{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T18:21:31Z","timestamp":1767982891996,"version":"3.49.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Wright State University Research Challenge"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Physiology & Neurobiology"],"published-print":{"date-parts":[[2011,1]]},"DOI":"10.1016\/j.resp.2010.09.013","type":"journal-article","created":{"date-parts":[[2010,9,25]],"date-time":"2010-09-25T04:43:58Z","timestamp":1285389838000},"page":"90-96","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Inhibition of adenylate cyclase attenuates muscarinic Ca2+ signaling by a PKA-independent mechanism in rat carotid body Type I cells"],"prefix":"10.1016","volume":"175","author":[{"given":"Carrie M.","family":"Thompson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher N.","family":"Wyatt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.resp.2010.09.013_bib0005","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1038\/302832a0","article-title":"Auto-inhibition of brain histamine release mediated by a novel class (H3) of histamine receptor","volume":"302","author":"Arrang","year":"1983","journal-title":"Nature"},{"key":"10.1016\/j.resp.2010.09.013_bib0010","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1152\/japplphysiol.91590.2008","article-title":"Contribution of the carotid body chemoreceptors to eupneic ventilation in the intact, unanesthetized dog","volume":"106","author":"Blain","year":"2009","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.resp.2010.09.013_bib0015","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/nrm1197","article-title":"Epac: a new cAMP target and new avenues in cAMP research","volume":"4","author":"Bos","year":"2003","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"10.1016\/j.resp.2010.09.013_bib0020","doi-asserted-by":"crossref","first-page":"2444","DOI":"10.1073\/pnas.68.10.2444","article-title":"Interaction of the subunits of adenosine 3\u2032:5\u2032-cyclic monophosphate-dependent protein kinase of muscle","volume":"68","author":"Brostrom","year":"1971","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.resp.2010.09.013_bib0025","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.resp.2009.07.002","article-title":"Presynaptic regulation of isolated neonatal rat carotid body type I cells by histamine","volume":"168","author":"Burlon","year":"2009","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2010.09.013_bib0030","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1111\/j.1471-4159.2008.05704.x","article-title":"An antagonistic interaction between A2B adenosine and D2 dopamine receptors modulates the function of rat carotid body chemoreceptor cells","volume":"107","author":"Conde","year":"2008","journal-title":"J. Neurochem."},{"issue":"Pt 2","key":"10.1016\/j.resp.2010.09.013_bib0035","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1113\/jphysiol.1997.sp021861","article-title":"Muscarinic and nicotinic receptors raise intracellular Ca2+ levels in rat carotid body type I cells","volume":"498","author":"Dasso","year":"1997","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2010.09.013_bib0040","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/24884","article-title":"Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP","volume":"396","author":"de Rooij","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.resp.2010.09.013_bib0045","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.resp.2008.09.005","article-title":"Modulatory effects of histamine on cat carotid body chemoreception","volume":"164","author":"Del Rio","year":"2008","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2010.09.013_bib0050","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s004180050256","article-title":"Golgi-disturbing agents","volume":"109","author":"Dinter","year":"1998","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.resp.2010.09.013_bib0055","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1113\/jphysiol.1965.sp007637","article-title":"Presence of acetylcholine and transmitter release from carotid body chemoreceptors","volume":"178","author":"Eyzaguirre","year":"1965","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2010.09.013_bib0060","doi-asserted-by":"crossref","first-page":"7991","DOI":"10.1523\/JNEUROSCI.0268-08.2008","article-title":"Application of an Epac activator enhances neurotransmitter release at excitatory central synapses","volume":"28","author":"Gekel","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.resp.2010.09.013_bib0065","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1146\/annurev.pa.20.040180.002051","article-title":"Protein phosphorylation catalyzed by cyclic AMP-dependent and cyclic GMP-dependent protein kinases","volume":"20","author":"Glass","year":"1980","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.resp.2010.09.013_bib0070","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1152\/physrev.1994.74.4.829","article-title":"Carotid body chemoreceptors: from natural stimuli to sensory discharges","volume":"74","author":"Gonzalez","year":"1994","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.resp.2010.09.013_bib0075","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1113\/jphysiol.2006.119644","article-title":"Cell physiology of cAMP sensor Epac","volume":"577","author":"Holz","year":"2006","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2010.09.013_bib0080","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1113\/jphysiol.2005.087510","article-title":"A cAMP and Ca2+ coincidence detector in support of Ca2+-induced Ca2+ release in mouse pancreatic beta cells","volume":"566","author":"Kang","year":"2005","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2010.09.013_bib0085","doi-asserted-by":"crossref","first-page":"8279","DOI":"10.1074\/jbc.M211682200","article-title":"Epac-selective cAMP analog 8-pCPT-2\u2032-O-Me-cAMP as a stimulus for Ca2+-induced Ca2+ release and exocytosis in pancreatic beta-cells","volume":"278","author":"Kang","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.resp.2010.09.013_bib0090","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1126\/science.282.5397.2275","article-title":"A family of cAMP-binding proteins that directly activate Rap1","volume":"282","author":"Kawasaki","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.resp.2010.09.013_bib0095","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1111\/j.1471-4159.2004.02740.x","article-title":"Evidence for histamine as a transmitter in rat carotid body sensor cells","volume":"91","author":"Koerner","year":"2004","journal-title":"J. Neurochem."},{"key":"10.1016\/j.resp.2010.09.013_bib0100","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0034-5687(99)00017-1","article-title":"Acetylcholine contributes to hypoxic chemotransmission in co-cultures of rat type 1 cells and petrosal neurons","volume":"115","author":"Nurse","year":"1999","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.resp.2010.09.013_bib0105","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.brainres.2010.01.091","article-title":"Muscarinic modulation of TASK-like background potassium channel in rat carotid body chemoreceptor cells","volume":"1323","author":"Ortiz","year":"2010","journal-title":"Brain Res."},{"key":"10.1016\/j.resp.2010.09.013_bib0110","doi-asserted-by":"crossref","first-page":"5298","DOI":"10.1093\/emboj\/17.18.5298","article-title":"The Golgi apparatus is an inositol 1,4,5-trisphosphate-sensitive Ca2+ store, with functional properties distinct from those of the endoplasmic reticulum","volume":"17","author":"Pinton","year":"1998","journal-title":"Embo J."},{"key":"10.1016\/j.resp.2010.09.013_bib0115","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1016\/S0021-9258(19)77178-6","article-title":"Purification and properties of rabbit skeletal muscle adenosine 3\u2032,5\u2032-monophosphate-dependent protein kinases","volume":"246","author":"Reimann","year":"1971","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.resp.2010.09.013_bib0120","doi-asserted-by":"crossref","first-page":"4015","DOI":"10.1113\/jphysiol.2009.172072","article-title":"EPAC signalling pathways are involved in low PO2 chemoreception in carotid body chemoreceptor cells","volume":"587","author":"Rocher","year":"2009","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2010.09.013_bib0125","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.resp.2006.12.010","article-title":"Role of acetylcholine in neurotransmission of the carotid body","volume":"157","author":"Shirahata","year":"2007","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.resp.2010.09.013_bib0130","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1113\/jphysiol.2008.157461","article-title":"Epac mediates PACAP-dependent long-term depression in the hippocampus","volume":"587","author":"Ster","year":"2009","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2010.09.013_bib0135","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.neulet.2009.12.077","article-title":"Evidence for functional, inhibitory, histamine H3 receptors in rat carotid body Type I cells","volume":"471","author":"Thompson","year":"2010","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.resp.2010.09.013_bib0140","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.ceca.2005.07.003","article-title":"Cytosolic Ca2+ signals depending on the functional state of the Golgi in HeLa cells","volume":"38","author":"Vanoevelen","year":"2005","journal-title":"Cell Calcium"},{"key":"10.1016\/j.resp.2010.09.013_bib0145","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1002\/cbic.200800216","article-title":"8-pCPT-2\u2032-O-Me-cAMP-AM: an improved Epac-selective cAMP analogue","volume":"9","author":"Vliem","year":"2008","journal-title":"Chembiochem"},{"key":"10.1016\/j.resp.2010.09.013_bib0150","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/0304-3940(89)90030-X","article-title":"Effects of hypoxia on cyclic nucleotide formation in rabbit carotid body in vitro","volume":"105","author":"Wang","year":"1989","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.resp.2010.09.013_bib0155","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/0306-4522(93)90399-Z","article-title":"Nicotinic acetylcholine receptors in isolated type I cells of the neonatal rat carotid body","volume":"54","author":"Wyatt","year":"1993","journal-title":"Neuroscience"},{"key":"10.1016\/j.resp.2010.09.013_bib0160","doi-asserted-by":"crossref","first-page":"C1592","DOI":"10.1152\/ajpcell.00546.2005","article-title":"Adenosine stimulates depolarization and rise in cytoplasmic [Ca2+] in type I cells of rat carotid bodies","volume":"290","author":"Xu","year":"2006","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"Pt 1","key":"10.1016\/j.resp.2010.09.013_bib0165","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.1469-7793.2000.t01-1-00143.x","article-title":"Co-release of ATP and ACh mediates hypoxic signalling at rat carotid body chemoreceptors","volume":"525","author":"Zhang","year":"2000","journal-title":"J. Physiol."},{"key":"10.1016\/j.resp.2010.09.013_bib0170","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1523\/JNEUROSCI.3703-04.2005","article-title":"cAMP acts on exchange protein activated by cAMP\/cAMP-regulated guanine nucleotide exchange protein to regulate transmitter release at the crayfish neuromuscular junction","volume":"25","author":"Zhong","year":"2005","journal-title":"J. Neurosci."}],"container-title":["Respiratory Physiology & Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904810003691?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1569904810003691?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T22:22:40Z","timestamp":1761603760000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1569904810003691"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,1]]}},"alternative-id":["S1569904810003691"],"URL":"https:\/\/doi.org\/10.1016\/j.resp.2010.09.013","relation":{},"ISSN":["1569-9048"],"issn-type":[{"value":"1569-9048","type":"print"}],"subject":[],"published":{"date-parts":[[2011,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibition of adenylate cyclase attenuates muscarinic Ca2+ signaling by a PKA-independent mechanism in rat carotid body Type I cells","name":"articletitle","label":"Article Title"},{"value":"Respiratory Physiology & Neurobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resp.2010.09.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}