{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:16:56Z","timestamp":1791181016845,"version":"4.1.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"2-3","license":[{"start":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T00:00:00Z","timestamp":1185926400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T00:00:00Z","timestamp":1185926400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Physiology & Neurobiology"],"published-print":{"date-parts":[[2007,8]]},"DOI":"10.1016\/j.resp.2007.01.011","type":"journal-article","created":{"date-parts":[[2007,2,2]],"date-time":"2007-02-02T17:24:04Z","timestamp":1170437044000},"page":"281-289","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Vitamin A deficiency increases airway resistance following C-fiber stimulation"],"prefix":"10.1016","volume":"157","author":[{"given":"S.E.","family":"McGowan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.resp.2007.01.011_bib1","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1034\/j.1399-3038.2002.00010.x","article-title":"Vitamin A status in children with asthma","volume":"13","author":"Arora","year":"2002","journal-title":"Pediatr. Allergy Immunol."},{"key":"10.1016\/j.resp.2007.01.011_bib2","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1093\/jn\/130.5.1159","article-title":"Vitamin A deficiency injures lung and liver parenchyma and impairs function of rat type II pneumocytes","volume":"130","author":"Baybutt","year":"2000","journal-title":"J. Nutr."},{"key":"10.1016\/j.resp.2007.01.011_bib3","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1038\/sj.bjp.0701274","article-title":"Increased function of inhibitory neuronal M2 muscarinic receptors in diabetic rat lungs","volume":"121","author":"Belmonte","year":"1997","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.resp.2007.01.011_bib4","first-page":"R845","article-title":"Capsaicin challenge reflex bronchoconstriction, and local action of substance P","volume":"254","author":"Bergren","year":"1988","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.resp.2007.01.011_bib5","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1152\/jappl.2001.90.2.695","article-title":"Chronic tobacco smoke exposure increases airway sensitivity to capsaicin in awake guinea pigs","volume":"90","author":"Bergren","year":"2001","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2007.01.011_bib6","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1016\/j.lfs.2004.04.021","article-title":"Depressed ventilatory reflexes after capsaicin challenge in streptozotocin-treated rats","volume":"75","author":"Bergren","year":"2004","journal-title":"Life Sci."},{"key":"10.1016\/j.resp.2007.01.011_bib7","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/0378-1119(96)81752-5","article-title":"Cloning of a cDNA encoding rat aldehyde dehydrogenase with high activity for retinal oxidation","volume":"166","author":"Bhat","year":"1995","journal-title":"Gene"},{"key":"10.1016\/j.resp.2007.01.011_bib8","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0022-3565(25)09528-X","article-title":"Identification of the primary muscarinic autoreceptor subtype in rat striatum as m2 through a correlation of in vivo microdialysis and in vitro receptor binding data","volume":"273","author":"Billard","year":"1995","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.resp.2007.01.011_bib9","first-page":"1078","article-title":"Indoor air pollution in developing countries: a major environmental and public health challenge","volume":"78","author":"Bruce","year":"2000","journal-title":"Bull. World Health Org."},{"key":"10.1016\/j.resp.2007.01.011_bib10","first-page":"1","article-title":"Afferent vagal C fibre innervation of the lungs and airways and its functional significance","volume":"99","author":"Coleridge","year":"1984","journal-title":"Rev. Physiol. Biochem. Pharmacol."},{"key":"10.1016\/j.resp.2007.01.011_bib11","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1172\/JCI119763","article-title":"Pretreatment with antibody to eosinophil major basic protein prevents hyperresponsiveness by protectin neuronal M2 muscarinic receptors in antigen-challenged guinea pigs","volume":"100","author":"Evans","year":"1997","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.resp.2007.01.011_bib12","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1096\/fj.03-0648fje","article-title":"Loss of vagally mediated bradycardia and bronchoconstriction in mice lacking M2 or M3 muscarinic acetylcholine receptors","volume":"18","author":"Fisher","year":"2004","journal-title":"FASEB J."},{"key":"10.1016\/j.resp.2007.01.011_bib13","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1111\/j.1476-5381.1984.tb16539.x","article-title":"Muscarinic inhibitory receptors in pulmonary parasympathetic nerves in the guinea-pig","volume":"83","author":"Fryer","year":"1984","journal-title":"Br. J. Pharmocol."},{"key":"10.1016\/j.resp.2007.01.011_bib14","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1152\/japplphysiol.00107.2003","article-title":"Hypersensitivity of pulmonary C fibers induced by adenosine in anesthetized rats","volume":"95","author":"Gu","year":"2003","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2007.01.011_bib15","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1080\/08958370050085138","article-title":"Combined respiratory effects of cold air with SO2 or NO2 in repeated 10-minute exposures of hyperventilating guinea pigs","volume":"12","author":"Halinen","year":"2000","journal-title":"Inhal. Toxicol."},{"key":"10.1016\/j.resp.2007.01.011_bib16","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1152\/jappl.1987.63.1.36","article-title":"Low-frequency respiratory mechanical impedance in the rat","volume":"63","author":"Hantos","year":"1987","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2007.01.011_bib17","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1254\/jphs.92.209","article-title":"Effects of muscarinic receptor antagonists with or without M2R antagonist activity on cholinergic reflex bronchoconstriction in ovalbumin-sensitized and -challenged mice","volume":"92","author":"Hirose","year":"2003","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.resp.2007.01.011_bib18","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1046\/j.1365-2222.2001.01222.x","article-title":"Dietary fats and asthma in teenagers: analyses of the first Nutrition and Health Survey in Taiwan: (NAHSIT)","volume":"31","author":"Huang","year":"2001","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.resp.2007.01.011_bib19","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1172\/JCI1114","article-title":"Virus- and interferon-induced loss of inhibitory M2 muscarinic receptor function and gene expression in cultured airway parasympathetic neurons","volume":"102","author":"Jacoby","year":"1998","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.resp.2007.01.011_bib20","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1017\/PHN2006944","article-title":"Vitamin A status among children in China","volume":"9","author":"Jiang","year":"2006","journal-title":"Public Health Nutr."},{"key":"10.1016\/j.resp.2007.01.011_bib21","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1152\/jappl.1988.65.3.1007","article-title":"Afferent neural pathways in cough and reflex bronchoconstriction","volume":"65","author":"Karlsson","year":"1988","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2007.01.011_bib22","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1093\/ije\/30.3.457","article-title":"Association between vitamin A status and lung function level in children aged 6\u20139 years in Wukro Wereda, Northern Ethiopia","volume":"30","author":"Kassaye","year":"2001","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.resp.2007.01.011_bib23","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/ar.a.10005","article-title":"Functional morphology and physiological properties of bronchial C-fiber afferents","volume":"270A","author":"Lee","year":"2003","journal-title":"Anat. Rec."},{"key":"10.1016\/j.resp.2007.01.011_bib24","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1034\/j.1399-3003.1999.14a10.x","article-title":"Respiratory tract inflammation during the induction of chronic bronchitis in rats: role of C-fibres","volume":"14","author":"Long","year":"1999","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.resp.2007.01.011_bib25","first-page":"R86","article-title":"Synergistic interactions between airway afferent nerve subtypes mediating reflex bronchospasm in guinea pigs","volume":"283","author":"Mazzone","year":"2002","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.resp.2007.01.011_bib26","first-page":"L437","article-title":"Retinoic acid reverses the airway hyperresponsiveness but not the parenchymal defect that is associated with vitamin A deficiency","volume":"286","author":"McGowan","year":"2004","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.resp.2007.01.011_bib27","first-page":"L1031","article-title":"Vitamin A deficiency promotes bronchial hyperreactivity in rats by altering muscarinic M(2) receptor function","volume":"282","author":"McGowan","year":"2002","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.resp.2007.01.011_bib28","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/1465-9921-6-77","article-title":"Vitamin A deficiency alters the pulmonary parenchymal elastic modulus and elastic fiber concentration in rats","volume":"6","author":"McGowan","year":"2005","journal-title":"Respir. Res."},{"key":"10.1016\/j.resp.2007.01.011_bib29","doi-asserted-by":"crossref","first-page":"50080","DOI":"10.1074\/jbc.M306619200","article-title":"Desensitization of capsaicin-activated currents in the vanilloid receptor TRPV1 is decreased by the cyclic AMP-dependent protein kinase pathway","volume":"278","author":"Mohapatra","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.resp.2007.01.011_bib30","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1093\/ije\/dyg278","article-title":"Factor analysis of household factors: are they associated with respiratory conditions in Chinese children?","volume":"33","author":"Qian","year":"2004","journal-title":"Int. J. Epidemiol."},{"issue":"Suppl. 1","key":"10.1016\/j.resp.2007.01.011_bib31","doi-asserted-by":"crossref","first-page":"S78","DOI":"10.1038\/sj.jea.7500362","article-title":"Exposure-response relationships between lifetime exposure to residential coal smoke and respiratory symptoms and illnesses in Chinese children","volume":"14","author":"Qian","year":"2004","journal-title":"J. Exposure Anal. Environ. Epidemiol."},{"key":"10.1016\/j.resp.2007.01.011_bib32","series-title":"Fundamentals of Biostatistics","author":"Rosner","year":"1990"},{"key":"10.1016\/j.resp.2007.01.011_bib33","series-title":"Methods in Enzymology","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0076-6879(90)90027-X","article-title":"Preparation of vitamin A-deficient rats and mice","author":"Smith","year":"1990"},{"key":"10.1016\/j.resp.2007.01.011_bib34","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1124\/mol.64.6.1444","article-title":"Role of muscarinic receptor subtypes in the constriction of peripheral airways: studies on receptor-deficient mice","volume":"64","author":"Struckmann","year":"2003","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.resp.2007.01.011_bib35","doi-asserted-by":"crossref","first-page":"e2","DOI":"10.1136\/oem.60.8.e2","article-title":"Respiratory effects of sulphur dioxide: a hierarchical multicity analysis in the APHEA 2 study","volume":"60","author":"Sunyer","year":"2003","journal-title":"Occ. Environ. Med."},{"key":"10.1016\/j.resp.2007.01.011_bib36","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1152\/japplphysiol.00222.2006","article-title":"Transduction mechanisms in airway sensory nerves","volume":"101","author":"Taylor-Clark","year":"2006","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2007.01.011_bib37","first-page":"211","article-title":"Vitamin A in human nutrition. Public health considerations","volume":"vol. 2","author":"Underwood","year":"1994"},{"key":"10.1016\/j.resp.2007.01.011_bib38","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1146\/annurev.nutr.19.1.303","article-title":"Micronutrient malnutrition: policies and programs for control and their implications","volume":"19","author":"Underwood","year":"1999","journal-title":"Ann. Rev. Nutr."},{"key":"10.1016\/j.resp.2007.01.011_bib39","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1034\/j.1399-3003.2000.016003514.x","article-title":"Indirect bronchial hyperresponsiveness in asthma: mechanisms, pharmacology, and implications for clinical research","volume":"16","author":"Van Schoor","year":"2000","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.resp.2007.01.011_bib40","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1152\/jappl.1999.86.1.294","article-title":"Methacholine causes reflex bronchoconstriction","volume":"86","author":"Wagner","year":"1999","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2007.01.011_bib41","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/0034-5687(96)00014-X","article-title":"Vagal bronchopulmonary C-fibers and acute ventilatory response to inhaled irritants","volume":"104","author":"Wang","year":"1996","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2007.01.011_bib42","doi-asserted-by":"crossref","first-page":"2857S","DOI":"10.1093\/jn\/132.9.2857S","article-title":"Extent of vitamin A deficiency among preschool children and women of reproductive age","volume":"132","author":"West","year":"2002","journal-title":"J. Nutr."},{"key":"10.1016\/j.resp.2007.01.011_bib43","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.phrs.2004.12.004","article-title":"Protective effect of ipratropium bromide on bronchoconstriction induced by sulfur dioxide exposure during apricot sufurization processes that causes asthma-like syndrome in agricultural environment","volume":"51","author":"Yildrim","year":"2005","journal-title":"Pharmacol. Res."}],"container-title":["Respiratory Physiology & Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904807000328?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904807000328?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T22:14:52Z","timestamp":1761603292000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569904807000328"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8]]},"references-count":43,"journal-issue":{"issue":"2-3","published-print":{"date-parts":[[2007,8]]}},"alternative-id":["S1569904807000328"],"URL":"https:\/\/doi.org\/10.1016\/j.resp.2007.01.011","relation":{},"ISSN":["1569-9048"],"issn-type":[{"value":"1569-9048","type":"print"}],"subject":[],"published":{"date-parts":[[2007,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vitamin A deficiency increases airway resistance following C-fiber stimulation","name":"articletitle","label":"Article Title"},{"value":"Respiratory Physiology & Neurobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resp.2007.01.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}