{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T16:53:22Z","timestamp":1773420802438,"version":"3.50.1"},"reference-count":42,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Physiology & Neurobiology"],"published-print":{"date-parts":[[2007,12]]},"DOI":"10.1016\/j.resp.2007.03.007","type":"journal-article","created":{"date-parts":[[2007,4,11]],"date-time":"2007-04-11T16:40:43Z","timestamp":1176309643000},"page":"278-282","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Ion and liquid transport across the bronchiolar epithelium"],"prefix":"10.1016","volume":"159","author":[{"given":"Sabine","family":"Blouquit-Laye","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierry","family":"Chinet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.resp.2007.03.007_bib1","first-page":"L594","article-title":"Microperfusion of sheep bronchioles","volume":"260","author":"Al-Bazzaz","year":"1991","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.resp.2007.03.007_bib2","first-page":"L193","article-title":"Regulation of Na and Cl transport in sheep distal airways","volume":"267","author":"Al-Bazzaz","year":"1994","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.resp.2007.03.007_bib3","first-page":"L1028","article-title":"Ion transport by sheep distal airways in a miniature chamber","volume":"281","author":"Al-Bazzaz","year":"2001","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.resp.2007.03.007_bib4","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1152\/jappl.1992.73.5.2021","article-title":"Regional bioelectric properties of porcine airway epithelium","volume":"73","author":"Ballard","year":"1992","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2007.03.007_bib5","first-page":"L79","article-title":"Bioelectric properties of proximal bronchiolar epithelium","volume":"267","author":"Ballard","year":"1994","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.resp.2007.03.007_bib6","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1165\/rcmb.4869","article-title":"Characterization of ion and fluid transport in human bronchioles","volume":"27","author":"Blouquit","year":"2002","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.resp.2007.03.007_bib7","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1164\/rccm.200506-987OC","article-title":"Ion and fluid transport properties of small airways in cystic fibrosis","volume":"174","author":"Blouquit","year":"2006","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.resp.2007.03.007_bib8","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1164\/ajrccm.157.6.9707011","article-title":"Number and proliferation of basal and parabasal cells in normal human airway epithelium","volume":"157","author":"Boers","year":"1998","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.resp.2007.03.007_bib9","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1164\/ajrccm.159.5.9806044","article-title":"Number and proliferation of Clara cells in normal human airway epithelium","volume":"159","author":"Boers","year":"1999","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.resp.2007.03.007_bib10","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1172\/JCI114316","article-title":"Chloride secretory response of cystic fibrosis human airway epithelia. Preservation of calcium but not protein kinase C- and A-dependent mechanisms","volume":"84","author":"Boucher","year":"1989","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.resp.2007.03.007_bib11","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1164\/ajrccm.150.1.8025763","article-title":"Human airway ion transport","volume":"150","author":"Boucher","year":"1994","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.resp.2007.03.007_bib12","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1111\/j.1469-7793.1999.0631u.x","article-title":"Molecular insights into the physiology of the \u2018thin film\u2019 of airway surface liquid","volume":"516","author":"Boucher","year":"1999","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2007.03.007_bib13","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s00424-002-0955-1","article-title":"Regulation of airway surface liquid volume by human airway epithelia","volume":"445","author":"Boucher","year":"2003","journal-title":"Eur. J. Physiol."},{"key":"10.1016\/j.resp.2007.03.007_bib14","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1183\/09031936.03.00057003","article-title":"New concepts of the pathogenesis of cystic fibrosis lung disease","volume":"23","author":"Boucher","year":"2004","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.resp.2007.03.007_bib15","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1152\/ajpcell.1992.263.2.C348","article-title":"Chloride secretory response to extracellular ATP in human normal and CF nasal epithelia","volume":"263","author":"Clarke","year":"1992","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.resp.2007.03.007_bib16","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1164\/ajrccm.154.5.8912731","article-title":"Cystic fibrosis","volume":"154","author":"Davis","year":"1996","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.resp.2007.03.007_bib17","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1172\/JCI117028","article-title":"Expression of the cystic fibrosis gene in adult human lung","volume":"93","author":"Engelhardt","year":"1994","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.resp.2007.03.007_bib18","article-title":"Structure and function","volume":"vol. I","author":"Fishman","year":"1988"},{"key":"10.1016\/j.resp.2007.03.007_bib19","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1172\/JCI118463","article-title":"Transepithelial water permeability in microperfused distal airways. Evidence for channel-mediated water transport","volume":"97","author":"Folkesson","year":"1996","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.resp.2007.03.007_bib20","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1113\/jphysiol.1992.sp019240","article-title":"Second-messenger regulation of sodium transport in mammalian airway epithelia","volume":"453","author":"Graham","year":"1992","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2007.03.007_bib21","first-page":"L289","article-title":"Regulation of ion transport across porcine distal bronchi","volume":"270","author":"Inglis","year":"1996","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.resp.2007.03.007_bib22","first-page":"621","article-title":"Effect of luminal nucleotides on Cl\u2212 secretion and Na+ absorption in distal bronchi","volume":"438","author":"Inglis","year":"1999","journal-title":"Eur. J. Physiol."},{"key":"10.1016\/j.resp.2007.03.007_bib23","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0272-5231(21)00424-X","article-title":"Abnormal respiratory epithelial ion transport in cystic fibrosis","volume":"7","author":"Knowles","year":"1986","journal-title":"Clin. Chest Med."},{"key":"10.1016\/j.resp.2007.03.007_bib24","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1056\/NEJM199108223250802","article-title":"Activation by extracellular nucleotides of chloride secretion in the airway epithelia of patients with cystic fibrosis","volume":"325","author":"Knowles","year":"1991","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.resp.2007.03.007_bib25","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1172\/JCI2729","article-title":"The amiloride-inhibitable Na+ conductance is reduced by the cystic fibrosis transmembrane conductance regulator in normal but not in cystic fibrosis airways","volume":"102","author":"Mall","year":"1998","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.resp.2007.03.007_bib26","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1172\/JCI2687","article-title":"Coordinated clearance of periciliary liquid and mucus from airway surfaces","volume":"102","author":"Matsui","year":"1998","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.resp.2007.03.007_bib27","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1097\/00004032-199107000-00013","article-title":"Radon dosimetry based on the depth distribution of nuclei in human and rat lungs","volume":"61","author":"Mercer","year":"1991","journal-title":"Health Phys."},{"key":"10.1016\/j.resp.2007.03.007_bib28","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1165\/ajrcmb.10.6.8003339","article-title":"Cell number and distribution in human and rat airways","volume":"10","author":"Mercer","year":"1994","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.resp.2007.03.007_bib29","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1164\/ajrccm.163.1.9909114","article-title":"Expression of \u03b1-, \u03b2-, and \u03b3-hENaC mRNA in the human nasal, bronchial, and distal lung epithelium","volume":"163","author":"Pitkanen","year":"2001","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.resp.2007.03.007_bib30","doi-asserted-by":"crossref","first-page":"281","DOI":"10.3109\/01902148309061521","article-title":"Comparison of nonciliated tracheal epithelial cells in six mammalian species: ultrastructure and population densities","volume":"5","author":"Plopper","year":"1983","journal-title":"Exp. Lung Res."},{"key":"10.1016\/j.resp.2007.03.007_bib31","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3109\/01902148309061506","article-title":"Distribution of nonciliated bronchiolar epithelial (Clara) cells in intra- and extra-pulmonary airways of the rabbit","volume":"5","author":"Plopper","year":"1983","journal-title":"Exp. Lung Res."},{"key":"10.1016\/j.resp.2007.03.007_bib32","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1183\/09031936.93.06040498","article-title":"Identification of serous-like cells in the surface epithelium of human bronchioles","volume":"3","author":"Rogers","year":"1993","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.resp.2007.03.007_bib33","series-title":"Cystic Fibrosis","first-page":"131","article-title":"The pathology of cystic fibrosis","author":"Sheppard","year":"1995"},{"key":"10.1016\/j.resp.2007.03.007_bib34","doi-asserted-by":"crossref","first-page":"35751","DOI":"10.1074\/jbc.M505832200","article-title":"Normal and cystic fibrosis airway surface liquid homeostasis: the effects of phasic shear stress and viral infections","volume":"280","author":"Tarran","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.resp.2007.03.007_bib35","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1073\/pnas.92.6.2293","article-title":"Molecular analysis of the ovine cystic fibrosis transmmbrane conductance regulator gene","volume":"92","author":"Tebbutt","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.resp.2007.03.007_bib36","doi-asserted-by":"crossref","first-page":"C893","DOI":"10.1152\/ajpcell.1989.256.4.C893","article-title":"Na and Cl transport across rabbit nonciliated bronchiolar epithelial (Clara) cells","volume":"256","author":"Van Scott","year":"1989","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.resp.2007.03.007_bib37","first-page":"L30","article-title":"Purinergic regulation of ion transport across nonciliated bronchiolar epithelial (Clara) cells","volume":"269","author":"Van Scott","year":"1995","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.resp.2007.03.007_bib38","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1165\/ajrcmb.13.3.7654389","article-title":"Beta-adrenergic regulation of Cl and HCO3\u2212 secretion by Clara cells","volume":"13","author":"Van Scott","year":"1995","journal-title":"Am. J. Respir. Cell. Mol. Biol."},{"key":"10.1016\/j.resp.2007.03.007_bib39","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1164\/ajrccm.154.6.8970383","article-title":"Mucociliary clearance in the airways","volume":"154","author":"Wanner","year":"1996","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.resp.2007.03.007_bib40","series-title":"Morphometry of the Human Lung","author":"Weibel","year":"1963"},{"key":"10.1016\/j.resp.2007.03.007_bib41","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1113\/jphysiol.1992.sp019300","article-title":"Intracellular pH and its relationship to regulation of ion transport in normal and cystic fibrosis human nasal epithelia","volume":"455","author":"Willumsen","year":"1992","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2007.03.007_bib42","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1465-9921-6-7","article-title":"Predominant constitutive CFTR conductance in small airways","volume":"6","author":"Wang","year":"2005","journal-title":"Respir. Res."}],"container-title":["Respiratory Physiology & Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904807001048?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904807001048?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T22:14:18Z","timestamp":1761603258000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569904807001048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12]]},"references-count":42,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["S1569904807001048"],"URL":"https:\/\/doi.org\/10.1016\/j.resp.2007.03.007","relation":{},"ISSN":["1569-9048"],"issn-type":[{"value":"1569-9048","type":"print"}],"subject":[],"published":{"date-parts":[[2007,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ion and liquid transport across the bronchiolar epithelium","name":"articletitle","label":"Article Title"},{"value":"Respiratory Physiology & Neurobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resp.2007.03.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}