","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1113\/jphysiol.1965.sp007758","article-title":"Action potentials in fibres from receptors in the epicardium and myocardium of the dog's left ventricle","volume":"181","author":"Sleight","year":"1965","journal-title":"J. Physiol. Lond."},{"key":"10.1016\/j.resp.2006.02.014_bib93","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1152\/jappl.1993.75.2.613","article-title":"Lack of importance of the superior laryngeal nerves in citric acid cough in humans","volume":"75","author":"Stockwell","year":"1993","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2006.02.014_bib94","first-page":"157","article-title":"Study of the respiratory defensive reflexes in conscious cats in the acute phase of deficient oxygen supply into the organism","volume":"84","author":"Tatar","year":"1985","journal-title":"Bratisl. Lek. Listy"},{"key":"10.1016\/j.resp.2006.02.014_bib95","first-page":"41","article-title":"Effects of hypoxia on respiratory defence reflexes. Effects of thirty hours\u2019 oxygen deficiency on cough, the expiration reflex and sneezing in awake cats","volume":"34","author":"Tatar","year":"1985","journal-title":"Physiol. Bohemoslov."},{"key":"10.1016\/j.resp.2006.02.014_bib96","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1159\/000194868","article-title":"Changes induced by severe hypoxia in respiratory defence reflexes in anaesthetised cats","volume":"49","author":"Tatar","year":"1986","journal-title":"Respiration"},{"key":"10.1016\/j.resp.2006.02.014_bib97","first-page":"533","article-title":"Changes of airway defence reflexes in the course of five-hour hypercapnia in conscious cats","volume":"85","author":"Tatar","year":"1986","journal-title":"Bratisl. Lek. Listy"},{"issue":"Suppl. 10","key":"10.1016\/j.resp.2006.02.014_bib98","first-page":"65","article-title":"Effect of denervation of peripheral chemoreceptors on cough during hypoxia","volume":"23","author":"Tatar","year":"1987","journal-title":"Bull. Eur. Physiopathol. Respir."},{"key":"10.1016\/j.resp.2006.02.014_bib99","first-page":"195","article-title":"Effect of hypoxia and hypercapnia on the airways defence reflexes","volume":"70","author":"Tatar","year":"1987","journal-title":"Acta Physiol. Hung."},{"key":"10.1016\/j.resp.2006.02.014_bib100","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1113\/jphysiol.1988.sp017212","article-title":"Lung C-fibre receptor activation and defensive reflexes in anesthetized cats","volume":"402","author":"Tatar","year":"1988","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2006.02.014_bib101","series-title":"International Congress of Physiological Sciences","first-page":"386","article-title":"Mechanically-induced cough is depressed by acute hyperoxia in anaesthetized cats","author":"Tatar","year":"1989"},{"issue":"Suppl. 10","key":"10.1016\/j.resp.2006.02.014_bib102","first-page":"141s","article-title":"Effects of lung inflation on airways defence reflexes","volume":"3","author":"Tatar","year":"1990","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.resp.2006.02.014_bib103","unstructured":"Tatar, M., Nagyova, B., 1991. Abdominal capsaicin-sensitive receptor activation and mechanically-induced cough in anesthetized cats. Abstracts of Regional Meeting of International Union of Physiological Sciences, Prague, June 30\u2013July 5, p. 98."},{"issue":"Suppl. A","key":"10.1016\/j.resp.2006.02.014_bib104","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0954-6111(06)80255-6","article-title":"Veratrine-induced reflexes and cough","volume":"85","author":"Tatar","year":"1991","journal-title":"Respir. Med."},{"key":"10.1016\/j.resp.2006.02.014_bib105","first-page":"143","article-title":"Laryngeal and tracheobronchial cough in anaesthetized cats and guinea-pigs","volume":"54","author":"Tatar","year":"1994","journal-title":"Stud. Pneumol. Phtiseol."},{"key":"10.1016\/j.resp.2006.02.014_bib106","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1152\/jappl.1994.76.6.2672","article-title":"Laryngeal and tracheobronchial cough in anesthetized dogs","volume":"76","author":"Tatar","year":"1994","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2006.02.014_bib107","first-page":"284","article-title":"The effect of experimental gastroesophageal reflux on the cough in anaesthetized cats","volume":"97","author":"Tatar","year":"1996","journal-title":"Bratisl. Lek. Listy"},{"key":"10.1016\/j.resp.2006.02.014_bib108","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1006\/pulp.1996.0051","article-title":"The role of partial laryngeal denervation on the cough reflex in awake guinea-pigs and rabbits","volume":"9","author":"Tatar","year":"1996","journal-title":"Pulm. Pharmacol."},{"key":"10.1016\/j.resp.2006.02.014_bib109","unstructured":"Tatar, M., 1997. Intensity of cough reflex is modulated by peripheral chemoreceptors. Abstracts of Minisymposium \u201cDisorders of Breathing Control\u201d, Martin, October 8, p. 3."},{"issue":"Suppl. 25","key":"10.1016\/j.resp.2006.02.014_bib110","first-page":"182","article-title":"The effect of experimental rhinitis on chemically-induced cough in awake guinea-pigs","volume":"10","author":"Tatar","year":"1997","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.resp.2006.02.014_bib111","first-page":"264","article-title":"Experimental modulation of the cough reflex","volume":"12","author":"Tatar","year":"2002","journal-title":"Eur. Respir. Rev."},{"issue":"Suppl. 45","key":"10.1016\/j.resp.2006.02.014_bib112","first-page":"172","article-title":"Effect of acidification of distal esophagus on cough sensitivity in patient with gastroesophageal reflux disease","volume":"22","author":"Tatar","year":"2003","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.resp.2006.02.014_bib113","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1002\/jnr.490150414","article-title":"Effect of nicotine aerosol on slowly adapting receptors in the airways of the dog","volume":"15","author":"Taylor","year":"1986","journal-title":"J. Neurol. Res."},{"key":"10.1016\/j.resp.2006.02.014_bib114","first-page":"465","article-title":"Expiration reflex intensity in rats induced by the inflation of the lung","volume":"30","author":"Turcan","year":"1981","journal-title":"Physiol. Bohemoslov."},{"key":"10.1016\/j.resp.2006.02.014_bib115","first-page":"33","article-title":"Influence of short-term lung inflation on the magnitude of expiratory reflex in the ferrets under normal condition and during experimental pneumothorax","volume":"79","author":"Turcan","year":"1983","journal-title":"Bratisl. Lek. Listy"},{"key":"10.1016\/j.resp.2006.02.014_bib116","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1113\/jphysiol.1954.sp005033","article-title":"Respiratory reflexes from the trachea and bronchi of the cat","volume":"123","author":"Widdicombe","year":"1954","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2006.02.014_bib117","first-page":"163","article-title":"Respiratory reflexes in man and other mammalian species","volume":"21","author":"Widdicombe","year":"1961","journal-title":"Clin. Sci."},{"key":"10.1016\/j.resp.2006.02.014_bib118","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1183\/09031936.95.08071193","article-title":"Neurophysiology of the cough reflex","volume":"8","author":"Widdicombe","year":"1995","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.resp.2006.02.014_bib119","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1006\/pulp.1996.0054","article-title":"Sensory mechanisms of cough","volume":"9","author":"Widdicombe","year":"1996","journal-title":"Pulm. Pharmacol."},{"key":"10.1016\/j.resp.2006.02.014_bib120","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0034-5687(98)00076-0","article-title":"Afferent receptors in the airways and cough","volume":"114","author":"Widdicombe","year":"1998","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2006.02.014_bib121","doi-asserted-by":"crossref","unstructured":"Widdicombe, J., Fontana, G., 2006. Cough: what's in a name. Eur. J. Respir., in press.","DOI":"10.1183\/09031936.06.00096905"},{"key":"10.1016\/j.resp.2006.02.014_bib122","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0034-5687(00)00201-2","article-title":"Airway receptors","author":"Widdicombe","year":"2001","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2006.02.014_bib123","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.resp.2005.04.013","article-title":"Physiological and pathophysiological down-regulation of cough","volume":"150","author":"Widdicombe","year":"2006","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2006.02.014_bib124","first-page":"411","article-title":"Report of experiments on the physiology of the lungs and air-tubes","volume":"Aug.","author":"Williams","year":"1841","journal-title":"Rep. Br. Assn. Adv. Sci."},{"key":"10.1016\/j.resp.2006.02.014_bib125","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1042\/cs0710519","article-title":"Respiratory and cardiovascular effects of central and peripheral intravenous injection of capsaicin in man: evidence for pulmonary chemosensitivity","volume":"71","author":"Winning","year":"1986","journal-title":"Clin. Sci."},{"key":"10.1016\/j.resp.2006.02.014_bib126","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1001\/jama.1973.03220110047013","article-title":"The tympanic membrane: a source of the cough reflex","volume":"23","author":"Wolff","year":"1973","journal-title":"JAMA"},{"key":"10.1016\/j.resp.2006.02.014_bib127","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/j.1365-2125.1995.tb04448.x","article-title":"Effect of dose adjustment on enalapril-induced cough and the response to inhaled capsaicin","volume":"39","author":"Yeo","year":"1995","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.resp.2006.02.014_bib128","doi-asserted-by":"crossref","first-page":"271","DOI":"10.2220\/biomedres.17.271","article-title":"Skin stimulation with cold water inhibits capsaicin-induced cough, and decreases substance P-like immunoreactivity in guinea-pig lungs","volume":"17","author":"Yoshihara","year":"1996","journal-title":"Biomed. Res."}],"container-title":["Respiratory Physiology &amp; Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904806000978?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904806000978?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T22:11:32Z","timestamp":1761603092000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569904806000978"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7]]},"references-count":128,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,7]]}},"alternative-id":["S1569904806000978"],"URL":"https:\/\/doi.org\/10.1016\/j.resp.2006.02.014","relation":{},"ISSN":["1569-9048"],"issn-type":[{"value":"1569-9048","type":"print"}],"subject":[],"published":{"date-parts":[[2006,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Regulation of cough by secondary sensory inputs","name":"articletitle","label":"Article Title"},{"value":"Respiratory Physiology & Neurobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resp.2006.02.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}