{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T15:05:39Z","timestamp":1779894339180,"version":"3.53.1"},"reference-count":37,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Physiology &amp; Neurobiology"],"published-print":{"date-parts":[[2007,6]]},"DOI":"10.1016\/j.resp.2006.11.002","type":"journal-article","created":{"date-parts":[[2006,12,22]],"date-time":"2006-12-22T17:36:58Z","timestamp":1166809018000},"page":"320-330","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Multi-organ system model of O2 and CO2 transport during isocapnic and poikilocapnic hypoxia"],"prefix":"10.1016","volume":"156","author":[{"given":"Haiying","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald M.","family":"Saidel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco E.","family":"Cabrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.resp.2006.11.002_bib1","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1152\/japplphysiol.01385.2003","article-title":"Ventilatory, cerebrovascular, and cardiovascular interactions in acute hypoxia: regulation by carbon dioxide","volume":"97","author":"Ainslie","year":"2004","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2006.11.002_bib2","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1114\/1.138","article-title":"Heterogeneity of capillary transit times in modeling multiple indicator dilution data","volume":"26","author":"Audi","year":"1998","journal-title":"Ann. Biomed. Eng."},{"key":"10.1016\/j.resp.2006.11.002_bib3","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1378\/chest.108.4.899","article-title":"Left ventricular systolic performance during acute hypoxemia","volume":"108","author":"Cargill","year":"1995","journal-title":"Chest"},{"key":"10.1016\/j.resp.2006.11.002_bib4","doi-asserted-by":"crossref","first-page":"H194","DOI":"10.1152\/ajpheart.1981.241.2.H194","article-title":"Small vessel and total coronary blood volume during intracoronary adenosine","volume":"241","author":"Crystal","year":"1981","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.resp.2006.11.002_bib5","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1007\/s10439-004-7821-6","article-title":"Blood HbO2 and HbCO2 dissociation curves at varied O2, CO2, pH, 2,3-DPG and temperature levels","volume":"32","author":"Dash","year":"2004","journal-title":"Ann. Biomed. Eng."},{"key":"10.1016\/j.resp.2006.11.002_bib6","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1007\/s10439-005-9066-4","article-title":"Simultaneous blood-tissue exchange of oxygen, carbon dioxide, bicarbonate, and hydrogen ion","volume":"34","author":"Dash","year":"2006","journal-title":"Ann. Biomed. Eng."},{"key":"10.1016\/j.resp.2006.11.002_bib7","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1172\/JCI111216","article-title":"Systemic circulatory adjustments to acute hypoxia and reoxygenation in unanesthetized sheep","volume":"73","author":"Davidson","year":"1984","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.resp.2006.11.002_bib8","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1152\/jappl.1988.64.4.1451","article-title":"Carbon dioxide effects on the ventilatory response to sustained hypoxia","volume":"64","author":"Easton","year":"1988","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2006.11.002_bib9","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1152\/jappl.1986.61.3.906","article-title":"Ventilatory response to sustained hypoxia in normal adults","volume":"61","author":"Easton","year":"1986","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2006.11.002_bib10","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1002\/ana.410040407","article-title":"Measurement of regional cerebral blood volume by emission tomography","volume":"4","author":"Grubb","year":"1978","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.resp.2006.11.002_bib11","series-title":"Textbook of Medical Physiology","author":"Guyton","year":"2000"},{"key":"10.1016\/j.resp.2006.11.002_bib12","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1152\/jappl.2000.88.2.599","article-title":"Diuretic effect of hypoxia, hypocapnia, and hyperpnea in humans: relation to hormones and O2 chemosensitivity","volume":"88","author":"Hildebrandt","year":"2000","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2006.11.002_bib13","unstructured":"Hindmarsh, A.C., 1983. ODEPACK, a systematized collection of ODE solvers. In Scientific Computing. North-Holland, Amsterdam, 55\u201364."},{"key":"10.1016\/j.resp.2006.11.002_bib14","doi-asserted-by":"crossref","first-page":"947","DOI":"10.2170\/jjphysiol.45.947","article-title":"Ventilatory depression during mild hypoxia in adult humans","volume":"45","author":"Honda","year":"1995","journal-title":"Jpn. J. Physiol."},{"key":"10.1016\/j.resp.2006.11.002_bib15","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1152\/japplphysiol.01186.2002","article-title":"Relationship between middle cerebral artery blood velocity and end-tidal PCO2 in the hypocapnic-hypercapnic range in humans","volume":"95","author":"Ide","year":"2003","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2006.11.002_bib16","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1152\/ajpheart.1980.239.4.H545","article-title":"Influence of CO2 on cardiovascular response to hypoxia in conscious dogs","volume":"239","author":"Koehler","year":"1980","journal-title":"Am. J. Physiol. Heart. Circ. Physiol."},{"key":"10.1016\/j.resp.2006.11.002_bib17","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1152\/jappl.1967.23.3.381","article-title":"Comparative circulatory responses to systemic hypoxia in man and in unanesthetized dog","volume":"23","author":"Kontos","year":"1967","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2006.11.002_bib18","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1145\/355769.355773","article-title":"Design and testing of a generalized reduced gradient code for nonlinear programming","volume":"4","author":"Lasdon","year":"1978","journal-title":"ACM Trans. Math. Software"},{"key":"10.1016\/j.resp.2006.11.002_bib19","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1152\/jappl.1999.87.6.2218","article-title":"Adenosine contributes to hypoxia-induced forearm vasodilation in humans","volume":"87","author":"Leuenberger","year":"1999","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2006.11.002_bib20","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1152\/jappl.1997.82.2.667","article-title":"Extended models of the ventilatory response to sustained isocapnic hypoxia in humans","volume":"82","author":"Liang","year":"1997","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2006.11.002_bib21","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0034-5687(01)00325-5","article-title":"Effects of neural drives on breathing in the awake state in humans","volume":"129","author":"Longobardo","year":"2002","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2006.11.002_bib22","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0034-5687(97)00024-8","article-title":"The effect of hypoxia on the ventilatory response to carbon dioxide in man","volume":"108","author":"Mohan","year":"1997","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2006.11.002_bib23","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1152\/jappl.1984.56.1.207","article-title":"Variable inhibition by falling CO2 of hypoxic ventilatory response in humans","volume":"56","author":"Moore","year":"1984","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2006.11.002_bib24","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1152\/jappl.1990.68.2.441","article-title":"Modulation of respiration during brain hypoxia","volume":"68","author":"Neubauer","year":"1990","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2006.11.002_bib25","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1152\/jappl.1993.74.4.2007","article-title":"A mathematical model of the human ventilatory response to isocapnic hypoxia","volume":"74","author":"Painter","year":"1993","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2006.11.002_bib26","doi-asserted-by":"crossref","first-page":"E522","DOI":"10.1152\/ajpendo.2000.278.3.E522","article-title":"Regulation of glycogen phosphorylase and PDH during exercise in human skeletal muscle during hypoxia","volume":"278","author":"Parolin","year":"2000","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.resp.2006.11.002_bib27","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1152\/jappl.1996.81.3.1084","article-title":"Dynamics of the cerebral blood flow response to step changes in end-tidal PCO2 and PO2 in humans","volume":"81","author":"Poulin","year":"1996","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2006.11.002_bib28","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1152\/jappl.1975.38.1.16","article-title":"Ventilatory effects of hypoxia and their dependence on PCO2","volume":"38","author":"Rebuck","year":"1975","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2006.11.002_bib29","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1152\/jappl.1995.79.2.373","article-title":"Hypoxic ventilatory decline: site of action","volume":"79","author":"Robbins","year":"1995","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2006.11.002_bib30","doi-asserted-by":"crossref","first-page":"H932","DOI":"10.1152\/ajpheart.1990.259.3.H932","article-title":"Effects of hypercapnia and hypoxia on the cardiovascular system: vascular capacitance and aortic chemoreceptors","volume":"259","author":"Rothe","year":"1990","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.resp.2006.11.002_bib31","series-title":"Computational Transport Phenomena: Numerical Methods for the Solution of Transport Problems.","author":"Schiesser","year":"1997"},{"key":"10.1016\/j.resp.2006.11.002_bib32","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1172\/JCI106455","article-title":"Cerebrovascular response to acute hypocapnic and eucapnic hypoxia in normal man","volume":"49","author":"Shapiro","year":"1970","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.resp.2006.11.002_bib33","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1006\/jtbi.2002.3001","article-title":"A Compartmental Model for Oxygen Transport in Brain Microcirculation in the Presence of Blood Substitutes","volume":"216","author":"Sharan","year":"2002","journal-title":"J. Theor. Biol."},{"key":"10.1016\/j.resp.2006.11.002_bib34","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1152\/jappl.1989.66.4.1674","article-title":"No effect of brain blood flow on ventilatory depression during sustained hypoxia","volume":"66","author":"Suzuki","year":"1989","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2006.11.002_bib35","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1114\/B:ABME.0000049037.65204.4c","article-title":"A computational model of the human respiratory control system: responses to hypoxia and hypercapnia","volume":"32","author":"Topor","year":"2004","journal-title":"Ann. Biomed. Eng."},{"key":"10.1016\/j.resp.2006.11.002_bib36","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1046\/j.1365-2281.2001.00349.x","article-title":"An integrated model of the human ventilatory control system: the response to hypercapnia","volume":"21","author":"Ursino","year":"2001","journal-title":"Clin. Physiol."},{"key":"10.1016\/j.resp.2006.11.002_bib37","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1046\/j.1365-2281.2001.00350.x","article-title":"An integrated model of the human ventilatory control system: the response to hypoxia","volume":"21","author":"Ursino","year":"2001","journal-title":"Clin. Physiol."}],"container-title":["Respiratory Physiology &amp; Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904806002965?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904806002965?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T22:13:11Z","timestamp":1761603191000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569904806002965"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,6]]}},"alternative-id":["S1569904806002965"],"URL":"https:\/\/doi.org\/10.1016\/j.resp.2006.11.002","relation":{},"ISSN":["1569-9048"],"issn-type":[{"value":"1569-9048","type":"print"}],"subject":[],"published":{"date-parts":[[2007,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multi-organ system model of O2 and CO2 transport during isocapnic and poikilocapnic hypoxia","name":"articletitle","label":"Article Title"},{"value":"Respiratory Physiology & Neurobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resp.2006.11.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}