{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:37:57Z","timestamp":1778632677946,"version":"3.51.4"},"reference-count":59,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T00:00:00Z","timestamp":1175385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T00:00:00Z","timestamp":1175385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Physiology & Neurobiology"],"published-print":{"date-parts":[[2007,4]]},"DOI":"10.1016\/j.resp.2006.07.001","type":"journal-article","created":{"date-parts":[[2006,10,3]],"date-time":"2006-10-03T08:04:53Z","timestamp":1159862693000},"page":"47-60","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Ventilatory roll off during sustained hypercapnia is gender specific in pekin ducks"],"prefix":"10.1016","volume":"156","author":[{"given":"Graham A.A.","family":"Dodd","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graham R.","family":"Scott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William K.","family":"Milsom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.resp.2006.07.001_bib1","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1152\/jappl.1998.84.6.2099","article-title":"Hypercapnia-induced long-term depression of respiratory activity requires alpha2-adrenergic receptors","volume":"84","author":"Bach","year":"1998","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2006.07.001_bib2","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0034-5687(01)00280-8","article-title":"Respiratory plasticity: differential actions of continuous and episodic hypoxia and hypercapnia","volume":"129","author":"Baker","year":"2001","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2006.07.001_bib3","doi-asserted-by":"crossref","first-page":"R317","DOI":"10.1152\/ajpregu.1999.276.2.R317","article-title":"Chronic hypercapnia resets CO2 sensitivity of avian intrapulmonary chemoreceptors","volume":"276","author":"Bebout","year":"1999","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.resp.2006.07.001_bib4","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/0034-5687(79)90083-5","article-title":"The contribution of the peripheral chemoreceptors to the ventilatory response to CO2 in anesthetized cats during hyperoxia","volume":"37","author":"Berkenbosch","year":"1979","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2006.07.001_bib5","series-title":"Cell Calcium","author":"Bianchi","year":"1968"},{"key":"10.1016\/j.resp.2006.07.001_bib6","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0034-5687(86)90010-1","article-title":"Carotid body hypercapnia does not elicit ventilatory acclimatization in goats","volume":"65","author":"Bisgard","year":"1986","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2006.07.001_bib7","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1242\/jeb.134.1.79","article-title":"Acid-base regulation and blood gases in the anuran amphibian, Bufo marinus, during environmental hypercapnia","volume":"134","author":"Boutilier","year":"1988","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.resp.2006.07.001_bib8","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1242\/jeb.82.1.331","article-title":"Acid-base relationships in the blood of the toad, Bufo marinus. I. The effects of environmental CO2","volume":"82","author":"Boutilier","year":"1979","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.resp.2006.07.001_bib9","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1152\/physrev.1978.58.3.604","article-title":"Control of breathing in birds compared with mammals","volume":"58","author":"Bouverot","year":"1978","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.resp.2006.07.001_bib10","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0034-5687(74)90053-X","article-title":"Ventilatory responses to CO2 in intact and chronically chemodenervated peking ducks","volume":"22","author":"Bouverot","year":"1974","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2006.07.001_bib11","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/0034-5687(72)90072-2","article-title":"Arterial chemoreceptors in the domestic fowl","volume":"15","author":"Bouverot","year":"1972","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2006.07.001_bib12","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1152\/jappl.1982.53.6.1397","article-title":"Control of ventilation in running birds: effects of hypoxia, hyperoxia, and CO2","volume":"53","author":"Brackenbury","year":"1982","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2006.07.001_bib13","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1152\/jappl.1971.31.4.632","article-title":"Rapid method for determination of total carbon dioxide in small blood samples","volume":"31","author":"Cameron","year":"1971","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2006.07.001_bib14","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1086\/physzool.62.4.30157933","article-title":"Acid-base homeostasis: past and present perspectives","volume":"62","author":"Cameron","year":"1989","journal-title":"Physiol. Zool."},{"key":"10.1016\/j.resp.2006.07.001_bib15","first-page":"R854","article-title":"Effects of hypoxia and hypercapnia on VT, f, and VI of nestling and adult bank swallows","volume":"253","author":"Colby","year":"1987","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.resp.2006.07.001_bib16","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0034-5687(02)00005-1","article-title":"Frequency responses to hypoxia and hypercapnia in carotid body-denervated conscious rats","volume":"130","author":"Coles","year":"2002","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2006.07.001_bib17","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1152\/japplphysiol.00548.2003","article-title":"Respiratory effects in humans of a 5-day elevation of end-tidal Pco2 by 8torr","volume":"95","author":"Crosby","year":"2003","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2006.07.001_bib18","doi-asserted-by":"crossref","first-page":"R532","DOI":"10.1152\/ajpregu.00812.2004","article-title":"Specific carotid body chemostimulation is sufficient to elicit phrenic poststimulus frequency decline in a novel in situ dual-perfused rat preparation","volume":"289","author":"Day","year":"2005","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.resp.2006.07.001_bib19","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1152\/physrev.1982.62.1.262","article-title":"Mediation of ventilatory adaptations","volume":"62","author":"Dempsey","year":"1982","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.resp.2006.07.001_bib20","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0034-5687(87)80005-1","article-title":"Effects of H+ versus CO2 on ventilation in the pekin duck","volume":"68","author":"Dodd","year":"1987","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2006.07.001_bib21","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.3382\/ps.0421236","article-title":"Death and pulmonary alterations following bilateral, cervical vagotomy in the fowl","volume":"42","author":"Fedde","year":"1963","journal-title":"Poultry Sci."},{"key":"10.1016\/j.resp.2006.07.001_bib22","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1242\/jeb.122.1.13","article-title":"The effects of hypercapnia on the arterial acid-base status in the tegu lizard, Tupinambis nigropunctatus","volume":"122","author":"Glass","year":"1986","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.resp.2006.07.001_bib23","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/0034-5687(79)90082-3","article-title":"Relative contribution of central and peripheral chemoreceptors to the ventilatory response to CO2 during hyperoxia","volume":"37","author":"Heeringa","year":"1979","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2006.07.001_bib24","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.resp.2004.02.013","article-title":"CO2 transduction mechanisms in avian intrapulmonary chemoreceptors: experiments and models","volume":"144","author":"Hempleman","year":"2004","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2006.07.001_bib25","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1051\/rnd:19700618","article-title":"Blood pH and cation levels in relation to egg-shell formation","volume":"10","author":"Hodges","year":"1970","journal-title":"Ann. Biol. Animale Biochim. Biophys."},{"key":"10.1016\/j.resp.2006.07.001_bib26","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0010-406X(67)90131-4","article-title":"Acute respiratory acidosis in the domestic fowl","volume":"21","author":"Hunt","year":"1967","journal-title":"Comp. Biochem. Physiol."},{"key":"10.1016\/j.resp.2006.07.001_bib27","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/0034-5687(84)90013-6","article-title":"Acid-base and ventilatory adaptation in conscious dogs during chronic hypercapnia","volume":"58","author":"Jennings","year":"1984","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2006.07.001_bib28","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1113\/jphysiol.1970.sp009280","article-title":"Effect of carotid body denervation upon the respiratory response to hypoxia and hypercapnia in the duck","volume":"211","author":"Jones","year":"1970","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2006.07.001_bib29","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/0300-9629(94)90341-7","article-title":"Cardiopulmonary responses of burrowing owls (Athene cunicularia) to acute hypercapnia and hypoxia","volume":"108A","author":"Kilgore","year":"1994","journal-title":"Comp. Biochem. Physiol."},{"key":"10.1016\/j.resp.2006.07.001_bib30","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S1095-6433(01)00393-2","article-title":"Plasticity in respiratory motor control: intermittent hypoxia and hypercapnia activate opposing serotonergic and noradrenergic modulatory systems","volume":"130A","author":"Kinkead","year":"2001","journal-title":"Comp. Biochem. Physiol."},{"key":"10.1016\/j.resp.2006.07.001_bib31","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0034-5687(94)90049-3","article-title":"Chemoreceptors and control of episodic breathing in the bullfrog (Rana catesbeiana)","volume":"95","author":"Kinkead","year":"1994","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2006.07.001_bib32","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0034-5687(00)00134-1","article-title":"Ventilatory responses to hypercapnia and hypoxia following chronic hypercapnia in the rat","volume":"122","author":"Kondo","year":"2000","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2006.07.001_bib33","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1016\/S1357-2725(03)00050-5","article-title":"CO2\/H+ sensing: peripheral and central chemoreception","volume":"35","author":"Lahiri","year":"2003","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.resp.2006.07.001_bib34","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1152\/jappl.1981.51.1.78","article-title":"Ventilation during prolonged hypercapnia in the rat","volume":"51","author":"Lai","year":"1981","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2006.07.001_bib35","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.resp.2003.11.003","article-title":"Hypercapnia selectively attenuates the somato-sympathetic reflex","volume":"140","author":"Makeham","year":"2004","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2006.07.001_bib36","first-page":"316","article-title":"Phylogeny of respiratory chemoreceptor function in vertebrates","volume":"101","author":"Milsom","year":"1998","journal-title":"Zoology-Analysis Complex Syst."},{"key":"10.1016\/j.resp.2006.07.001_bib37","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S1569-9048(02)00035-6","article-title":"Phylogeny of CO2\/H+ chemoreception in vertebrates","volume":"131","author":"Milsom","year":"2002","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2006.07.001_bib38","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.resp.2004.06.021","article-title":"Evolutionary trends in airway CO2\/H+ chemoreception","volume":"144","author":"Milsom","year":"2004","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2006.07.001_bib39","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1152\/jappl.1981.50.6.1121","article-title":"On chemoreceptor control of ventilatory responses to CO2 in unanesthetized ducks","volume":"50","author":"Milsom","year":"1981","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2006.07.001_bib40","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1079\/WPS19680021","article-title":"Role of acid-base balance in the physiology of egg shell formation","volume":"24","author":"Mongin","year":"1968","journal-title":"World Poultry Sci. J."},{"key":"10.1016\/j.resp.2006.07.001_bib41","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0301-0082(99)00008-8","article-title":"CO2, brainstem chemoreceptors and breathing","volume":"59","author":"Nattie","year":"1999","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.resp.2006.07.001_bib42","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1152\/jappl.1981.50.3.566","article-title":"CSF acid-base regulation and ventilation during acute hypercapnia in the newborn dog","volume":"50","author":"Nattie","year":"1981","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2006.07.001_bib43","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1242\/jeb.100.1.23","article-title":"Role of peripheral chemoreceptors and central chemosensitivity in the regulation of respiration and circulation","volume":"100","author":"O\u2019Regan","year":"1982","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.resp.2006.07.001_bib44","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/0034-5687(77)90042-1","article-title":"Ventilatory responses to CO2 in chicken: intrapulmonary and systemic chemoreceptors","volume":"30","author":"Osborne","year":"1977","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2006.07.001_bib45","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1126\/science.162.3861.1499","article-title":"Receptors sensitive to carbon dioxide in lungs of chicken","volume":"162","author":"Peterson","year":"1968","journal-title":"Science"},{"key":"10.1016\/j.resp.2006.07.001_bib46","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/0034-5687(78)90008-7","article-title":"Ventilatory response to CO2 in birds. 1. Measurements in the unanesthetized duck","volume":"35","author":"Powell","year":"1978","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2006.07.001_bib47","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0034-5687(98)00026-7","article-title":"Time domains of the hypoxic ventilatory response","volume":"112","author":"Powell","year":"1998","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2006.07.001_bib48","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0300-9629(73)90566-5","article-title":"Phosphate excretion in the laying fowl","volume":"46A","author":"Prashad","year":"1973","journal-title":"Comp. Biochem. Physiol."},{"key":"10.1016\/j.resp.2006.07.001_bib49","doi-asserted-by":"crossref","first-page":"C1493","DOI":"10.1152\/ajpcell.00282.2004","article-title":"Cellular mechanisms involved in CO2 and acid signaling in chemosensitive neurons","volume":"287","author":"Putnam","year":"2004","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.resp.2006.07.001_bib50","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1152\/jappl.1963.18.6.1071","article-title":"Respiratory acclimatization to carbon dioxide","volume":"18","author":"Schaefer","year":"1963","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2006.07.001_bib51","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/0034-5687(78)90009-9","article-title":"Ventilatory response to CO2 in birds. 2. Contribution by intra-pulmonary CO2 receptors","volume":"35","author":"Scheid","year":"1978","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2006.07.001_bib52","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0034-5687(75)90079-1","article-title":"Metabolic changes in avian blood and their effects on determination of blood gases and pH","volume":"23","author":"Scheid","year":"1975","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2006.07.001_bib53","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1152\/ajplegacy.1966.210.5.997","article-title":"Acidification of mucosal fluid by transport of bicarbonate ion in turtle bladders","volume":"210","author":"Schilb","year":"1966","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.resp.2006.07.001_bib54","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1242\/jeb.114.1.661","article-title":"Ventilatory and acid-base responses to long-term hypercapnia in the freshwater turtle, Chrysemys Picta Bellii","volume":"114","author":"Silver","year":"1985","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.resp.2006.07.001_bib55","first-page":"R1228","article-title":"Ionic compensation with no renal response to chronic hypercapnia in Chrysemys picta bellii","volume":"251","author":"Silver","year":"1986","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.resp.2006.07.001_bib56","first-page":"R887","article-title":"Chemoreceptor modulation of endogenous respiratory rhythms in vertebrates","volume":"259","author":"Smatresk","year":"1990","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.resp.2006.07.001_bib57","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1152\/jn.2002.88.2.604","article-title":"CO2 and pH independently modulate L-type Ca2+ current in rabbit carotid body glomus cells","volume":"88","author":"Summers","year":"2002","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.resp.2006.07.001_bib58","doi-asserted-by":"crossref","first-page":"F492","DOI":"10.1152\/ajprenal.1985.248.4.F492","article-title":"Adaptive changes in renal acidification in response to chronic respiratory acidosis","volume":"248","author":"Tannen","year":"1985","journal-title":"Am. J. Physiol. Renal Fluid Electrolyte Physiol."},{"key":"10.1016\/j.resp.2006.07.001_bib59","doi-asserted-by":"crossref","first-page":"R686","DOI":"10.1152\/ajpregu.1998.274.3.R686","article-title":"Circadian rhythms in diving behavior and ventilatory response to asphyxia in canvasback ducks","volume":"274","author":"Woodin","year":"1998","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."}],"container-title":["Respiratory Physiology & Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904806002187?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904806002187?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T22:12:05Z","timestamp":1761603125000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569904806002187"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4]]},"references-count":59,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,4]]}},"alternative-id":["S1569904806002187"],"URL":"https:\/\/doi.org\/10.1016\/j.resp.2006.07.001","relation":{},"ISSN":["1569-9048"],"issn-type":[{"value":"1569-9048","type":"print"}],"subject":[],"published":{"date-parts":[[2007,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ventilatory roll off during sustained hypercapnia is gender specific in pekin ducks","name":"articletitle","label":"Article Title"},{"value":"Respiratory Physiology & Neurobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resp.2006.07.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}