{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:34:22Z","timestamp":1790364862547,"version":"4.1.0"},"reference-count":131,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Physiology &amp; Neurobiology"],"published-print":{"date-parts":[[2007,7]]},"DOI":"10.1016\/j.resp.2007.01.007","type":"journal-article","created":{"date-parts":[[2007,1,21]],"date-time":"2007-01-21T07:08:28Z","timestamp":1169363308000},"page":"12-21","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":66,"title":["Adequate stimuli of the carotid body: More than an oxygen sensor?"],"prefix":"10.1016","volume":"157","author":[{"given":"Prem","family":"Kumar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismaeel","family":"Bin-Jaliah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.resp.2007.01.007_bib1","first-page":"78P","article-title":"The distribution of oxygen tension in the carotid body of the cat","volume":"216","author":"Acker","year":"1971","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2007.01.007_bib2","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/BF00591569","article-title":"The kinetics of local tissue PO2 decrease after perfusion stop within the carotid body of the cat in vivo and in vitro","volume":"369","author":"Acker","year":"1977","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.resp.2007.01.007_bib3","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1113\/jphysiol.1981.sp013735","article-title":"The effects of stimulation of autonomic nerves on carotid body blood flow in the cat","volume":"315","author":"Acker","year":"1981","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2007.01.007_bib4","first-page":"885","article-title":"Importance of oxygen supply in the carotid body for chemoreception","volume":"46","author":"Acker","year":"1987","journal-title":"Biomed. Biochim. Acta"},{"key":"10.1016\/j.resp.2007.01.007_bib5","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0006-8993(93)90407-E","article-title":"Thermal dependence of chemosensory activity in the carotid body superfused in vitro","volume":"600","author":"Alcayaga","year":"1993","journal-title":"Brain Res."},{"key":"10.1016\/j.resp.2007.01.007_bib6","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1111\/j.1469-7793.1998.773bj.x","article-title":"Angiotensin AT1 receptor-mediated excitation of rat carotid body chemoreceptor afferent activity","volume":"510","author":"Allen","year":"1998","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2007.01.007_bib7","series-title":"The Peripheral Arterial Chemoreceptors","first-page":"141","article-title":"Metabolic dissociation of carotid body chemoreceptor responses to different types of stimulation: preliminary findings","author":"Almaraz","year":"1984"},{"key":"10.1016\/j.resp.2007.01.007_bib8","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1113\/jphysiol.1986.sp016254","article-title":"Effects of high potassium on the release of [3H]dopamine from the cat carotid body in vitro","volume":"379","author":"Almaraz","year":"1986","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2007.01.007_bib9","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/0034-5687(88)90093-X","article-title":"Carotid sinus receptors participate in glucose homeostasis","volume":"72","author":"Alvarez-Buylla","year":"1988","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2007.01.007_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0034-5687(90)90002-G","article-title":"Acute changes in osmolality and renin and respiratory control of arterial PCO2 and [H+]","volume":"80","author":"Anderson","year":"1990","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2007.01.007_bib11","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1113\/jphysiol.1986.sp016311","article-title":"The effect of potassium on carotid body chemoreceptor discharge in the anaesthetized cat","volume":"381","author":"Band","year":"1986","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2007.01.007_bib12","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/0034-5687(88)90088-6","article-title":"The effect of hypoxia on the response of the carotid body chemoreceptor to potassium in the anaesthetized cat","volume":"72","author":"Band","year":"1988","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2007.01.007_bib13","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1113\/jphysiol.2001.015750","article-title":"A possible dual site of action for carbon monoxide-mediated chemoexcitation in the rat carotid body","volume":"543","author":"Barbe","year":"2002","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2007.01.007_bib14","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.1152\/jappl.1988.65.6.2484","article-title":"Measurement of carotid body blood flow in cats by use of radioactive microspheres","volume":"65","author":"Barnett","year":"1988","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2007.01.007_bib15","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1002\/neu.480060507","article-title":"Thermal responses of carotid body cells","volume":"6","author":"Baron","year":"1975","journal-title":"J. Neurobiol."},{"key":"10.1016\/j.resp.2007.01.007_bib16","doi-asserted-by":"crossref","first-page":"C35","DOI":"10.1152\/ajpcell.1977.233.1.C35","article-title":"Effects of temperature on some membrane characteristics of carotid body cells","volume":"233","author":"Baron","year":"1977","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.resp.2007.01.007_bib17","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1007\/BF00373936","article-title":"Effect of arterial carbon dioxide pressure on chemoreceptor action potentials in the carotid sinus nerves","volume":"262","author":"Bartels","year":"1956","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.resp.2007.01.007_bib18","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1152\/ajplegacy.1939.127.1.94","article-title":"Respiratory and vasomotor effects of variation in carotid body temperature: a study of the mechanism of chemoreceptor stimulation","volume":"127","author":"Bernthal","year":"1939","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.resp.2007.01.007_bib19","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1113\/jphysiol.2003.058321","article-title":"Indirect sensing of insulin-induced hypoglycaemia by the carotid body in the rat","volume":"556","author":"Bin-Jaliah","year":"2004","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2007.01.007_bib20","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1113\/jphysiol.2004.080085","article-title":"Carbon dioxide sensitivity during hypoglycaemia-induced, elevated metabolism in the anaesthetized rat","volume":"563","author":"Bin-Jaliah","year":"2005","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2007.01.007_bib21","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1113\/jphysiol.1970.sp009108","article-title":"The relation between carotid body chemoreceptor discharge, carotid sinus pressure and carotid body venous flow","volume":"208","author":"Biscoe","year":"1970","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2007.01.007_bib22","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1113\/jphysiol.1970.sp009109","article-title":"The frequency of nerve impulses in single carotid body chemoreceptor afferent fibres recorded in vivo with intact circulation","volume":"208","author":"Biscoe","year":"1970","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2007.01.007_bib23","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/0034-5687(71)90063-6","article-title":"The responses of carotid body chemoreceptors in the cat to sudden changes of hypercapnic and hypoxic stimuli","volume":"13","author":"Black","year":"1971","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2007.01.007_bib24","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1152\/jappl.1987.62.2.389","article-title":"Central chemoreceptors","volume":"62","author":"Bruce","year":"1987","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2007.01.007_bib25","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1113\/jphysiol.1991.sp018542","article-title":"Intracellular pH and its regulation in isolated type I carotid body cells of the neonatal rat","volume":"436","author":"Buckler","year":"1991","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2007.01.007_bib26","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1113\/jphysiol.1991.sp018902","article-title":"Effects of extracellular pH, PCO2 and HCO3\u2212 on intracellular pH in isolated type-I cells of the neonatal rat carotid-body","volume":"444","author":"Buckler","year":"1991","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2007.01.007_bib27","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/978-1-4615-2572-1_5","article-title":"Role of intracellular pH and [Ca2+]i in acid chemoreception in type-I cells of the carotid body","volume":"360","author":"Buckler","year":"1994","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.resp.2007.01.007_bib28","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1152\/jappl.1989.67.4.1578","article-title":"Evidence for second metabolic pathway for O2 from PtiO2 measurements in denervated cat carotid body","volume":"67","author":"Buerk","year":"1989","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2007.01.007_bib29","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1113\/jphysiol.1988.sp017176","article-title":"Effects of potassium, oxygen and carbon dioxide on the steady-state discharge of cat carotid body chemoreceptors","volume":"401","author":"Burger","year":"1988","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2007.01.007_bib30","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.1469-7793.1997.187bi.x","article-title":"Development of carotid chemoreceptor dynamic and steady-state sensitivity to CO2 in the newborn lamb","volume":"503","author":"Calder","year":"1997","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2007.01.007_bib31","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1111\/j.1469-7793.1997.497bg.x","article-title":"Swelling- and cAMP-activated Cl- currents in isolated rat carotid body type I cells","volume":"503","author":"Carpenter","year":"1997","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2007.01.007_bib32","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.resp.2005.04.009","article-title":"Postnatal development of carotid body glomus cell O2 sensitivity","volume":"149","author":"Carroll","year":"2005","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2007.01.007_bib33","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1159\/000146193","article-title":"Dimensions and volume of the carotid-body in the adult cat, and their relation to the specific blood-flow through the organ\u2014a histological and morphometric study","volume":"126","author":"Clarke","year":"1986","journal-title":"Acta Anatom."},{"key":"10.1016\/j.resp.2007.01.007_bib34","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1159\/000147511","article-title":"A morphological-study of the size of the vascular compartment of the carotid-body in a nonhuman primate (Cercopithecus ethiopus), and a comparison with the cat and rat","volume":"147","author":"Clarke","year":"1993","journal-title":"Acta Anatom."},{"key":"10.1016\/j.resp.2007.01.007_bib35","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1113\/jphysiol.1954.sp005143","article-title":"Observations on the volume of blood flow and oxygen utilization of the carotid body in the cat","volume":"125","author":"De Burgh Daly","year":"1954","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2007.01.007_bib36","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1113\/jphysiol.1952.sp004813","article-title":"Carotid chemoceptor impulse activity during inhalation of carbon monoxide mixtures","volume":"118","author":"Duke","year":"1952","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2007.01.007_bib37","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/BF00213792","article-title":"The distribution of thoracic glomus tissue (aortic bodies) in the rat","volume":"232","author":"Easton","year":"1983","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.resp.2007.01.007_bib38","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1113\/jphysiol.1961.sp006804","article-title":"Chemoreceptor activity of the carotid body of the cat","volume":"159","author":"Eyzaguirre","year":"1961","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2007.01.007_bib39","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0034-5687(91)90039-L","article-title":"Thermal effects on ventilation in cats: participation of carotid body chemoreceptors","volume":"86","author":"Fadic","year":"1991","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2007.01.007_bib40","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1152\/ajplegacy.1970.218.2.518","article-title":"Oxygen consumption of the carotid body","volume":"218","author":"Fay","year":"1970","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.resp.2007.01.007_bib41","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1113\/jphysiol.1969.sp008981","article-title":"A study of chemoreceptor and baroreceptor A and C-fibres in the cat carotid nerve","volume":"205","author":"Fidone","year":"1969","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2007.01.007_bib42","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/0034-5687(69)90037-1","article-title":"Carotid chemoreceptor response to intermittent or sustained stimulation in the cat","volume":"6","author":"Fitzgerald","year":"1969","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2007.01.007_bib43","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1007\/s004240000445","article-title":"Functional expression of angiotensin II receptors in type-I cells of the rat carotid body","volume":"441","author":"Fung","year":"2001","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.resp.2007.01.007_bib44","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/BF00582612","article-title":"The effects of blood osmolality changes on cat carotid body chemoreceptors in vivo","volume":"380","author":"Gallego","year":"1979","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.resp.2007.01.007_bib45","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1152\/jn.1979.42.3.665","article-title":"Thermal and osmotic responses of arterial receptors","volume":"42","author":"Gallego","year":"1979","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.resp.2007.01.007_bib46","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0034-5687(94)90127-9","article-title":"The ventilatory response to changes in arterial oxygen content","volume":"96","author":"Garland","year":"1994","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2007.01.007_bib47","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0034-5687(68)90054-6","article-title":"Response of the perfused carotid body to changes in pH and PCO2","volume":"4","author":"Gray","year":"1968","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2007.01.007_bib48","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/978-1-4615-2572-1_9","article-title":"Chemoreceptor function in the fetus and neonate","volume":"360","author":"Hanson","year":"1994","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.resp.2007.01.007_bib49","first-page":"165P","article-title":"Effects of acetazolamide and benzolamide on the response of the carotid chemoreceptors to CO2","volume":"284","author":"Hanson","year":"1978","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2007.01.007_bib50","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1152\/jappl.1978.44.5.696","article-title":"Anemia as a stimulus to aortic and carotid chemoreceptors in the cat","volume":"44","author":"Hatcher","year":"1978","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2007.01.007_bib51","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1152\/jn.1961.24.6.561","article-title":"Quantitation of chemoreceptor activity: interrelation of hypoxia and hypercapnia","volume":"24","author":"Hornbein","year":"1961","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.resp.2007.01.007_bib52","first-page":"145","article-title":"Phrenic nerve activity during artificial ventilation at different body temperatures and its relationships with carotid chemosensory activity","volume":"27","author":"Iturriaga","year":"1994","journal-title":"Biol. Res."},{"key":"10.1016\/j.resp.2007.01.007_bib53","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/j.1748-1716.1952.tb00872.x","article-title":"Impulse activity in the carotid sinus nerve following intra-carotid injection of potassium chloride, veratrine, sodium citrate, adenosine-triphosphate and alpha dinitrophenol","volume":"25","author":"Jarisch","year":"1952","journal-title":"Acta Physiol. Scand."},{"key":"10.1016\/j.resp.2007.01.007_bib54","first-page":"R1125","article-title":"Angiotensin stimulates respiration in spontaneously hypertensive rats","volume":"278","author":"Jennings","year":"2000","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.resp.2007.01.007_bib55","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1093\/oxfordjournals.bmb.a069999","article-title":"The excitation mechanism of the carotid body","volume":"19","author":"Joels","year":"1963","journal-title":"Br. Med. Bull."},{"key":"10.1016\/j.resp.2007.01.007_bib56","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.2337\/diabetes.49.9.1434","article-title":"Evidence that carotid bodies play an important role in glucoregulation in vivo","volume":"49","author":"Koyama","year":"2000","journal-title":"Diabetes"},{"key":"10.1016\/j.resp.2007.01.007_bib57","first-page":"E742","article-title":"Role of carotid bodies in control of the neuroendocrine response to exercise","volume":"281","author":"Koyama","year":"2001","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.resp.2007.01.007_bib58","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1113\/jphysiol.1988.sp016933","article-title":"Do oxygen tension variations contribute to the respiratory oscillations of chemoreceptor discharge in the cat?","volume":"395","author":"Kumar","year":"1988","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2007.01.007_bib59","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/0034-5687(75)90017-1","article-title":"Stimulus interaction in the responses of carotid body chemoreceptor single afferent fibers","volume":"24","author":"Lahiri","year":"1975","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2007.01.007_bib60","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1152\/jappl.1980.48.5.781","article-title":"Relative responses of aortic body and carotid body chemoreceptors to hypotension","volume":"48","author":"Lahiri","year":"1980","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2007.01.007_bib61","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1152\/jappl.1981.50.3.580","article-title":"Relative responses of aortic body and carotid body chemoreceptors to carboxyhemoglobinemia","volume":"50","author":"Lahiri","year":"1981","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2007.01.007_bib62","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/0034-5687(93)90050-K","article-title":"CO reveals dual mechanisms of O2 chemoreception in the cat carotid body","volume":"94","author":"Lahiri","year":"1993","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2007.01.007_bib63","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1016\/S1357-2725(03)00050-5","article-title":"CO2\/H+ sensing: peripheral and central chemoreception","volume":"35","author":"Lahiri","year":"2003","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.resp.2007.01.007_bib64","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1152\/japplphysiol.00684.2003","article-title":"Regulation of the angiotensin-converting enzyme activity by a time-course hypoxia in the carotid body","volume":"96","author":"Lam","year":"2004","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2007.01.007_bib65","first-page":"162P","article-title":"Interaction of temperature and CO2 in the adult rat carotid body, in vitro","volume":"489P","author":"Landauer","year":"1995","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2007.01.007_bib66","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/j.1748-1716.1951.tb00805.x","article-title":"Chemoreceptor impulse activity following haemorrhage","volume":"23","author":"Landgren","year":"1951","journal-title":"Acta Physiol. Scand."},{"key":"10.1016\/j.resp.2007.01.007_bib67","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1113\/expphysiol.1964.sp001717","article-title":"The effect of blood pressure upon chemoreceptor discharge to hypoxia and the modification of this effect by the sympathic-adrenal system","volume":"49","author":"Lee","year":"1964","journal-title":"Q. J. Exp. Physiol."},{"key":"10.1016\/j.resp.2007.01.007_bib68","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/BF00592402","article-title":"Carotid body oxygen consumption of the cat in vitro","volume":"323","author":"Leitner","year":"1971","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.resp.2007.01.007_bib69","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/S1357-2725(02)00180-2","article-title":"Renin-angiotensin system in the carotid body","volume":"35","author":"Leung","year":"2003","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.resp.2007.01.007_bib70","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1042\/cs0670427","article-title":"Arterial plasma potassium measured continuosly during exercise in man","volume":"67","author":"Linton","year":"1984","journal-title":"Clin. Sci."},{"key":"10.1016\/j.resp.2007.01.007_bib71","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0034-5687(85)90019-2","article-title":"The effect of potassium on carotid chemoreceptor activity and ventilation in the cat","volume":"59","author":"Linton","year":"1985","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2007.01.007_bib72","first-page":"104","article-title":"Potassium and breathing","volume":"5","author":"Linton","year":"1990","journal-title":"News Physiol. Sci."},{"key":"10.1016\/j.resp.2007.01.007_bib73","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1113\/jphysiol.1978.sp012163","article-title":"Effects of adrenoceptor stimulating and blocking agents on carotid body chemosensory inhibition","volume":"274","author":"Llados","year":"1978","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2007.01.007_bib74","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0959-4388(03)00093-X","article-title":"Oxygen and glucose sensing by carotid body glomus cells","volume":"13","author":"Lopez-Barneo","year":"2003","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.resp.2007.01.007_bib75","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/0304-3940(91)90313-I","article-title":"Effects of body temperature on chemosensory activity of the cat carotid body in situ","volume":"132","author":"Loyola","year":"1991","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.resp.2007.01.007_bib76","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1152\/physrev.1994.74.3.543","article-title":"Peripheral chemoreceptors and cardiovascular regulation","volume":"74","author":"Marshall","year":"1994","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.resp.2007.01.007_bib77","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/0-387-31311-7_38","article-title":"Adrenaline increases carotid body CO2 sensitivity: an in vivo study","volume":"580","author":"Maskell","year":"2006","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.resp.2007.01.007_bib78","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1152\/jappl.1994.77.3.1067","article-title":"Metabolic and ventilatory responses to anemic hypoxia in conscious rats","volume":"77","author":"Matsuoka","year":"1994","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2007.01.007_bib79","first-page":"R387","article-title":"Metabolic response to ambient temperature and hypoxia in sinoaortic-denervated rats","volume":"266","author":"Matsuoka","year":"1994","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.resp.2007.01.007_bib80","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/BF01148090","article-title":"The ultrastructure and connections of blood vessels supplying the rat carotid body and carotid sinus","volume":"12","author":"McDonald","year":"1983","journal-title":"J. Neurocytol."},{"key":"10.1016\/j.resp.2007.01.007_bib81","first-page":"580P","article-title":"Response of carotid chemoreceptors to elevated arterial potassium in anaesthetized cats ventilated with air or 100% oxygen","volume":"446","author":"McLoughlin","year":"1992","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2007.01.007_bib82","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/0034-5687(94)00108-C","article-title":"Effects of potassium and lactic acid on chemoreceptor discharge in anaesthetized cats","volume":"99","author":"McLoughlin","year":"1995","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2007.01.007_bib83","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1152\/jn.1974.37.6.1287","article-title":"Effects of temperature on carotid chemoreceptor and baroreceptor activity","volume":"37","author":"McQueen","year":"1974","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.resp.2007.01.007_bib84","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.1476-5381.1981.tb09964.x","article-title":"Effect of adenosine on carotid chemoreceptor activity in the cat","volume":"74","author":"McQueen","year":"1981","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.resp.2007.01.007_bib85","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0165-1838(94)00179-N","article-title":"Endothelins and rat carotid body: autoradiographic and functional pharmacological studies","volume":"53","author":"McQueen","year":"1995","journal-title":"J. Auton. Nerv. Syst."},{"key":"10.1016\/j.resp.2007.01.007_bib86","first-page":"797","article-title":"Renal effects of electrical stimulation of the carotid sinus nerve","volume":"65","author":"Michaelis","year":"1969","journal-title":"Surgery"},{"key":"10.1016\/j.resp.2007.01.007_bib87","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1113\/jphysiol.2002.024125","article-title":"Effects of osmotic changes on the chemoreceptor cell of rat carotid body","volume":"546","author":"Molnar","year":"2003","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2007.01.007_bib88","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1146\/annurev.physiol.62.1.847","article-title":"Ventilatory responses to changes in temperature in mammals and other vertebrates","volume":"62","author":"Mortola","year":"2000","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.resp.2007.01.007_bib89","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/978-1-4684-5188-7_36","article-title":"Two cytochrome oxygen consumption model and mechanism for carotid body chemoreception","volume":"200","author":"Nair","year":"1986","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.resp.2007.01.007_bib90","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1111\/j.1748-1716.1952.tb00847.x","article-title":"Studies on the regulation of respiration in acute hypoxia; with an appendix on respiratory control during prolonged hypoxia","volume":"24","author":"Nielsen","year":"1952","journal-title":"Acta Physiol. Scand."},{"key":"10.1016\/j.resp.2007.01.007_bib91","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.autneu.2005.04.008","article-title":"Neurotransmission and neuromodulation in the chemosensory carotid body","volume":"120","author":"Nurse","year":"2005","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.resp.2007.01.007_bib92","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/BF00581416","article-title":"Arterial chemoreceptor inhibition by a single inspirate containing carbon monoxide is accounted for by raised arterial PO2","volume":"393","author":"Nye","year":"1982","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.resp.2007.01.007_bib93","first-page":"64P","article-title":"The effect of hyperkalaemia on the activity of pulmonary stretch receptors in the cat","volume":"391","author":"Nye","year":"1987","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2007.01.007_bib94","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1139\/y01-056","article-title":"Respiratory and metabolic effects of decreased osmolality in conscious rats","volume":"79","author":"O\u2019Connor","year":"2001","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.resp.2007.01.007_bib95","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/BF02938055","article-title":"Oxygen usage of the cat carotid body perfused with cell-free solutions","volume":"148","author":"O\u2019Regan","year":"1979","journal-title":"Ir. J. Med. Sci."},{"key":"10.1016\/j.resp.2007.01.007_bib96","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0006-8993(86)90806-1","article-title":"Effects of 2-deoxy-d-glucose on in vitro cat carotid body","volume":"371","author":"Obeso","year":"1986","journal-title":"Brain Res."},{"key":"10.1016\/j.resp.2007.01.007_bib97","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1152\/jappl.1993.74.5.2387","article-title":"Effect of low O2 on glucose uptake in rabbit carotid body","volume":"74","author":"Obeso","year":"1993","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2007.01.007_bib98","first-page":"1117","article-title":"The sensitivity to hypoxia of peripheral and central respiratory control mechanisms under normo- and hypothermic conditions","volume":"15","author":"Oruc","year":"1979","journal-title":"Bull. Eur. Physiopathol. Respir."},{"key":"10.1016\/j.resp.2007.01.007_bib99","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1113\/jphysiol.1971.sp009556","article-title":"The responses of chemoreceptors at reduced temperatures","volume":"217","author":"Paintal","year":"1971","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2007.01.007_bib100","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/nn812","article-title":"Low glucose-sensing cells in the carotid body","volume":"5","author":"Pardal","year":"2002","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.resp.2007.01.007_bib101","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0034-5687(88)90107-7","article-title":"The effect of beta adrenergic blockade on the carotid body response to hyperkalaemia in the cat","volume":"74","author":"Paterson","year":"1988","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2007.01.007_bib102","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1152\/jappl.1992.72.3.811","article-title":"Potassium and ventilation in exercise","volume":"72","author":"Paterson","year":"1992","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2007.01.007_bib103","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1113\/jphysiol.1995.sp020749","article-title":"Postnatal development of CO2-O2 interaction in the rat carotid body in vitro","volume":"485","author":"Pepper","year":"1995","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2007.01.007_bib104","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1113\/jphysiol.1996.sp021426","article-title":"Extracellular potassium and chemosensitivity in the rat carotid body, in vitro","volume":"493","author":"Pepper","year":"1996","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2007.01.007_bib105","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1152\/jappl.1974.37.5.635","article-title":"Frequency response of carotid body chemoreceptors in the cat to changes of PaCO2, PaO2, and pHa","volume":"37","author":"Ponte","year":"1974","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2007.01.007_bib106","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1111\/j.1440-1681.2005.04209.x","article-title":"Cardiovascular alterations by chronic intermittent hypoxia: importance of carotid body chemoreflexes","volume":"32","author":"Prabhakar","year":"2005","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.resp.2007.01.007_bib107","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1113\/jphysiol.1970.sp009171","article-title":"The effect of hypoxia, hypercapnia and hypotension upon carotid body blood flow and oxygen consumption in the cat","volume":"209","author":"Purves","year":"1970","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2007.01.007_bib108","doi-asserted-by":"crossref","first-page":"C1493","DOI":"10.1152\/ajpcell.00282.2004","article-title":"Cellular mechanisms involved in CO2 and acid signaling in chemosensitive neurons","volume":"287","author":"Putnam","year":"2004","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.resp.2007.01.007_bib109","doi-asserted-by":"crossref","first-page":"465","DOI":"10.2174\/1567202043361857","article-title":"Endothelins and nitric oxide: vasoactive modulators of carotid body chemoreception","volume":"1","author":"Rey","year":"2004","journal-title":"Curr. Neurovasc. Res."},{"key":"10.1016\/j.resp.2007.01.007_bib110","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1111\/j.1749-6632.1984.tb12363.x","article-title":"Histochemical localization of carbonic anhydrase in the cat carotid body","volume":"429","author":"Ridderstrale","year":"1984","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/j.resp.2007.01.007_bib111","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/0006-8993(84)91026-6","article-title":"Effects of low pH on synthesis and release of catecholamines in the cat carotid body in vitro","volume":"309","author":"Rigual","year":"1984","journal-title":"Brain Res."},{"key":"10.1016\/j.resp.2007.01.007_bib112","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1113\/jphysiol.1991.sp018441","article-title":"Release of dopamine and chemoreceptor discharge induced by low pH and high PCO2 stimulation of the cat carotid body","volume":"433","author":"Rigual","year":"1991","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2007.01.007_bib113","doi-asserted-by":"crossref","first-page":"C614","DOI":"10.1152\/ajpcell.1991.261.4.C614","article-title":"Optical measurements of the dependence of chemoreception on oxygen pressure in the cat carotid body","volume":"261","author":"Rumsey","year":"1991","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.resp.2007.01.007_bib114","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0304-3940(90)90504-3","article-title":"Effect of adenosine on isolated and superfused cat carotid body activity","volume":"113","author":"Runold","year":"1990","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.resp.2007.01.007_bib115","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/0006-8993(72)90236-3","article-title":"Mechanism of efferent inhibition of carotid body chemoreceptors in the cat","volume":"45","author":"Sampson","year":"1972","journal-title":"Brain Res."},{"key":"10.1016\/j.resp.2007.01.007_bib116","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/BF00586966","article-title":"Increased blood osmolarity and its effect on respiration of dehydrating men","volume":"309","author":"Senay","year":"1969","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.resp.2007.01.007_bib117","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.brainres.2003.09.013","article-title":"The hypothalamic paraventricular nucleus and carotid receptors modulate hyperglycemia induced by hemorrhage","volume":"993","author":"Silveira","year":"2003","journal-title":"Brain Res."},{"key":"10.1016\/j.resp.2007.01.007_bib118","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0034-5687(88)90079-5","article-title":"Ventilatory effects of potassium during hyperoxia, normoxia and hypoxia in anaesthetized cats","volume":"72","author":"Sneyd","year":"1988","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2007.01.007_bib119","first-page":"1843","article-title":"The metabolism of the central nervous system in vivo","volume":"III","author":"Sokoloff","year":"1960"},{"key":"10.1016\/j.resp.2007.01.007_bib120","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/BF02486561","article-title":"Oxygen consumption of the isolated carotid body tissue (cat)","volume":"366","author":"Starlinger","year":"1976","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.resp.2007.01.007_bib121","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/978-1-4615-2966-8_34","article-title":"Update on the bicarbonate hypothesis","volume":"337","author":"Torrance","year":"1993","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.resp.2007.01.007_bib122","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1111\/j.1469-7793.1999.419ac.x","article-title":"Presynaptic action of adenosine on a 4-aminopyridine-sensitive current in the rat carotid body","volume":"515","author":"Vandier","year":"1999","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2007.01.007_bib123","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/j.1469-7793.2001.0165j.x","article-title":"Responses of single-unit carotid body chemoreceptors in adult rats","volume":"531","author":"Vidruk","year":"2001","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2007.01.007_bib124","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0034-5687(96)00076-X","article-title":"Effect of ambient temperature on respiratory chemoreflex in unanaesthetized kittens","volume":"106","author":"Watanabe","year":"1996","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2007.01.007_bib125","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1203\/00006450-199809000-00015","article-title":"Elevation of metabolic rate by pyrogen administration does not affect the gain of respiratory peripheral chemoreflexes in unanaesthetised kittens","volume":"44","author":"Watanabe","year":"1998","journal-title":"Ped. Res."},{"key":"10.1016\/j.resp.2007.01.007_bib126","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1152\/ajplegacy.1973.225.4.986","article-title":"Oxygen tension measurements in carotid body of the cat","volume":"225","author":"Whalen","year":"1973","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.resp.2007.01.007_bib127","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1152\/jappl.1976.41.2.180","article-title":"PO2 in the carotid body perfused and\/or superfused with cell-free media","volume":"41","author":"Whalen","year":"1976","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2007.01.007_bib128","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1152\/jappl.1981.50.1.129","article-title":"Cat carotid body: oxygen consumption and other parameters","volume":"50","author":"Whalen","year":"1981","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2007.01.007_bib129","first-page":"2668","article-title":"Carotid bodies and ventilatory control dynamics in man","volume":"39","author":"Whipp","year":"1980","journal-title":"Fed. Proc."},{"key":"10.1016\/j.resp.2007.01.007_bib130","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/978-1-4615-2572-1_40","article-title":"The carotid bodies as thermosensors: experiments in vitro and in situ, and importance for ventilatory regulation","volume":"360","author":"Zapata","year":"1994","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.resp.2007.01.007_bib131","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1113\/jphysiol.2006.121871","article-title":"Neurotransmitter mechanisms mediating low-glucose signaling in co-cultures and fresh tissue slices of rat carotid body","volume":"578","author":"Zhang","year":"2007","journal-title":"J. Physiol."}],"container-title":["Respiratory Physiology &amp; Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904807000110?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904807000110?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T22:12:55Z","timestamp":1761603175000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569904807000110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,7]]},"references-count":131,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,7]]}},"alternative-id":["S1569904807000110"],"URL":"https:\/\/doi.org\/10.1016\/j.resp.2007.01.007","relation":{},"ISSN":["1569-9048"],"issn-type":[{"value":"1569-9048","type":"print"}],"subject":[],"published":{"date-parts":[[2007,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Adequate stimuli of the carotid body: More than an oxygen sensor?","name":"articletitle","label":"Article Title"},{"value":"Respiratory Physiology & Neurobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resp.2007.01.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}