{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:10:12Z","timestamp":1791245412452,"version":"4.1.0"},"reference-count":77,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Physiology & Neurobiology"],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1016\/j.resp.2010.08.010","type":"journal-article","created":{"date-parts":[[2010,8,23]],"date-time":"2010-08-23T04:32:28Z","timestamp":1282537948000},"page":"292-298","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":69,"title":["Mechanisms for acute oxygen sensing in the carotid body"],"prefix":"10.1016","volume":"174","author":[{"given":"Chris","family":"Peers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher N.","family":"Wyatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Mark","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.resp.2010.08.010_bib0005","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.bbrc.2004.05.195","article-title":"Hypoxemia and blunted hypoxic ventilatory responses in mice lacking heme oxygenase-2","volume":"320","author":"Adachi","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.resp.2010.08.010_bib0010","doi-asserted-by":"crossref","first-page":"C620","DOI":"10.1152\/ajpcell.00542.2008","article-title":"General redox environment and carotid body chemoreceptor function","volume":"296","author":"Agapito","year":"2009","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.resp.2010.08.010_bib0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj2840001","article-title":"Control of respiration and ATP synthesis in mammalian mitochondria and cells","volume":"284","author":"Brown","year":"1992","journal-title":"Biochem. J."},{"key":"10.1016\/j.resp.2010.08.010_bib0020","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1113\/jphysiol.1994.sp020143","article-title":"Effects of hypoxia on membrane potential and intracellular calcium in rat neonatal carotid body type I cells","volume":"476","author":"Buckler","year":"1994","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2010.08.010_bib0025","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1113\/jphysiol.1997.sp021890","article-title":"A novel oxygen-sensitive potassium channel in rat carotid body type I cells","volume":"498","author":"Buckler","year":"1997","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2010.08.010_bib0030","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.1469-7793.2000.00135.x","article-title":"An oxygen-, acid- and anaesthetic-sensitive TASK-like background potassium channel in rat arterial chemoreceptor cells","volume":"525","author":"Buckler","year":"2000","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2010.08.010_bib0035","doi-asserted-by":"crossref","first-page":"C945","DOI":"10.1152\/ajpcell.00495.2007","article-title":"Functional mitochondria are required for O2 but not CO2 sensing in immortalized adrenomedullary chromaffin cells","volume":"294","author":"Buttigieg","year":"2008","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.resp.2010.08.010_bib0040","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1152\/jappl.2000.88.5.1880","article-title":"Cellular oxygen sensing by mitochondria: old questions, new insight","volume":"88","author":"Chandel","year":"2000","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2010.08.010_bib0045","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/S0006-8993(96)00987-0","article-title":"Two types of voltage-gated K channels in carotid body cells of adult cats","volume":"742","author":"Chou","year":"1996","journal-title":"Brain Res."},{"key":"10.1016\/j.resp.2010.08.010_bib0050","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s10863-008-9166-6","article-title":"The inhibition of mitochondrial cytochrome oxidase by the gases carbon monoxide, nitric oxide, hydrogen cyanide and hydrogen sulfide: chemical mechanism and physiological significance","volume":"40","author":"Cooper","year":"2008","journal-title":"J. Bioenerg. Biomembr."},{"key":"10.1016\/j.resp.2010.08.010_bib0055","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1042\/bj2720743","article-title":"Involvement of an NAD(P)H oxidase as a pO2 sensor protein in the rat carotid body","volume":"272","author":"Cross","year":"1990","journal-title":"Biochem. J."},{"key":"10.1016\/j.resp.2010.08.010_bib0060","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1097\/WNR.0b013e3282f51045","article-title":"Modulation of hTREK-1 by carbon monoxide","volume":"19","author":"Dallas","year":"2008","journal-title":"Neuroreport"},{"key":"10.1016\/j.resp.2010.08.010_bib0065","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/978-90-481-2259-2_6","article-title":"Modulation of O2 sensitive K+ channels by AMP-activated protein kinase","volume":"648","author":"Dallas","year":"2009","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.resp.2010.08.010_bib0070","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1113\/jphysiol.1992.sp019114","article-title":"Mitochondrial-function in type-I cells isolated from rabbit arterial chemoreceptors","volume":"450","author":"Duchen","year":"1992","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2010.08.010_bib0075","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1113\/jphysiol.1992.sp019115","article-title":"Relative mitochondrial-membrane potential and [Ca2+]i in type-I cells isolated from the rabbit carotid-body","volume":"450","author":"Duchen","year":"1992","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2010.08.010_bib0080","doi-asserted-by":"crossref","first-page":"11619","DOI":"10.1074\/jbc.273.19.11619","article-title":"Intracellular signaling by reactive oxygen species during hypoxia in cardiomyocytes","volume":"273","author":"Duranteau","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.resp.2010.08.010_bib0085","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1016\/j.freeradbiomed.2009.02.019","article-title":"Hypoxic activation of AMPK is dependent on mitochondrial ROS but independent of an increase in AMP\/ATP ratio","volume":"46","author":"Emerling","year":"2009","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.resp.2010.08.010_bib0090","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1113\/jphysiol.2006.108381","article-title":"AMP-activated protein kinase and the regulation of Ca2+ signalling in O2-sensing cells","volume":"574","author":"Evans","year":"2006","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2010.08.010_bib0095","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/j.1749-6632.2009.05041.x","article-title":"Ion channel regulation by AMPK: the route of hypoxia-response coupling in the carotid body and pulmonary artery","volume":"1177","author":"Evans","year":"2009","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.resp.2010.08.010_bib0100","doi-asserted-by":"crossref","first-page":"41504","DOI":"10.1074\/jbc.M510040200","article-title":"Does AMP-activated protein kinase couple inhibition of mitochondrial oxidative phosphorylation by hypoxia to calcium signaling in O2-sensing cells?","volume":"280","author":"Evans","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.resp.2010.08.010_bib0105","doi-asserted-by":"crossref","DOI":"10.1096\/fasebj.24.1_supplement.1026.22","article-title":"Hypoxia vs hydrogen sulfide (H2S) acting at the carotid body (CB) and elsewhere systemically","volume":"24","author":"Fitzgerald","year":"2010","journal-title":"FASEB J."},{"key":"10.1016\/j.resp.2010.08.010_bib0110","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1242\/jeb.201.8.1129","article-title":"Mitochondrial oxygen affinity, respiratory flux control and excess capacity of cytochrome c oxidase","volume":"201","author":"Gnaiger","year":"1998","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.resp.2010.08.010_bib0115","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1152\/physrev.1994.74.4.829","article-title":"Carotid body chemoreceptors: from natural stimuli to sensory discharges","volume":"74","author":"Gonzalez","year":"1994","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.resp.2010.08.010_bib0120","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1159\/000109449","article-title":"Oxygen sensing in the carotid body","volume":"4","author":"Gonzalez","year":"1995","journal-title":"Biol. Signals"},{"key":"10.1016\/j.resp.2010.08.010_bib0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.tibs.2010.04.002","article-title":"Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes","author":"Hamanaka","year":"2010","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.resp.2010.08.010_bib0130","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1097\/00000542-199702000-00006","article-title":"Hypoxic pulmonary vasoconstriction in human lungs. A stimulus-response study","volume":"86","author":"Hambraeus-Jonzon","year":"1997","journal-title":"Anesthesiology"},{"key":"10.1016\/j.resp.2010.08.010_bib0135","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1038\/nrm2249","article-title":"AMP-activated\/SNF1 protein kinases: conserved guardians of cellular energy","volume":"8","author":"Hardie","year":"2007","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"10.1016\/j.resp.2010.08.010_bib0140","doi-asserted-by":"crossref","first-page":"5179","DOI":"10.1210\/en.2003-0982","article-title":"Minireview: the AMP-activated protein kinase cascade: the key sensor of cellular energy status","volume":"144","author":"Hardie","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.resp.2010.08.010_bib0145","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1146\/annurev.biochem.67.1.821","article-title":"The AMP-activated\/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell?","volume":"67","author":"Hardie","year":"1998","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.resp.2010.08.010_bib0150","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1113\/jphysiol.2006.108944","article-title":"AMP-activated protein kinase \u2013 development of the energy sensor concept","volume":"574","author":"Hardie","year":"2006","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2010.08.010_bib0155","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1469-7793.1997.049bo.x","article-title":"Developmental changes in isolated rat type I carotid body cell K+ currents and their modulation by hypoxia","volume":"501","author":"Hatton","year":"1997","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2010.08.010_bib0160","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.cmet.2010.04.001","article-title":"Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation","volume":"11","author":"Hawley","year":"2010","journal-title":"Cell Metab."},{"key":"10.1016\/j.resp.2010.08.010_bib0165","doi-asserted-by":"crossref","first-page":"C27","DOI":"10.1152\/ajpcell.2002.282.1.C27","article-title":"Characteristics of carotid body chemosensitivity in NADPH oxidase-deficient mice","volume":"282","author":"He","year":"2002","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.resp.2010.08.010_bib0170","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0006-8993(89)91280-8","article-title":"Ionic currents on type-I cells of the rabbit carotid body measured by voltage-clamp experiments and the effect of hypoxia","volume":"486","author":"Hescheler","year":"1989","journal-title":"Brain Res."},{"key":"10.1016\/j.resp.2010.08.010_bib0175","first-page":"400","article-title":"Sinus carotidien et reflexes respiratoires. II. Influences respiratoires reflexes de l\u2019acidose, de l\u2019alcalose, de l\u2019anhydride carbonique, de l\u2019ion hydrogene et de l\u2019anoxemie: sinus carotidiens et echanges respiratoires dans les poumons et au dela poumons","volume":"39","author":"Heymans","year":"1930","journal-title":"Arch. Int. Pharmacodyn. Ther."},{"key":"10.1016\/j.resp.2010.08.010_bib0180","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1152\/physiol.00032.2008","article-title":"Modulation of BKCa channel gating by endogenous signaling molecules","volume":"24","author":"Hou","year":"2009","journal-title":"Physiology"},{"key":"10.1016\/j.resp.2010.08.010_bib0185","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.brainresrev.2004.05.007","article-title":"Neurotransmission in the carotid body: transmitters and modulators between glomus cells and petrosal ganglion nerve terminals","volume":"47","author":"Iturriaga","year":"2004","journal-title":"Brain Res. Brain Res. Rev."},{"key":"10.1016\/j.resp.2010.08.010_bib0190","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1146\/annurev.ph.48.030186.003415","article-title":"The relation of free radical production to hyperoxia","volume":"48","author":"Jamieson","year":"1986","journal-title":"Ann. Rev. Physiol."},{"key":"10.1016\/j.resp.2010.08.010_bib0195","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cmet.2004.12.003","article-title":"AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism","volume":"1","author":"Kahn","year":"2005","journal-title":"Cell Metab."},{"key":"10.1016\/j.resp.2010.08.010_bib0200","doi-asserted-by":"crossref","first-page":"2963","DOI":"10.1113\/jphysiol.2009.171181","article-title":"Heteromeric TASK-1\/TASK-3 is the major oxygen-sensitive background K+ channel in rat carotid body glomus cells","volume":"587","author":"Kim","year":"2009","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2010.08.010_bib0205","doi-asserted-by":"crossref","first-page":"5819","DOI":"10.1113\/jphysiol.2009.180372","article-title":"AMP-activated protein kinase inhibits TREK channels","volume":"587","author":"Kreneisz","year":"2009","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2010.08.010_bib0210","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1042\/bse0430043","article-title":"Sensing hypoxia in the carotid body: from stimulus to response","volume":"43","author":"Kumar","year":"2007","journal-title":"Essays Biochem."},{"key":"10.1016\/j.resp.2010.08.010_bib0215","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/978-90-481-2259-2_26","article-title":"Systemic effects resulting from carotid body stimulation-invited article","volume":"648","author":"Kumar","year":"2009","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.resp.2010.08.010_bib0220","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/j.1469-7793.2001.00211.x","article-title":"Divergent roles of glycolysis and the mitochondrial electron transport chain in hypoxic pulmonary vasoconstriction of the rat: identity of the hypoxic sensor","volume":"536","author":"Leach","year":"2001","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2010.08.010_bib0225","doi-asserted-by":"crossref","first-page":"L294","DOI":"10.1152\/ajplung.2000.278.2.L294","article-title":"Energy state, pH, and vasomotor tone during hypoxia in precontracted pulmonary and femoral arteries","volume":"278","author":"Leach","year":"2000","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.resp.2010.08.010_bib0230","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1089\/ars.2009.2926","article-title":"A crucial role for hydrogen sulfide in oxygen sensing via modulating large conductance calcium-activated potassium channels","volume":"12","author":"Li","year":"2010","journal-title":"Antioxid. Redox Signal"},{"key":"10.1016\/j.resp.2010.08.010_bib0235","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1126\/science.2456613","article-title":"Chemotransduction in the carotid body: K+ current modulated by PO2 in type I chemoreceptor cells","volume":"241","author":"Lopez-Barneo","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.resp.2010.08.010_bib0240","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1152\/jn.1972.35.4.405","article-title":"Mitochondrial respiratory chain of carotid body and chemoreceptor response to changes in oxygen tension","volume":"35","author":"Mills","year":"1972","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.resp.2010.08.010_bib0245","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/j.1469-7793.1997.175bf.x","article-title":"Hypoxia-induced catecholamine secretion in isolated newborn rat adrenal chromaffin cells is mimicked by inhibition of mitochondrial respiration","volume":"504","author":"Mojet","year":"1997","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2010.08.010_bib0250","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1113\/expphysiol.2009.049312","article-title":"Neurotransmitter and neuromodulatory mechanisms at peripheral arterial chemoreceptors","volume":"95","author":"Nurse","year":"2010","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.resp.2010.08.010_bib0255","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1085\/jgp.200609591","article-title":"Acute oxygen sensing in heme oxygenase-2 null mice","volume":"128","author":"Ortega-Saenz","year":"2006","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.resp.2010.08.010_bib0260","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/0-387-31311-7_32","article-title":"Differential expression of oxygen sensitivity in voltage-dependent K channels in inbred strains of mice","volume":"580","author":"Otsubo","year":"2006","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.resp.2010.08.010_bib0265","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/0-306-46825-5_22","article-title":"Chemosensing at the carotid body. Involvement of a HERG-like potassium current in glomus cells","volume":"475","author":"Overholt","year":"2000","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.resp.2010.08.010_bib0270","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1152\/jn.2000.83.3.1150","article-title":"HERG-Like potassium current regulates the resting membrane potential in glomus cells of the rabbit carotid body","volume":"83","author":"Overholt","year":"2000","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.resp.2010.08.010_bib0275","doi-asserted-by":"crossref","first-page":"L710","DOI":"10.1152\/ajplung.00149.2002","article-title":"Essential role of complex II of the respiratory chain in hypoxia-induced ROS generation in the pulmonary vasculature","volume":"284","author":"Paddenberg","year":"2003","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.resp.2010.08.010_bib0280","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0304-3940(90)90846-2","article-title":"Hypoxic suppression of K+ currents in type-I carotid-body cells \u2013 selective effect on the Ca2+-activated K+ current","volume":"119","author":"Peers","year":"1990","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.resp.2010.08.010_bib0285","doi-asserted-by":"crossref","first-page":"10719","DOI":"10.1073\/pnas.1005866107","article-title":"H2S mediates O2 sensing in the carotid body","volume":"107","author":"Peng","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.resp.2010.08.010_bib0290","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1113\/jphysiol.2004.062281","article-title":"Characterization of the Kv channels of mouse carotid body chemoreceptor cells and their role in oxygen sensing","volume":"557","author":"Perez-Garcia","year":"2004","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2010.08.010_bib0295","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1073\/pnas.92.6.1994","article-title":"Carbon monoxide: a role in carotid body chemoreception","volume":"92","author":"Prabhakar","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.resp.2010.08.010_bib0300","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.ejphar.2008.07.035","article-title":"AMP-activated protein kinase and hypoxic pulmonary vasoconstriction","volume":"595","author":"Robertson","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.resp.2010.08.010_bib0305","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1113\/jphysiol.1991.sp018442","article-title":"Ionic mechanisms for the transduction of acidic stimuli in rabbit carotid body glomus cells","volume":"433","author":"Rocher","year":"1991","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2010.08.010_bib0310","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1113\/jphysiol.2002.018382","article-title":"Molecular identification of Kvalpha subunits that contribute to the oxygen-sensitive K+ current of chemoreceptor cells of the rabbit carotid body","volume":"542","author":"Sanchez","year":"2002","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2010.08.010_bib0315","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/j.1469-7793.2001.0209k.x","article-title":"Reduced to oxidized glutathione ratios and oxygen sensing in calf and rabbit carotid body chemoreceptor cells","volume":"537","author":"Sanz-Alfayate","year":"2001","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2010.08.010_bib0320","first-page":"L803","article-title":"Adenine nucleotides via activation of ATP-sensitive K+ channels modulate hypoxic response in rat pulmonary artery","volume":"270","author":"Shigemori","year":"1996","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.resp.2010.08.010_bib0325","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/BF00370457","article-title":"Whole-cell and perforated-patch recordings from O2-sensitive rat carotid body cells grown in short- and long-term culture","volume":"418","author":"Stea","year":"1991","journal-title":"Pflug. Arch. \u2013 Eur. J. Physiol."},{"key":"10.1016\/j.resp.2010.08.010_bib0330","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/nature02003","article-title":"Haem can bind to and inhibit mammalian calcium-dependent Slo1 BK channels","volume":"425","author":"Tang","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.resp.2010.08.010_bib0335","doi-asserted-by":"crossref","DOI":"10.1016\/j.resp.2010.05.016","article-title":"Mechanism of inhibition by hydrogen sulfide of native and recombinant BK(Ca) channels","author":"Telezhkin","year":"2010","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2010.08.010_bib0340","doi-asserted-by":"crossref","first-page":"10208","DOI":"10.1073\/pnas.91.21.10208","article-title":"Hypoxia induces voltage-dependent Ca2+ entry and quantal dopamine secretion in carotid body glomus cells","volume":"91","author":"Urena","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.resp.2010.08.010_bib0345","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0006-8993(75)90239-5","article-title":"Loss of chemoreceptive properties of the rabbit carotid body after destruction of the glomus cells","volume":"100","author":"Verna","year":"1975","journal-title":"Brain Res."},{"key":"10.1016\/j.resp.2010.08.010_bib0350","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.resp.2006.01.003","article-title":"Postnatal development of carotid body glomus cell response to hypoxia","volume":"154","author":"Wasicko","year":"2006","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2010.08.010_bib0355","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1126\/science.1105010","article-title":"Hemoxygenase-2 is an oxygen sensor for a calcium-sensitive potassium channel","volume":"306","author":"Williams","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.resp.2010.08.010_bib0360","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1113\/jphysiol.2003.058131","article-title":"The effect of mitochondrial inhibitors on membrane currents in isolated neonatal rat carotid body type I cells","volume":"556","author":"Wyatt","year":"2004","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2010.08.010_bib0365","doi-asserted-by":"crossref","first-page":"8092","DOI":"10.1074\/jbc.M608742200","article-title":"AMP-activated protein kinase mediates carotid body excitation by hypoxia","volume":"282","author":"Wyatt","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.resp.2010.08.010_bib0370","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/0306-4522(93)90399-Z","article-title":"Nicotinic acetylcholine-receptors in isolated type-I cells of the neonatal rat carotid-body","volume":"54","author":"Wyatt","year":"1993","journal-title":"Neuroscience"},{"key":"10.1016\/j.resp.2010.08.010_bib0375","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1113\/jphysiol.1995.sp020606","article-title":"Ca2+-activated K+ channels in isolated type-I cells of the neonatal rat carotid-body","volume":"483","author":"Wyatt","year":"1995","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2010.08.010_bib0380","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00441-006-0178-4","article-title":"Hypoxia induces production of nitric oxide and reactive oxygen species in glomus cells of rat carotid body","volume":"325","author":"Yamamoto","year":"2006","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.resp.2010.08.010_bib0385","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.1469-7793.2000.t01-1-00143.x","article-title":"Co-release of ATP and ACh mediates hypoxic signalling at rat carotid body chemoreceptors","volume":"525","author":"Zhang","year":"2000","journal-title":"J. Physiol."}],"container-title":["Respiratory Physiology & Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904810003149?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904810003149?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T22:23:39Z","timestamp":1761603819000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569904810003149"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12]]},"references-count":77,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["S1569904810003149"],"URL":"https:\/\/doi.org\/10.1016\/j.resp.2010.08.010","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.722337573.793553536","asserted-by":"object"}]},"ISSN":["1569-9048"],"issn-type":[{"value":"1569-9048","type":"print"}],"subject":[],"published":{"date-parts":[[2010,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mechanisms for acute oxygen sensing in the carotid body","name":"articletitle","label":"Article Title"},{"value":"Respiratory Physiology & Neurobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resp.2010.08.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}