{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:24:23Z","timestamp":1790519063594,"version":"4.1.0"},"reference-count":72,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Physiology & Neurobiology"],"published-print":{"date-parts":[[2007,7]]},"DOI":"10.1016\/j.resp.2007.01.021","type":"journal-article","created":{"date-parts":[[2007,3,6]],"date-time":"2007-03-06T06:54:53Z","timestamp":1173164093000},"page":"22-29","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["AMP-activated protein kinase and chemotransduction in the carotid body"],"prefix":"10.1016","volume":"157","author":[{"given":"Christopher N.","family":"Wyatt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Mark","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Pt 3","key":"10.1016\/j.resp.2007.01.021_bib1","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1113\/jphysiol.1997.sp021890","article-title":"A novel oxygen-sensitive potassium current in rat carotid body type I cells","volume":"498","author":"Buckler","year":"1997","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2007.01.021_bib2","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1113\/jphysiol.1994.sp020143","article-title":"Effects of hypoxia on membrane potential and intracellular calcium in rat neonatal carotid body type I cells","volume":"476","author":"Buckler","year":"1994","journal-title":"J. Physiol."},{"issue":"Pt 3","key":"10.1016\/j.resp.2007.01.021_bib3","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1111\/j.1469-7793.1998.819ba.x","article-title":"Effects of mitochondrial uncouplers on intracellular calcium, pH and membrane potential in rat carotid body type I cells","volume":"513","author":"Buckler","year":"1998","journal-title":"J. Physiol."},{"issue":"Pt 1","key":"10.1016\/j.resp.2007.01.021_bib4","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.1469-7793.2000.00135.x","article-title":"An oxygen-, acid- and anaesthetic-sensitive TASK-like background potassium channel in rat arterial chemoreceptor cells","volume":"525","author":"Buckler","year":"2000","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2007.01.021_bib5","first-page":"330","article-title":"Sur la structure et l\u2019innervation du sinus carotidien de l\u2019homme et des mammiferes: nouveau faits sur l\u2019innervation et la fonction du glomus caroticum","volume":"24","author":"De Castro","year":"1928","journal-title":"Trab. Lab. Invest. Biol. Univ. Madrid"},{"key":"10.1016\/j.resp.2007.01.021_bib6","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1113\/jphysiol.1992.sp019114","article-title":"Mitochondrial function in type I cells isolated from rabbit arterial chemoreceptors","volume":"450","author":"Duchen","year":"1992","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2007.01.021_bib7","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1113\/jphysiol.1992.sp019115","article-title":"Relative mitochondrial membrane potential and [Ca2+]i in type I cells isolated from the rabbit carotid body","volume":"450","author":"Duchen","year":"1992","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2007.01.021_bib8","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1113\/jphysiol.1987.sp016766","article-title":"Effects of chronic hypoxia from birth on the ventilatory response to acute hypoxia in the newborn rat","volume":"392","author":"Eden","year":"1987","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2007.01.021_bib9","series-title":"Hypoxic Pulmonary Vasoconstriction: Cellular and Molecular Mechanisms","first-page":"313","article-title":"Hypoxia, cell metabolism, and cADPR accumulation","author":"Evans","year":"2004"},{"key":"10.1016\/j.resp.2007.01.021_bib10","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1113\/expphysiol.2006.033514","article-title":"AMP-activated protein kinase underpins hypoxic pulmonary vasoconstriction and carotid body excitation by hypoxia in mammals","volume":"91","author":"Evans","year":"2006","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.resp.2007.01.021_bib11","doi-asserted-by":"crossref","first-page":"41504","DOI":"10.1074\/jbc.M510040200","article-title":"Does AMP-activated protein kinase couple inhibition of mitochondrial oxidative phosphorylation by hypoxia to calcium signaling in O2-sensing cells?","volume":"280","author":"Evans","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.resp.2007.01.021_bib12","doi-asserted-by":"crossref","first-page":"2927","DOI":"10.1073\/pnas.88.7.2927","article-title":"Single K+ channels in membrane patches of arterial chemoreceptor cells are modulated by O2 tension","volume":"88","author":"Ganfornina","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.resp.2007.01.021_bib13","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1242\/jeb.201.8.1129","article-title":"Mitochondrial oxygen affinity, respiratory flux control and excess capacity of cytochrome c oxidase","volume":"201","author":"Gnaiger","year":"1998","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.resp.2007.01.021_bib14","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1152\/physrev.1994.74.4.829","article-title":"Carotid body chemoreceptors: from natural stimuli to sensory discharges","volume":"74","author":"Gonzalez","year":"1994","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.resp.2007.01.021_bib15","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S1569-9048(02)00047-2","article-title":"Significance of ROS in oxygen sensing in cell systems with sensitivity to physiological hypoxia","volume":"132","author":"Gonzalez","year":"2002","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2007.01.021_bib16","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1242\/jcs.02891","article-title":"Plectin scaffolds recruit energy-controlling AMP-activated protein kinase (AMPK) in differentiated myofibres","volume":"119","author":"Gregor","year":"2006","journal-title":"J. Cell. Sci."},{"key":"10.1016\/j.resp.2007.01.021_bib17","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ceb.2005.01.006","article-title":"New roles for the LKB1\u2192AMPK pathway","volume":"17","author":"Hardie","year":"2005","journal-title":"Curr. Opin. Cell. Biol."},{"key":"10.1016\/j.resp.2007.01.021_bib18","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1002\/bies.10009","article-title":"AMP-activated protein kinase: the energy charge hypothesis revisited","volume":"23","author":"Hardie","year":"2001","journal-title":"Bioessays"},{"key":"10.1016\/j.resp.2007.01.021_bib19","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1113\/jphysiol.2006.108944","article-title":"AMP-activated protein kinase\u2014development of the energy sensor concept","volume":"574","author":"Hardie","year":"2006","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2007.01.021_bib20","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/1475-4924-2-28","article-title":"Complexes between the LKB1 tumor suppressor, STRAD alpha\/beta and MO25 alpha\/beta are upstream kinases in the AMP-activated protein kinase cascade","volume":"2","author":"Hawley","year":"2003","journal-title":"J. Biol."},{"key":"10.1016\/j.resp.2007.01.021_bib21","doi-asserted-by":"crossref","first-page":"27186","DOI":"10.1074\/jbc.270.45.27186","article-title":"5\u2032-AMP activates the AMP-activated protein kinase cascade, and Ca2+\/calmodulin activates the calmodulin-dependent protein kinase I cascade, via three independent mechanisms","volume":"270","author":"Hawley","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.resp.2007.01.021_bib22","first-page":"54","article-title":"Sinus carotidien et reflexes respiratoires; sensibilite des sines carotidiens aux substances chimiques. Acion stimulante respiratoire reflex du sulfre de sodium, du cyanure de potassium, de la nicotine et de la lobeline","volume":"40","author":"Heymans","year":"1931","journal-title":"Arch. Int. Pharmacodyn. Ther."},{"key":"10.1016\/j.resp.2007.01.021_bib23","first-page":"400","article-title":"Sinus carotidien et reflexes respiratoires. II. Influences respiratoires reflexes de l\u2019acidose, de l\u2019alcalose, de l\u2019anhydride carbonique, de l\u2019ion hydrogene et de l\u2019anoxemie: sinus carotidiens et echanges respiratoires dans les poumons et au dela poumons","volume":"39","author":"Heymans","year":"1930","journal-title":"Arch. Int. Pharmacodyn. Ther."},{"key":"10.1016\/j.resp.2007.01.021_bib24","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1093\/carcin\/bgh253","article-title":"AMP-activated protein kinase activity is required for vanadate-induced hypoxia-inducible factor 1alpha expression in DU145 cells","volume":"25","author":"Hwang","year":"2004","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.resp.2007.01.021_bib25","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.brainresrev.2004.05.007","article-title":"Neurotransmission in the carotid body: transmitters and modulators between glomus cells and petrosal ganglion nerve terminals","volume":"47","author":"Iturriaga","year":"2004","journal-title":"Brain Res. Brain Res. Rev."},{"key":"10.1016\/j.resp.2007.01.021_bib26","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1073\/pnas.022634199","article-title":"Defective carotid body function and impaired ventilatory responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1 alpha","volume":"99","author":"Kline","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.resp.2007.01.021_bib27","series-title":"Arterial Chemoreceptors","first-page":"103","article-title":"The effect of metabolic inhibitors on carotid chemoreceptors","author":"Krylov","year":"1968"},{"key":"10.1016\/j.resp.2007.01.021_bib28","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1152\/jappl.1993.75.3.1035","article-title":"Contribution of in vivo microvascular PO2 in the cat carotid body chemotransduction","volume":"75","author":"Lahiri","year":"1993","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2007.01.021_bib29","doi-asserted-by":"crossref","first-page":"39653","DOI":"10.1074\/jbc.M306104200","article-title":"AMP-activated protein kinase activity is critical for hypoxia-inducible factor-1 transcriptional activity and its target gene expression under hypoxic conditions in DU145 cells","volume":"278","author":"Lee","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.resp.2007.01.021_bib30","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1042\/bst0310224","article-title":"AMP-activated protein kinase regulates gene expression by direct phosphorylation of nuclear proteins","volume":"31","author":"Leff","year":"2003","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.resp.2007.01.021_bib31","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.molcel.2006.01.010","article-title":"Hypoxia-induced energy stress regulates mRNA translation and cell growth","volume":"21","author":"Liu","year":"2006","journal-title":"Mol. Cell."},{"key":"10.1016\/j.resp.2007.01.021_bib32","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1126\/science.2456613","article-title":"Chemotransduction in the carotid body: K+ current modulated by PO2 in type I chemoreceptor cells","volume":"241","author":"Lopez-Barneo","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.resp.2007.01.021_bib33","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1002\/9780470035009.ch6","article-title":"Oxygen-sensing by ion channels and mitochondrial function in carotid body glomus cells","volume":"272","author":"Lopez-Barneo","year":"2006","journal-title":"Novartis Found Symp."},{"key":"10.1016\/j.resp.2007.01.021_bib34","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1038\/2251147a0","article-title":"Simultaneous measurement of cytochrome a3 reduction and chemoreceptor afferent activity in the carotid body","volume":"225","author":"Mills","year":"1970","journal-title":"Nature"},{"key":"10.1016\/j.resp.2007.01.021_bib35","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1152\/jn.1972.35.4.405","article-title":"Mitochondrial respiratory chain of carotid body and chemoreceptor response to changes in oxygen tension","volume":"35","author":"Mills","year":"1972","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.resp.2007.01.021_bib36","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S1569-9048(02)00020-4","article-title":"Carotid body chemosensory excitation induced by nitric oxide: involvement of oxidative metabolism","volume":"131","author":"Mosqueira","year":"2002","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2007.01.021_bib37","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1152\/jappl.1981.51.2.438","article-title":"Carotid body O2 chemoreception and mitochondrial oxidative phosphorylation","volume":"51","author":"Mulligan","year":"1981","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2007.01.021_bib38","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1002\/glia.20326","article-title":"AMP-dependent protein kinase alpha 2 isoform promotes hypoxia-induced VEGF expression in human glioblastoma","volume":"53","author":"Neurath","year":"2006","journal-title":"Glia"},{"key":"10.1016\/j.resp.2007.01.021_bib39","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1113\/jphysiol.2003.039693","article-title":"Rotenone selectively occludes sensitivity to hypoxia in rat carotid body glomus cells","volume":"548","author":"Ortega-Saenz","year":"2003","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2007.01.021_bib40","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1085\/jgp.200609591","article-title":"Acute oxygen sensing in heme oxygenase-2 null mice","volume":"128","author":"Ortega-Saenz","year":"2006","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.resp.2007.01.021_bib41","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0304-3940(90)90846-2","article-title":"Hypoxic suppression of K+ currents in type I carotid body cells: selective effect on the Ca(2+)-activated K+ current","volume":"119","author":"Peers","year":"1990","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.resp.2007.01.021_bib42","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1113\/jphysiol.2004.062281","article-title":"Characterization of the Kv channels of mouse carotid body chemoreceptor cells and their role in oxygen sensing","volume":"557","author":"Perez-Garcia","year":"2004","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2007.01.021_bib43","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/0006-8993(85)90901-1","article-title":"Calcium influx in cultured carotid body cells is stimulated by acetylcholine and hypoxia","volume":"347","author":"Pietruschka","year":"1985","journal-title":"Brain Res."},{"key":"10.1016\/j.resp.2007.01.021_bib44","doi-asserted-by":"crossref","first-page":"10933","DOI":"10.1128\/MCB.24.24.10933-10940.2004","article-title":"The mitochondrial SDHD gene is required for early embryogenesis, and its partial deficiency results in persistent carotid body glomus cell activation with full responsiveness to hypoxia","volume":"24","author":"Piruat","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.resp.2007.01.021_bib45","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1111\/j.1440-1681.2005.04209.x","article-title":"Cardiovascular alterations by chronic intermittent hypoxia: importance of carotid body chemoreflexes","volume":"32","author":"Prabhakar","year":"2005","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.resp.2007.01.021_bib46","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1113\/jphysiol.2004.072033","article-title":"Chronic intermittent hypoxia enhances cat chemosensory and ventilatory responses to hypoxia","volume":"560","author":"Rey","year":"2004","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2007.01.021_bib47","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1161\/hh1701.095632","article-title":"O(2) modulates large-conductance Ca(2+)-dependent K(+) channels of rat chemoreceptor cells by a membrane-restricted and CO-sensitive mechanism","volume":"89","author":"Riesco-Fagundo","year":"2001","journal-title":"Circ. Res."},{"key":"10.1016\/j.resp.2007.01.021_bib48","doi-asserted-by":"crossref","first-page":"C614","DOI":"10.1152\/ajpcell.1991.261.4.C614","article-title":"Optical measurements of the dependence of chemoreception on oxygen pressure in the cat carotid body","volume":"261","author":"Rumsey","year":"1991","journal-title":"Am. J. Physiol."},{"issue":"Pt 1","key":"10.1016\/j.resp.2007.01.021_bib49","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1042\/bj3340177","article-title":"AMP-activated protein kinase: greater AMP dependence, and preferential nuclear localization, of complexes containing the alpha2 isoform","volume":"334","author":"Salt","year":"1998","journal-title":"Biochem. J."},{"key":"10.1016\/j.resp.2007.01.021_bib50","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1113\/jphysiol.2002.018382","article-title":"Molecular identification of Kv alpha subunits that contribute to the oxygen-sensitive K+ current of chemoreceptor cells of the rabbit carotid body","volume":"542","author":"Sanchez","year":"2002","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2007.01.021_bib51","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1172\/JCI19874","article-title":"CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations","volume":"113","author":"Scott","year":"2004","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.resp.2007.01.021_bib52","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/0034-5687(66)90049-1","article-title":"Respiratory insensitivity to hypoxia in chronically hypoxic man","volume":"1","author":"Severinghaus","year":"1966","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2007.01.021_bib53","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/BF00370457","article-title":"Whole-cell and perforated-patch recordings from O2-sensitive rat carotid body cells grown in short- and long-term culture","volume":"418","author":"Stea","year":"1991","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.resp.2007.01.021_bib54","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1096\/fj.02-0166fje","article-title":"Unusual cytochrome a592 with low PO2 affinity correlates as putative oxygen sensor with rat carotid body chemoreceptor discharge","volume":"16","author":"Streller","year":"2002","journal-title":"FASEB J."},{"key":"10.1016\/j.resp.2007.01.021_bib55","doi-asserted-by":"crossref","first-page":"12443","DOI":"10.1074\/jbc.273.20.12443","article-title":"Identification of a novel AMP-activated protein kinase beta subunit isoform that is highly expressed in skeletal muscle","volume":"273","author":"Thornton","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.resp.2007.01.021_bib56","doi-asserted-by":"crossref","first-page":"10208","DOI":"10.1073\/pnas.91.21.10208","article-title":"Hypoxia induces voltage-dependent Ca2+ entry and quantal dopamine secretion in carotid body glomus cells","volume":"91","author":"Urena","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.resp.2007.01.021_bib57","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/0-387-31311-7_25","article-title":"Regulation of a TASK-like potassium channel in rat carotid body type I cells by ATP","volume":"580","author":"Varas","year":"2006","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.resp.2007.01.021_bib58","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0006-8993(75)90239-5","article-title":"Loss of chemoreceptive properties of the rabbit carotid body after destruction of the glomus cells","volume":"100","author":"Verna","year":"1975","journal-title":"Brain Res."},{"key":"10.1016\/j.resp.2007.01.021_bib59","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1042\/bj3540275","article-title":"Post-translational modifications of the beta-1 subunit of AMP-activated protein kinase affect enzyme activity and cellular localization","volume":"354","author":"Warden","year":"2001","journal-title":"Biochem. J."},{"key":"10.1016\/j.resp.2007.01.021_bib60","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1152\/jappl.1981.50.1.129","article-title":"Cat carotid body: oxygen consumption and other parameters","volume":"50","author":"Whalen","year":"1981","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2007.01.021_bib61","doi-asserted-by":"crossref","first-page":"L221","DOI":"10.1152\/ajplung.00010.2003","article-title":"Biophysical properties and metabolic regulation of a TASK-like potassium channel in rat carotid body type 1 cells","volume":"286","author":"Williams","year":"2004","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.resp.2007.01.021_bib62","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1126\/science.1105010","article-title":"Hemoxygenase-2 is an oxygen sensor for a calcium-sensitive potassium channel","volume":"306","author":"Williams","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.resp.2007.01.021_bib63","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/0014-5793(94)00887-6","article-title":"The primary oxygen sensor of the cat carotid body is cytochrome a3 of the mitochondrial respiratory chain","volume":"351","author":"Wilson","year":"1994","journal-title":"FEBS Lett."},{"key":"10.1016\/j.resp.2007.01.021_bib64","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.cmet.2005.06.005","article-title":"Ca2+\/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells","volume":"2","author":"Woods","year":"2005","journal-title":"Cell. Metab."},{"key":"10.1016\/j.resp.2007.01.021_bib65","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1113\/jphysiol.2003.058131","article-title":"The effect of mitochondrial inhibitors on membrane currents in isolated neonatal rat carotid body type I cells","volume":"556","author":"Wyatt","year":"2004","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2007.01.021_bib66","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/0-387-31311-7_29","article-title":"Does AMP-activated protein kinase couple hypoxic inhibition of oxidative phosphorylation to carotid body excitation?","volume":"580","author":"Wyatt","year":"2006","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.resp.2007.01.021_bib67","doi-asserted-by":"crossref","first-page":"8092","DOI":"10.1074\/jbc.M608742200","article-title":"AMP-activated protein kinase mediates carotid body excitation by hypoxia","volume":"282","author":"Wyatt","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.resp.2007.01.021_bib68","article-title":"The effect of AMP-kinase activators on oxygen-sensing type-I cells of the rat carotid body","author":"Wyatt","year":"2006","journal-title":"Br. J. Pharmacol."},{"issue":"Pt 3","key":"10.1016\/j.resp.2007.01.021_bib69","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1113\/jphysiol.1995.sp020606","article-title":"Ca(2+)-activated K+ channels in isolated type I cells of the neonatal rat carotid body","volume":"483","author":"Wyatt","year":"1995","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2007.01.021_bib70","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1073\/pnas.92.1.295","article-title":"O2-sensitive K+ currents in carotid body chemoreceptor cells from normoxic and chronically hypoxic rats and their roles in hypoxic chemotransduction","volume":"92","author":"Wyatt","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.resp.2007.01.021_bib71","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1113\/jphysiol.2003.058503","article-title":"Role of oxidative stress in intermittent hypoxia-induced immediate early gene activation in rat PC12 cells","volume":"557","author":"Yuan","year":"2004","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2007.01.021_bib72","doi-asserted-by":"crossref","first-page":"4321","DOI":"10.1074\/jbc.M407706200","article-title":"Ca2+\/calmodulin kinase-dependent activation of hypoxia inducible factor 1 transcriptional activity in cells subjected to intermittent hypoxia","volume":"280","author":"Yuan","year":"2005","journal-title":"J. Biol. Chem."}],"container-title":["Respiratory Physiology & Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904807000766?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904807000766?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T22:15:45Z","timestamp":1761603345000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569904807000766"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,7]]},"references-count":72,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,7]]}},"alternative-id":["S1569904807000766"],"URL":"https:\/\/doi.org\/10.1016\/j.resp.2007.01.021","relation":{},"ISSN":["1569-9048"],"issn-type":[{"value":"1569-9048","type":"print"}],"subject":[],"published":{"date-parts":[[2007,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"AMP-activated protein kinase and chemotransduction in the carotid body","name":"articletitle","label":"Article Title"},{"value":"Respiratory Physiology & Neurobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resp.2007.01.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}