{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T05:22:59Z","timestamp":1791091379094,"version":"4.1.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Physiology &amp; Neurobiology"],"published-print":{"date-parts":[[2010,9]]},"DOI":"10.1016\/j.resp.2010.07.006","type":"journal-article","created":{"date-parts":[[2010,7,25]],"date-time":"2010-07-25T05:22:34Z","timestamp":1280035354000},"page":"146-156","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["Physiological definition of upper airway obstructions in mouse model for Rett syndrome"],"prefix":"10.1016","volume":"173","author":[{"given":"Nicolas","family":"Voituron","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e9ment","family":"Menuet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Dutschmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9rard","family":"Hilaire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.resp.2010.07.006_bib0005","doi-asserted-by":"crossref","DOI":"10.1096\/fasebj.24.1_supplement.613.9","article-title":"Suppression of expiratory activity in a mouse model of Rett syndrome follows blockade of GABA reuptake and activation of serotonin type 1a receptors","volume":"24","author":"Abdala","year":"2010","journal-title":"FASEB J."},{"key":"10.1016\/j.resp.2010.07.006_bib0010","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.resp.2009.06.011","article-title":"Multiple pontomedullary mechanisms of respiratory rhythmogenesis","volume":"168","author":"Abdala","year":"2009","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2010.07.006_bib0015","doi-asserted-by":"crossref","first-page":"4218","DOI":"10.1523\/JNEUROSCI.4225-08.2009","article-title":"MeCP2-mediated transcription repression in the basolateral amygdala may underlie heightened anxiety in a mouse model of Rett syndrome","volume":"29","author":"Adachi","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.resp.2010.07.006_bib0020","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.resp.2009.03.005","article-title":"PHOX2B in respiratory control: lessons from congenital central hypoventilation syndrome and its mouse models","volume":"168","author":"Amiel","year":"2009","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2010.07.006_bib0025","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/13810","article-title":"Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2","volume":"23","author":"Amir","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.resp.2010.07.006_bib0030","first-page":"H190","article-title":"Lung inflation: effects on heart rate, respiration, and vagal afferent activity in seals","volume":"240","author":"Angell-James","year":"1981","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.resp.2010.07.006_bib0035","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1093\/ilar.50.3.248","article-title":"Breathing and sleep: measurement methods, genetic influences, and developmental impacts","volume":"50","author":"Baekey","year":"2009","journal-title":"ILAR J."},{"key":"10.1016\/j.resp.2010.07.006_bib0040","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.resp.2009.04.019","article-title":"The brainstem respiratory network: an overview of a half century of research","volume":"168","author":"Bianchi","year":"2009","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2010.07.006_bib0045","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/j.1469-8749.1990.tb08466.x","article-title":"Communication and oral-motor function in Rett syndrome","volume":"32","author":"Budden","year":"1990","journal-title":"Dev. Med. Child Neurol."},{"key":"10.1016\/j.resp.2010.07.006_bib0050","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1152\/physrev.1997.77.3.837","article-title":"Physiology of diving of birds and mammals","volume":"77","author":"Butler","year":"1997","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.resp.2010.07.006_bib0055","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S1569-9048(02)00037-X","article-title":"Inhibitory synaptic mechanisms regulating upper airway patency","volume":"131","author":"Dutschmann","year":"2002","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2010.07.006_bib0060","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s00424-002-0797-x","article-title":"Influence of nasotrigeminal afferents on medullary respiratory neurones and upper airway patency in the rat","volume":"444","author":"Dutschmann","year":"2002","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.resp.2010.07.006_bib0065","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.resp.2008.06.013","article-title":"Postnatal emergence of synaptic plasticity associated with dynamic adaptation of the respiratory motor pattern","volume":"164","author":"Dutschmann","year":"2008","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2010.07.006_bib0070","doi-asserted-by":"crossref","first-page":"4931","DOI":"10.1113\/jphysiol.2009.174599","article-title":"Learning to breathe: control of the inspiratory-expiratory phase transition shifts from sensory- to central-dominated during postnatal development in rats","volume":"587","author":"Dutschmann","year":"2009","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2010.07.006_bib0075","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1523\/JNEUROSCI.5261-09.2010","article-title":"Upper airway dysfunction of Tau-P301L mice correlates with tauopathy in midbrain and ponto-medullary brainstem nuclei","volume":"30","author":"Dutschmann","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.resp.2010.07.006_bib0080","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/nrn1871","article-title":"Looking for inspiration: new perspectives on respiratory rhythm","volume":"7","author":"Feldman","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.resp.2010.07.006_bib0085","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.neuron.2008.07.030","article-title":"Deletion of Mecp2 in Sim1-expressing neurons reveals a critical role for MeCP2 in feeding behavior, aggression, and the response to stress","volume":"59","author":"Fyffe","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.resp.2010.07.006_bib0090","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1152\/japplphysiol.01266.2007","article-title":"Neural control of breathing: insights from genetic mouse models","volume":"104","author":"Gaultier","year":"2008","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2010.07.006_bib0095","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1152\/japplphysiol.01383.2007","article-title":"Transcription factors and the genetic organization of brain stem respiratory neurons","volume":"104","author":"Gray","year":"2008","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2010.07.006_bib0100","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/85899","article-title":"A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome","volume":"27","author":"Guy","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1016\/j.resp.2010.07.006_bib0105","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1152\/physrev.1999.79.2.325","article-title":"Maturation of the mammalian respiratory system","volume":"79","author":"Hilaire","year":"1999","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.resp.2010.07.006_bib0110","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0079-6123(08)61855-5","article-title":"The emotional motor system","volume":"107","author":"Holstege","year":"1996","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.resp.2010.07.006_bib0115","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.neulet.2005.05.056","article-title":"Defect in normal developmental increase of the brain biogenic amine concentrations in the mecp2-null mouse","volume":"386","author":"Ide","year":"2005","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.resp.2010.07.006_bib0120","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.resp.2009.04.017","article-title":"Breathing disorders in Rett syndrome: progressive neurochemical dysfunction in the respiratory network after birth","volume":"168","author":"Katz","year":"2009","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2010.07.006_bib0125","first-page":"58","article-title":"Effect of diazepam on apnea attacks in a 6-year-old girl with Rett syndrome: a polysomnographic study","volume":"33","author":"Kurihara","year":"2001","journal-title":"No To Hattatsu"},{"key":"10.1016\/j.resp.2010.07.006_bib0130","doi-asserted-by":"crossref","first-page":"R224","DOI":"10.1152\/ajpregu.00592.2009","article-title":"The cardiovascular and endocrine responses to voluntary and forced diving in trained and untrained rats","volume":"298","author":"McCulloch","year":"2010","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.resp.2010.07.006_bib0135","doi-asserted-by":"crossref","first-page":"18267","DOI":"10.1073\/pnas.0608702103","article-title":"Enhanced anxiety and stress-induced corticosterone release are associated with increased Crh expression in a mouse model of Rett syndrome","volume":"103","author":"McGill","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.resp.2010.07.006_bib0140","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1152\/jn.00826.2007","article-title":"Early defects of GABAergic synapses in the brain stem of a MeCP2 mouse model of Rett syndrome","volume":"99","author":"Medrihan","year":"2008","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.resp.2010.07.006_bib0145","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1098\/rstb.2009.0074","article-title":"Pontine respiratory activity involved in inspiratory\/expiratory phase transition","volume":"364","author":"Morschel","year":"2009","journal-title":"Philos. Trans. R. Soc. Lond. B: Biol. Sci."},{"key":"10.1016\/j.resp.2010.07.006_bib0150","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1111\/j.1469-8749.1997.tb07440.x","article-title":"Feeding ability in Rett syndrome","volume":"39","author":"Morton","year":"1997","journal-title":"Dev. Med. Child Neurol."},{"key":"10.1016\/j.resp.2010.07.006_bib0155","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1111\/j.1469-8749.1997.tb07496.x","article-title":"Respiration patterns during feeding in Rett syndrome","volume":"39","author":"Morton","year":"1997","journal-title":"Dev. Med. Child Neurol."},{"key":"10.1016\/j.resp.2010.07.006_bib0160","first-page":"31","article-title":"Oropharyngeal dysfunction and gastroesophageal dysmotility are present in girls and women with Rett syndrome","volume":"29","author":"Motil","year":"1999","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"10.1016\/j.resp.2010.07.006_bib0165","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.resp.2008.04.005","article-title":"Breathing dysfunction in Rett syndrome: understanding epigenetic regulation of the respiratory network","volume":"164","author":"Ogier","year":"2008","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2010.07.006_bib0170","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1523\/JNEUROSCI.23-04-01478.2003","article-title":"A novel functional neuron group for respiratory rhythm generation in the ventral medulla","volume":"23","author":"Onimaru","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.resp.2010.07.006_bib0175","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.resp.2009.03.007","article-title":"Phox2b, RTN\/pFRG neurons and respiratory rhythmogenesis","volume":"168","author":"Onimaru","year":"2009","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2010.07.006_bib0180","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/BF01058153","article-title":"Stress and family functioning in parents of girls with Rett syndrome","volume":"22","author":"Perry","year":"1992","journal-title":"J. Autism Dev. Disord."},{"key":"10.1016\/j.resp.2010.07.006_bib0185","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1097\/00000542-198503000-00017","article-title":"Midazolam: pharmacology and uses","volume":"62","author":"Reves","year":"1985","journal-title":"Anesthesiology"},{"key":"10.1016\/j.resp.2010.07.006_bib0190","article-title":"Progressive noradrenergic deficits in the locus coeruleus of Mecp2 deficient mice","author":"Roux","year":"2009","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.resp.2010.07.006_bib0195","doi-asserted-by":"crossref","first-page":"2717","DOI":"10.1523\/JNEUROSCI.19-07-02717.1999","article-title":"Multifunctional laryngeal motoneurons: an intracellular study in the cat","volume":"19","author":"Shiba","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.resp.2010.07.006_bib0200","doi-asserted-by":"crossref","first-page":"3370","DOI":"10.1152\/jn.00985.2007","article-title":"Spatial and functional architecture of the mammalian brain stem respiratory network: a hierarchy of three oscillatory mechanisms","volume":"98","author":"Smith","year":"2007","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.resp.2010.07.006_bib0205","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.1098\/rstb.2009.0081","article-title":"Structural and functional architecture of respiratory networks in the mammalian brainstem","volume":"364","author":"Smith","year":"2009","journal-title":"Philos. Trans. R. Soc. Lond. B: Biol. Sci."},{"key":"10.1016\/j.resp.2010.07.006_bib0210","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1113\/jphysiol.2006.119966","article-title":"Breathing dysfunctions associated with impaired control of postinspiratory activity in Mecp2\u2212\/y knockout mice","volume":"579","author":"Stettner","year":"2007","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2010.07.006_bib0215","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.resp.2007.07.011","article-title":"Spontaneous central apneas occur in the C57BL\/6J mouse strain","volume":"160","author":"Stettner","year":"2008","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2010.07.006_bib0220","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.resp.2008.03.013","article-title":"GABA A mediated inhibition and post-inspiratory pattern of laryngeal constrictor motoneurons in rat","volume":"162","author":"Sun","year":"2008","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2010.07.006_bib0225","doi-asserted-by":"crossref","first-page":"12187","DOI":"10.1523\/JNEUROSCI.3156-09.2009","article-title":"Pathophysiology of locus ceruleus neurons in a mouse model of Rett syndrome","volume":"29","author":"Taneja","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.resp.2010.07.006_bib0230","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1038\/nn.2354","article-title":"Genetic identification of an embryonic parafacial oscillator coupling to the preBotzinger complex","volume":"12","author":"Thoby-Brisson","year":"2009","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.resp.2010.07.006_bib0235","doi-asserted-by":"crossref","first-page":"11521","DOI":"10.1523\/JNEUROSCI.4373-05.2005","article-title":"Mecp2 deficiency disrupts norepinephrine and respiratory systems in mice","volume":"25","author":"Viemari","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.resp.2010.07.006_bib0240","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.resp.2009.05.013","article-title":"Early breathing defects after moderate hypoxia or hypercapnia in a mouse model of Rett syndrome","volume":"168","author":"Voituron","year":"2009","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2010.07.006_bib0245","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.resp.2009.12.009","article-title":"Early abnormalities of post-sigh breathing in a mouse model of Rett syndrome","volume":"170","author":"Voituron","year":"2010","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2010.07.006_bib0250","doi-asserted-by":"crossref","first-page":"9941","DOI":"10.1523\/JNEUROSCI.2540-09.2009","article-title":"MeCP2 function in the basolateral amygdala in Rett syndrome","volume":"29","author":"Wu","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.resp.2010.07.006_bib0255","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.resp.2007.08.009","article-title":"Oral treatment with desipramine improves breathing and life span in Rett syndrome mouse model","volume":"160","author":"Zanella","year":"2008","journal-title":"Respir. Physiol. Neurobiol."}],"container-title":["Respiratory Physiology &amp; Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904810002545?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904810002545?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T22:21:22Z","timestamp":1761603682000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569904810002545"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9]]},"references-count":51,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,9]]}},"alternative-id":["S1569904810002545"],"URL":"https:\/\/doi.org\/10.1016\/j.resp.2010.07.006","relation":{},"ISSN":["1569-9048"],"issn-type":[{"value":"1569-9048","type":"print"}],"subject":[],"published":{"date-parts":[[2010,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Physiological definition of upper airway obstructions in mouse model for Rett syndrome","name":"articletitle","label":"Article Title"},{"value":"Respiratory Physiology & Neurobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resp.2010.07.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}