{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:44:59Z","timestamp":1792154699779,"version":"4.4.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002830","name":"Centre National d\u2019Etudes Spatiales","doi-asserted-by":"publisher","award":["NAG9-1425"],"award-info":[{"award-number":["NAG9-1425"]}],"id":[{"id":"10.13039\/501100002830","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002830","name":"Centre National d\u2019Etudes Spatiales","doi-asserted-by":"publisher","award":["NNJ04HF71G"],"award-info":[{"award-number":["NNJ04HF71G"]}],"id":[{"id":"10.13039\/501100002830","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000104","name":"National Aeronautics and Space Administration","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000104","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000016","name":"Canadian Space Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000844","name":"European Space Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000844","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Physiology &amp; Neurobiology"],"published-print":{"date-parts":[[2009,10]]},"DOI":"10.1016\/j.resp.2009.07.005","type":"journal-article","created":{"date-parts":[[2009,7,17]],"date-time":"2009-07-17T21:12:26Z","timestamp":1247865146000},"page":"S30-S33","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":215,"special_numbering":"S","title":["Cardiovascular adaptations, fluid shifts, and countermeasures related to space flight"],"prefix":"10.1016","volume":"169","author":[{"given":"Alan R.","family":"Hargens","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Richardson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.resp.2009.07.005_bib1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1152\/jappl.1996.81.1.19","article-title":"Central venous pressure in space","volume":"81","author":"Buckey","year":"1996","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2009.07.005_bib2","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1152\/japplphysiol.01400.2004","article-title":"Exercise within lower body negative pressure partially counteracts lumbar spine deconditioning associated with 28-day bed rest","volume":"99","author":"Cao","year":"2005","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2009.07.005_bib3","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1152\/jappl.2001.91.6.2517","article-title":"Changes in microvascular fluid filtration capacity during 120 days of 6 head-down tilt","volume":"91","author":"Christ","year":"2001","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2009.07.005_bib4","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1152\/jappl.2000.89.3.1046","article-title":"Alterations in skeletal perfusion with simulated microgravity: a possible mechanism for bone remodeling","volume":"89","author":"Colleran","year":"2000","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2009.07.005_bib5","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1152\/jappl.1999.86.4.1178","article-title":"Myogenic and vasoconstrictor responsiveness of skeletal muscle arterioles is diminished by hindlimb unloading","volume":"86","author":"Delp","year":"1999","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2009.07.005_bib6","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1152\/japplphysiol.01347.2006","article-title":"Arterial adaptations in microgravity contribute to orthostatic tolerance","volume":"102","author":"Delp","year":"2007","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2009.07.005_bib7","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1152\/japplphysiol.01162.2006","article-title":"Cardiac atrophy in women following bed rest","volume":"103","author":"Dorfman","year":"2007","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2009.07.005_bib8","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1152\/jappl.1996.81.1.408","article-title":"Central venous pressure in humans during microgravity","volume":"81","author":"Foldager","year":"1996","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2009.07.005_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1569-2574(08)60016-7","article-title":"General mechanisms of the effect of weightlessness on the human body","volume":"2","author":"Grigoriev","year":"1992","journal-title":"Adv. Space Biol. Med."},{"key":"10.1016\/j.resp.2009.07.005_bib10","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s00421-009-1009-6","article-title":"WISE-2005: effect of aerobic and resistive exercises on orthostatic tolerance during 60 days bed rest in women","volume":"106","author":"Guinet","year":"2009","journal-title":"Eur. J. Appl. Physiol."},{"key":"10.1016\/j.resp.2009.07.005_bib11","first-page":"934","article-title":"Lower body negative pressure to provide load bearing in space","volume":"62","author":"Hargens","year":"1991","journal-title":"Aviat. Space Environ. Med."},{"key":"10.1016\/j.resp.2009.07.005_bib12","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1152\/jappl.1996.81.1.105","article-title":"Regulation of body fluid compartments during short-term space flight","volume":"81","author":"Leach","year":"1996","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2009.07.005_bib13","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1097\/00005768-199707000-00008","article-title":"Upright exercise or supine lower body negative pressure exercise maintains exercise responses after bed rest","volume":"29","author":"Lee","year":"1997","journal-title":"Med. Sci. Sports Exerc."},{"key":"10.1016\/j.resp.2009.07.005_bib14","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1249\/mss.0b013e31806463d9","article-title":"Supine LBNP exercise maintains exercise capacity in male twins during 30-d bed rest","volume":"39","author":"Lee","year":"2007","journal-title":"Med. Sci. Sports Exerc."},{"key":"10.1016\/j.resp.2009.07.005_bib15","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1152\/japplphysiol.91502.2008","article-title":"LBNP exercise protects aerobic capacity and sprint speed of female twins during 30 days of bed rest","volume":"106","author":"Lee","year":"2009","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2009.07.005_bib16","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1161\/01.CIR.96.2.517","article-title":"Cardiac atrophy after bed-rest deconditioning: a nonneural mechanism for orthostatic intolerance","volume":"96","author":"Levine","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.resp.2009.07.005_bib17","doi-asserted-by":"crossref","first-page":"2274","DOI":"10.1152\/japplphysiol.00541.2006","article-title":"LBNP treadmill exercise maintains spine function and muscle strength in identical twins during 28 days simulated microgravity","volume":"102","author":"Macias","year":"2007","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2009.07.005_bib18","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0022-5347(06)00572-6","article-title":"Renal stone risk in a simulated microgravity environment: impact of treadmill exercise with lower body negative pressure","volume":"176","author":"Monga","year":"2006","journal-title":"J. Urol."},{"key":"10.1016\/j.resp.2009.07.005_bib19","doi-asserted-by":"crossref","first-page":"2469","DOI":"10.1152\/jappl.1991.71.6.2469","article-title":"Transcapillary fluid shifts in tissues of the head and neck during and after simulated microgravity","volume":"71","author":"Parazynski","year":"1991","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2009.07.005_bib20","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1097\/00005768-200209000-00008","article-title":"Lower-body negative-pressure exercise and bed-rest-mediated orthostatic intolerance","volume":"34","author":"Schneider","year":"2002","journal-title":"Med. Sci. Sports Exerc."},{"key":"10.1016\/j.resp.2009.07.005_bib21","doi-asserted-by":"crossref","unstructured":"Schneider, S.M., Lee S.M.C., Macias, B.R., Watenpaugh, D.E., Hargens, A.R., 2009. WISE-2005: exercise and nutrition countermeasures for upright V\u2022O2 peak during bed rest. Med. Sci. Sports Exerc., in press.","DOI":"10.1249\/MSS.0b013e3181aa04e5"},{"key":"10.1016\/j.resp.2009.07.005_bib22","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1359\/jbmr.2003.18.12.2223","article-title":"Evaluation of treadmill exercise in a lower body negative pressure chamber as a countermeasure for weightlessness-induced bone loss: a bed rest study with identical twins","volume":"18","author":"Smith","year":"2003","journal-title":"J. Bone Min. Res."},{"key":"10.1016\/j.resp.2009.07.005_bib23","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1152\/japplphysiol.00950.2006","article-title":"Microgravity-induced changes in aortic stiffness and their role in orthostatic intolerance","volume":"102","author":"Tuday","year":"2007","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2009.07.005_bib24","series-title":"Handbook of Physiology: Environmental Physiology","first-page":"631","article-title":"The cardiovascular system in microgravity","author":"Watenpaugh","year":"1996"},{"key":"10.1016\/j.resp.2009.07.005_bib25","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1152\/jappl.2000.89.1.218","article-title":"Supine lower body negative pressure exercise during bed rest maintains upright exercise capacity","volume":"89","author":"Watenpaugh","year":"2000","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2009.07.005_bib26","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1152\/japplphysiol.00132.2007","article-title":"Lower body negative pressure exercise plus brief postexercise lower body negative pressure improve post-bed rest orthostatic tolerance","volume":"103","author":"Watenpaugh","year":"2007","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2009.07.005_bib27","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1152\/jappl.1995.79.2.428","article-title":"Changes in sympathoadrenal response to standing in humans after spaceflight","volume":"79","author":"Whitson","year":"1995","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2009.07.005_bib28","doi-asserted-by":"crossref","first-page":"H1652","DOI":"10.1152\/ajpheart.00925.2004","article-title":"Simulated microgravity enhances cerebral artery vasoconstriction and vascular resistance through endothelial nitric oxide mechanism","volume":"288","author":"Wilkerson","year":"2005","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.resp.2009.07.005_bib29","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.1152\/jappl.2001.91.6.2415","article-title":"Vascular adaptation to microgravity: what have we learned?","volume":"91","author":"Zhang","year":"2001","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2009.07.005_bib30","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.bone.2006.09.014","article-title":"Lower body negative pressure treadmill exercise as a countermeasure for bed rest-induced bone loss in female identical twins","volume":"40","author":"Zwart","year":"2007","journal-title":"Bone"}],"container-title":["Respiratory Physiology &amp; Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904809001840?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904809001840?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T22:18:40Z","timestamp":1761603520000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569904809001840"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10]]},"references-count":30,"alternative-id":["S1569904809001840"],"URL":"https:\/\/doi.org\/10.1016\/j.resp.2009.07.005","relation":{},"ISSN":["1569-9048"],"issn-type":[{"value":"1569-9048","type":"print"}],"subject":[],"published":{"date-parts":[[2009,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cardiovascular adaptations, fluid shifts, and countermeasures related to space flight","name":"articletitle","label":"Article Title"},{"value":"Respiratory Physiology & Neurobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resp.2009.07.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}