{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T02:44:57Z","timestamp":1790736297089,"version":"4.1.0"},"reference-count":136,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Physiology &amp; Neurobiology"],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1016\/j.resp.2010.09.001","type":"journal-article","created":{"date-parts":[[2010,9,16]],"date-time":"2010-09-16T05:16:06Z","timestamp":1284614166000},"page":"307-316","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":113,"title":["Reactive oxygen species and the brain in sleep apnea"],"prefix":"10.1016","volume":"174","author":[{"given":"Yang","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelley X.L.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Gozal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.resp.2010.09.001_bib0005","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1523\/JNEUROSCI.4042-03.2004","article-title":"Beta-amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase","volume":"24","author":"Abramov","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.resp.2010.09.001_bib0010","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.yjmcc.2009.04.004","article-title":"NADPH oxidase signaling and cardiac myocyte function","volume":"47","author":"Akki","year":"2009","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.resp.2010.09.001_bib0015","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1212\/WNL.42.4.733","article-title":"Alternative excitotoxic hypotheses","volume":"42","author":"Albin","year":"1992","journal-title":"Neurology"},{"key":"10.1016\/j.resp.2010.09.001_bib0020","doi-asserted-by":"crossref","first-page":"686","DOI":"10.2174\/138920008786049285","article-title":"Classical inhibitors of NOX NAD(P)H oxidases are not specific","volume":"9","author":"Aldieri","year":"2008","journal-title":"Curr. Drug Metab."},{"key":"10.1016\/j.resp.2010.09.001_bib0025","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1007\/s10541-005-0102-7","article-title":"Mitochondrial metabolism of reactive oxygen species","volume":"70","author":"Andreyev","year":"2005","journal-title":"Biochemistry (Mosc.)"},{"key":"10.1016\/j.resp.2010.09.001_bib0030","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s00418-009-0563-7","article-title":"Peroxisomes and reactive oxygen species, a lasting challenge","volume":"131","author":"Angermuller","year":"2009","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.resp.2010.09.001_bib0035","doi-asserted-by":"crossref","first-page":"44735","DOI":"10.1074\/jbc.M302673200","article-title":"Synchronized whole cell oscillations in mitochondrial metabolism triggered by a local release of reactive oxygen species in cardiac myocytes","volume":"278","author":"Aon","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.resp.2010.09.001_bib0040","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1002\/ana.410380304","article-title":"Aging, energy, and oxidative stress in neurodegenerative diseases","volume":"38","author":"Beal","year":"1995","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.resp.2010.09.001_bib0045","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1152\/physrev.00044.2005","article-title":"The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology","volume":"87","author":"Bedard","year":"2007","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.resp.2010.09.001_bib0050","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1097\/01.mcp.0000183059.52924.39","article-title":"Neurobehavioral effects of obstructive sleep apnea: an overview and heuristic model","volume":"11","author":"Beebe","year":"2005","journal-title":"Curr. Opin. Pulm. Med."},{"key":"10.1016\/j.resp.2010.09.001_bib0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1365-2869.2002.00289.x","article-title":"Obstructive sleep apnea and the prefrontal cortex: towards a comprehensive model linking nocturnal upper airway obstruction to daytime cognitive and behavioral deficits","volume":"11","author":"Beebe","year":"2002","journal-title":"J. Sleep Res."},{"key":"10.1016\/j.resp.2010.09.001_bib0060","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1083\/jcb.200609074","article-title":"The Qo site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production","volume":"177","author":"Bell","year":"2007","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.resp.2010.09.001_bib0065","series-title":"Oxidative Phosphorylation, Biochemistry","author":"Berg","year":"2002"},{"key":"10.1016\/j.resp.2010.09.001_bib0070","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1113\/jphysiol.2003.055913","article-title":"Xanthine oxidoreductase and cardiovascular disease: molecular mechanisms and pathophysiological implications","volume":"555","author":"Berry","year":"2004","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2010.09.001_bib0075","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1080\/13813450802307451","article-title":"Metabolic effects of the obstructive sleep apnea syndrome and cardiovascular risk","volume":"114","author":"Bonsignore","year":"2008","journal-title":"Arch. Physiol. Biochem."},{"issue":"Suppl.","key":"10.1016\/j.resp.2010.09.001_bib0080","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1038\/nm1067","article-title":"Molecular pathways to neurodegeneration","volume":"10","author":"Bossy-Wetzel","year":"2004","journal-title":"Nat. Med."},{"key":"10.1016\/j.resp.2010.09.001_bib0085","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1042\/bj1340707","article-title":"The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen","volume":"134","author":"Boveris","year":"1973","journal-title":"Biochem. J."},{"key":"10.1016\/j.resp.2010.09.001_bib0090","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1146\/annurev.biochem.66.1.717","article-title":"The ATP synthase\u2014a splendid molecular machine","volume":"66","author":"Boyer","year":"1997","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.resp.2010.09.001_bib0095","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1089\/ars.2006.8.1651","article-title":"A wave of reactive oxygen species (ROS)-induced ROS release in a sea of excitable mitochondria","volume":"8","author":"Brady","year":"2006","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.resp.2010.09.001_bib0100","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.exger.2010.01.003","article-title":"The sites and topology of mitochondrial superoxide production","volume":"45","author":"Brand","year":"2010","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.resp.2010.09.001_bib0105","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1080\/10715769900301161","article-title":"Endogenous nitric oxide synthesis: biological functions and pathophysiology","volume":"31","author":"Bredt","year":"1999","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.resp.2010.09.001_bib0110","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1164\/rccm.200701-110OC","article-title":"Green tea catechin polyphenols attenuate behavioral and oxidative responses to intermittent hypoxia","volume":"177","author":"Burckhardt","year":"2008","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.resp.2010.09.001_bib0115","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/S0955-2863(02)00205-X","article-title":"Nutritional approaches to combat oxidative stress in Alzheimer's disease","volume":"13","author":"Butterfield","year":"2002","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.resp.2010.09.001_bib0120","doi-asserted-by":"crossref","first-page":"7887","DOI":"10.1073\/pnas.0702621104","article-title":"A semiquinone intermediate generated at the Qo site of the cytochrome bc1 complex: importance for the Q-cycle and superoxide production","volume":"104","author":"Cape","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.resp.2010.09.001_bib0125","doi-asserted-by":"crossref","first-page":"11715","DOI":"10.1073\/pnas.95.20.11715","article-title":"Mitochondrial reactive oxygen species trigger hypoxia-induced transcription","volume":"95","author":"Chandel","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.resp.2010.09.001_bib0130","doi-asserted-by":"crossref","first-page":"36027","DOI":"10.1074\/jbc.M304854200","article-title":"Production of reactive oxygen species by mitochondria: central role of complex III","volume":"278","author":"Chen","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.resp.2010.09.001_bib0135","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.bbrc.2010.05.137","article-title":"Isolating the segment of the mitochondrial electron transport chain responsible for mitochondrial damage during cardiac ischemia","volume":"397","author":"Chen","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.resp.2010.09.001_bib0140","doi-asserted-by":"crossref","first-page":"4082","DOI":"10.1523\/JNEUROSCI.4306-04.2005","article-title":"Thrombin-induced oxidative stress contributes to the death of hippocampal neurons in vivo: role of microglial NADPH oxidase","volume":"25","author":"Choi","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.resp.2010.09.001_bib0145","doi-asserted-by":"crossref","first-page":"4065","DOI":"10.1016\/S0021-9258(18)61312-2","article-title":"NADPH oxidase of human neutrophils. Subcellular localization and characterization of an arachidonate-activatable superoxide-generating system","volume":"262","author":"Clark","year":"1987","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.resp.2010.09.001_bib0150","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.bbabio.2010.01.032","article-title":"Redox signaling (cross-talk) from and to mitochondria involves mitochondrial pores and reactive oxygen species","volume":"1797","author":"Daiber","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.resp.2010.09.001_bib0155","doi-asserted-by":"crossref","first-page":"H356","DOI":"10.1152\/ajpheart.00341.2010","article-title":"NFATc3 contributes to intermittent hypoxia-induced arterial remodeling in mice","volume":"299","author":"de Frutos","year":"2010","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.resp.2010.09.001_bib0160","doi-asserted-by":"crossref","first-page":"L596","DOI":"10.1152\/ajplung.90568.2008","article-title":"NADPH oxidases and reactive oxygen species at different stages of chronic hypoxia-induced pulmonary hypertension in newborn piglets","volume":"297","author":"Dennis","year":"2009","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.resp.2010.09.001_bib0165","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.4161\/cbt.4.12.2233","article-title":"Cross talk between mitochondria and superoxide generating NADPH oxidase in breast and ovarian tumors","volume":"4","author":"Desouki","year":"2005","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.resp.2010.09.001_bib0170","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1091\/mbc.e09-12-1003","article-title":"The NADPH oxidase subunit NOX4 is a new target gene of the hypoxia-inducible factor-1","volume":"21","author":"Diebold","year":"2010","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.resp.2010.09.001_bib0175","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1161\/CIRCRESAHA.107.162800","article-title":"Molecular mechanisms of angiotensin II-mediated mitochondrial dysfunction: linking mitochondrial oxidative damage and vascular endothelial dysfunction","volume":"102","author":"Doughan","year":"2008","journal-title":"Circ. Res."},{"key":"10.1016\/j.resp.2010.09.001_bib0180","doi-asserted-by":"crossref","first-page":"C1594","DOI":"10.1152\/ajpcell.00298.2009","article-title":"Neuronal death during combined intermittent hypoxia\/hypercapnia is due to mitochondrial dysfunction","volume":"298","author":"Douglas","year":"2010","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.resp.2010.09.001_bib0185","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1152\/physrev.00018.2001","article-title":"Free radicals in the physiological control of cell function","volume":"82","author":"Droge","year":"2002","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.resp.2010.09.001_bib0190","doi-asserted-by":"crossref","first-page":"217","DOI":"10.3858\/emm.2009.41.4.058","article-title":"p47phox, the phagocyte NADPH oxidase\/NOX2 organizer: structure, phosphorylation and implication in diseases","volume":"41","author":"El-Benna","year":"2009","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.resp.2010.09.001_bib0195","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1152\/physiolgenomics.00217.2004","article-title":"Gene expression and phenotypic characterization of mouse heart after chronic constant or intermittent hypoxia","volume":"22","author":"Fan","year":"2005","journal-title":"Physiol. Genomics"},{"key":"10.1016\/j.resp.2010.09.001_bib0200","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.freeradbiomed.2006.02.012","article-title":"Nonezymatic formation of succinate in mitochondria under oxidative stress","volume":"41","author":"Fedotcheva","year":"2006","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.resp.2010.09.001_bib0205","doi-asserted-by":"crossref","first-page":"6181","DOI":"10.1523\/JNEUROSCI.23-15-06181.2003","article-title":"Critical role for microglial NADPH oxidase in rotenone-induced degeneration of dopaminergic neurons","volume":"23","author":"Gao","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.resp.2010.09.001_bib0210","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.neuroscience.2003.08.054","article-title":"Intermittent hypoxic exposure during light phase induces changes in cAMP response element binding protein activity in the rat CA1 hippocampal region: water maze performance correlates","volume":"122","author":"Goldbart","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.resp.2010.09.001_bib0215","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.brainres.2006.03.046","article-title":"High fat\/refined carbohydrate diet enhances the susceptibility to spatial learning deficits in rats exposed to intermittent hypoxia","volume":"1090","author":"Goldbart","year":"2006","journal-title":"Brain Res."},{"key":"10.1016\/j.resp.2010.09.001_bib0220","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.1523\/JNEUROSCI.21-07-02442.2001","article-title":"Behavioral and anatomical correlates of chronic episodic hypoxia during sleep in the rat","volume":"21","author":"Gozal","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.resp.2010.09.001_bib0225","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1097\/MCP.0b013e3282ef6880","article-title":"Neurocognitive and behavioral morbidity in children with sleep disorders","volume":"13","author":"Gozal","year":"2007","journal-title":"Curr. Opin. Pulm. Med."},{"key":"10.1016\/j.resp.2010.09.001_bib0230","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1164\/rccm.200608-1190PP","article-title":"Cardiovascular morbidity in obstructive sleep apnea: oxidative stress, inflammation, and much more","volume":"177","author":"Gozal","year":"2008","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.resp.2010.09.001_bib0235","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1164\/rccm.201001-0108OC","article-title":"Physical activity attenuates intermittent hypoxia-induced spatial learning deficits and oxidative stress","volume":"182","author":"Gozal","year":"2010","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.resp.2010.09.001_bib0240","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1046\/j.1460-9568.2003.02947.x","article-title":"Temporal aspects of spatial task performance during intermittent hypoxia in the rat: evidence for neurogenesis","volume":"18","author":"Gozal","year":"2003","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.resp.2010.09.001_bib0245","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1046\/j.1471-4159.2003.01973.x","article-title":"Increased susceptibility to intermittent hypoxia in aging rats: changes in proteasomal activity, neuronal apoptosis and spatial function","volume":"86","author":"Gozal","year":"2003","journal-title":"J. Neurochem."},{"key":"10.1016\/j.resp.2010.09.001_bib0250","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1046\/j.1471-4159.2002.01134.x","article-title":"Proteomic analysis of CA1 and CA3 regions of rat hippocampus and differential susceptibility to intermittent hypoxia","volume":"83","author":"Gozal","year":"2002","journal-title":"J. Neurochem."},{"key":"10.1016\/j.resp.2010.09.001_bib0255","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0304-3940(01)01853-5","article-title":"Developmental differences in cortical and hippocampal vulnerability to intermittent hypoxia in the rat","volume":"305","author":"Gozal","year":"2001","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.resp.2010.09.001_bib0260","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1042\/BJ20041835","article-title":"Activation and assembly of the NADPH oxidase: a structural perspective","volume":"386","author":"Groemping","year":"2005","journal-title":"Biochem. J."},{"key":"10.1016\/j.resp.2010.09.001_bib0265","first-page":"993","article-title":"Glucose-6-phosphate dehydrogenase: a novel therapeutic target in cardiovascular diseases","volume":"9","author":"Gupte","year":"2008","journal-title":"Curr. Opin. Investig. Drugs"},{"key":"10.1016\/j.resp.2010.09.001_bib0270","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1161\/01.RES.0000248212.86638.e9","article-title":"Free radicals, mitochondria, and oxidized lipids: the emerging role in signal transduction in vascular cells","volume":"99","author":"Gutierrez","year":"2006","journal-title":"Circ. Res."},{"key":"10.1016\/j.resp.2010.09.001_bib0275","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.cmet.2005.05.001","article-title":"Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing","volume":"1","author":"Guzy","year":"2005","journal-title":"Cell Metab."},{"key":"10.1016\/j.resp.2010.09.001_bib0280","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1113\/expphysiol.2006.033506","article-title":"Oxygen sensing by mitochondria at complex III: the paradox of increased reactive oxygen species during hypoxia","volume":"91","author":"Guzy","year":"2006","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.resp.2010.09.001_bib0285","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1111\/j.1471-4159.2004.02489.x","article-title":"Shift in the localization of sites of hydrogen peroxide production in brain mitochondria by mitochondrial stress","volume":"90","author":"Gyulkhandanyan","year":"2004","journal-title":"J. Neurochem."},{"key":"10.1016\/j.resp.2010.09.001_bib0290","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1111\/j.1471-4159.2006.03907.x","article-title":"Oxidative stress and neurodegeneration: where are we now?","volume":"97","author":"Halliwell","year":"2006","journal-title":"J. Neurochem."},{"key":"10.1016\/j.resp.2010.09.001_bib0295","doi-asserted-by":"crossref","first-page":"5557","DOI":"10.1074\/jbc.M210269200","article-title":"Voltage-dependent anion channels control the release of the superoxide anion from mitochondria to cytosol","volume":"278","author":"Han","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.resp.2010.09.001_bib0300","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1152\/japplphysiol.00766.2009","article-title":"Modulation of chronic hypoxia-induced chemoreceptor hypersensitivity by NADPH oxidase subunits in rat carotid body","volume":"108","author":"He","year":"2010","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2010.09.001_bib0305","doi-asserted-by":"crossref","first-page":"5169","DOI":"10.1016\/S0021-9258(18)99410-X","article-title":"Partial resolution of the enzymes catalyzing oxidative phosphorylation. XV. Reverse electron transfer in the flavin-cytochrome beta region of the respiratory chain of beef heart submitochondrial particles","volume":"242","author":"Hinkle","year":"1967","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.resp.2010.09.001_bib0310","doi-asserted-by":"crossref","first-page":"H101","DOI":"10.1152\/ajpheart.00699.2006","article-title":"Response of mitochondrial reactive oxygen species generation to steady-state oxygen tension: implications for hypoxic cell signaling","volume":"292","author":"Hoffman","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.resp.2010.09.001_bib0315","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.sleep.2009.05.015","article-title":"Apocynin attenuate spatial learning deficits and oxidative responses to intermittent hypoxia","volume":"11","author":"Hui-guo","year":"2010","journal-title":"Sleep Med."},{"key":"10.1016\/j.resp.2010.09.001_bib0320","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1016\/j.freeradbiomed.2006.01.009","article-title":"NOX1\/NADPH oxidase negatively regulates nerve growth factor-induced neurite outgrowth","volume":"40","author":"Ibi","year":"2006","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.resp.2010.09.001_bib0325","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S1567-7249(03)00084-9","article-title":"NADH-Ubiquinone oxidoreductase: substrate-dependent oxygen turnover to superoxide anion as a function of flavin mononucleotide","volume":"3","author":"Johnson","year":"2003","journal-title":"Mitochondrion"},{"key":"10.1016\/j.resp.2010.09.001_bib0330","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/BF02815202","article-title":"Oxidative stress and age-related neuronal deficits","volume":"28","author":"Joseph","year":"1996","journal-title":"Mol. Chem. Neuropathol."},{"key":"10.1016\/j.resp.2010.09.001_bib0335","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.atherosclerosis.2009.10.017","article-title":"Effect of intermittent hypoxia on atherosclerosis in apolipoprotein E-deficient mice","volume":"209","author":"Jun","year":"2010","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.resp.2010.09.001_bib0340","doi-asserted-by":"crossref","first-page":"3000","DOI":"10.1161\/STROKEAHA.107.489765","article-title":"NADPH oxidase plays a central role in blood\u2013brain barrier damage in experimental stroke","volume":"38","author":"Kahles","year":"2007","journal-title":"Stroke"},{"key":"10.1016\/j.resp.2010.09.001_bib0345","doi-asserted-by":"crossref","first-page":"C497","DOI":"10.1152\/ajpcell.00058.2010","article-title":"Dicarboxylate carrier-mediated glutathione transport is essential for reactive oxygen species homeostasis and normal respiration in rat brain mitochondria","volume":"299","author":"Kamga","year":"2010","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.resp.2010.09.001_bib0350","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1385\/MN:29:2:167","article-title":"Hydrogen peroxide as a diffusible signal molecule in synaptic plasticity","volume":"29","author":"Kamsler","year":"2004","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.resp.2010.09.001_bib0355","article-title":"NOX2 mediates intermittent hypoxia-induced mitochondrial complex i inhibition: relevance to blood pressure changes in rats","author":"Khan","year":"2010","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.resp.2010.09.001_bib0360","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1093\/sleep\/28.11.1412","article-title":"Apolipoprotein E-deficient mice exhibit increased vulnerability to intermittent hypoxia-induced spatial learning deficits","volume":"28","author":"Kheirandish","year":"2005","journal-title":"Sleep"},{"key":"10.1016\/j.resp.2010.09.001_bib0365","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1161\/01.HYP.0000163462.98381.7f","article-title":"Role of NAD(P)H oxidase- and mitochondria-derived reactive oxygen species in cardioprotection of ischemic reperfusion injury by angiotensin II","volume":"45","author":"Kimura","year":"2005","journal-title":"Hypertension"},{"key":"10.1016\/j.resp.2010.09.001_bib0370","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0014-5793(97)01159-9","article-title":"High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria","volume":"416","author":"Korshunov","year":"1997","journal-title":"FEBS Lett."},{"key":"10.1016\/j.resp.2010.09.001_bib0375","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1074\/jbc.M109.053058","article-title":"Constitutive reactive oxygen species generation from autophagosome\/lysosome in neuronal oxidative toxicity","volume":"285","author":"Kubota","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.resp.2010.09.001_bib0380","doi-asserted-by":"crossref","first-page":"4127","DOI":"10.1074\/jbc.M310341200","article-title":"Characterization of superoxide-producing sites in isolated brain mitochondria","volume":"279","author":"Kudin","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.resp.2010.09.001_bib0385","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1042\/bj20021121","article-title":"Complex I-mediated reactive oxygen species generation: modulation by cytochrome c and NAD(P)+ oxidation-reduction state","volume":"368","author":"Kushnareva","year":"2002","journal-title":"Biochem. J."},{"key":"10.1016\/j.resp.2010.09.001_bib0390","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/nri1312","article-title":"NOX enzymes and the biology of reactive oxygen","volume":"4","author":"Lambeth","year":"2004","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.resp.2010.09.001_bib0395","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1053\/smrv.2002.0261","article-title":"Obstructive sleep apnoea syndrome\u2014an oxidative stress disorder","volume":"7","author":"Lavie","year":"2003","journal-title":"Sleep Med. Rev."},{"key":"10.1016\/j.resp.2010.09.001_bib0400","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.1365-2869.2009.00789.x","article-title":"Heat-shock protein 70: expression in monocytes of patients with sleep apnoea and association with oxidative stress and tumour necrosis factor-alpha","volume":"19","author":"Lavie","year":"2010","journal-title":"J. Sleep Res."},{"key":"10.1016\/j.resp.2010.09.001_bib0405","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1183\/09031936.00086608","article-title":"Molecular mechanisms of cardiovascular disease in OSAHS: the oxidative stress link","volume":"33","author":"Lavie","year":"2009","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.resp.2010.09.001_bib0410","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1096\/fj.00-0608fje","article-title":"Genetic requirement of p47phox for superoxide production by murine microglia","volume":"15","author":"Lavigne","year":"2001","journal-title":"FASEB J."},{"key":"10.1016\/j.resp.2010.09.001_bib0415","doi-asserted-by":"crossref","first-page":"36228","DOI":"10.1074\/jbc.M606702200","article-title":"Link between mitochondria and NADPH oxidase 1 isozyme for the sustained production of reactive oxygen species and cell death","volume":"281","author":"Lee","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.resp.2010.09.001_bib0420","doi-asserted-by":"crossref","first-page":"8516","DOI":"10.1074\/jbc.M210432200","article-title":"Mitochondrial complex I inhibitor rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production","volume":"278","author":"Li","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.resp.2010.09.001_bib0425","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/nature05292","article-title":"Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases","volume":"443","author":"Lin","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.resp.2010.09.001_bib0430","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1046\/j.0022-3042.2002.00744.x","article-title":"Generation of reactive oxygen species by the mitochondrial electron transport chain","volume":"80","author":"Liu","year":"2002","journal-title":"J. Neurochem."},{"key":"10.1016\/j.resp.2010.09.001_bib0435","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1513\/pats.200708-135MG","article-title":"Epidemiology of pediatric obstructive sleep apnea","volume":"5","author":"Lumeng","year":"2008","journal-title":"Proc. Am. Thorac. Soc."},{"key":"10.1016\/j.resp.2010.09.001_bib0440","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1164\/rccm.200201-050OC","article-title":"Brain morphology associated with obstructive sleep apnea","volume":"166","author":"Macey","year":"2002","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.resp.2010.09.001_bib0445","first-page":"967","article-title":"Brain structural changes in obstructive sleep apnea","volume":"31","author":"Macey","year":"2008","journal-title":"Sleep"},{"key":"10.1016\/j.resp.2010.09.001_bib0450","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1113\/jphysiol.2008.165597","article-title":"NADPH oxidase activity is necessary for acute intermittent hypoxia-induced phrenic long-term facilitation","volume":"587","author":"MacFarlane","year":"2009","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2010.09.001_bib0455","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1016\/j.freeradbiomed.2010.03.008","article-title":"HIF-1 alpha signaling is augmented during intermittent hypoxia by induction of the Nrf2 pathway in NOX1-expressing adenocarcinoma A549 cells","volume":"48","author":"Malec","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.resp.2010.09.001_bib0460","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1016\/j.addr.2009.05.008","article-title":"Regulated production of free radicals by the mitochondrial electron transport chain: cardiac ischemic preconditioning","volume":"61","author":"Matsuzaki","year":"2009","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.resp.2010.09.001_bib0465","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0014-5793(75)80359-0","article-title":"The protonmotive Q cycle: a general formulation","volume":"59","author":"Mitchell","year":"1975","journal-title":"FEBS Lett."},{"key":"10.1016\/j.resp.2010.09.001_bib0470","doi-asserted-by":"crossref","first-page":"49064","DOI":"10.1074\/jbc.M407715200","article-title":"Complex III releases superoxide to both sides of the inner mitochondrial membrane","volume":"279","author":"Muller","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.resp.2010.09.001_bib0475","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.freeradbiomed.2005.08.044","article-title":"Phospholipase A2, reactive oxygen species, and lipid peroxidation in cerebral ischemia","volume":"40","author":"Muralikrishna Adibhatla","year":"2006","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.resp.2010.09.001_bib0480","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BJ20081386","article-title":"How mitochondria produce reactive oxygen species","volume":"417","author":"Murphy","year":"2009","journal-title":"Biochem. J."},{"key":"10.1016\/j.resp.2010.09.001_bib0485","doi-asserted-by":"crossref","first-page":"34402","DOI":"10.1074\/jbc.M103766200","article-title":"Tetrahydrobiopterin scavenges superoxide in dopaminergic neurons","volume":"276","author":"Nakamura","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.resp.2010.09.001_bib0490","doi-asserted-by":"crossref","first-page":"22999","DOI":"10.1074\/jbc.274.33.22999","article-title":"The p67(phox) activation domain regulates electron flow from NADPH to flavin in flavocytochrome b(558)","volume":"274","author":"Nisimoto","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.resp.2010.09.001_bib0495","doi-asserted-by":"crossref","first-page":"5144","DOI":"10.1073\/pnas.87.13.5144","article-title":"Oxidative damage to brain proteins, loss of glutamine synthetase activity, and production of free radicals during ischemia\/reperfusion-induced injury to gerbil brain","volume":"87","author":"Oliver","year":"1990","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.resp.2010.09.001_bib0500","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.mad.2010.02.005","article-title":"Mitochondrial redox metabolism: aging, longevity and dietary effects","volume":"131","author":"Page","year":"2010","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.resp.2010.09.001_bib0505","doi-asserted-by":"crossref","first-page":"4666","DOI":"10.4049\/jimmunol.0803392","article-title":"IL-13-induced oxidative stress via microglial NADPH oxidase contributes to death of hippocampal neurons in vivo","volume":"183","author":"Park","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.resp.2010.09.001_bib0510","doi-asserted-by":"crossref","first-page":"4903","DOI":"10.1523\/JNEUROSCI.4768-08.2009","article-title":"NADPH oxidase is required for the sensory plasticity of the carotid body by chronic intermittent hypoxia","volume":"29","author":"Peng","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.resp.2010.09.001_bib0515","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1513\/pats.200709-155MG","article-title":"The epidemiology of adult obstructive sleep apnea","volume":"5","author":"Punjabi","year":"2008","journal-title":"Proc. Am. Thorac. Soc."},{"key":"10.1016\/j.resp.2010.09.001_bib0520","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1074\/jbc.M307657200","article-title":"NADPH oxidase mediates lipopolysaccharide-induced neurotoxicity and proinflammatory gene expression in activated microglia","volume":"279","author":"Qin","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.resp.2010.09.001_bib0525","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1038\/jcbfm.2009.57","article-title":"Dynamic changes in brain bioenergetics during obstructive sleep apnea","volume":"29","author":"Rae","year":"2009","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.resp.2010.09.001_bib0530","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/S0891-5849(00)00338-5","article-title":"Superoxides from mitochondrial complex III: the role of manganese superoxide dismutase","volume":"29","author":"Raha","year":"2000","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.resp.2010.09.001_bib0535","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/j.freeradbiomed.2008.06.012","article-title":"Hypoxia activates NADPH oxidase to increase [ROS]i and [Ca2+]i through the mitochondrial ROS-PKCepsilon signaling axis in pulmonary artery smooth muscle cells","volume":"45","author":"Rathore","year":"2008","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.resp.2010.09.001_bib0540","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1164\/rccm.200209-1050OC","article-title":"Intermittent hypoxia is associated with oxidative stress and spatial learning deficits in the rat","volume":"167","author":"Row","year":"2003","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.resp.2010.09.001_bib0545","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1089\/ars.2009.2625","article-title":"Mechanisms and implications of reactive oxygen species generation during the unfolded protein response: roles of endoplasmic reticulum oxidoreductases, mitochondrial electron transport, and NADPH oxidase","volume":"11","author":"Santos","year":"2009","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.resp.2010.09.001_bib0550","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0272-5231(03)00014-5","article-title":"Neuropsychological impairment and quality of life in obstructive sleep apnea","volume":"24","author":"Sateia","year":"2003","journal-title":"Clin. Chest Med."},{"key":"10.1016\/j.resp.2010.09.001_bib0555","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1161\/CIRCRESAHA.109.205138","article-title":"NADPH oxidase Nox2 is required for hypoxia-induced mobilization of endothelial progenitor cells","volume":"105","author":"Schroder","year":"2009","journal-title":"Circ. Res."},{"key":"10.1016\/j.resp.2010.09.001_bib0560","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1146\/annurev.biophys.30.1.23","article-title":"Structures and proton-pumping strategies of mitochondrial respiratory enzymes","volume":"30","author":"Schultz","year":"2001","journal-title":"Annu. Rev. Biophys. Biomol. Struct."},{"key":"10.1016\/j.resp.2010.09.001_bib0565","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1164\/ajrccm.162.2.9908091","article-title":"Enhanced release of superoxide from polymorphonuclear neutrophils in obstructive sleep apnea. Impact of continuous positive airway pressure therapy","volume":"162","author":"Schulz","year":"2000","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.resp.2010.09.001_bib0570","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0006-8993(03)03364-X","article-title":"NADPH oxidase immunoreactivity in the mouse brain","volume":"988","author":"Serrano","year":"2003","journal-title":"Brain Res."},{"key":"10.1016\/j.resp.2010.09.001_bib0575","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.nbd.2007.07.013","article-title":"Manganese superoxide dismutase protects mouse cortical neurons from chronic intermittent hypoxia-mediated oxidative damage","volume":"28","author":"Shan","year":"2007","journal-title":"Neurobiol. Dis."},{"issue":"Spec No","key":"10.1016\/j.resp.2010.09.001_bib0580","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/0378-4274(92)90230-H","article-title":"Role of reactive oxygen species in cell toxicity","volume":"64\u201365","author":"Sies","year":"1992","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.resp.2010.09.001_bib0585","doi-asserted-by":"crossref","first-page":"44784","DOI":"10.1074\/jbc.M207217200","article-title":"Topology of superoxide production from different sites in the mitochondrial electron transport chain","volume":"277","author":"St-Pierre","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.resp.2010.09.001_bib0590","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1089\/ars.2008.2331","article-title":"Mitochondrial reactive oxygen species production in excitable cells: modulators of mitochondrial and cell function","volume":"11","author":"Stowe","year":"2009","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.resp.2010.09.001_bib0595","doi-asserted-by":"crossref","first-page":"RC53","DOI":"10.1523\/JNEUROSCI.20-01-j0006.2000","article-title":"NADPH oxidase contributes directly to oxidative stress and apoptosis in nerve growth factor-deprived sympathetic neurons","volume":"20","author":"Tammariello","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.resp.2010.09.001_bib0600","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.mcn.2005.01.007","article-title":"Synaptic localization of a functional NADPH oxidase in the mouse hippocampus","volume":"29","author":"Tejada-Simon","year":"2005","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.resp.2010.09.001_bib0605","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1113\/jphysiol.2003.049478","article-title":"Mitochondrial formation of reactive oxygen species","volume":"552","author":"Turrens","year":"2003","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2010.09.001_bib0610","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/0003-9861(85)90293-0","article-title":"Ubisemiquinone is the electron donor for superoxide formation by complex III of heart mitochondria","volume":"237","author":"Turrens","year":"1985","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.resp.2010.09.001_bib0615","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/0003-9861(82)90519-7","article-title":"Hyperoxia increases H2O2 release by lung mitochondria and microsomes","volume":"217","author":"Turrens","year":"1982","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.resp.2010.09.001_bib0620","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1093\/sleep\/27.2.194","article-title":"Long-term intermittent hypoxia in mice: protracted hypersomnolence with oxidative injury to sleep-wake brain regions","volume":"27","author":"Veasey","year":"2004","journal-title":"Sleep"},{"key":"10.1016\/j.resp.2010.09.001_bib0625","first-page":"64","article-title":"Sleep fragmentation differentially modifies EEG delta power during slow wave sleep in socially isolated and paired mice","volume":"2","author":"Vijay","year":"2009","journal-title":"Sleep Sci."},{"key":"10.1016\/j.resp.2010.09.001_bib0630","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1046\/j.1471-4159.2001.00548.x","article-title":"DeltaPsi(m)-Dependent and -independent production of reactive oxygen species by rat brain mitochondria","volume":"79","author":"Votyakova","year":"2001","journal-title":"J. Neurochem."},{"key":"10.1016\/j.resp.2010.09.001_bib0635","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1096\/fj.00-0300com","article-title":"Altered mitochondrial function and overgeneration of reactive oxygen species precede the induction of apoptosis by 1-O-octadecyl-2-methyl-rac-glycero-3-phosphocholine in p53-defective hepatocytes","volume":"15","author":"Vrablic","year":"2001","journal-title":"FASEB J."},{"key":"10.1016\/j.resp.2010.09.001_bib0640","first-page":"290","article-title":"Susceptibility of LDL to oxidative stress in obstructive sleep apnea","volume":"21","author":"Wali","year":"1998","journal-title":"Sleep"},{"key":"10.1016\/j.resp.2010.09.001_bib0645","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1089\/ars.2007.1969","article-title":"First evidence for a crosstalk between mitochondrial and NADPH oxidase-derived reactive oxygen species in nitroglycerin-triggered vascular dysfunction","volume":"10","author":"Wenzel","year":"2008","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.resp.2010.09.001_bib0650","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1089\/ars.2009.2392","article-title":"Cross-talk between mitochondria and NADPH oxidase: effects of mild mitochondrial dysfunction on angiotensin II-mediated increase in Nox isoform expression and activity in vascular smooth muscle cells","volume":"11","author":"Wosniak","year":"2009","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.resp.2010.09.001_bib0655","doi-asserted-by":"crossref","first-page":"12132","DOI":"10.1073\/pnas.0603670103","article-title":"The inflammatory NADPH oxidase enzyme modulates motor neuron degeneration in amyotrophic lateral sclerosis mice","volume":"103","author":"Wu","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.resp.2010.09.001_bib0660","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.freeradbiomed.2008.11.026","article-title":"Beta-cell death and proliferation after intermittent hypoxia: role of oxidative stress","volume":"46","author":"Xu","year":"2009","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.resp.2010.09.001_bib0665","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.neuroscience.2004.03.055","article-title":"Increased oxidative stress is associated with chronic intermittent hypoxia-mediated brain cortical neuronal cell apoptosis in a mouse model of sleep apnea","volume":"126","author":"Xu","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.resp.2010.09.001_bib0670","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2133\/dmpk.20.1","article-title":"Possible involvement of singlet oxygen species as multiple oxidants in p450 catalytic reactions","volume":"20","author":"Yasui","year":"2005","journal-title":"Drug Metab. Pharmacokinet."},{"key":"10.1016\/j.resp.2010.09.001_bib0675","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1164\/rccm.200504-581OC","article-title":"NADPH oxidase mediates hypersomnolence and brain oxidative injury in a murine model of sleep apnea","volume":"172","author":"Zhan","year":"2005","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.resp.2010.09.001_bib0680","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.bbabio.2006.04.029","article-title":"Mitochondrial ROS-induced ROS release: an update and review","volume":"1757","author":"Zorov","year":"2006","journal-title":"Biochim. Biophys. Acta"}],"container-title":["Respiratory Physiology &amp; Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904810003460?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904810003460?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T22:22:23Z","timestamp":1761603743000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569904810003460"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12]]},"references-count":136,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["S1569904810003460"],"URL":"https:\/\/doi.org\/10.1016\/j.resp.2010.09.001","relation":{},"ISSN":["1569-9048"],"issn-type":[{"value":"1569-9048","type":"print"}],"subject":[],"published":{"date-parts":[[2010,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reactive oxygen species and the brain in sleep apnea","name":"articletitle","label":"Article Title"},{"value":"Respiratory Physiology & Neurobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resp.2010.09.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}